Details of the Target

General Information of Target

Target ID LDTP06429
Target Name Splicing factor 1 (SF1)
Gene Name SF1
Gene ID 7536
Synonyms
ZFM1; ZNF162; Splicing factor 1; Mammalian branch point-binding protein; BBP; mBBP; Transcription factor ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIED
LTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALN
PDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGK
GSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLR
KMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDP
QSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMS
TTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGP
PPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPP
PPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGS
IPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPP
PPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAPPPPPPQN
Target Bioclass
Other
Family
BBP/SF1 family
Subcellular location
Nucleus
Function Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
Uniprot ID
Q15637
Ensemble ID
ENST00000227503.13
HGNC ID
HGNC:12950

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.M242V; p.G572R .
CHL1 SNV: p.A348P .
COLO800 SNV: p.G4V .
HCC15 SNV: p.G487W .
HCT116 SNV: p.S20I .
HCT15 SNV: p.S182Y .
JURKAT Deletion: p.V573SfsTer23 .
KMCH1 SNV: p.G627E .
KMS12BM SNV: p.P583L .
MCC13 SNV: p.P41S .
MEWO SNV: p.P326S .
NCIH1793 SNV: p.R135L .
SKOV3 SNV: p.Q228Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		2.79  LDD0215  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K174(10.00); K184(8.12); K187(2.78)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
BTD
 Probe Info  		C171(2.46); C279(1.94)  LDD1700  [5]
HHS-475
 Probe Info  		Y147(0.83); Y52(1.18)  LDD0264  [6]
HHS-465
 Probe Info  		Y52(9.32)  LDD2237  [7]
Acrolein
 Probe Info  		H110(0.00); C279(0.00)  LDD0221  [8]
DBIA
 Probe Info  		C279(0.85); C292(0.92); C282(0.99)  LDD1507  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		K174(0.00); K165(0.00); K306(0.00); K227(0.00)  LDD0199  [11]
m-APA
 Probe Info  		N.A.  LDD2231  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
IA-alkyne
 Probe Info  		C279(0.00); C171(0.00)  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C279(0.00); C292(0.00); C282(0.00); C171(0.00)  LDD0037  [12]
ATP probe
 Probe Info  		N.A.  LDD0035  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [15]
WYneN
 Probe Info  		N.A.  LDD0021  [16]
WYneO
 Probe Info  		N.A.  LDD0022  [16]
IPM
 Probe Info  		N.A.  LDD0005  [16]
NHS
 Probe Info  		N.A.  LDD0010  [16]
Phosphinate-6
 Probe Info  		C279(0.00); C292(0.00)  LDD0018  [17]
1c-yne
 Probe Info  		K16(0.00); K227(0.00); K139(0.00)  LDD0228  [18]
1d-yne
 Probe Info  		N.A.  LDD0357  [18]
W1
 Probe Info  		N.A.  LDD0236  [19]
NAIA_5
 Probe Info  		C282(0.00); C279(0.00)  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.11  LDD0471  [21]
FFF probe13
 Probe Info  		13.57  LDD0475  [21]
FFF probe2
 Probe Info  		16.32  LDD0463  [21]
FFF probe3
 Probe Info  		13.30  LDD0464  [21]
VE-P
 Probe Info  		N.A.  LDD0396  [22]
SAHA-CA-3PAP
 Probe Info  		6.00  LDD0363  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C171(0.54)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C279(0.36); C171(0.54)  LDD2112  [5]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C171(1.13)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C279(0.79)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C279(1.13); C171(1.56)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C171(0.85)  LDD2103  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C171(0.28)  LDD2132  [5]
 LDCM0214  AC1 HEK-293T C279(0.85); C292(0.92); C282(0.99)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C279(0.99); C292(0.99); C282(1.15)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C279(1.00); C292(1.00); C282(1.02)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C279(1.00); C292(1.00)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C279(1.00); C292(1.07)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C279(1.00); C292(1.01)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C279(0.90); C292(0.96); C282(1.01)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C279(0.98); C292(1.01); C282(0.81)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C279(0.98); C292(0.71); C282(0.79)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C279(1.03); C292(1.01); C282(0.96)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C279(0.94); C292(0.99)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C279(1.00); C292(0.94)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C279(0.95); C292(1.19)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C279(0.99); C292(1.09)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C279(1.05); C292(0.92); C282(1.11)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C279(0.88); C292(0.91); C282(1.09)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C279(1.02); C292(0.99); C282(0.86)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C279(0.96); C292(0.99); C282(1.08)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C279(0.98); C292(0.98)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C279(0.95); C292(0.98)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C279(0.96); C292(0.95); C282(1.04)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C279(0.95); C292(1.10)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C279(0.96); C292(1.02)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C279(1.00); C292(0.93); C282(0.97)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C279(0.89); C292(0.93); C282(0.94)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C279(1.00); C292(1.06); C282(0.95)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C279(0.90); C292(0.91); C282(1.02)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C279(0.95); C292(0.96)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C279(1.00); C292(1.06)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C279(0.98); C292(1.01)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C279(1.03); C292(0.98)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C279(0.99); C292(0.94)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C279(0.98); C292(0.91); C282(0.90)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C279(0.89); C292(1.01); C282(0.99)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C279(0.85); C292(0.97); C282(0.91)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C279(0.99); C292(0.98); C282(1.05)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C279(1.05); C292(0.99)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C279(0.97); C292(0.98)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C279(0.96); C292(1.10)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C279(1.01); C292(1.01)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C279(1.02); C292(0.91); C282(1.13)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C279(0.88); C292(1.02); C282(1.06)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C279(1.04); C292(0.94)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C279(0.99); C292(1.01); C282(1.27)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C279(0.96); C292(1.01); C282(0.97)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C279(0.94); C292(1.00)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C279(0.98); C292(0.99)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C279(1.02); C292(1.06)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C279(1.00); C292(1.03)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C279(1.02); C292(0.92); C282(0.99)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C279(0.91); C292(0.85); C282(0.92)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C279(0.98); C292(0.94); C282(1.01)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C279(1.01); C292(0.92); C282(0.97)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C279(1.00); C292(0.91)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C279(0.95); C292(0.88)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C279(1.00); C292(0.85)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C279(1.00); C292(0.92)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C279(1.03); C292(0.89)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C279(0.95); C292(0.90); C282(1.10)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C279(1.04); C292(0.99)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C279(0.97); C292(0.92); C282(0.94)  LDD1569  [9]
 LDCM0545  Acetamide MDA-MB-231 C279(0.42); C171(0.30)  LDD2138  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C279(0.99); C171(0.87)  LDD2113  [5]
 LDCM0248  AKOS034007472 HEK-293T C279(1.01); C292(0.97)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C279(0.92); C292(0.96); C282(0.99)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C279(1.00); C292(0.95); C282(0.98)  LDD1514  [9]
 LDCM0498  BS-3668 MDA-MB-231 C171(0.45)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa C171(0.00); H110(0.00); C279(0.00)  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C279(0.38)  LDD2227  [20]
 LDCM0367  CL1 HEK-293T C279(1.02)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C279(0.79); C292(0.69)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C279(0.92); C292(0.87); C282(1.03)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C279(1.01)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C279(0.89); C292(0.90); C282(0.99)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C279(0.96); C282(0.98)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C279(1.03); C292(0.98); C282(0.94)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C279(0.96)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C279(0.90); C292(0.94); C282(1.00)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C279(0.96); C282(0.98)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C279(0.96); C292(1.00); C282(1.08)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C279(0.95)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C279(0.93); C292(0.84)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C279(0.85); C292(0.87); C282(0.87)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C279(0.86); C282(0.93)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C279(0.88); C292(0.98); C282(1.06)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C279(1.01)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C279(0.87); C292(0.89); C282(0.96)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C279(0.94); C282(0.99)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C279(1.01); C292(0.98); C282(1.12)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C279(0.98)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C279(0.94); C292(0.98); C282(0.99)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C279(0.97); C282(1.10)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C279(1.13); C292(0.84); C282(0.85)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C279(1.06); C292(0.98); C282(1.05)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C279(1.05)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C279(0.94); C292(1.00); C282(1.04)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C279(0.86); C282(0.95)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C279(0.96); C292(0.98); C282(1.07)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C279(1.04)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C279(0.98); C292(0.88); C282(0.92)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C279(0.95); C282(0.92)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C279(0.95); C292(0.94); C282(1.04)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C279(1.08)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C279(1.05); C292(0.99); C282(0.97)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C279(0.95); C282(0.98)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C279(1.12); C292(0.99); C282(1.05)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C279(0.86); C292(0.80); C282(0.98)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C279(1.12); C292(1.04); C282(0.93)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C279(1.04); C292(0.99); C282(1.03)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C279(1.01); C292(0.91); C282(0.95)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C279(1.03); C292(0.97)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C279(0.97); C292(0.76)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C279(1.00); C292(0.81)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C279(1.05); C292(0.97)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C279(1.08); C292(0.91); C282(1.06)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C279(0.95)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C279(1.02); C292(1.00); C282(0.98)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C279(1.02); C282(1.02)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C279(0.95); C292(1.05); C282(1.03)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C279(0.93); C292(0.97); C282(1.02)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C279(0.99); C282(1.04)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C279(1.02); C292(0.96); C282(1.21)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C279(0.98); C292(0.96); C282(0.98)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C279(1.06); C292(1.11)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C279(0.82); C292(0.83)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C279(1.02); C292(1.18)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C279(1.02); C292(0.96)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C279(1.02); C292(0.88); C282(1.00)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C279(1.01)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C279(1.00); C282(0.98)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C279(1.06); C292(0.89); C282(0.96)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C279(1.02); C292(1.05); C282(1.10)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C279(0.89); C292(0.94); C282(0.98)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C279(1.00); C292(0.96); C282(0.92)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C279(1.13); C292(0.94); C282(1.00)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C279(0.97); C292(1.00)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C279(0.84); C292(0.91)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C279(0.93); C292(0.90)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C279(0.98); C292(0.92)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C279(1.00); C292(0.93); C282(1.03)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C279(1.06)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C279(0.92); C292(0.88); C282(1.08)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C279(1.00); C292(0.92); C282(0.95)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C279(1.03); C292(0.90); C282(1.00)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C279(0.85); C292(0.81); C282(0.95)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C279(0.87); C292(0.88); C282(0.77)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C279(0.98); C292(0.92); C282(0.92)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C279(0.94); C292(0.94)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C279(0.79); C292(0.71)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C279(0.93); C292(0.92)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C279(0.98); C292(0.90)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C279(1.06); C292(0.86); C282(0.76)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C279(1.01); C292(0.72); C282(0.92)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C279(1.08)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C279(1.00); C292(0.95); C282(1.00)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C279(1.03); C282(1.04)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C279(0.96); C292(0.88); C282(0.96)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C279(0.91); C292(0.94); C282(1.01)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C279(0.99); C292(0.91); C282(0.82)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C279(0.99); C292(0.91); C282(0.94)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C279(1.01); C292(0.95)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C279(0.91); C292(0.99)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C279(0.95); C292(0.93); C282(0.93)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C279(0.97); C292(0.99)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C279(1.01); C292(0.94)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C279(1.07); C292(0.87); C282(1.07)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C279(0.96)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C279(1.00); C292(0.97); C282(1.05)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C279(1.04); C292(1.00); C282(0.93)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C279(0.79); C292(0.85); C282(0.96)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C279(0.99); C292(1.05); C282(1.03)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C279(1.04); C292(1.00); C282(1.00)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C279(0.74); C292(0.61)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C279(1.08); C292(1.01)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C279(0.96); C292(1.07)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C279(0.99); C292(0.90)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C279(0.97); C292(0.90)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C279(0.96); C292(0.85); C282(0.90)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C279(1.04)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C279(0.99); C292(0.90); C282(0.92)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C279(0.93); C282(0.88)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C279(0.95); C292(0.94); C282(0.97)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C279(0.96); C292(0.93); C282(0.93)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C279(1.01); C292(0.81)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C279(0.76); C292(0.72); C282(0.74)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C279(1.04); C292(0.94); C282(0.95)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C279(0.96); C292(0.91)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C279(0.91); C292(0.82)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C279(0.94); C292(0.89)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C279(0.78); C292(0.69)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C279(0.91); C292(0.80); C282(0.88)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C279(0.99)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C279(0.92); C292(0.92); C282(0.88)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C279(0.93); C282(0.94)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C279(0.97); C282(0.94)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C282(0.78); C292(0.75); C279(0.64)  LDD1702  [5]
 LDCM0625  F8 Ramos C171(0.94); C279(1.64); 1.17  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C171(0.59); C279(0.60); 1.77  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C171(14.67); C279(0.67); 2.98  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C171(0.55); C279(0.28); 1.47  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C171(1.28); C279(1.00); 1.38  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C171(0.82); C279(0.84); 0.78  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C171(0.48); C279(0.48); 1.09  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C171(0.96); C279(0.80); 1.28  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C171(1.73); C279(1.27)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C171(1.45); C279(0.82); 1.15  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C171(1.16); C279(0.21); 0.89  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C171(1.74); C279(1.24); 1.34  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C171(1.04); C279(1.01); 1.44  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C171(0.70); C279(0.31); 1.31  LDD2201  [24]
 LDCM0468  Fragment33 HEK-293T C279(0.94); C282(0.96)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C171(1.08); C279(0.81); 1.29  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C171(0.54); C279(0.78); 1.32  LDD2184  [24]
 LDCM0427  Fragment51 HEK-293T C279(1.07); C292(0.96); C282(0.95)  LDD1631  [9]
 LDCM0610  Fragment52 Ramos C171(1.49); C279(1.28); 2.10  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C171(1.39); C279(1.75); 1.94  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C171(0.52); C279(0.71); 1.94  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C171(0.49); C279(0.57); 1.41  LDD2188  [24]
 LDCM0116  HHS-0101 DM93 Y147(0.83); Y52(1.18)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y52(0.66); Y147(1.94)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y52(0.50); Y147(0.78)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y52(2.01); Y147(2.56)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y52(0.64); Y147(1.70)  LDD0268  [6]
 LDCM0107  IAA HeLa H110(0.00); C279(0.00)  LDD0221  [8]
 LDCM0022  KB02 Ramos C171(0.51); C279(0.59); 2.77  LDD2182  [24]
 LDCM0023  KB03 MDA-MB-231 C282(0.82); C279(0.42)  LDD1701  [5]
 LDCM0024  KB05 Ramos C171(0.37); C279(0.73); 2.92  LDD2185  [24]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C171(0.92)  LDD2102  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C279(0.36); C171(0.49)  LDD2121  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C279(0.49); C171(0.39)  LDD2089  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C171(0.87)  LDD2090  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C279(1.36); C171(0.94)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C171(2.74)  LDD2094  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C171(0.43)  LDD2096  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C279(0.92); C171(0.67)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C171(0.56)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C279(1.06)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C279(0.25)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C279(1.84); C171(0.90)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C171(0.47); C282(0.52)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C171(1.57)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C171(0.29)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C279(0.75); C171(0.95)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C171(0.41)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C279(0.67); C171(0.55)  LDD2109  [5]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C171(0.61)  LDD2110  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C279(0.79); C171(0.86)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C171(0.45)  LDD2114  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C279(0.72); C171(0.39)  LDD2115  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C171(0.71)  LDD2116  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C279(1.00); C171(0.76)  LDD2118  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C279(3.32); C171(2.85)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C171(1.04)  LDD2120  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C171(0.46)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C279(0.72); C171(0.60)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C279(0.65); C171(0.51)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C171(0.65)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C279(0.68); C171(0.51)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C279(0.94); C171(1.04)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C171(1.00)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C279(1.01); C171(0.94)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C279(0.74); C171(0.45)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C279(0.81); C171(0.51)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C279(0.77); C171(0.77)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C279(0.72); C171(0.74)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C279(0.93); C171(0.90)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C171(2.46); C279(1.94)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C279(0.72); C171(0.94)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C279(0.29); C171(0.57)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C171(1.33)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C279(3.58); C171(4.16)  LDD2144  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C279(0.33)  LDD2145  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C279(0.81); C171(0.90)  LDD2146  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C171(5.99)  LDD2147  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C279(0.63); C171(0.46)  LDD2148  [5]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C171(0.57)  LDD2149  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C171(0.51)  LDD2150  [5]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C171(0.51)  LDD2151  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C171(1.77)  LDD2153  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C279(0.19)  LDD2207  [25]
 LDCM0096  SAHA K562 6.00  LDD0363  [23]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 2 (PRMT2) Protein arginine N-methyltransferase family P55345
Probable ATP-dependent RNA helicase DDX17 (DDX17) DEAD box helicase family Q92841
Probable ATP-dependent RNA helicase DDX5 (DDX5) DEAD box helicase family P17844
Thioredoxin-like protein 4B (TXNL4B) DIM1 family Q9NX01
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788
Serine/threonine-protein kinase Kist (UHMK1) Ser/Thr protein kinase family Q8TAS1
Tyrosine-protein kinase ABL2 (ABL2) Tyr protein kinase family P42684
E3 ubiquitin-protein ligase TRIM69 (TRIM69) TRIM/RBCC family Q86WT6
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit alpha-1 (KPNA2) Importin alpha family P52292
Importin subunit alpha-5 (KPNA1) Importin alpha family P52294
Importin subunit alpha-7 (KPNA6) Importin alpha family O60684
Other
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Splicing factor 1 (SF1) BBP/SF1 family Q15637
Protein FAM168A (FAM168A) FAM168 family Q92567
KH homology domain-containing protein 4 (KHDC4) KHDC4 family Q7Z7F0
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
Pre-mRNA-processing factor 40 homolog A (PRPF40A) PRPF40 family O75400
Protein transport protein Sec23A (SEC23A) SEC23/SEC24 family Q15436
Splicing factor 3A subunit 2 (SF3A2) SF3A2 family Q15428
Splicing factor U2AF 65 kDa subunit (U2AF2) Splicing factor SR family P26368
Probable cytosolic iron-sulfur protein assembly protein CIAO1 (CIAO1) WD repeat CIA1 family O76071
Calcium homeostasis endoplasmic reticulum protein (CHERP) . Q8IWX8
Centrosomal protein of 104 kDa (CEP104) . O60308
Cytoplasmic protein NCK2 (NCK2) . O43639
Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) . Q99729
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) . O14979
Splicing factor 3A subunit 1 (SF3A1) . Q15459
Splicing factor 45 (RBM17) . Q96I25
Splicing factor, suppressor of white-apricot homolog (SFSWAP) . Q12872
Ubiquitin-like protein 5 (UBL5) . Q9BZL1

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
23 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.