Details of the Target

General Information of Target

Target ID LDTP04959
Target Name Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)
Gene Name PPP1CA
Gene ID 5499
Synonyms
PPP1A; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; PP-1A; EC 3.1.3.16
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLK
ICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFL
LRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDL
QSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHD
LDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
KNKGKYGQFSGLNPGGRPITPPRNSAKAKK
Target Type
Successful
Target Bioclass
Enzyme
Family
PPP phosphatase family, PP-1 subfamily
Subcellular location
Cytoplasm
Function
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Dephosphorylates CENPA. Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy.; (Microbial infection) Necessary for alphaviruses replication.
TTD ID
T59845
Uniprot ID
P62136
DrugMap ID
TTFLH0E
Ensemble ID
ENST00000312989.11
HGNC ID
HGNC:9281
ChEMBL ID
CHEMBL2164

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 Deletion: p.F225YfsTer52 .
CAMA1 SNV: p.E5K; p.E116K .
J82 SNV: p.Q49E .
MOLT4 SNV: p.V28I; p.D203N; p.D242N IA-alkyne    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.87  LDD0402  [1]
A-EBA
 Probe Info  		5.84  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
N1
 Probe Info  		3.81  LDD0242  [3]
TH211
 Probe Info  		Y137(13.63); Y134(12.00)  LDD0257  [4]
TH216
 Probe Info  		Y134(20.00); Y70(11.65)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K147(1.30); K26(1.49); K305(1.21)  LDD0277  [6]
OPA-S-S-alkyne
 Probe Info  		K141(2.78)  LDD3494  [7]
Probe 1
 Probe Info  		Y306(5.51)  LDD3495  [8]
SAHA-CA-4PAP
 Probe Info  		4.00  LDD0360  [9]
AHL-Pu-1
 Probe Info  		C127(2.29)  LDD0169  [10]
DBIA
 Probe Info  		C202(4.72); C172(5.46)  LDD0209  [11]
HHS-482
 Probe Info  		Y134(0.66); Y137(0.99)  LDD0285  [12]
HHS-475
 Probe Info  		Y70(0.59); Y306(0.67); Y137(0.68); Y255(0.89)  LDD0264  [13]
HHS-465
 Probe Info  		Y134(10.00); Y137(10.00); Y306(7.17)  LDD2237  [14]
ATP probe
 Probe Info  		K26(0.00); K6(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C245(0.00); C105(0.00); C127(0.00); C62(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C171(0.00); C140(0.00); C155(0.00); C202(0.00)  LDD0032  [17]
IPIAA_H
 Probe Info  		C245(0.00); C105(0.00); C171(0.00); C127(0.00)  LDD0030  [18]
IPIAA_L
 Probe Info  		C245(0.00); C202(0.00); C62(0.00); C140(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C245(0.00); C105(0.00); C62(0.00); C171(0.00)  LDD0037  [16]
BTD
 Probe Info  		N.A.  LDD0004  [19]
JW-RF-010
 Probe Info  		C140(0.00); C127(0.00)  LDD0026  [20]
TFBX
 Probe Info  		N.A.  LDD0027  [20]
WYneN
 Probe Info  		C245(0.00); C127(0.00)  LDD0021  [19]
ENE
 Probe Info  		N.A.  LDD0006  [19]
IPM
 Probe Info  		N.A.  LDD0005  [19]
NHS
 Probe Info  		K260(0.00); K6(0.00); K147(0.00)  LDD0010  [19]
SF
 Probe Info  		Y134(0.00); Y255(0.00); Y137(0.00); Y70(0.00)  LDD0028  [21]
Acrolein
 Probe Info  		C171(0.00); C127(0.00); C140(0.00); C158(0.00)  LDD0217  [22]
Cinnamaldehyde
 Probe Info  		C127(0.00); C245(0.00); H125(0.00)  LDD0220  [22]
Crotonaldehyde
 Probe Info  		C140(0.00); C127(0.00); H173(0.00); C245(0.00)  LDD0219  [22]
Methacrolein
 Probe Info  		C171(0.00); C127(0.00); C140(0.00); C245(0.00)  LDD0218  [22]
W1
 Probe Info  		N.A.  LDD0236  [23]
AOyne
 Probe Info  		5.30  LDD0443  [24]
NAIA_5
 Probe Info  		C202(0.00); C39(0.00)  LDD2223  [25]
TER-AC
 Probe Info  		N.A.  LDD0426  [26]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe2
 Probe Info  		5.27  LDD0463  [27]
STS-2
 Probe Info  		N.A.  LDD0139  [28]
VE-P
 Probe Info  		N.A.  LDD0396  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C127(1.32)  LDD2103  [30]
 LDCM0025  4SU-RNA DM93 C62(2.32); C171(10.47)  LDD0170  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C127(2.29)  LDD0169  [10]
 LDCM0214  AC1 HEK-293T C127(1.03); C245(0.94); C140(0.92); C62(1.01)  LDD1507  [31]
 LDCM0215  AC10 HEK-293T C127(0.93); C245(1.03); C140(1.00); C62(0.98)  LDD1508  [31]
 LDCM0226  AC11 HEK-293T C127(1.03); C245(1.04); C140(1.05); C62(1.04)  LDD1509  [31]
 LDCM0237  AC12 HEK-293T C127(1.02); C245(0.99); C140(0.90); C62(0.99)  LDD1510  [31]
 LDCM0259  AC14 HEK-293T C127(1.01); C245(0.93); C140(0.95); C62(0.92)  LDD1512  [31]
 LDCM0270  AC15 HEK-293T C127(1.00); C245(0.82); C140(0.98); C62(0.98)  LDD1513  [31]
 LDCM0276  AC17 HEK-293T C127(1.05); C245(0.88); C140(1.04); C62(0.99)  LDD1515  [31]
 LDCM0277  AC18 HEK-293T C127(0.93); C245(1.00); C140(1.04); C62(1.02)  LDD1516  [31]
 LDCM0278  AC19 HEK-293T C127(1.01); C245(1.12); C140(1.00); C62(1.06)  LDD1517  [31]
 LDCM0279  AC2 HEK-293T C127(0.95); C245(0.99); C140(1.01); C62(1.02)  LDD1518  [31]
 LDCM0280  AC20 HEK-293T C127(0.99); C245(0.94); C140(0.92); C62(0.97)  LDD1519  [31]
 LDCM0281  AC21 HEK-293T C127(0.99); C245(0.94); C140(1.02); C62(1.09)  LDD1520  [31]
 LDCM0282  AC22 HEK-293T C127(1.00); C245(0.99); C140(0.93); C62(0.95)  LDD1521  [31]
 LDCM0283  AC23 HEK-293T C127(0.93); C245(0.86); C140(1.01); C62(1.06)  LDD1522  [31]
 LDCM0284  AC24 HEK-293T C127(0.98); C245(0.99); C140(0.95); C62(0.96)  LDD1523  [31]
 LDCM0285  AC25 HEK-293T C127(1.05); C245(1.02); C140(0.96); C62(0.95)  LDD1524  [31]
 LDCM0286  AC26 HEK-293T C127(1.00); C245(1.01); C140(1.03); C62(1.03)  LDD1525  [31]
 LDCM0287  AC27 HEK-293T C127(1.01); C245(1.00); C140(1.08); C62(1.16)  LDD1526  [31]
 LDCM0288  AC28 HEK-293T C127(0.99); C245(0.90); C140(0.93); C62(1.02)  LDD1527  [31]
 LDCM0289  AC29 HEK-293T C127(1.09); C245(0.91); C140(0.94); C62(1.01)  LDD1528  [31]
 LDCM0290  AC3 HEK-293T C127(1.00); C245(1.04); C140(1.03); C62(1.11)  LDD1529  [31]
 LDCM0291  AC30 HEK-293T C127(1.01); C245(1.01); C140(0.97); C62(1.10)  LDD1530  [31]
 LDCM0292  AC31 HEK-293T C127(1.02); C245(0.84); C140(1.00); C62(1.03)  LDD1531  [31]
 LDCM0293  AC32 HEK-293T C127(1.01); C245(1.00); C140(0.99); C62(1.04)  LDD1532  [31]
 LDCM0294  AC33 HEK-293T C127(1.05); C245(0.96); C140(0.94); C62(0.92)  LDD1533  [31]
 LDCM0295  AC34 HEK-293T C127(0.93); C245(0.98); C140(0.96); C62(1.06)  LDD1534  [31]
 LDCM0296  AC35 HEK-293T C127(0.98); C245(0.94); C140(1.01); C62(1.05)  LDD1535  [31]
 LDCM0297  AC36 HEK-293T C127(0.99); C245(0.97); C140(0.86); C62(0.99)  LDD1536  [31]
 LDCM0298  AC37 HEK-293T C127(1.00); C245(0.92); C140(0.94); C62(0.94)  LDD1537  [31]
 LDCM0299  AC38 HEK-293T C127(0.98); C245(0.94); C140(0.99); C62(0.96)  LDD1538  [31]
 LDCM0300  AC39 HEK-293T C127(0.96); C245(1.17); C140(0.92); C62(0.98)  LDD1539  [31]
 LDCM0301  AC4 HEK-293T C127(0.98); C245(0.93); C140(0.90); C62(1.06)  LDD1540  [31]
 LDCM0302  AC40 HEK-293T C127(0.97); C245(1.04); C140(0.98); C62(0.98)  LDD1541  [31]
 LDCM0303  AC41 HEK-293T C127(0.98); C245(0.86); C140(0.89); C62(1.01)  LDD1542  [31]
 LDCM0304  AC42 HEK-293T C127(0.95); C245(0.98); C140(0.93); C62(0.92)  LDD1543  [31]
 LDCM0305  AC43 HEK-293T C127(0.99); C245(1.05); C140(1.03); C62(0.96)  LDD1544  [31]
 LDCM0306  AC44 HEK-293T C127(1.00); C245(0.94); C140(0.96); C62(0.93)  LDD1545  [31]
 LDCM0307  AC45 HEK-293T C127(0.97); C245(0.95); C140(0.90); C62(0.94)  LDD1546  [31]
 LDCM0308  AC46 HEK-293T C127(0.98); C245(0.92); C140(0.94); C62(0.93)  LDD1547  [31]
 LDCM0309  AC47 HEK-293T C127(0.97); C245(0.87); C140(0.91); C62(1.01)  LDD1548  [31]
 LDCM0310  AC48 HEK-293T C127(0.98); C245(0.96); C140(0.90); C62(0.98)  LDD1549  [31]
 LDCM0311  AC49 HEK-293T C127(1.00); C245(0.95); C140(0.93); C62(1.02)  LDD1550  [31]
 LDCM0312  AC5 HEK-293T C127(1.04); C245(0.91); C140(0.91); C62(1.02)  LDD1551  [31]
 LDCM0313  AC50 HEK-293T C127(0.94); C245(1.03); C140(0.98); C62(1.17)  LDD1552  [31]
 LDCM0314  AC51 HEK-293T C127(0.98); C245(1.00); C140(1.02); C62(1.00)  LDD1553  [31]
 LDCM0315  AC52 HEK-293T C127(0.96); C245(1.02); C140(0.92); C62(1.05)  LDD1554  [31]
 LDCM0316  AC53 HEK-293T C127(0.96); C245(0.90); C140(0.90); C62(0.93)  LDD1555  [31]
 LDCM0317  AC54 HEK-293T C127(0.99); C245(0.99); C140(0.93); C62(1.04)  LDD1556  [31]
 LDCM0318  AC55 HEK-293T C127(0.94); C245(0.95); C140(0.94); C62(0.98)  LDD1557  [31]
 LDCM0319  AC56 HEK-293T C127(0.96); C245(0.93); C140(0.95); C62(0.97)  LDD1558  [31]
 LDCM0320  AC57 HEK-293T C127(0.96); C245(0.86); C140(0.90); C62(0.95)  LDD1559  [31]
 LDCM0321  AC58 HEK-293T C127(0.95); C245(1.00); C140(0.97); C62(1.01)  LDD1560  [31]
 LDCM0322  AC59 HEK-293T C127(0.95); C245(0.96); C140(1.05); C62(0.97)  LDD1561  [31]
 LDCM0323  AC6 HEK-293T C127(0.99); C245(0.99); C140(0.96); C62(0.95)  LDD1562  [31]
 LDCM0324  AC60 HEK-293T C127(0.97); C245(0.88); C140(0.85); C62(1.03)  LDD1563  [31]
 LDCM0325  AC61 HEK-293T C127(0.96); C245(0.93); C140(0.88); C62(0.97)  LDD1564  [31]
 LDCM0326  AC62 HEK-293T C127(1.02); C245(1.01); C140(1.01); C62(0.97)  LDD1565  [31]
 LDCM0327  AC63 HEK-293T C127(0.96); C245(0.83); C140(0.96); C62(0.95)  LDD1566  [31]
 LDCM0328  AC64 HEK-293T C127(0.94); C245(0.96); C140(0.94); C62(0.94)  LDD1567  [31]
 LDCM0334  AC7 HEK-293T C127(0.91); C245(1.02); C140(0.89); C62(1.01)  LDD1568  [31]
 LDCM0345  AC8 HEK-293T C127(1.03); C245(0.99); C140(0.98); C62(1.00)  LDD1569  [31]
 LDCM0520  AKOS000195272 MDA-MB-231 C62(1.02)  LDD2113  [30]
 LDCM0248  AKOS034007472 HEK-293T C127(0.98); C245(0.89); C140(0.89); C62(0.94)  LDD1511  [31]
 LDCM0356  AKOS034007680 HEK-293T C127(1.02); C245(0.89); C140(0.90); C62(1.05)  LDD1570  [31]
 LDCM0275  AKOS034007705 HEK-293T C127(1.01); C245(1.04); C140(0.91); C62(0.89)  LDD1514  [31]
 LDCM0156  Aniline NCI-H1299 11.60  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C171(0.00); C245(0.00); C140(0.00); C127(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C127(0.99)  LDD2227  [25]
 LDCM0367  CL1 HEK-293T C127(0.96); C245(1.01); C140(1.02); C62(0.96)  LDD1571  [31]
 LDCM0368  CL10 HEK-293T C127(1.11); C245(1.02); C140(0.72); C62(0.94)  LDD1572  [31]
 LDCM0369  CL100 HEK-293T C127(1.03); C245(0.90); C140(0.99); C62(0.97)  LDD1573  [31]
 LDCM0370  CL101 HEK-293T C127(0.99); C245(0.99); C140(1.00); C62(0.95)  LDD1574  [31]
 LDCM0371  CL102 HEK-293T C127(1.01); C245(0.95); C140(0.93); C62(0.86)  LDD1575  [31]
 LDCM0372  CL103 HEK-293T C127(0.99); C140(1.01); C62(1.00); C105(1.04)  LDD1576  [31]
 LDCM0373  CL104 HEK-293T C127(1.02); C245(0.99); C140(1.00); C62(1.02)  LDD1577  [31]
 LDCM0374  CL105 HEK-293T C127(0.97); C245(1.01); C140(1.02); C62(0.92)  LDD1578  [31]
 LDCM0375  CL106 HEK-293T C127(1.00); C245(1.01); C140(0.96); C62(0.98)  LDD1579  [31]
 LDCM0376  CL107 HEK-293T C127(1.01); C140(1.04); C62(1.03); C105(1.05)  LDD1580  [31]
 LDCM0377  CL108 HEK-293T C127(1.00); C245(0.99); C140(1.00); C62(1.02)  LDD1581  [31]
 LDCM0378  CL109 HEK-293T C127(1.02); C245(1.03); C140(1.01); C62(1.01)  LDD1582  [31]
 LDCM0379  CL11 HEK-293T C127(1.05); C245(0.87); C140(0.84); C62(1.04)  LDD1583  [31]
 LDCM0380  CL110 HEK-293T C127(1.01); C245(0.96); C140(0.95); C62(0.90)  LDD1584  [31]
 LDCM0381  CL111 HEK-293T C127(1.05); C140(0.86); C62(1.05); C105(1.09)  LDD1585  [31]
 LDCM0382  CL112 HEK-293T C127(1.00); C245(1.03); C140(0.97); C62(0.98)  LDD1586  [31]
 LDCM0383  CL113 HEK-293T C127(1.01); C245(0.98); C140(1.05); C62(1.00)  LDD1587  [31]
 LDCM0384  CL114 HEK-293T C127(0.98); C245(0.95); C140(0.92); C62(0.93)  LDD1588  [31]
 LDCM0385  CL115 HEK-293T C127(0.95); C140(1.01); C62(0.98); C105(1.03)  LDD1589  [31]
 LDCM0386  CL116 HEK-293T C127(0.95); C245(0.92); C140(1.02); C62(1.01)  LDD1590  [31]
 LDCM0387  CL117 HEK-293T C127(0.95); C245(0.96); C140(1.02); C62(0.94)  LDD1591  [31]
 LDCM0388  CL118 HEK-293T C127(0.96); C245(0.93); C140(0.98); C62(0.94)  LDD1592  [31]
 LDCM0389  CL119 HEK-293T C127(0.96); C140(0.98); C62(1.01); C105(1.05)  LDD1593  [31]
 LDCM0390  CL12 HEK-293T C127(1.01); C245(1.17); C140(0.82); C62(1.02)  LDD1594  [31]
 LDCM0391  CL120 HEK-293T C127(0.95); C245(0.97); C140(1.01); C62(0.99)  LDD1595  [31]
 LDCM0392  CL121 HEK-293T C127(0.96); C245(1.02); C140(1.03); C62(0.98)  LDD1596  [31]
 LDCM0393  CL122 HEK-293T C127(1.03); C245(0.90); C140(0.96); C62(0.98)  LDD1597  [31]
 LDCM0394  CL123 HEK-293T C127(0.95); C140(0.92); C62(0.98); C105(1.02)  LDD1598  [31]
 LDCM0395  CL124 HEK-293T C127(0.92); C245(1.01); C140(1.00); C62(1.02)  LDD1599  [31]
 LDCM0396  CL125 HEK-293T C127(0.93); C245(1.03); C140(1.13); C62(0.96)  LDD1600  [31]
 LDCM0397  CL126 HEK-293T C127(0.95); C245(1.01); C140(1.06); C62(0.93)  LDD1601  [31]
 LDCM0398  CL127 HEK-293T C127(0.96); C140(1.05); C62(0.95); C105(1.10)  LDD1602  [31]
 LDCM0399  CL128 HEK-293T C127(0.97); C245(0.92); C140(1.03); C62(1.04)  LDD1603  [31]
 LDCM0400  CL13 HEK-293T C127(0.92); C245(0.93); C140(1.02); C62(0.98)  LDD1604  [31]
 LDCM0401  CL14 HEK-293T C127(1.01); C245(0.96); C140(1.01); C62(1.01)  LDD1605  [31]
 LDCM0402  CL15 HEK-293T C127(0.96); C140(0.95); C62(0.90); C105(1.15)  LDD1606  [31]
 LDCM0403  CL16 HEK-293T C127(1.04); C245(0.99); C140(1.07); C62(1.05)  LDD1607  [31]
 LDCM0404  CL17 HEK-293T C127(1.11); C245(0.81); C140(0.93); C62(1.02)  LDD1608  [31]
 LDCM0405  CL18 HEK-293T C127(1.01); C245(1.07); C140(0.97); C62(1.02)  LDD1609  [31]
 LDCM0406  CL19 HEK-293T C127(1.00); C245(0.97); C140(0.95); C62(1.05)  LDD1610  [31]
 LDCM0407  CL2 HEK-293T C127(1.04); C245(0.98); C140(0.99); C62(1.03)  LDD1611  [31]
 LDCM0408  CL20 HEK-293T C127(0.96); C245(0.97); C140(0.97); C62(0.95)  LDD1612  [31]
 LDCM0409  CL21 HEK-293T C127(0.96); C245(0.88); C140(0.98); C62(0.90)  LDD1613  [31]
 LDCM0410  CL22 HEK-293T C127(1.11); C245(0.99); C140(0.81); C62(0.97)  LDD1614  [31]
 LDCM0411  CL23 HEK-293T C127(1.02); C245(0.96); C140(0.79); C62(1.00)  LDD1615  [31]
 LDCM0412  CL24 HEK-293T C127(1.03); C245(1.13); C140(0.80); C62(0.97)  LDD1616  [31]
 LDCM0413  CL25 HEK-293T C127(1.03); C245(1.06); C140(1.09); C62(1.14)  LDD1617  [31]
 LDCM0414  CL26 HEK-293T C127(1.09); C245(1.05); C140(1.04); C62(0.98)  LDD1618  [31]
 LDCM0415  CL27 HEK-293T C127(1.00); C140(0.98); C62(1.08); C105(1.16)  LDD1619  [31]
 LDCM0416  CL28 HEK-293T C127(1.05); C245(0.93); C140(1.02); C62(0.98)  LDD1620  [31]
 LDCM0417  CL29 HEK-293T C127(1.08); C245(1.08); C140(1.05); C62(1.04)  LDD1621  [31]
 LDCM0418  CL3 HEK-293T C127(0.98); C140(1.07); C62(1.11); C105(1.01)  LDD1622  [31]
 LDCM0419  CL30 HEK-293T C127(1.01); C245(1.06); C140(0.98); C62(1.05)  LDD1623  [31]
 LDCM0420  CL31 HEK-293T C127(1.03); C245(1.12); C140(0.89); C62(0.97)  LDD1624  [31]
 LDCM0421  CL32 HEK-293T C127(1.02); C245(1.00); C140(1.01); C62(0.98)  LDD1625  [31]
 LDCM0422  CL33 HEK-293T C127(0.93); C245(1.01); C140(0.94); C62(0.95)  LDD1626  [31]
 LDCM0423  CL34 HEK-293T C127(1.07); C245(1.12); C140(0.72); C62(0.96)  LDD1627  [31]
 LDCM0424  CL35 HEK-293T C127(1.07); C245(1.03); C140(0.80); C62(0.99)  LDD1628  [31]
 LDCM0425  CL36 HEK-293T C127(1.00); C245(1.06); C140(0.83); C62(0.92)  LDD1629  [31]
 LDCM0426  CL37 HEK-293T C127(1.06); C245(1.10); C140(1.12); C62(1.05)  LDD1630  [31]
 LDCM0428  CL39 HEK-293T C127(1.00); C140(0.94); C62(0.93); C105(0.95)  LDD1632  [31]
 LDCM0429  CL4 HEK-293T C127(1.03); C245(1.00); C140(1.09); C62(1.07)  LDD1633  [31]
 LDCM0430  CL40 HEK-293T C127(1.07); C245(0.92); C140(1.01); C62(1.06)  LDD1634  [31]
 LDCM0431  CL41 HEK-293T C127(1.01); C245(0.88); C140(0.96); C62(0.96)  LDD1635  [31]
 LDCM0432  CL42 HEK-293T C127(0.98); C245(1.11); C140(0.97); C62(1.02)  LDD1636  [31]
 LDCM0433  CL43 HEK-293T C127(1.07); C245(1.03); C140(0.94); C62(1.04)  LDD1637  [31]
 LDCM0434  CL44 HEK-293T C127(1.02); C245(1.11); C140(0.94); C62(0.92)  LDD1638  [31]
 LDCM0435  CL45 HEK-293T C127(1.02); C245(0.95); C140(0.99); C62(0.98)  LDD1639  [31]
 LDCM0436  CL46 HEK-293T C127(1.06); C245(0.94); C140(0.73); C62(0.98)  LDD1640  [31]
 LDCM0437  CL47 HEK-293T C127(1.08); C245(0.94); C140(0.76); C62(0.96)  LDD1641  [31]
 LDCM0438  CL48 HEK-293T C127(1.07); C245(1.07); C140(0.82); C62(0.91)  LDD1642  [31]
 LDCM0439  CL49 HEK-293T C127(1.03); C245(1.04); C140(1.11); C62(1.06)  LDD1643  [31]
 LDCM0440  CL5 HEK-293T C127(1.09); C245(0.91); C140(0.95); C62(1.09)  LDD1644  [31]
 LDCM0441  CL50 HEK-293T C127(1.10); C245(0.96); C140(0.96); C62(0.96)  LDD1645  [31]
 LDCM0443  CL52 HEK-293T C127(1.03); C245(0.99); C140(1.03); C62(1.11)  LDD1646  [31]
 LDCM0444  CL53 HEK-293T C127(1.02); C245(0.92); C140(0.93); C62(0.93)  LDD1647  [31]
 LDCM0445  CL54 HEK-293T C127(0.96); C245(1.08); C140(0.85); C62(1.00)  LDD1648  [31]
 LDCM0446  CL55 HEK-293T C127(1.09); C245(1.06); C140(0.95); C62(1.04)  LDD1649  [31]
 LDCM0447  CL56 HEK-293T C127(1.05); C245(1.04); C140(0.95); C62(1.02)  LDD1650  [31]
 LDCM0448  CL57 HEK-293T C127(1.03); C245(0.92); C140(0.96); C62(0.89)  LDD1651  [31]
 LDCM0449  CL58 HEK-293T C127(1.04); C245(1.02); C140(0.75); C62(0.89)  LDD1652  [31]
 LDCM0450  CL59 HEK-293T C127(1.03); C245(0.83); C140(0.81); C62(0.98)  LDD1653  [31]
 LDCM0451  CL6 HEK-293T C127(0.95); C245(1.09); C140(0.96); C62(1.09)  LDD1654  [31]
 LDCM0452  CL60 HEK-293T C127(1.04); C245(1.05); C140(0.81); C62(0.94)  LDD1655  [31]
 LDCM0453  CL61 HEK-293T C127(1.05); C245(1.01); C140(1.08); C62(1.06)  LDD1656  [31]
 LDCM0454  CL62 HEK-293T C127(1.06); C245(0.96); C140(1.01); C62(0.51)  LDD1657  [31]
 LDCM0455  CL63 HEK-293T C127(1.00); C140(1.05); C62(1.04); C105(1.07)  LDD1658  [31]
 LDCM0456  CL64 HEK-293T C127(1.01); C245(0.91); C140(0.97); C62(1.01)  LDD1659  [31]
 LDCM0457  CL65 HEK-293T C127(1.05); C245(0.89); C140(0.93); C62(0.95)  LDD1660  [31]
 LDCM0458  CL66 HEK-293T C127(1.02); C245(1.00); C140(0.92); C62(1.07)  LDD1661  [31]
 LDCM0459  CL67 HEK-293T C127(1.03); C245(1.01); C140(0.92); C62(1.05)  LDD1662  [31]
 LDCM0460  CL68 HEK-293T C127(1.03); C245(0.98); C140(0.98); C62(0.89)  LDD1663  [31]
 LDCM0461  CL69 HEK-293T C127(0.98); C245(1.04); C140(0.90); C62(0.94)  LDD1664  [31]
 LDCM0462  CL7 HEK-293T C127(0.98); C245(1.03); C140(1.00); C62(1.12)  LDD1665  [31]
 LDCM0463  CL70 HEK-293T C127(1.07); C245(1.06); C140(0.78); C62(0.97)  LDD1666  [31]
 LDCM0464  CL71 HEK-293T C127(1.02); C245(0.95); C140(0.77); C62(0.94)  LDD1667  [31]
 LDCM0465  CL72 HEK-293T C127(1.05); C245(0.98); C140(0.82); C62(0.92)  LDD1668  [31]
 LDCM0466  CL73 HEK-293T C127(1.00); C245(1.04); C140(1.09); C62(1.00)  LDD1669  [31]
 LDCM0467  CL74 HEK-293T C127(1.04); C245(1.05); C140(1.06); C62(1.02)  LDD1670  [31]
 LDCM0469  CL76 HEK-293T C127(1.02); C245(0.99); C140(1.00); C62(1.08)  LDD1672  [31]
 LDCM0470  CL77 HEK-293T C127(1.04); C245(0.93); C140(0.92); C62(1.01)  LDD1673  [31]
 LDCM0471  CL78 HEK-293T C127(0.97); C245(1.04); C140(0.95); C62(1.00)  LDD1674  [31]
 LDCM0472  CL79 HEK-293T C127(1.07); C245(1.15); C140(0.96); C62(1.09)  LDD1675  [31]
 LDCM0473  CL8 HEK-293T C127(0.81); C245(1.02); C140(0.89); C62(0.94)  LDD1676  [31]
 LDCM0474  CL80 HEK-293T C127(1.06); C245(1.11); C140(1.01); C62(0.99)  LDD1677  [31]
 LDCM0475  CL81 HEK-293T C127(1.03); C245(0.99); C140(1.03); C62(1.02)  LDD1678  [31]
 LDCM0476  CL82 HEK-293T C127(1.03); C245(0.99); C140(0.81); C62(0.95)  LDD1679  [31]
 LDCM0477  CL83 HEK-293T C127(0.98); C245(0.84); C140(0.83); C62(0.94)  LDD1680  [31]
 LDCM0478  CL84 HEK-293T C127(1.02); C245(1.05); C140(0.86); C62(0.99)  LDD1681  [31]
 LDCM0479  CL85 HEK-293T C127(1.01); C245(1.04); C140(1.19); C62(0.97)  LDD1682  [31]
 LDCM0480  CL86 HEK-293T C127(1.09); C245(1.05); C140(1.10); C62(1.01)  LDD1683  [31]
 LDCM0481  CL87 HEK-293T C127(1.00); C140(1.02); C62(1.08); C105(1.15)  LDD1684  [31]
 LDCM0482  CL88 HEK-293T C127(0.99); C245(0.96); C140(1.07); C62(1.06)  LDD1685  [31]
 LDCM0483  CL89 HEK-293T C127(0.97); C245(0.90); C140(0.87); C62(1.05)  LDD1686  [31]
 LDCM0484  CL9 HEK-293T C127(1.04); C245(1.01); C140(1.01); C62(1.00)  LDD1687  [31]
 LDCM0485  CL90 HEK-293T C127(0.93); C245(1.03); C140(0.88); C62(1.01)  LDD1688  [31]
 LDCM0486  CL91 HEK-293T C127(0.98); C245(1.05); C140(1.02); C62(1.01)  LDD1689  [31]
 LDCM0487  CL92 HEK-293T C127(1.00); C245(0.98); C140(0.90); C62(1.02)  LDD1690  [31]
 LDCM0488  CL93 HEK-293T C127(1.04); C245(0.96); C140(0.88); C62(0.98)  LDD1691  [31]
 LDCM0489  CL94 HEK-293T C127(1.04); C245(0.95); C140(0.82); C62(0.92)  LDD1692  [31]
 LDCM0490  CL95 HEK-293T C127(0.90); C245(0.86); C140(0.77); C62(0.95)  LDD1693  [31]
 LDCM0491  CL96 HEK-293T C127(0.96); C245(0.99); C140(0.87); C62(0.91)  LDD1694  [31]
 LDCM0492  CL97 HEK-293T C127(1.01); C245(1.00); C140(1.03); C62(0.94)  LDD1695  [31]
 LDCM0493  CL98 HEK-293T C127(1.02); C245(0.98); C140(0.96); C62(0.93)  LDD1696  [31]
 LDCM0494  CL99 HEK-293T C127(0.98); C140(0.95); C62(0.95); C105(0.90)  LDD1697  [31]
 LDCM0495  E2913 HEK-293T C127(0.98); C140(0.99); C62(0.99); C105(1.12)  LDD1698  [31]
 LDCM0468  Fragment33 HEK-293T C127(1.00); C140(1.04); C62(0.97); C105(1.10)  LDD1671  [31]
 LDCM0427  Fragment51 HEK-293T C127(1.11); C245(1.01); C140(1.00); C62(1.01)  LDD1631  [31]
 LDCM0116  HHS-0101 DM93 Y70(0.59); Y306(0.67); Y137(0.68); Y255(0.89)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y70(0.38); Y137(0.53); Y306(0.62); Y134(0.75)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y306(0.31); Y137(0.61); Y134(0.92); Y255(1.24)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y306(0.64); Y137(0.85); Y134(1.28); Y255(1.51)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y306(0.79); Y137(0.89); Y134(1.54); Y255(1.96)  LDD0268  [13]
 LDCM0107  IAA HeLa C171(0.00); H248(0.00); H125(0.00); C127(0.00)  LDD0221  [22]
 LDCM0123  JWB131 DM93 Y134(0.66); Y137(0.99)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y134(0.54); Y137(0.77)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y134(1.06); Y137(1.11)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y134(3.34); Y137(3.33)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y134(2.02); Y137(2.26)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y134(0.09); Y137(1.19)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y134(0.38); Y137(0.43)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y134(0.89); Y137(0.99)  LDD0292  [12]
 LDCM0022  KB02 HEK-293T C127(0.79); C245(0.95); C62(1.08); C140(0.87)  LDD1492  [31]
 LDCM0023  KB03 Jurkat C202(4.72); C172(5.46)  LDD0209  [11]
 LDCM0024  KB05 HEK-293T C127(0.96); C245(0.94); C62(1.10); C140(0.88)  LDD1502  [31]
 LDCM0109  NEM HeLa H248(0.00); H125(0.00); H239(0.00); C127(0.00)  LDD0223  [22]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C62(0.66)  LDD2104  [30]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C62(1.09)  LDD2109  [30]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C62(1.35)  LDD2123  [30]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C62(1.48)  LDD2136  [30]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C62(1.20)  LDD2137  [30]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C62(0.93)  LDD2141  [30]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C127(0.76)  LDD2146  [30]
 LDCM0096  SAHA K562 4.00  LDD0360  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Serine/threonine-protein kinase WNK1 (WNK1) Ser/Thr protein kinase family Q9H4A3
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Serine/threonine-protein kinase LMTK1 (AATK) Tyr protein kinase family Q6ZMQ8
Protein phosphatase inhibitor 2 (PPP1R2) Protein phosphatase inhibitor 2 family P41236
Protein phosphatase inhibitor 2 family member B (PPP1R2B) Protein phosphatase inhibitor 2 family Q6NXS1
Protein phosphatase inhibitor 2 family member C (PPP1R2C) Protein phosphatase inhibitor 2 family O14990
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) PTEN phosphatase protein family P60484
E3 ubiquitin-protein ligase SH3RF2 (SH3RF2) SH3RF family Q8TEC5
S-phase kinase-associated protein 1 (SKP1) SKP1 family P63208
Kinesin-like protein KIF18A (KIF18A) Kinesin family Q8NI77
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Short transient receptor potential channel 4-associated protein (TRPC4AP) . Q8TEL6
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Huntingtin (HTT) Huntingtin family P42858
Protein S100-B (S100B) S-100 family P04271
Apoptotic protease-activating factor 1 (APAF1) . O14727
Cadherin-1 (CDH1) . P12830
Synaptotagmin-like protein 2 (SYTL2) . Q9HCH5
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine/serine-rich nuclear protein 1 (CSRNP1) AXUD1 family Q96S65
Cysteine/serine-rich nuclear protein 2 (CSRNP2) AXUD1 family Q9H175
Cell division cycle 5-like protein (CDC5L) CEF1 family Q99459
RelA-associated inhibitor (PPP1R13L) IASPP family Q8WUF5
Forkhead box protein P3 (FOXP3) . Q9BZS1
Y-box-binding protein 3 (YBX3) . P16989
Other
Click To Hide/Show 42 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apoptosis-stimulating of p53 protein 1 (PPP1R13B) ASPP family Q96KQ4
Apoptosis-stimulating of p53 protein 2 (TP53BP2) ASPP family Q13625
Consortin (CNST) CNST family Q6PJW8
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) EIF-2-alpha family P05198
RNA polymerase II elongation factor ELL (ELL) ELL/occludin family P55199
Disks large homolog 3 (DLG3) MAGUK family Q92796
MICOS complex subunit MIC19 (CHCHD3) MICOS complex subunit Mic19 family Q9NX63
U3 small nucleolar ribonucleoprotein protein MPP10 (MPHOSPH10) MPP10 family O00566
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) PPP1R15 family O75807
Protein phosphatase 1 regulatory subunit 15B (PPP1R15B) PPP1R15 family Q5SWA1
Protein phosphatase 1 regulatory subunit 37 (PPP1R37) PPP1R37 family O75864
Retinoblastoma-associated protein (RB1) Retinoblastoma protein (RB) family P06400
Telomere-associated protein RIF1 (RIF1) RIF1 family Q5UIP0
Ribosomal RNA processing protein 1 homolog B (RRP1B) RRP1 family Q14684
Protein phosphatase 1 regulatory subunit 7 (PPP1R7) SDS22 family Q15435
Protein SFI1 homolog (SFI1) SFI1 family A8K8P3
Shugoshin 2 (SGO2) Shugoshin family Q562F6
Taperin (TPRN) Taperin family Q4KMQ1
Transmembrane protein 132D (TMEM132D) TMEM132 family Q14C87
Torsin-1A-interacting protein 1 (TOR1AIP1) TOR1AIP family Q5JTV8
Axin-1 (AXIN1) . O15169
CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) . O95400
Centrosomal protein of 192 kDa (CEP192) . Q8TEP8
Kinetochore scaffold 1 (KNL1) . Q8NG31
Neurabin-2 (PPP1R9B) . Q96SB3
Nuclear inhibitor of protein phosphatase 1 (PPP1R8) . Q12972
Phostensin (PPP1R18) . Q6NYC8
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) . Q96T49
Protein phosphatase 1 regulatory subunit 26 (PPP1R26) . Q5T8A7
Protein phosphatase 1 regulatory subunit 27 (PPP1R27) . Q86WC6
Protein phosphatase 1 regulatory subunit 3B (PPP1R3B) . Q86XI6
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) . Q9UQK1
Protein phosphatase 1 regulatory subunit 3D (PPP1R3D) . O95685
Serine/threonine-protein phosphatase 1 regulatory subunit 10 (PPP1R10) . Q96QC0
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Stabilizer of axonemal microtubules 4 (SAXO4) . Q7Z5V6
Tuberin (TSC2) . P49815
WW domain-binding protein 11 (WBP11) . Q9Y2W2
YLP motif-containing protein 1 (YLPM1) . P49750
Zinc finger FYVE domain-containing protein 1 (ZFYVE1) . Q9HBF4
Zinc finger FYVE domain-containing protein 9 (ZFYVE9) . O95405

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cantharidin Small molecular drug D0Z2RA
Investigative
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cantharidic_acid Small molecular drug D0M0TM
Microcystin-lr Small molecular drug D0O1BJ
Norcantharidin Small molecular drug D0W4IL
Palasonin Small molecular drug D06EUA
Tautomycin Small molecular drug D09CAI
268-trimethyl-3-amino-9-benzyl-9-methoxynonanoic Acid . DB02506

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
26 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
29 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
30 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402