Details of the Target

General Information of Target

Target ID LDTP01414
Target Name Metastasis-associated protein MTA2 (MTA2)
Gene Name MTA2
Gene ID 9219
Synonyms
MTA1L1; PID; Metastasis-associated protein MTA2; Metastasis-associated 1-like 1; MTA1-L1 protein; p53 target protein in deacetylase complex
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAANMYRVGDYVYFENSSSNPYLVRRIEELNKTANGNVEAKVVCLFRRRDISSSLNSLAD
SNAREFEEESKQPGVSEQQRHQLKHRELFLSRQFESLPATHIRGKCSVTLLNETDILSQY
LEKEDCFFYSLVFDPVQKTLLADQGEIRVGCKYQAEIPDRLVEGESDNRNQQKMEMKVWD
PDNPLTDRQIDQFLVVARAVGTFARALDCSSSIRQPSLHMSAAAASRDITLFHAMDTLQR
NGYDLAKAMSTLVPQGGPVLCRDEMEEWSASEAMLFEEALEKYGKDFNDIRQDFLPWKSL
ASIVQFYYMWKTTDRYIQQKRLKAAEADSKLKQVYIPTYTKPNPNQIISVGSKPGMNGAG
FQKGLTCESCHTTQSAQWYAWGPPNMQCRLCASCWIYWKKYGGLKTPTQLEGATRGTTEP
HSRGHLSRPEAQSLSPYTTSANRAKLLAKNRQTFLLQTTKLTRLARRMCRDLLQPRRAAR
RPYAPINANAIKAECSIRLPKAAKTPLKIHPLVRLPLATIVKDLVAQAPLKPKTPRGTKT
PINRNQLSQNRGLGGIMVKRAYETMAGAGVPFSANGRPLASGIRSSSQPAAKRQKLNPAD
APNPVVFVATKDTRALRKALTHLEMRRAARRPNLPLKVKPTLIAVRPPVPLPAPSHPAST
NEPIVLED
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function May function as a transcriptional coregulator. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin.
Uniprot ID
O94776
Ensemble ID
ENST00000278823.7
HGNC ID
HGNC:7411

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.Y129TfsTer33
SNV: p.R80C		 DBIA    Probe Info 
HCT116 Deletion: p.Y129TfsTer33 DBIA    Probe Info 
HCT15 SNV: p.A270V DBIA    Probe Info 
JURKAT SNV: p.Q93Ter; p.S581P Compound 10    Probe Info 
MOLT4 SNV: p.R514W; p.I542T IA-alkyne    Probe Info 
NUGC3 SNV: p.D10Y; p.G164Ter DBIA    Probe Info 
SG231 SNV: p.E67K DBIA    Probe Info 
SJSA1 SNV: p.M274I DBIA    Probe Info 
SNGM SNV: p.P541Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.35  LDD0402  [1]
A-EBA
 Probe Info  		2.35  LDD0215  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
TH211
 Probe Info  		Y437(20.00); Y483(20.00)  LDD0257  [4]
TH214
 Probe Info  		Y437(14.14)  LDD0258  [4]
TH216
 Probe Info  		Y483(18.84); Y13(17.68); Y437(5.02)  LDD0259  [4]
STPyne
 Probe Info  		K492(5.18); K508(9.51); K84(3.70)  LDD0277  [5]
ONAyne
 Probe Info  		K152(10.00)  LDD0275  [5]
SAHA-CA-4PAP
 Probe Info  		14.00  LDD0269  [6]
BTD
 Probe Info  		C209(2.49); C495(1.64)  LDD1700  [7]
Sulforaphane-probe2
 Probe Info  		2.28  LDD0042  [8]
AHL-Pu-1
 Probe Info  		C126(3.26)  LDD0170  [9]
HHS-482
 Probe Info  		Y437(0.63)  LDD0285  [10]
HHS-475
 Probe Info  		Y437(0.90); Y22(0.92); Y153(1.60)  LDD0264  [11]
HHS-465
 Probe Info  		Y437(10.00)  LDD2237  [12]
DBIA
 Probe Info  		C261(1.43); C394(1.61); C391(1.44)  LDD0080  [13]
ATP probe
 Probe Info  		N.A.  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C209(0.00); C106(0.00); C126(0.00); C261(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
Lodoacetamide azide
 Probe Info  		C209(0.00); C261(0.00); C106(0.00); C126(0.00)  LDD0037  [15]
NAIA_4
 Probe Info  		N.A.  LDD2226  [17]
TFBX
 Probe Info  		C495(0.00); C209(0.00)  LDD0027  [18]
WYneN
 Probe Info  		N.A.  LDD0021  [19]
Compound 10
 Probe Info  		C209(0.00); C44(0.00)  LDD2216  [20]
ENE
 Probe Info  		N.A.  LDD0006  [19]
IPM
 Probe Info  		N.A.  LDD0005  [19]
SF
 Probe Info  		N.A.  LDD0028  [21]
Phosphinate-6
 Probe Info  		C44(0.00); C209(0.00)  LDD0018  [22]
1c-yne
 Probe Info  		K595(0.00); K341(0.00); K522(0.00)  LDD0228  [23]
Acrolein
 Probe Info  		C495(0.00); C209(0.00)  LDD0217  [24]
Crotonaldehyde
 Probe Info  		C495(0.00); C44(0.00)  LDD0219  [24]
Methacrolein
 Probe Info  		C209(0.00); C495(0.00); C44(0.00); C261(0.00)  LDD0218  [24]
W1
 Probe Info  		N.A.  LDD0236  [25]
AOyne
 Probe Info  		4.70  LDD0443  [26]
NAIA_5
 Probe Info  		C495(0.00); C209(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		6.37  LDD0464  [27]
STS-2
 Probe Info  		N.A.  LDD0138  [28]
SAHA-CA-3PAP
 Probe Info  		N.A.  LDD0363  [6]
SAHA-CA-8PAP
 Probe Info  		N.A.  LDD0362  [6]
DA-2
 Probe Info  		N.A.  LDD0072  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C209(0.64); C495(0.37)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C209(0.73); C495(0.68)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C209(0.54)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C209(0.72); C495(0.99)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C261(0.85)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C209(1.36); C495(1.23)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C495(0.88)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C495(0.51)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C209(0.62); C495(0.90)  LDD2131  [7]
 LDCM0025  4SU-RNA DM93 C126(3.26)  LDD0170  [9]
 LDCM0026  4SU-RNA+native RNA DM93 C126(3.37)  LDD0171  [9]
 LDCM0214  AC1 HCT 116 C209(1.17); C261(1.20)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C126(0.84); C209(1.18); C261(0.98); C391(0.68)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C126(0.68); C209(0.85); C261(0.63); C391(0.77)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C126(0.73); C209(0.90); C261(0.61); C391(0.60)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C126(0.77); C209(0.81); C261(0.69); C391(0.81)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C126(1.00); C209(0.97); C261(0.66); C391(0.66)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C126(0.86); C209(0.92); C261(0.89); C391(0.84)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C126(0.87); C209(0.89); C261(0.58); C391(0.67)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C126(0.69); C209(0.95); C261(0.60); C391(0.65)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C126(1.01); C209(1.16); C261(0.62); C391(0.72)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C126(0.74); C209(0.82); C261(0.62); C391(0.59)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C126(0.86); C209(0.74); C261(0.61); C391(0.69)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C126(1.00); C209(1.18); C261(1.12); C391(0.65)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C126(0.82); C209(0.86); C261(0.58); C391(0.62)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C126(0.71); C209(0.88); C261(0.60); C391(0.73)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C126(0.81); C209(0.97); C261(0.63); C391(0.68)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C106(0.87); C209(0.94); C261(1.05); C394(0.97)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C106(0.60); C209(1.10); C261(0.97); C394(0.98)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C106(0.47); C209(1.19); C261(0.89); C394(0.98)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C106(0.50); C209(1.27); C261(0.90); C394(0.90)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C106(0.60); C209(1.16); C261(0.93); C394(0.95)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C106(0.58); C209(1.08); C261(1.04); C394(1.01)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C106(0.63); C209(1.10); C261(0.98); C394(0.85)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C126(0.91); C209(1.20); C261(1.02); C391(0.78)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C106(0.69); C209(1.19); C261(0.96); C394(1.29)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C106(0.50); C209(1.22); C261(1.09); C394(1.34)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C106(0.53); C209(1.22); C261(1.05); C394(1.01)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C106(0.71); C209(0.99); C261(1.12); C394(1.64)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C106(0.53); C209(0.97); C261(1.09); C394(1.27)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C106(0.53); C209(1.06); C261(0.97); C394(1.11)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C106(0.54); C209(1.23); C261(1.05); C394(1.13)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C106(0.59); C209(1.16); C261(1.12); C394(1.11)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C126(0.87); C209(1.16); C261(1.38); C391(1.44)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C126(0.92); C209(0.91); C261(1.22); C391(0.85)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C126(0.93); C209(1.01); C261(1.20); C391(0.82)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C126(1.33); C209(0.82); C261(1.16); C391(1.05)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C126(0.86); C209(0.99); C261(1.06); C391(0.75)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C126(0.78); C209(1.00); C261(1.20); C391(0.81)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C126(0.80); C209(1.03); C261(0.97); C391(0.87)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C126(0.97); C209(1.00); C261(1.06); C391(0.79)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C126(0.77); C209(1.06); C261(1.02); C391(0.77)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C126(0.71); C209(0.92); C261(1.04); C391(0.76)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C126(0.74); C209(1.10); C261(0.92); C391(0.84)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C126(0.83); C209(1.19); C261(1.06); C391(0.69)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C126(0.89); C209(1.06); C261(1.11); C391(0.68)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C126(0.75); C209(1.06); C261(1.07); C391(0.69)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C126(0.84); C209(1.10); C261(0.96); C391(0.74)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C126(0.72); C209(1.03); C261(1.19); C391(0.71)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C261(0.72); C106(0.73); C126(0.80); C391(0.85)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C106(0.45); C391(0.64); C394(0.77); C261(0.87)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C106(0.57); C391(0.62); C394(0.75); C261(0.94)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C106(0.54); C391(0.63); C394(0.78); C126(0.84)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C106(0.49); C391(0.57); C394(0.72); C261(1.00)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C391(0.48); C106(0.51); C394(0.73); C126(0.86)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C106(0.55); C391(0.56); C394(0.73); C126(0.75)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C391(0.63); C261(0.89); C126(0.94); C394(0.97)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C106(0.62); C126(0.84); C394(0.86); C391(0.87)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C106(0.60); C394(0.82); C391(0.85); C126(0.89)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C106(0.48); C391(0.77); C394(0.86); C126(0.88)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C106(0.45); C391(0.53); C394(0.66); C126(1.05)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C106(0.50); C126(0.86); C209(1.14); C261(0.92)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C106(0.49); C126(1.01); C209(1.17); C261(1.15)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C106(0.78); C126(1.10); C209(1.07); C261(1.04)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C106(0.68); C126(1.11); C209(0.93); C261(1.01)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C106(0.91); C261(0.97); C391(0.98); C394(1.02)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C106(0.66); C394(0.66); C391(0.85); C126(1.37)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C106(0.75); C391(1.04); C394(1.04); C209(1.12)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C261(1.02); C209(1.08)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C106(0.78); C261(0.79); C391(1.10); C394(1.15)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C394(0.84); C106(0.92); C391(0.98); C126(1.16)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C106(0.86); C391(0.92); C394(0.92); C261(1.01)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C106(0.85); C394(0.89); C391(0.93); C261(1.06)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C106(0.89); C261(0.95); C209(1.07); C126(1.24)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C261(0.86); C394(0.96); C391(1.00); C209(1.03)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C261(0.76); C391(0.81); C394(0.82); C209(1.09)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C261(0.81); C391(0.89); C394(0.92); C126(1.22)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C391(0.72); C394(0.75); C261(0.78); C209(1.05)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C261(0.66); C391(0.79); C394(0.82); C209(0.92)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C209(1.03); C261(1.29)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C261(0.62); C391(0.81); C394(0.89); C209(1.13)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C261(0.71); C391(0.75); C394(0.79); C209(1.03)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C391(0.68); C261(0.68); C394(0.69); C126(1.17)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C261(0.72); C394(0.87); C391(0.89); C209(1.20)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C261(0.67); C394(0.71); C391(0.91); C209(1.25)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C209(0.82); C126(1.01); C391(1.06); C394(1.06)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C126(0.90); C391(0.96); C394(0.96); C209(0.98)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C209(0.86); C126(0.94); C391(1.10); C394(1.10)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C209(0.85); C261(0.94); C391(1.01); C394(1.01)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C391(0.72); C394(0.72); C126(0.76); C261(0.96)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C209(1.15); C261(1.19)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C391(0.96); C394(0.96); C126(1.00); C209(1.08)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C391(0.86); C394(0.86); C126(0.86); C261(0.99)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C391(0.82); C394(0.82); C126(0.88); C261(0.96)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C391(0.83); C394(0.83); C209(0.94); C126(1.01)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C391(0.82); C394(0.82); C126(0.90); C209(1.02)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C391(0.83); C394(0.83); C126(0.93); C261(1.09)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C394(0.83); C209(0.96); C126(1.10); C261(1.17)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C394(0.83); C126(0.97); C261(1.08); C209(1.13)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C126(0.83); C394(0.85); C261(1.12); C209(1.14)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C394(1.00); C126(1.14); C261(1.20); C209(1.25)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C261(1.16); C209(1.19)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C126(1.07); C261(1.15); C209(1.27); C394(1.49)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C261(0.95); C209(1.09); C126(1.17); C394(1.27)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C126(1.03); C394(1.07); C209(1.08); C261(1.13)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C261(0.83); C209(1.16); C394(1.24); C126(1.29)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C261(1.11); C209(1.11); C126(1.15); C394(1.33)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C261(0.67); C394(0.74); C209(1.26); C126(1.29)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C261(0.93); C394(1.07); C209(1.47); C126(1.48)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C391(0.70); C394(0.70); C261(0.97); C126(1.06)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C261(0.74); C391(0.78); C394(0.78); C209(1.16)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C391(0.79); C394(0.79); C126(0.90); C261(0.93)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C261(0.83); C126(0.93); C391(0.95); C394(0.99)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C261(0.91); C391(0.93); C394(0.93); C126(1.15)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C391(0.67); C394(0.67); C261(0.83); C126(0.89)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C391(0.92); C394(0.92); C261(0.96); C126(1.27)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C391(0.67); C394(0.67); C261(0.96); C126(0.98)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C391(0.64); C394(0.64); C126(0.97); C261(1.36)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C391(0.63); C394(0.63); C261(0.82); C126(0.83)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C391(0.63); C394(0.63); C261(0.81); C126(0.86)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C391(0.46); C394(0.46); C126(0.64); C261(0.81)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C391(0.76); C126(0.82); C394(0.92); C106(1.00)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C391(0.74); C106(0.84); C394(0.88); C126(0.97)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C391(0.86); C394(0.94); C261(1.00); C126(1.01)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C391(0.57); C394(0.57); C126(0.77); C106(0.96)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C391(0.75); C394(0.76); C126(0.90); C106(1.13)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C394(0.84); C391(0.84); C126(1.03); C261(1.14)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C394(0.66); C391(0.71); C261(1.01); C126(1.04)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C394(0.73); C391(0.77); C106(0.94); C126(1.08)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C391(0.69); C394(0.83); C106(0.92); C126(1.02)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C391(0.68); C394(0.79); C126(0.92); C106(0.94)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C391(0.64); C126(0.79); C394(0.81); C106(0.96)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C391(0.70); C394(0.78); C126(0.83); C106(0.97)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C391(0.71); C394(0.74); C126(0.84); C261(1.00)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C391(0.73); C261(0.84); C394(0.90); C126(1.03)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C394(0.73); C391(0.80); C126(0.89); C106(0.96)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C391(0.72); C126(0.82); C394(0.85); C106(0.88)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C391(0.54); C394(0.65); C126(0.99); C106(1.04)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C261(1.01); C209(1.23); C126(1.41)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C261(0.96); C209(1.20); C126(1.23)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C209(1.01); C261(1.04); C126(1.13)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C261(0.78); C209(0.88); C126(1.31)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C261(0.81); C209(0.86); C126(1.00)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C261(0.80); C209(1.01); C126(1.08)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C261(0.80); C209(1.13); C126(1.47)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C261(0.72); C209(0.76); C126(1.33)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C209(1.06); C261(1.28); C126(1.38)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C261(1.03); C209(1.07); C126(1.24)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C261(0.91); C209(0.94); C126(1.18)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C209(0.85); C126(1.23); C261(1.68)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C261(0.77); C209(0.88); C126(1.30)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C209(0.95); C261(1.40); C126(1.47)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C261(0.73); C209(1.05); C126(1.57)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C394(0.30); C391(0.46); C126(0.58); C261(0.64)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C261(0.63); C394(0.67); C391(0.69); C126(0.77)  LDD0683  [13]
 LDCM0520  AKOS000195272 MDA-MB-231 C209(0.77); C495(0.82)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C126(0.81); C209(1.06); C261(1.10); C391(0.76)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C391(0.79); C394(0.81); C126(0.90); C209(1.04)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C391(0.61); C261(0.81); C394(0.86); C126(1.01)  LDD0592  [13]
 LDCM0020  ARS-1620 HCC44 C209(1.14); C394(1.14); C261(0.98)  LDD2171  [13]
 LDCM0108  Chloroacetamide HeLa C261(0.00); C495(0.00); C44(0.00); C209(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C495(1.90); C209(1.01)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C126(0.93); C209(0.99); C394(1.01); C261(1.07)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C394(0.60); C126(0.99); C261(0.99); C209(1.31)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C261(1.07); C209(1.18)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C391(0.73); C126(0.81); C261(0.95); C209(1.06)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C391(0.85); C126(0.94); C261(1.00); C209(1.03)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C391(0.83); C126(0.89); C261(1.06); C209(1.08)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C391(0.89); C261(0.94); C126(0.99); C209(1.12)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C106(0.67); C394(0.69); C391(0.82); C126(1.15)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C106(0.64); C394(0.73); C391(0.91); C126(1.20)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C106(0.69); C394(0.71); C391(0.87); C126(1.11)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C106(0.69); C394(0.74); C391(0.86); C261(1.09)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C106(0.74); C391(0.95); C394(0.96); C126(1.09)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C394(0.58); C126(0.99); C261(1.09); C209(1.44)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C106(0.63); C394(0.64); C391(0.70); C261(1.00)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C394(0.69); C391(0.74); C106(0.77); C261(0.93)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C394(0.79); C391(0.80); C261(0.81); C209(0.90)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C261(0.63); C394(0.70); C391(0.72); C126(0.93)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C261(0.61); C394(0.79); C391(0.81); C126(0.98)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C261(0.66); C394(0.74); C391(0.77); C209(1.15)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C261(0.67); C394(0.72); C391(0.83); C209(1.01)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C391(0.77); C394(0.77); C126(1.02); C261(1.08)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C126(0.77); C391(0.78); C394(0.78); C209(1.00)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C126(0.92); C391(1.01); C394(1.01); C261(1.03)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C394(0.56); C126(1.14); C261(1.19); C209(1.27)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C126(0.71); C391(0.86); C394(0.86); C209(0.97)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C126(0.73); C394(0.76); C261(0.88); C209(0.90)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C261(1.03); C126(1.07); C394(1.07); C209(1.12)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C394(0.96); C261(0.98); C126(1.03); C209(1.12)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C261(1.00); C394(1.05); C126(1.17); C209(1.17)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C391(0.74); C394(0.74); C261(0.77); C126(0.88)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C261(0.80); C126(0.82); C209(0.95); C391(1.79)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C261(0.84); C126(0.86); C391(0.90); C394(0.90)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C391(0.76); C394(0.76); C261(0.93); C126(1.00)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C394(0.79); C261(1.14); C126(1.21); C209(1.46)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C394(0.69); C209(0.99); C261(1.13); C126(1.28)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C394(0.90); C126(0.91); C261(1.08); C209(1.50)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C209(0.99); C126(1.01); C261(1.01); C394(1.10)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C126(0.86); C261(0.88); C391(0.89); C209(0.90)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C126(1.05); C209(1.07); C261(1.24); C391(1.28)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C391(0.85); C126(0.98); C394(1.00); C209(1.06)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C126(0.87); C394(1.07); C209(1.13); C261(1.27)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C261(0.87); C391(0.91); C209(1.02); C394(1.04)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C391(0.91); C261(0.95); C394(1.04); C209(1.14)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C394(1.07); C261(1.17); C391(1.19); C209(1.47)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C261(0.78); C209(1.04); C391(1.10); C394(1.13)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C394(0.85); C391(0.89); C261(1.02); C209(1.12)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C126(1.28); C209(1.21); C261(0.81); C391(0.87)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C126(1.21); C209(1.10); C261(0.93); C391(0.96)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C126(1.01); C209(1.07); C261(0.92); C391(0.99)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C126(1.21); C209(0.96); C261(0.84); C391(0.97)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C126(1.23); C209(1.13); C261(0.77); C391(1.15)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C126(0.85); C209(1.22); C261(1.17); C394(0.87)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C126(1.49); C209(1.10); C261(1.13); C391(1.36)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C209(1.05); C261(0.86); C391(0.88)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C209(1.41); C261(1.00); C391(0.99)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C209(0.93); C261(0.96); C391(1.13)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C209(1.09); C261(0.87); C391(1.13)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C209(1.15); C261(0.90); C391(0.91)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C209(1.22); C261(0.76); C391(1.56)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C209(1.17); C261(1.14); C391(0.86)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C209(1.24); C261(1.03); C391(1.12)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C126(0.87); C209(1.15); C261(0.95); C394(1.05)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C209(1.06); C261(0.74); C391(1.05)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C209(1.06); C261(0.96); C391(1.33)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C209(1.42); C261(0.94); C391(1.59)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C209(1.19); C261(0.89); C391(1.14)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C209(1.22); C261(1.10); C391(1.05)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C209(1.62); C261(0.79); C391(0.96)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C209(0.74); C261(1.15); C394(0.77)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C209(0.83); C261(0.97); C394(0.76)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C209(0.72); C261(1.11); C394(0.88)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C209(0.78); C261(1.32); C394(1.09)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C126(1.03); C209(1.02); C261(1.16); C394(1.03)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C209(0.76); C261(0.98); C394(0.92)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C209(0.80); C261(1.00); C394(0.78)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C209(0.68); C261(0.79); C394(0.77)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C209(0.84); C261(1.02); C394(0.95)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C209(0.70); C261(0.96); C394(0.91)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C209(0.71); C261(1.02); C394(1.07)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C209(0.85); C261(0.92); C394(1.23)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C209(0.74); C261(1.25); C394(1.13)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C209(0.88); C261(1.06); C394(1.16)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C209(0.85); C261(1.14); C394(1.07)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C126(0.96); C209(1.19); C261(1.18); C394(0.80)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C209(0.90); C261(1.07); C394(0.97)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C126(0.86); C209(0.98); C261(0.91)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C126(0.94); C209(1.02); C261(1.00)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C126(0.76); C209(1.08); C261(0.85)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C126(0.83); C209(1.17); C261(0.99)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C126(0.81); C209(1.09); C261(0.95)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C126(0.86); C209(1.30); C261(0.97)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C126(1.01); C209(1.20); C261(0.95)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C126(0.98); C209(1.07); C261(0.86)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C126(1.01); C209(1.01); C261(1.13)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C126(0.98); C209(1.39); C261(1.23); C394(0.67)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C126(0.87); C209(1.01); C261(0.91)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C126(0.87); C209(1.15); C261(0.78)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C126(0.98); C209(1.10); C261(0.83)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C126(1.77); C209(1.14); C261(0.82)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C126(1.29); C209(1.03); C261(0.78)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C209(1.08); C261(1.04)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C209(0.99); C261(0.93)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C209(1.08); C261(0.92)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C209(1.23); C261(0.95)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C126(1.15); C209(1.60); C261(1.05); C394(0.86)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C209(1.07); C261(1.21)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C209(1.23); C261(0.97)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C209(1.30); C261(1.05)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C209(1.38); C261(0.98)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C209(1.69); C261(1.04)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C209(1.21); C261(0.94)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C209(1.14); C261(0.96)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C209(1.23); C261(0.99)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C209(1.36); C261(1.06)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C209(1.97); C261(1.11)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C126(1.10); C209(1.33); C261(1.17); C394(0.85)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C209(1.04); C261(0.97)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C209(1.04); C261(0.97)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C209(1.15); C261(1.07)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C209(1.20); C261(1.07)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C209(1.13); C261(0.99)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C209(1.21); C261(0.84)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C209(1.07); C261(1.01)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C209(1.05); C261(0.86)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C209(1.19); C261(1.00)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C209(1.04); C261(1.02)  LDD0811  [13]
 LDCM0495  E2913 HEK-293T C209(0.92); C261(1.03); C126(0.96); C106(1.07)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C44(1.21); C261(1.15)  LDD1702  [7]
 LDCM0625  F8 Ramos C209(0.90)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C209(1.18)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C209(1.13)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C209(1.11)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C209(1.09)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C209(1.04)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C209(1.03)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C209(0.87)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C209(1.06)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C209(0.81)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C209(0.99)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C209(1.21)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C209(0.96)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C209(1.25)  LDD2201  [31]
 LDCM0468  Fragment33 HCT 116 C126(0.93); C209(1.07); C261(0.88)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C209(1.03)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C209(0.94)  LDD2184  [31]
 LDCM0427  Fragment51 HCT 116 C209(1.37); C261(0.63); C391(1.18)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C209(1.40)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C209(1.23)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C209(1.05)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C209(1.11)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y437(0.90); Y22(0.92); Y153(1.60)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y437(0.76); Y22(1.59); Y153(1.63)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y437(0.76); Y153(0.93); Y22(1.86)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y437(0.81); Y22(2.53)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y437(0.62); Y22(1.88)  LDD0268  [11]
 LDCM0107  IAA HeLa C495(0.00); C44(0.00)  LDD0221  [24]
 LDCM0123  JWB131 DM93 Y437(0.63)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y437(0.46)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y437(0.90)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y437(4.64)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y437(2.11)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y437(1.67)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y437(0.24)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y437(1.15)  LDD0292  [10]
 LDCM0022  KB02 HCT 116 C261(1.43); C394(1.61); C391(1.44)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C261(1.59); C394(1.46); C391(1.73)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C261(2.21); C394(1.59); C391(1.39)  LDD0082  [13]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C209(0.95); C495(0.89)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C261(0.65)  LDD2121  [7]
 LDCM0109  NEM HeLa H233(0.00); H219(0.00); C44(0.00)  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C495(0.65); C261(0.68)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C209(1.26); C495(1.43); C261(0.96)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C495(1.07)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C495(0.92)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C495(1.09)  LDD2094  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C209(0.68); C495(1.03)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C495(0.53)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C209(1.04); C495(0.99)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C209(0.51); C495(0.42); C44(0.44)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C209(1.02); C495(0.90); C261(0.88)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C44(0.59)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C209(1.06); C495(1.25)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C209(0.62)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C209(1.06); C495(0.90); C261(0.82)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C495(0.44)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C209(0.67); C495(0.89); C261(0.69)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C209(1.36); C44(0.85)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C209(1.05); C495(0.93)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C209(0.64); C495(0.49); C44(0.49)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C209(0.59); C495(0.43)  LDD2115  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C209(2.26); C495(2.17)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C495(0.90); C261(0.89)  LDD2120  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C209(0.85); C495(0.65); C261(1.13)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C209(0.89); C495(0.81); C261(0.79)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C209(0.99); C495(0.96); C261(1.08)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C495(0.96)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C209(1.15); C495(0.93)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C209(0.60); C495(0.57)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C209(0.49)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C209(1.50); C495(1.09)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C209(1.35); C495(1.15); C261(1.04)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C209(0.98); C495(0.97); C261(0.76)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C209(2.49); C495(1.64)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C209(0.79); C495(0.66)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C209(0.44); C495(0.46); C44(0.59)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C495(1.10); C261(1.12)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C209(2.68); C495(2.74); C261(1.70)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C209(6.88); C495(1.65); C44(1.90)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C209(0.92); C495(0.82); C261(0.75)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C495(2.25)  LDD2147  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C495(0.45)  LDD2150  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C209(2.22)  LDD2153  [7]
 LDCM0628  OTUB2-COV-1 HEK-293T C209(0.79); C209(0.70)  LDD2207  [32]
 LDCM0131  RA190 MM1.R C209(1.30)  LDD0304  [33]
 LDCM0096  SAHA K562 14.00  LDD0269  [6]
 LDCM0003  Sulforaphane MCF-7 2.28  LDD0042  [8]
 LDCM0021  THZ1 HCT 116 C209(1.14); C394(1.14); C261(0.98)  LDD2173  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase EHMT2 (EHMT2) Histone-lysine methyltransferase family Q96KQ7
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Parkinson disease protein 7 (PARK7) Peptidase C56 family Q99497
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger E-box-binding homeobox 2 (ZEB2) Delta-EF1/ZFH-1 C2H2-type zinc-finger family O60315
Zinc finger protein 827 (ZNF827) Krueppel C2H2-type zinc-finger protein family Q17R98
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-binding protein RBBP7 (RBBP7) WD repeat RBAP46/RBAP48/MSI1 family Q16576

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
29 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.