Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name	SAHA-CA-3PAP			Probe Info
Probe concentration	1 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	LFQ
Competitor Name	SAHA			Competitor Info
Competitor Concentration	20 uM
*In Vivo* Experiment Model**	Model Type		Cell lysate
	Derived Tissue		Peripheral blood
	Disease Model	Chronic myeloid leukemia [ICD-11:2A20]
	Model Name	Human chronic myeloid leukemia cell lysate (K562)

Interaction Altas of This Experiment [1]

Enzyme

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Target ID	Target Name	Binding Ratio
LDTP18123	Isochorismatase domain-containing protein 2 (ISOC2)	10.4
LDTP09865	Histone deacetylase 2 (HDAC2)	8.7
LDTP02497	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT)	4.0
LDTP05918	Histone deacetylase 1 (HDAC1)	.
LDTP13136	Histone deacetylase 6 (HDAC6)	.

Transcription factor

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Target ID	Target Name					Binding Ratio
LDTP01414	Metastasis-associated protein MTA2 (MTA2)					.

Other

Click to Show/Hide to Show 3 Protein Related to This Bioclass

Target ID	Target Name	Binding Ratio
LDTP06429	Splicing factor 1 (SF1)	6.0
LDTP10823	Paired amphipathic helix protein Sin3a (SIN3A)	.
LDTP19372	Tetratricopeptide repeat protein 38 (TTC38)	.

References

1	Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.