Details of the Target

General Information of Target

Target ID LDTP09865
Target Name Histone deacetylase 2 (HDAC2)
Gene Name HDAC2
Gene ID 3066
Synonyms
Histone deacetylase 2; HD2; EC 3.5.1.98; Protein deacylase HDAC2; EC 3.5.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSSSPAGLEGSDLSSINTMMSAVMSVGKVTENGGSPQGIKSPSKPPGPNRIGRRNQETK
EEKSSYNCPLCEKICTTQHQLTMHIRQHNTDTGGADHSCSICGKSLSSASSLDRHMLVHS
GERPYKCTVCGQSFTTNGNMHRHMKIHEKDPNSATATAPPSPLKRRRLSSKRKLSHDAES
EREDPAPAKKMVEDGQSGDLEKKADEVFHCPVCFKEFVCKYGLETHMETHSDNPLRCDIC
CVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCRKFPRISQA
WCETNLRRCISEQHRFVCDTCDKAFPMLCSLALHKQTHVAADQGQEKPQATPLPGDALDQ
KGFLALLGLQHTKDVRPAPAEEPLPDDNQAIQLQTLKCQLPQDPGCTNLLSLSPFEAASL
GGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQILKMAASA
PPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQASPGCISP
SLPPPPLKLLKGSVEAASNAHLLQSKSGTQPHAATRLSLQQPRAELPGQPEMKTQLEQDS
IIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVLYPCRFCNQVFAFSGVLRA
HVRSHLGISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPFTVKANCERHLRK
KHLKATRKDIEKNIEYVSSSAAELVDAFCAPDTVCRLCGEDLKHYRALRIHMRTHCGRGL
GGGHKGRKPFECKECSAAFAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGPAEAPAAE
ASGRGEDSGCAALGDCKPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPL
DFSQKGLALVQVKQENISFLSPSSLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPE
EEAGSSEQPSPCPAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQLAVPIYS
SALVSSPPLVGSSALLSGTALLRPLRPKPPLLLPKPPVTEELPPLASIAQIISSVSSAPT
LLKTKVADPGPASTGSNTTASDSLGGSVPKAATTATPAATTSPKESSEPPAPASSPEAAS
PTEQGPAGTSKKRGRKRGMRSRPRANSGGVDLDSSGEFASIEKMLATTDTNKFSPFLQTA
EDNTQDEVAGAPADHHGPSDEEQGSPPEDKLLRAKRNSYTNCLQKITCPHCPRVFPWASS
LQRHMLTHTDSQSDAETAAAAGEVLDLTSRDREQPSEGATELRQVAGDAPVEQATAETAS
PVHREEHGRGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLMDFKLAEGDGE
AGAGGAASQEQKLACDTCGKSFKFLGTLSRHRKAHGRQEPKDEKGDGASTAEEGPQPAPE
QEEKPPETPAEVVESAPGAGEAPAEKLAEETEGPSDGESAAEKRSSEKSDDDKKPKTDSP
KSVASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKHSLVRHQR
IHQKARHAKHHGKDSDKEERGEEDSENESTHSGNNAVSENEAELAPNASNHMAVTRSRKE
GLASATKDCSHREEKVTAGWPSEPGQGDLNPESPAALGQDLLEPRSKRPAHPILATADGA
SQLVGME
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Histone deacetylase family, HD type 1 subfamily
Subcellular location
Nucleus
Function
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively.
TTD ID
T51191
Uniprot ID
Q92769
DrugMap ID
TTCKXRW
Ensemble ID
ENST00000368632.6
HGNC ID
HGNC:4853
ChEMBL ID
CHEMBL1937

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO829 SNV: p.R409Ter DBIA    Probe Info 
HCT15 Deletion: p.T459QfsTer47 .
Ishikawa (Heraklio) 02 ER SNV: p.E453D DBIA    Probe Info 
LNCaP clone FGC SNV: p.A62V DBIA    Probe Info 
NCIH1944 SNV: p.K145T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y359(20.00); Y68(20.00); Y238(16.62); Y222(7.31)  LDD0257  [2]
TH216
 Probe Info  		Y359(20.00); Y68(15.62); Y222(10.03)  LDD0259  [2]
STPyne
 Probe Info  		K362(7.14); K75(1.30)  LDD0277  [3]
SAHA-CA-4PAP
 Probe Info  		20.00  LDD0269  [4]
THZ1-DTB
 Probe Info  		C111(0.93)  LDD0460  [5]
BTD
 Probe Info  		C274(0.79)  LDD2089  [6]
AHL-Pu-1
 Probe Info  		C417(8.13)  LDD0169  [7]
HHS-475
 Probe Info  		Y88(0.89)  LDD0264  [8]
HHS-465
 Probe Info  		Y88(10.00)  LDD2237  [9]
DBIA
 Probe Info  		C274(1.28)  LDD0080  [10]
ATP probe
 Probe Info  		K32(0.00); K9(0.00); K10(0.00); K362(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C274(0.00); C262(0.00); C13(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C262(0.00); C274(0.00); C101(0.00)  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C274(0.00); C417(0.00); C13(0.00); C262(0.00)  LDD0037  [12]
IPM
 Probe Info  		N.A.  LDD0025  [14]
NHS
 Probe Info  		K243(0.00); K90(0.00)  LDD0010  [15]
SF
 Probe Info  		Y88(0.00); Y49(0.00); Y3(0.00); Y202(0.00)  LDD0028  [16]
TFBX
 Probe Info  		N.A.  LDD0148  [14]
Phosphinate-6
 Probe Info  		C101(0.00); C285(0.00)  LDD0018  [17]
1c-yne
 Probe Info  		N.A.  LDD0228  [18]
Acrolein
 Probe Info  		C274(0.00); C417(0.00)  LDD0217  [19]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [19]
Methacrolein
 Probe Info  		N.A.  LDD0218  [19]
AOyne
 Probe Info  		13.60  LDD0443  [20]
NAIA_5
 Probe Info  		C13(0.00); C274(0.00); C111(0.00); C101(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.11  LDD0475  [22]
STS-1
 Probe Info  		N.A.  LDD0136  [23]
STS-2
 Probe Info  		N.A.  LDD0138  [23]
VE-P
 Probe Info  		N.A.  LDD0396  [24]
SAHA-CA-3PAP
 Probe Info  		8.71  LDD0363  [4]
SAHA-CA-8PAP
 Probe Info  		18.68  LDD0362  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C274(0.48)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C274(0.64)  LDD2112  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C274(0.88)  LDD2131  [6]
 LDCM0025  4SU-RNA DM93 C101(2.17)  LDD0170  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C417(8.13)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C101(0.64); C111(0.64); C262(1.60); C274(1.25)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C262(1.11); C274(0.98)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C262(1.12); C274(1.04)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C262(0.95); C274(0.92)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C262(0.87); C274(0.94)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C262(0.90); C274(0.97)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C262(0.98); C274(0.96)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C262(0.77); C274(0.96)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C262(0.93); C274(0.95)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C262(0.93); C274(1.07)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C262(0.84); C274(1.05)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C262(0.81); C274(0.88)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C262(1.20); C274(1.10)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C262(0.79); C274(0.94)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C262(0.71); C274(0.97)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C262(0.87); C274(0.97)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C262(1.24); C274(1.08)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C262(1.15); C274(1.12)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C262(1.22); C274(1.19)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C262(1.19); C274(1.02)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C262(1.09); C274(1.06)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C262(1.20); C274(1.07)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C262(1.14); C274(1.04)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C262(1.10); C274(1.05)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C262(1.15); C274(1.17)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C262(1.11); C274(1.14)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C262(1.08); C274(1.17)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C262(1.15); C274(1.17)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C262(1.20); C274(0.99)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C262(1.09); C274(1.05)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C262(1.25); C274(1.09)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C262(1.32); C274(1.09)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C262(0.89); C274(1.13)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C262(0.98); C274(1.21)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C262(1.31); C274(1.33)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C262(1.47); C274(1.08)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C262(1.08); C274(1.24)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C262(1.13); C274(1.27)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C262(0.86); C274(1.10)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C262(0.98); C274(1.10)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C262(0.95); C274(1.16)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C262(0.98); C274(1.18)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C262(0.97); C274(1.09)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C262(1.48); C274(1.12)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C262(1.09); C274(1.01)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C262(1.08); C274(1.14)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C262(1.04); C274(1.17)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C262(1.00); C274(1.27)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C262(0.71); C274(1.03)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C262(0.76); C274(1.12)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C262(0.80); C274(1.09)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C262(0.93); C274(1.04)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C262(0.81); C274(1.13)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C262(0.65); C274(1.11)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C262(0.78); C274(1.07)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C274(0.95); C262(1.09)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C262(0.65); C274(1.04)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C262(0.66); C274(1.01)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C262(0.82); C274(1.19)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C262(0.57); C274(1.13)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C262(0.77); C274(1.05)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C262(0.81); C274(1.02)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C262(0.70); C274(1.00)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C262(0.84); C274(0.95)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C274(1.03); C262(1.18)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C274(1.25); C262(1.36)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C274(1.02); C262(1.17)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C101(0.81); C111(0.81); C274(1.06); C262(1.31)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C274(1.02); C262(1.07)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C262(0.96); C274(1.00)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C262(1.02); C274(1.09)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C274(1.03); C262(1.05)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C274(0.99); C262(1.24)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C262(1.05); C274(1.07)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C262(0.88); C274(1.05)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C274(0.95); C262(1.04)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C262(0.80); C274(0.99)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C262(0.93); C274(1.01)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C101(0.71); C111(0.71); C274(1.13); C262(1.24)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C274(1.01); C262(1.25)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C274(0.96); C262(1.09)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C262(0.97); C274(0.99)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C274(0.99); C262(1.14)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C274(1.01); C262(1.18)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C274(0.99); C262(1.12)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C274(0.98); C262(1.14)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C262(1.02); C274(1.07)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C274(0.97); C262(0.99)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C262(0.83); C274(0.92)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C101(0.96); C111(0.96); C262(0.97); C274(1.12)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C262(1.01); C274(1.03)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C262(0.92); C274(1.21)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C262(0.83); C274(0.96)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C262(0.96); C274(1.03)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C262(0.99); C274(1.04)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C262(0.99); C274(1.21)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C262(0.98); C274(1.08)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C262(0.83); C274(1.12)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C262(0.92); C274(1.18)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C262(0.82); C274(1.09)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C101(0.64); C111(0.64); C262(1.02); C274(1.17)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C262(0.87); C274(1.10)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C262(0.83); C274(1.12)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C262(0.88); C274(1.23)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C262(0.80); C274(1.03)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C262(0.84); C274(1.12)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C262(0.81); C274(1.16)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C262(0.60); C274(1.09)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C274(1.33); C262(1.37)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C274(1.33); C262(1.37)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C274(1.22); C262(1.24)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C274(1.03); C262(1.24)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C274(1.39); C262(1.59)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C262(1.33); C274(1.38)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C262(1.13); C274(1.39)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C274(1.40); C262(1.48)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C262(1.33); C274(1.36)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C262(1.25); C274(1.53)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C262(1.53); C274(1.58)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C262(0.94); C274(1.30)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C274(0.86); C262(1.27)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C274(0.82); C262(1.16)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C274(1.01); C262(1.15)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C262(0.79); C274(0.86)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C274(0.85); C262(1.05)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C274(0.90); C262(1.16)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C262(0.66); C274(0.92)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C274(0.83); C262(0.96)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C262(0.51); C274(0.92)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C274(0.84); C262(0.98)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C274(0.90); C262(1.02)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C274(0.82); C262(1.29)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C274(0.88); C262(1.09)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C274(1.02); C262(1.16)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C274(0.92); C262(1.34)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C274(0.89); C262(0.96)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C262(0.27); C274(0.91)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C274(1.11); C262(1.18)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C274(1.00); C262(1.25)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C274(1.01); C262(1.08)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C274(0.91); C262(1.10)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C274(0.99); C262(1.27)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C274(0.92); C262(1.17)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C274(1.03); C262(1.27)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C274(0.96); C262(1.09)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C274(1.00); C262(1.07)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C274(1.11); C262(1.30)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C274(1.08); C262(1.21)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C274(1.00); C262(1.19)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C274(0.94); C262(1.35)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C274(0.90); C262(1.17)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C274(1.07); C262(1.18)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C262(0.58); C274(0.79)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C262(0.83); C274(0.95)  LDD0683  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C274(0.85)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C262(1.08); C274(0.99)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C274(1.06); C262(1.15)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C274(0.99); C262(1.17)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 11.56  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C274(0.70)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C262(0.00); C417(0.00); H69(0.00); C274(0.00)  LDD0222  [19]
 LDCM0632  CL-Sc Hep-G2 C417(1.00)  LDD2227  [21]
 LDCM0367  CL1 HCT 116 C274(0.90); C262(0.98)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C262(1.03); C274(1.11)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C101(0.70); C111(0.70); C262(1.00); C274(1.14)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C274(0.81); C262(1.18)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C274(1.04); C262(1.05)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C274(0.90); C262(1.17)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C274(0.92); C262(1.18)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C274(0.98); C262(1.08)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C262(1.12); C274(1.19)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C262(0.98); C274(1.23)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C262(1.06); C274(1.12)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C262(0.95); C274(1.07)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C262(0.99); C274(1.13)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C274(1.06); C262(1.13)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C262(0.95); C274(1.07)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C262(0.77); C274(0.85)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C274(0.97); C262(1.07)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C262(0.90); C274(1.01)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C274(0.87); C262(0.93)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C274(1.00); C262(1.00)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C262(0.72); C274(0.94)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C262(0.89); C274(1.08)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C262(0.98); C274(1.12)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C262(0.89); C274(0.99)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C262(0.86); C274(1.12)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C262(0.78); C274(1.01)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C262(0.85); C274(1.07)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C262(0.78); C274(1.20)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C262(0.82); C274(1.11)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C262(0.80); C274(1.12)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C262(0.84); C274(1.23)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C262(1.01); C274(1.18)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C274(1.19); C262(1.42)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C274(0.98); C262(1.08)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C274(1.07); C262(1.20)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C262(0.93); C274(1.15)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C262(0.84); C274(1.21)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C262(0.97); C274(0.99)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C274(0.93); C262(3.34)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C274(0.85); C262(0.85)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C274(0.91); C262(0.97)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C274(1.03); C262(1.69)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C274(1.17); C262(1.66)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C274(0.93); C262(0.98)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C262(0.99); C274(1.20)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C262(1.03); C274(1.17)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C262(1.34); C274(1.32)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C262(1.39); C274(1.08)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C262(0.96); C274(0.96)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C262(1.08); C274(1.07)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C262(2.07); C274(1.20)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C262(1.01); C274(0.91)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C262(0.94); C274(1.33)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C101(0.99); C111(0.99); C262(1.16); C274(1.01)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C101(1.27); C111(1.27); C262(1.19); C274(1.23)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C101(1.52); C111(1.52); C262(1.62); C274(1.16)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C101(1.23); C111(1.23); C262(1.29); C274(1.03)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C101(0.93); C111(0.93); C262(1.12); C274(1.05)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C101(0.99); C111(0.99); C262(1.20); C274(1.00)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C101(0.93); C111(0.93); C262(1.07); C274(0.99)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C101(1.04); C111(1.04); C262(1.04); C274(0.97)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C262(1.13); C274(1.04)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C101(0.96); C111(0.96); C262(1.17); C274(1.13)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C101(0.92); C111(0.92); C262(0.94); C274(0.98)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C101(0.66); C111(0.66); C262(0.74); C274(1.04)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C101(0.96); C111(0.96); C262(1.14); C274(1.00)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C101(1.27); C111(1.27); C262(1.30); C274(1.03)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C101(1.17); C111(1.17); C262(1.48); C274(1.15)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C262(0.97); C274(1.12)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C262(0.96); C274(1.05)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C262(1.08); C274(0.99)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C262(1.15); C274(0.94)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C262(1.00); C274(0.92)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C262(0.99); C274(0.88)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C262(1.12); C274(0.99)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C262(0.99); C274(0.95)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C262(0.88); C274(0.87)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C262(1.07); C274(1.00)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C262(1.09); C274(0.99)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C262(0.93); C274(1.06)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C262(0.82); C274(0.98)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C262(1.13); C274(1.09)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C262(0.94); C274(1.01)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C262(1.22); C274(1.04)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C262(1.01); C274(1.04)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C101(0.70); C111(0.70); C274(1.04)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C101(0.66); C111(0.66); C274(0.99)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C101(0.96); C111(0.96); C274(0.96)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C101(1.25); C111(1.25); C274(1.05)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C101(1.01); C111(1.01); C274(0.98)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C101(0.88); C111(0.88); C274(1.09)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C101(0.83); C111(0.83); C274(1.09)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C101(0.88); C111(0.88); C274(0.94)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C101(1.32); C111(1.32); C274(1.04)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C262(1.19); C274(1.13)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C101(1.13); C111(1.13); C274(1.02)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C101(0.68); C111(0.68); C274(0.90)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C101(0.88); C111(0.88); C274(1.02)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C101(0.76); C111(0.76); C274(0.92)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C101(0.78); C111(0.78); C274(0.91)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C101(1.25); C111(1.25); C274(1.01)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C101(0.90); C111(0.90); C274(0.99)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C101(0.94); C111(0.94); C274(1.08)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C101(1.06); C111(1.06); C274(0.97)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C262(1.04); C274(1.10)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C101(1.52); C111(1.52); C274(1.09)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C101(0.92); C111(0.92); C274(1.02)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C101(0.99); C111(0.99); C274(1.05)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C101(0.97); C111(0.97); C274(1.09)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C101(0.77); C111(0.77); C274(1.13)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C101(0.99); C111(0.99); C274(1.16)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C101(0.89); C111(0.89); C274(1.07)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C101(1.00); C111(1.00); C274(1.00)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C101(1.16); C111(1.16); C274(1.05)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C101(0.63); C111(0.63); C274(1.03)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C262(1.03); C274(1.14)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C101(1.13); C111(1.13); C274(1.00)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C101(0.83); C111(0.83); C262(0.95); C274(1.04)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C101(1.55); C111(1.55); C262(0.97); C274(1.08)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C101(0.71); C111(0.71); C262(0.95); C274(1.05)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C101(0.61); C111(0.61); C262(0.99); C274(1.03)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C101(0.98); C111(0.98); C262(0.98); C274(1.12)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C101(1.35); C111(1.35); C262(0.83); C274(1.05)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C101(1.02); C111(1.02); C262(1.09); C274(1.05)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C101(0.81); C111(0.81); C262(0.94); C274(1.10)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C101(0.73); C111(0.73); C262(1.01); C274(1.13)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C417(0.87); C13(1.00); C274(1.06); C262(1.03)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C274(0.96)  LDD1702  [6]
 LDCM0625  F8 Ramos C417(1.34)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C417(0.75)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C417(0.99)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C417(0.61)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C417(0.87)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C417(0.67)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C417(0.59)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C417(0.95)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C417(1.36)  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C417(0.86)  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C417(1.05)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C417(1.12)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C417(0.92)  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C417(0.94)  LDD2201  [26]
 LDCM0468  Fragment33 HCT 116 C101(0.71); C111(0.71); C274(0.96)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C417(0.94)  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C417(0.92)  LDD2184  [26]
 LDCM0427  Fragment51 HCT 116 C101(0.80); C111(0.80); C262(0.86); C274(1.09)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C417(1.16)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C417(1.09)  LDD2205  [26]
 LDCM0569  Fragment7 Ramos C417(0.85)  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C417(0.78)  LDD2188  [26]
 LDCM0116  HHS-0101 DM93 Y88(0.89)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y88(0.75)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y88(0.72)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y88(0.78)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y88(0.74)  LDD0268  [8]
 LDCM0107  IAA HeLa C274(0.00); H69(0.00); H345(0.00)  LDD0221  [19]
 LDCM0022  KB02 HCT 116 C274(1.28)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C274(1.60)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C274(1.36)  LDD0082  [10]
 LDCM0109  NEM HeLa N.A.  LDD0223  [19]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C274(0.79)  LDD2089  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C274(0.89)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C274(1.02)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C274(0.52)  LDD2100  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C274(0.51)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C274(1.18)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C274(0.95)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C274(0.68)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C274(0.74)  LDD2109  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C274(1.06)  LDD2135  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C274(0.82)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C274(0.83)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C274(0.53)  LDD2141  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C274(1.67)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C274(0.87)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C274(0.55)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C274(0.48)  LDD2150  [6]
 LDCM0096  SAHA K562 20.00  LDD0269  [4]
 LDCM0021  THZ1 HeLa S3 C111(0.93)  LDD0460  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 516 (ZNF516) Krueppel C2H2-type zinc-finger protein family Q92618
Zinc finger protein 827 (ZNF827) Krueppel C2H2-type zinc-finger protein family Q17R98
DNA-binding protein RFX5 (RFX5) RFX family P48382
Zinc finger protein SNAI1 (SNAI1) Snail C2H2-type zinc-finger protein family O95863
B-cell lymphoma/leukemia 11B (BCL11B) . Q9C0K0
Metastasis-associated protein MTA1 (MTA1) . Q13330
Methyl-CpG-binding domain protein 1 (MBD1) . Q9UIS9
Myc proto-oncogene protein (MYC) . P01106
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Breast cancer metastasis-suppressor 1 (BRMS1) BRMS1 family Q9HCU9
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Nucleophosmin (NPM1) Nucleoplasmin family P06748
Steroid receptor RNA activator 1 (SRA1) SRA1 family Q9HD15
Host cell factor 1 (HCFC1) . P51610
Paired amphipathic helix protein Sin3a (SIN3A) . Q96ST3

The Drug(s) Related To This Target

Approved
Click To Hide/Show 15 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aminophylline Small molecular drug DB01223
Atorvastatin Small molecular drug DB01076
Decitabine Small molecular drug DB01262
Fluvastatin Small molecular drug DB01095
Lovastatin Small molecular drug DB00227
Oxtriphylline Small molecular drug DB01303
Phenylbutyric Acid Small molecular drug DB06819
Pravastatin Small molecular drug DB00175
Propanoic Acid Small molecular drug DB03766
Romidepsin Small molecular drug DB06176
Simvastatin Small molecular drug DB00641
Theophylline Small molecular drug DB00277
Valproic Acid Small molecular drug DB00313
Vorinostat Small molecular drug DB02546
Tixocortol . DB09091
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Chr-3996 Small molecular drug D06TKI
Investigative
Click To Hide/Show 99 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(E)-8-biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one Small molecular drug D0KE3I
1,1,1-trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one Small molecular drug D06BKA
1,1,1-trifluoro-8-phenoxy-octan-2-one Small molecular drug D04ETX
2-(Allyloxy)-n8-hydroxy-n1-phenyloctanediamide Small molecular drug D0D2US
2-(Benzyloxy)-n7-hydroxy-n1-phenylheptanediamide Small molecular drug D0FI2F
2-(Methylsulfonylthio)Ethyl 2-propylpentanoate Small molecular drug D0H1FZ
4-benzoylamino-n-hydroxy-benzamide Small molecular drug D09ZNU
4-butyrylamino-n-hydroxy-benzamide Small molecular drug D05LLX
4-chloro-n-(5-hydroxycarbamoyl-pentyl)-benzamide Small molecular drug D0A5LS
4-dimethylamino-n-(6-mercapto-hexyl)-benzamide Small molecular drug D06XNP
4-hydroxy-n-(5-hydroxycarbamoyl-pentyl)-benzamide Small molecular drug D04NSP
4-phenylbutyrohydroxamic Acid Small molecular drug D02NWS
5-(4-chloro-phenyl)-pentanoic Acid Hydroxyamide Small molecular drug D0V2ZO
5-(4-hydroxyphenyl)-3h-1,2-dithiole-3-thione Small molecular drug D06IQB
5-(Biphenyl-4-yl)-pentanoic Acid N-hydroxyamide Small molecular drug D0K3MR
5-mercapto-pentanoic Acid Phenylamide Small molecular drug D0D2KE
6-(2-bromo-acetylamino)-hexanoic Acid Phenylamide Small molecular drug D02MQM
6-benzenesulfinylhexanoic Acid Hydroxamide Small molecular drug D00ZSD
6-benzenesulfonylhexanoic Acid Hydroxamide Small molecular drug D05AHZ
6-mercapto-hexanoic Acid Phenylamide Small molecular drug D0B3ZM
6-phenoxy-hexane-1-thiol Small molecular drug D09YBN
6-phenylsulfanylhexanoic Acid Hydroxamide Small molecular drug D0S9JF
7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one Small molecular drug D0B2ZJ
7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one Small molecular drug D0Z3BM
7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one Small molecular drug D02WZK
7-(Biphenyl-4-yloxy)-heptanoic Acid Hydroxyamide Small molecular drug D04LLD
7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one Small molecular drug D05VFP
7-biphenyl-4-yl-heptanoic Acid Hydroxyamide Small molecular drug D01RJY
7-mercapto-heptanoic Acid Benzothiazol-2-ylamide Small molecular drug D0Z5KX
7-mercapto-heptanoic Acid Biphenyl-3-ylamide Small molecular drug D05XAN
7-mercapto-heptanoic Acid Biphenyl-4-ylamide Small molecular drug D01XWZ
7-mercapto-heptanoic Acid Phenylamide Small molecular drug D00SEE
7-mercapto-heptanoic Acid Pyridin-3-ylamide Small molecular drug D07FJU
7-mercapto-heptanoic Acid Quinolin-3-ylamide Small molecular drug D0T4IY
7-phenoxy-heptanoic Acid Hydroxyamide Small molecular drug D05ZGM
8-(Biphenyl-3-yloxy)-1,1,1-trifluoro-octan-2-one Small molecular drug D0NL6C
8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one Small molecular drug D0AX7B
8-(Biphenyl-4-yloxy)-2-oxo-octanoic Acid Small molecular drug D03XXI
8-mercapto-octanoic Acid Phenylamide Small molecular drug D0XZ9Q
8-oxo-8-phenyl-octanoic Acid Small molecular drug D0RU1X
8-oxo-8-phenyl-octanoic Acid Hydroxyamide Small molecular drug D0S0WK
8-phenyl-octanoic Acid Hydroxyamide Small molecular drug D0H9DS
9,9,9-trifluoro-8-oxo-nonanoic Acid Phenylamide Small molecular drug D00KFF
9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one Small molecular drug D05FEJ
Abexinostat Small molecular drug DB12565
Cyclostellettamine Derivative Small molecular drug D0C0VP
Mocetinostat Small molecular drug DB11830
N-(2-amino-5-(Benzofuran-2-yl)Phenyl)Benzamide Small molecular drug D0Q4LX
N-(2-amino-5-(Furan-2-yl)Phenyl)Benzamide Small molecular drug D0I2KC
N-(2-amino-5-(Furan-3-yl)Phenyl)Benzamide Small molecular drug D0A4KW
N-(2-amino-5-(Pyridin-4-yl)Phenyl)Benzamide Small molecular drug D07BMT
N-(2-amino-5-(Thiazol-2-yl)Phenyl)Benzamide Small molecular drug D0Y4SD
N-(2-amino-5-(Thiophen-2-yl)Phenyl)Nicotinamide Small molecular drug D0Q2GM
N-(2-aminophenyl)-4-methoxybenzamide Small molecular drug D0YO6M
N-(2-aminophenyl)Benzamide Small molecular drug D0U8FC
N-(2-aminophenyl)Nicotinamide Small molecular drug D04UVL
N-(2-aminophenyl)Quinoxaline-6-carboxamide Small molecular drug D01FYB
N-(2-mercapto-ethyl)-n'-phenyl-oxalamide Small molecular drug D0F0KS
N-(2-mercapto-ethyl)-n'-phenyl-succinamide Small molecular drug D01MFV
N-(3'-acetyl-4-aminobiphenyl-3-yl)Benzamide Small molecular drug D08USK
N-(4'-acetyl-4-aminobiphenyl-3-yl)Benzamide Small molecular drug D01TSM
N-(4-amino-3'-methoxybiphenyl-3-yl)Benzamide Small molecular drug D06IWR
N-(4-amino-3'-methylbiphenyl-3-yl)Benzamide Small molecular drug D07WSB
N-(4-amino-4'-bromobiphenyl-3-yl)Benzamide Small molecular drug D0H4SC
N-(4-amino-4'-fluorobiphenyl-3-yl)Benzamide Small molecular drug D08YLO
N-(4-amino-4'-methoxybiphenyl-3-yl)Benzamide Small molecular drug D0W2PX
N-(4-amino-4'-vinylbiphenyl-3-yl)Benzamide Small molecular drug D05RWU
N-(4-aminobiphenyl-3-yl)Benzamide Small molecular drug D0MD7H
N-(4-aminobiphenyl-3-yl)Nicotinamide Small molecular drug D0M9LJ
N-(4-hydroxybiphenyl-3-yl)Benzamide Small molecular drug D0E0TA
N-(5-hydroxycarbamoyl-pentyl)-4-nitro-benzamide Small molecular drug D0C2KD
N-(6-hydroxycarbamoyl-hexyl)-benzamide Small molecular drug D0YY9M
N-(6-mercapto-hexyl)-benzamide Small molecular drug D04HSS
N-hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide Small molecular drug D04ZDI
N-hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide Small molecular drug D0QO0L
N-hydroxy-4-(2-phenyl-butyrylamino)-benzamide Small molecular drug D06VBN
N-hydroxy-4-(4-phenyl-butyrylamino)-benzamide Small molecular drug D0S7WQ
N-hydroxy-4-(5-phenyl-pentanoylamino)-benzamide Small molecular drug D0R5VG
N-hydroxy-4-(Pentanoylamino-methyl)-benzamide Small molecular drug D0Z7YS
N-hydroxy-4-(Phenylacetylamino-methyl)-benzamide Small molecular drug D02UTC
N-hydroxy-4-phenylacetylamino-benzamide Small molecular drug D01XXN
N-hydroxy-e-3-(4'-chlorobiphenyl-4-yl)-acrylamide Small molecular drug D02TQA
N-hydroxy-e-3-(4'-cyanobiphenyl-4-yl)-acrylamide Small molecular drug D0W9BH
N-hydroxy-e-3-(Biphenyl-4-yl)-acrylamide Small molecular drug D0AK8Q
N7-hydroxy-2-methoxy-n1-phenylheptanediamide Small molecular drug D03TNE
N7-hydroxy-n1-phenyl-2-propoxyheptanediamide Small molecular drug D03TQD
N8,2-dihydroxy-n1-phenyloctanediamide Small molecular drug D09SVH
N8-hydroxy-2-methoxy-n1-phenyloctanediamide Small molecular drug D01AVS
Octanedioic Acid Bis-hydroxyamide Small molecular drug D07YZZ
Octanedioic Acid Hydroxyamide Pyridin-2-ylamide Small molecular drug D0E8KR
Octanedioic Acid Hydroxyamide Pyridin-4-ylamide Small molecular drug D04GGW
Pracinostat Small molecular drug DB05223
Psammaplin A Small molecular drug D0N0TS
Santacruzamate A Small molecular drug D09RKA
St-2986 Small molecular drug D0N9AK
St-2987 Small molecular drug D0T0SK
Thioacetic Acid S-(6-phenylcarbamoyl-hexyl) Ester Small molecular drug D05GVY
Kar-1880 . D06YYY
N-hydroxy-4-(3-phenyl-propionylamino)-benzamide . D0R4BS
Patented
Click To Hide/Show 16 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid29671355-compound-11 Small molecular drug D0EH2K
Pmid29671355-compound-21 Small molecular drug D0LP1K
Pmid29671355-compound-23 Small molecular drug D00HXJ
Pmid29671355-compound-25 Small molecular drug D0RA0D
Pmid29671355-compound-31 Small molecular drug D0DI9S
Pmid29671355-compound-43 Small molecular drug D0BP8I
Pmid29671355-compound-44 Small molecular drug D0N2DK
Pmid29671355-compound-55 Small molecular drug D0OU0J
Pmid29671355-compound-56 Small molecular drug D0CH8Q
Pmid29671355-compound-59 Small molecular drug D0C9NX
Pmid29671355-compound-61 Small molecular drug D0JB4S
Pmid29671355-compound-62 Small molecular drug D07WAT
Pmid29671355-compound-67 Small molecular drug D0M0RE
Pmid29671355-compound-74 Small molecular drug D0N2FN
Pmid29671355-compound-8 Small molecular drug D0LN1T
Pmid29671355-compound-9 Small molecular drug D0Q1QY

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578