Details of the Probe

General Information of Probe

Probe ID
LDPC0253
Probe Name
THZ1-DTB
Probe Type
ABPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 5 Molecular Weight (mw) 1022.649
Lipid-water partition coefficient (xlogp) 6.826
Rotatable Bond Count (rotbonds) 33
Hydrogen Bond Donor Count (hbonddonor) 8
Hydrogen Bond Acceptor Count (hbondacc) 13
Chemical Identifiers
Formula
C53H68ClN11O8
Canonical SMILES
CC1NC(=O)NC1CCCCCC(=O)NCCOCCOCCOCCNCCC(=O)CCN(C)CC=CC(=O)Nc1ccc(C(=O)Nc2cccc(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)c2)cc1
InChI
InChI=1S/C53H68ClN11O8/c1-37-46(63-53(70)59-37)13-4-3-5-15-48(67)56-25-29-72-31-33-73-32-30-71-28-24-55-23-21-42(66)22-27-65(2)26-9-16-49(68)60-39-19-17-38(18-20-39)51(69)61-40-10-8-11-41(34-40)62-52-58-36-45(54)50(64-52)44-35-57-47-14-7-6-12-43(44)47/h6-12,14,16-20,34-37,46,55,57H,3-5,13,15,21-33H2,1-2H3,(H,56,67)(H,60,68)(H,61,69)(H,58,62,64)(H2,59,63,70)/b16-9+/t37-,46+/m1/s1
InChIKey
HRXJVICEPGPJPY-KZWKZLSRSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

164 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
2-hydroxyacyl-CoA lyase 2 (ILVBL) LDTP00032 C315(1.05)  LDD0460 
26S proteasome regulatory subunit 10B (PSMC6) LDTP04987 C193(1.06)  LDD0460 
26S proteasome regulatory subunit 8 (PSMC5) LDTP04963 C112(1.12)  LDD0460 
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) LDTP10954 C214(0.84)  LDD0460 
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) LDTP03611 C199(0.91)  LDD0460 
6-phosphogluconate dehydrogenase, decarboxylating (PGD) LDTP04499 C171(1.32)  LDD0460 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 C447(1.06); C442(0.99)  LDD0460 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 C65(1.02)  LDD0460 
Actin, aortic smooth muscle (ACTA2) LDTP04999 C219(1.08)  LDD0460 
Actin, cytoplasmic 1 (ACTB) LDTP04876 C217(1.11); C285(0.99); C272(1.00); C257(1.01)  LDD0460 
Adenine phosphoribosyltransferase (APRT) LDTP02220 C83(1.07)  LDD0460 
Adenylosuccinate synthetase isozyme 2 (ADSS2) LDTP03541 C182(1.14); C280(0.67)  LDD0460 
ADP-ribose glycohydrolase MACROD1 (MACROD1) LDTP11059 C246(1.01)  LDD0460 
ADP-ribosylation factor 1 (ARF1) LDTP05192 C159(1.08)  LDD0460 
Aflatoxin B1 aldehyde reductase member 3 (AKR7A3) LDTP01508 C186(1.06)  LDD0460 
Alanine--tRNA ligase, cytoplasmic (AARS1) LDTP04262 C947(1.04)  LDD0460 
Alcohol dehydrogenase class-3 (ADH5) LDTP02587 C100(0.95); C97(0.96)  LDD0460 
Aldehyde dehydrogenase family 16 member A1 (ALDH16A1) LDTP15371 C71(1.03)  LDD0460 
Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) LDTP04253 C478(1.05)  LDD0460 
Alpha-enolase (ENO1) LDTP02159 C119(1.12); C339(1.07); C337(1.04); C119(1.02)  LDD0460 
Aminopeptidase B (RNPEP) LDTP15993 C181(1.08)  LDD0460 
Anaphase-promoting complex subunit 7 (ANAPC7) LDTP13409 C417(1.08)  LDD0460 
Arginine--tRNA ligase, cytoplasmic (RARS1) LDTP04601 C369(1.06)  LDD0460 
Argininosuccinate synthase (ASS1) LDTP01807 C132(1.09)  LDD0460 
Asparagine synthetase [glutamine-hydrolyzing] (ASNS) LDTP02264 C158(1.02)  LDD0460 
Asparagine--tRNA ligase, cytoplasmic (NARS1) LDTP00866 C202(1.10); C438(1.02)  LDD0460 
ATP-citrate synthase (ACLY) LDTP04561 C633(1.06)  LDD0460 
ATP-dependent 6-phosphofructokinase, muscle type (PFKM) LDTP02261 C550(1.10)  LDD0460 
ATP-dependent 6-phosphofructokinase, platelet type (PFKP) LDTP05314 C718(1.01); C123(1.02); C641(1.07)  LDD0460 
ATP-dependent RNA helicase DDX19B (DDX19B) LDTP13618 C225(1.07)  LDD0460 
Aurora kinase A (AURKA) LDTP00491 C33(1.37)  LDD0460 
Bifunctional glutamate/proline--tRNA ligase (EPRS1) LDTP02222 C1448(1.14); C1480(1.05)  LDD0460 
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) LDTP03159 C288(1.06); C295(0.99)  LDD0460 
Carbamoyl-phosphate synthase [ammonia], mitochondrial (CPS1) LDTP03591 C1337(1.16); C1327(1.14); C1126(1.09); C761(1.06)  LDD0460 
Catechol O-methyltransferase (COMT) LDTP03145 C145(1.11)  LDD0460 
Cathepsin B (CTSB) LDTP02223 C108(2.18)  LDD0461 
Cathepsin D (CTSD) LDTP02198 C329(1.06)  LDD0460 
Cell division control protein 42 homolog (CDC42) LDTP04886 C157(1.06); C105(1.00)  LDD0460 
CTP synthase 1 (CTPS1) LDTP02922 C216(0.94)  LDD0460 
Cyclin-dependent kinase 12 (CDK12) LDTP12852 C1039(6.20)  LDD0460 
Cyclin-dependent kinase 13 (CDK13) LDTP06019 C1017(3.84)  LDD0460 
Cyclin-dependent kinase 7 (CDK7) LDTP04379 C312(8.02)  LDD0460 
Cytochrome P450 1B1 (CYP1B1) LDTP06608 C92(1.73)  LDD0460 
D-3-phosphoglycerate dehydrogenase (PHGDH) LDTP00701 C369(1.14); C295(1.05); C200(1.01); C421(0.96)  LDD0460 
Dehydrogenase/reductase SDR family member 7 (DHRS7) LDTP13959 C233(1.02)  LDD0460 
DNA repair nuclease/redox regulator APEX1 (APEX1) LDTP03398 C208(1.09)  LDD0460 
DNA replication licensing factor MCM4 (MCM4) LDTP03680 C212(1.11); C572(1.01)  LDD0460 
DNA-dependent protein kinase catalytic subunit (PRKDC) LDTP05136 C223(1.13); C3347(1.13); C232(1.06); C2093(1.06)  LDD0460 
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) LDTP05369 C376(1.05)  LDD0460 
Dual specificity protein kinase TTK (TTK) LDTP03679 C465(1.26)  LDD0460 
E3 ubiquitin-protein ligase HUWE1 (HUWE1) LDTP08135 C612(1.01)  LDD0460 
Elongation factor 1-alpha 1 (EEF1A1) LDTP05071 C234(1.06); C411(1.07); C363(1.03); C370(1.04)  LDD0460 
Elongation factor 2 (EEF2) LDTP02672 C693(1.10); C728(1.14); C651(1.08); C591(1.07)  LDD0460 
Elongation factor Tu, mitochondrial (TUFM) LDTP04251 C293(1.17)  LDD0460 
Endoplasmic reticulum chaperone BiP (HSPA5) LDTP02534 C420(1.01)  LDD0460 
Enoyl-CoA delta isomerase 2 (ECI2) LDTP01245 C282(1.09)  LDD0460 
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) LDTP02770 C276(1.08); C237(1.04)  LDD0460 
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) LDTP03915 C434(1.11); C269(1.09)  LDD0460 
Farnesyl pyrophosphate synthase (FDPS) LDTP02721 C333(1.06)  LDD0460 
Fatty acid synthase (FASN) LDTP04243 C212(1.14); C2468(1.17); C2202(1.13); C1141(1.05)  LDD0460 
Flap endonuclease 1 (FEN1) LDTP03872 C235(1.08)  LDD0460 
Fructose-bisphosphate aldolase A (ALDOA) LDTP02008 C178(1.14); C339(1.09); C290(1.05); C73(1.02)  LDD0460 
Glucose-6-phosphate isomerase (GPI) LDTP02162 C404(1.05)  LDD0460 
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (GFPT1) LDTP05481 C264(1.17); C55(1.10)  LDD0460 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 C152(1.15); C156(1.12); C247(1.01)  LDD0460 
Glycogen synthase kinase-3 beta (GSK3B) LDTP04319 C14(1.48)  LDD0460 
GMP synthase [glutamine-hydrolyzing] (GMPS) LDTP04333 C456(1.03)  LDD0460 
GTP-binding nuclear protein Ran (RAN) LDTP05007 C120(1.11); C112(1.08)  LDD0460 
Heat shock cognate 71 kDa protein (HSPA8) LDTP02541 C17(1.05)  LDD0460 
Heat shock protein HSP 90-alpha (HSP90AA1) LDTP02225 C481(1.16); C597(1.07); C529(1.08)  LDD0460 
Hexokinase-2 (HK2) LDTP04531 C628(1.06)  LDD0460 
Histone deacetylase 2 (HDAC2) LDTP09865 C111(0.93)  LDD0460 
Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) LDTP01782 C106(1.07)  LDD0460 
Isochorismatase domain-containing protein 1 (ISOC1) LDTP19851 C120(1.02)  LDD0460 
Isoleucine--tRNA ligase, cytoplasmic (IARS1) LDTP03947 C400(1.13); C87(1.07); C357(1.00); C433(0.97)  LDD0460 
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) LDTP06006 C80(1.04)  LDD0460 
Ketosamine-3-kinase (FN3KRP) LDTP16025 C24(1.04)  LDD0460 
L-lactate dehydrogenase A chain (LDHA) LDTP01766 C163(1.11); C293(1.05); C185(0.94)  LDD0460 
L-lactate dehydrogenase B chain (LDHB) LDTP02179 C294(1.03)  LDD0460 
Lactoylglutathione lyase (GLO1) LDTP05434 C139(1.09)  LDD0460 
Leukotriene A-4 hydrolase (LTA4H) LDTP02385 C275(0.96)  LDD0460 
Lysine--tRNA ligase (KARS1) LDTP06294 C427(1.04)  LDD0460 
Macrophage migration inhibitory factor (MIF) LDTP02713 C81(1.10)  LDD0460 
Malate dehydrogenase, cytoplasmic (MDH1) LDTP03907 C137(1.00)  LDD0460 
Malate dehydrogenase, mitochondrial (MDH2) LDTP03908 C212(1.12); C89(1.01); C93(1.00)  LDD0460 
Methionine--tRNA ligase, cytoplasmic (MARS1) LDTP04730 C12(1.04)  LDD0460 
Mitochondrial-processing peptidase subunit beta (PMPCB) LDTP01220 C419(1.04)  LDD0460 
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) LDTP00747 C302(1.30)  LDD0460 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 C184(1.16); C64(1.11)  LDD0460 
NAD(P)H-hydrate epimerase (NAXE) LDTP09110 C127(1.06); C115(1.05); C91(1.03)  LDD0460 
NADH dehydrogenase iron-sulfur protein 8, mitochondrial (NDUFS8) LDTP00218 C121(1.06)  LDD0460 
NADP-dependent malic enzyme (ME1) LDTP04164 C468(1.13)  LDD0460 
Neutral alpha-glucosidase AB (GANAB) LDTP06192 C423(1.04); C502(1.05)  LDD0460 
Neutral cholesterol ester hydrolase 1 (NCEH1) LDTP07591 C186(2.47)  LDD0461 
Nicotinamide N-methyltransferase (NNMT) LDTP03891 C170(1.10); C159(1.05); C165(1.01)  LDD0460 
Nucleoside diphosphate kinase A (NME1) LDTP02796 C109(1.04); C145(1.03)  LDD0460 
Peptidyl-prolyl cis-trans isomerase A (PPIA) LDTP05028 C62(1.05); C161(1.02)  LDD0460 
Peroxiredoxin-1 (PRDX1) LDTP05503 C173(1.15)  LDD0460 
Peroxiredoxin-2 (PRDX2) LDTP03626 C172(1.14)  LDD0460 
Peroxiredoxin-6 (PRDX6) LDTP03510 C91(1.14); C47(1.02)  LDD0460 
Phosphoglycerate kinase 1 (PGK1) LDTP01787 C99(1.11); C367(1.07); C380(1.06); C50(1.06)  LDD0460 
Phosphoglycerate mutase 1 (PGAM1) LDTP02963 C55(1.06); C153(1.05)  LDD0460 
Phospholipid scramblase 1 (PLSCR1) LDTP00558 C148(1.05)  LDD0460 
Phosphoribosylformylglycinamidine synthase (PFAS) LDTP00527 C697(1.00); C1285(1.02); C1287(1.01)  LDD0460 
Phosphoserine aminotransferase (PSAT1) LDTP14198 C80(1.09); C98(1.08); C291(0.98)  LDD0460 
Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2) LDTP05623 C229(1.11)  LDD0460 
Probable aminopeptidase NPEPL1 (NPEPL1) LDTP09126 C67(1.03)  LDD0460 
Probable ATP-dependent RNA helicase DDX5 (DDX5) LDTP02924 C234(1.11); C221(1.02)  LDD0460 
Probable phosphoglycerate mutase 4 (PGAM4) LDTP15391 C55(1.00)  LDD0460 
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) LDTP00285 C562(1.10)  LDD0460 
Proliferation-associated protein 2G4 (PA2G4) LDTP13750 C49(1.06)  LDD0460 
Prostaglandin E synthase (PTGES) LDTP00407 C137(1.09)  LDD0460 
Protein arginine N-methyltransferase 5 (PRMT5) LDTP00418 C22(1.11)  LDD0460 
Protein disulfide-isomerase A6 (PDIA6) LDTP06314 C297(1.01); C55(0.99); C58(0.95)  LDD0460 
Protein kinase C theta type (PRKCQ) LDTP05433 C661(2.76)  LDD0460 
Protein phosphatase methylesterase 1 (PPME1) LDTP14092 C381(1.13); C347(1.05)  LDD0460 
Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) LDTP03644 C262(1.04)  LDD0460 
Pyruvate kinase PKM (PKM) LDTP02733 C49(1.20); C152(1.10); C326(1.08); C474(1.05)  LDD0460 
Ras-related C3 botulinum toxin substrate 2 (RAC2) LDTP02768 C157(1.10)  LDD0460 
Ras-related protein Rap-1A (RAP1A) LDTP05009 C139(1.11)  LDD0460 
Regulator of nonsense transcripts 1 (UPF1) LDTP09921 C657(1.01)  LDD0460 
Rho-related GTP-binding protein RhoC (RHOC) LDTP02248 C16(1.09)  LDD0460 
Ribose-phosphate pyrophosphokinase 2 (PRPS2) LDTP02592 C91(1.06)  LDD0460 
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) LDTP04471 C579(1.18)  LDD0460 
Ribosyldihydronicotinamide dehydrogenase [quinone] (NQO2) LDTP02824 C223(1.23)  LDD0460 
RNA cytidine acetyltransferase (NAT10) LDTP11690 C255(1.03)  LDD0460 
RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) LDTP05588 C673(1.01)  LDD0460 
S-adenosylmethionine synthase isoform type-2 (MAT2A) LDTP03577 C149(1.06)  LDD0460 
S-formylglutathione hydrolase (ESD) LDTP02521 C176(1.06); C181(1.05); C243(1.04)  LDD0460 
S-phase kinase-associated protein 1 (SKP1) LDTP05052 C62(1.18)  LDD0460 
Sepiapterin reductase (SPR) LDTP03730 C159(1.07); C10(1.02)  LDD0460 
Serine hydroxymethyltransferase, mitochondrial (SHMT2) LDTP03689 C80(1.03); C119(1.07)  LDD0460 
Serine/threonine-protein kinase N3 (PKN3) LDTP07546 C840(3.30)  LDD0460 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) LDTP03522 C390(1.05); C148(1.09)  LDD0460 
Sialic acid synthase (NANS) LDTP12473 C180(0.97)  LDD0460 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 C97(1.06)  LDD0460 
Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2) LDTP04392 C372(1.06)  LDD0460 
Sorbitol dehydrogenase (SORD) LDTP05258 C130(1.09); C120(1.02)  LDD0460 
Spliceosome RNA helicase DDX39B (DDX39B) LDTP05991 C75(1.11)  LDD0460 
Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA) LDTP03572 C89(1.05)  LDD0460 
Thioredoxin (TXN) LDTP02502 C73(1.15)  LDD0460 
Thioredoxin reductase 2, mitochondrial (TXNRD2) LDTP12297 C86(0.99); C91(1.00)  LDD0460 
Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3) LDTP03515 C229(1.02)  LDD0460 
Thioredoxin-related transmembrane protein 1 (TMX1) LDTP11874 C106(1.03)  LDD0460 
Threonine--tRNA ligase 1, cytoplasmic (TARS1) LDTP03365 C630(1.10); C343(1.06); C107(1.10)  LDD0460 
Transaldolase (TALDO1) LDTP03847 C250(1.05)  LDD0460 
Transitional endoplasmic reticulum ATPase (VCP) LDTP04665 C572(1.09); C415(1.02)  LDD0460 
Transketolase (TKT) LDTP03487 C386(1.10); C413(0.99); C417(1.01)  LDD0460 
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) LDTP03912 C713(1.01)  LDD0460 
Trifunctional purine biosynthetic protein adenosine-3 (GART) LDTP03156 C646(1.02); C237(0.99)  LDD0460 
Triosephosphate isomerase (TPI1) LDTP04851 C127(1.10)  LDD0460 
Tryptophan--tRNA ligase, cytoplasmic (WARS1) LDTP03222 C309(1.08)  LDD0460 
Tubulin alpha-1B chain (TUBA1B) LDTP05074 C315(1.09); C347(1.08); C213(1.10); C200(1.03)  LDD0460 
Tubulin alpha-1C chain (TUBA1C) LDTP11074 C376(1.05); C295(0.99)  LDD0460 
Tubulin alpha-3C chain (TUBA3C) LDTP02452 C347(1.14); C376(1.06); C295(1.05); C25(1.06)  LDD0460 
Tubulin alpha-4A chain (TUBA4A) LDTP05075 C54(1.10)  LDD0460 
Ubiquitin carboxyl-terminal hydrolase 14 (USP14) LDTP04618 C415(1.03); C114(0.99)  LDD0460 
Ubiquitin carboxyl-terminal hydrolase 5 (USP5) LDTP04074 C335(1.19)  LDD0460 
Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) LDTP04442 C85(1.03)  LDD0460 
Ubiquitin-like modifier-activating enzyme 1 (UBA1) LDTP03166 C278(1.09); C1040(1.06); C234(1.04); C632(1.00)  LDD0460 
V-type proton ATPase catalytic subunit A (ATP6V1A) LDTP03859 C240(1.11); C532(1.06)  LDD0460 
Valine--tRNA ligase (VARS1) LDTP03366 C112(1.08); C917(1.05); C41(1.03)  LDD0460 
Vesicle-fusing ATPase (NSF) LDTP04096 C599(1.09)  LDD0460 
Vitamin K epoxide reductase complex subunit 1 (VKORC1) LDTP11070 C43(1.08); C51(1.02)  LDD0460 
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⏷ Show the Full List of 164 Enzyme
34 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein theta (YWHAQ) LDTP03385 C237(1.36); C134(1.10)  LDD0460 
ADP/ATP translocase 2 (SLC25A5) LDTP02087 C129(1.11)  LDD0460 
Annexin A5 (ANXA5) LDTP02307 C316(1.06)  LDD0460 
ATP synthase subunit alpha, mitochondrial (ATP5F1A) LDTP03327 C294(1.03)  LDD0460 
ATP-binding cassette sub-family F member 1 (ABCF1) LDTP09149 C365(0.98)  LDD0460 
Cation-dependent mannose-6-phosphate receptor (M6PR) LDTP03061 C244(1.07)  LDD0460 
Chloride intracellular channel protein 1 (CLIC1) LDTP00244 C178(1.06); C223(1.03)  LDD0460 
Clathrin heavy chain 1 (CLTC) LDTP05252 C1205(1.21); C753(1.05); C934(1.05); C328(1.00)  LDD0460 
Copine-3 (CPNE3) LDTP01133 C506(0.98)  LDD0460 
EH domain-containing protein 1 (EHD1) LDTP11934 C138(1.10)  LDD0460 
Exportin-1 (XPO1) LDTP00501 C164(1.16)  LDD0460 
Exportin-2 (CSE1L) LDTP04662 C85(1.09); C842(1.06); C344(1.05)  LDD0460 
Exportin-5 (XPO5) LDTP12142 C941(1.02)  LDD0460 
Golgi resident protein GCP60 (ACBD3) LDTP11877 C129(1.08)  LDD0460 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 C590(1.08); C589(1.05); C521(1.08); C366(1.03)  LDD0460 
Importin subunit alpha-1 (KPNA2) LDTP04501 C133(1.08); C272(1.06)  LDD0460 
Importin subunit alpha-7 (KPNA6) LDTP01031 C340(1.00)  LDD0460 
Importin subunit beta-1 (KPNB1) LDTP06242 C228(1.10); C585(0.97)  LDD0460 
Importin-5 (IPO5) LDTP00266 C733(1.08); C420(1.10); C944(1.02); C1078(0.98)  LDD0460 
Importin-7 (IPO7) LDTP01574 C736(1.24); C757(1.10)  LDD0460 
Leucine-rich repeat-containing protein 59 (LRRC59) LDTP10081 C277(1.08); C59(1.06)  LDD0460 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 C129(1.12); C129(1.06)  LDD0460 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 C159(1.02)  LDD0460 
Neutral amino acid transporter B(0) (SLC1A5) LDTP06462 C39(0.99)  LDD0460 
Protein SEC13 homolog (SEC13) LDTP04707 C245(1.10); C234(1.03)  LDD0460 
Small ribosomal subunit protein RACK1 (RACK1) LDTP05057 C168(1.09); C249(1.08); C153(1.08); C286(1.00)  LDD0460 
Sodium/potassium-transporting ATPase subunit beta-3 (ATP1B3) LDTP04624 C154(1.00); C170(0.97)  LDD0460 
Solute carrier family 35 member F6 (SLC35F6) LDTP08817 C36(2.18)  LDD0461 
T-complex protein 1 subunit delta (CCT4) LDTP04391 C252(1.15); C120(0.99)  LDD0460 
Transferrin receptor protein 1 (TFRC) LDTP01969 C558(1.09)  LDD0460 
Translocator protein (TSPO) LDTP03546 C19(1.01)  LDD0460 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 C48(2.04)  LDD0461 
Transportin-1 (TNPO1) LDTP09949 C103(1.10); C285(1.08); C790(1.06); C142(1.02)  LDD0460 
Tubulin beta-1 chain (TUBB1) LDTP11916 C201(1.00); C211(0.99)  LDD0460 
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⏷ Show the Full List of 34 Transporter and channel
6 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
eIF5-mimic protein 2 (BZW1) LDTP07940 C35(1.04)  LDD0460 
Enhancer of rudimentary homolog (ERH) LDTP05194 C28(1.10)  LDD0460 
FACT complex subunit SSRP1 (SSRP1) LDTP05577 C200(0.93)  LDD0460 
Signal transducer and activator of transcription 1-alpha/beta (STAT1) LDTP03969 C255(1.02)  LDD0460 
Signal transducer and activator of transcription 3 (STAT3) LDTP03903 C259(1.09)  LDD0460 
Signal transducer and activator of transcription 6 (STAT6) LDTP03970 C356(1.05)  LDD0460 
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⏷ Show the Full List of 6 Transcription factor
122 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein sigma (SFN) LDTP03618 C38(1.04)  LDD0460 
Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) LDTP03871 C123(1.07)  LDD0460 
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) LDTP09843 C123(1.03)  LDD0460 
Actin-related protein 2/3 complex subunit 4 (ARPC4) LDTP04844 C21(0.98)  LDD0460 
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) LDTP05770 C306(1.03); C291(0.88)  LDD0460 
Annexin A4 (ANXA4) LDTP02354 C108(1.06)  LDD0460 
Annexin A7 (ANXA7) LDTP03030 C363(1.07)  LDD0460 
Apoptosis inhibitor 5 (API5) LDTP11575 C234(1.04)  LDD0460 
Band 4.1-like protein 2 (EPB41L2) LDTP00778 C232(1.07)  LDD0460 
Bifunctional purine biosynthesis protein ATIC (ATIC) LDTP03612 C241(1.05)  LDD0460 
Bromodomain and WD repeat-containing protein 1 (BRWD1) LDTP12589 C248(2.21)  LDD0461 
CDGSH iron-sulfur domain-containing protein 2 (CISD2) LDTP08902 C92(1.08)  LDD0460 
Centromere/kinetochore protein zw10 homolog (ZW10) LDTP00720 C568(1.02)  LDD0460 
Coatomer subunit gamma-1 (COPG1) LDTP14216 C129(1.01)  LDD0460 
CYFIP-related Rac1 interactor B (CYRIB) LDTP12642 C223(1.06)  LDD0460 
Cysteine and glycine-rich protein 1 (CSRP1) LDTP03106 C167(1.10)  LDD0460 
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) LDTP06083 C4438(1.06)  LDD0460 
Destrin (DSTN) LDTP04887 C163(1.03)  LDD0460 
Dynactin subunit 2 (DCTN2) LDTP05922 C240(1.08)  LDD0460 
Dynein light chain 1, cytoplasmic (DYNLL1) LDTP05049 C24(1.09)  LDD0460 
EKC/KEOPS complex subunit TPRKB (TPRKB) LDTP13974 C167(0.95)  LDD0460 
Elongation factor 1-gamma (EEF1G) LDTP03367 C194(1.13); C68(1.11); C266(1.08); C210(1.00)  LDD0460 
Endoplasmin (HSP90B1) LDTP02734 C645(1.11); C576(1.04)  LDD0460 
Eukaryotic translation initiation factor 3 subunit L (EIF3L) LDTP13813 C417(1.13)  LDD0460 
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) LDTP05421 C662(0.95)  LDD0460 
Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) LDTP00766 C928(1.15)  LDD0460 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 C102(1.17)  LDD0460 
Ezrin (EZR) LDTP02779 C117(1.03)  LDD0460 
Fanconi anemia group D2 protein (FANCD2) LDTP11421 C729(1.08)  LDD0460 
Fascin (FSCN1) LDTP06598 C80(1.08); C61(1.02)  LDD0460 
Heat shock 70 kDa protein 4 (HSPA4) LDTP03695 C380(1.06); C290(1.05); C417(1.03)  LDD0460 
Heat shock protein 75 kDa, mitochondrial (TRAP1) LDTP05697 C573(2.06)  LDD0461 
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) LDTP04952 C145(1.09); C132(1.04)  LDD0460 
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) LDTP05259 C389(1.01)  LDD0460 
Hippocalcin-like protein 1 (HPCAL1) LDTP03841 C185(1.05)  LDD0460 
Inverted formin-2 (INF2) LDTP06681 C38(1.05)  LDD0460 
Lamina-associated polypeptide 2, isoform alpha (TMPO) LDTP03967 C570(0.86)  LDD0460 
Large ribosomal subunit protein eL20 (RPL18A) LDTP05360 C109(1.06)  LDD0460 
Large ribosomal subunit protein eL22 (RPL22) LDTP03728 C25(1.04)  LDD0460 
Large ribosomal subunit protein eL32 (RPL32) LDTP05025 C91(2.16)  LDD0461 
Large ribosomal subunit protein P1 (RPLP1) LDTP02107 C61(1.05)  LDD0460 
Large ribosomal subunit protein uL1 (RPL10A) LDTP05024 C74(1.17); C66(1.11)  LDD0460 
Large ribosomal subunit protein uL10 (RPLP0) LDTP02109 C27(1.16); C119(1.04)  LDD0460 
Large ribosomal subunit protein uL10m (MRPL10) LDTP08154 C180(1.01)  LDD0460 
Large ribosomal subunit protein uL11 (RPL12) LDTP03517 C141(1.06); C162(1.07)  LDD0460 
Large ribosomal subunit protein uL14 (RPL23) LDTP05008 C28(1.02)  LDD0460 
Large ribosomal subunit protein uL15 (RPL27A) LDTP04105 C70(1.13)  LDD0460 
Large ribosomal subunit protein uL16 (RPL10) LDTP03395 C49(0.98)  LDD0460 
Large ribosomal subunit protein uL18 (RPL5) LDTP04106 C100(1.09); C144(1.05)  LDD0460 
Large ribosomal subunit protein uL2 (RPL8) LDTP05027 C114(1.06)  LDD0460 
Large ribosomal subunit protein uL3 (RPL3) LDTP03865 C114(1.10)  LDD0460 
Large ribosomal subunit protein uL30 (RPL7) LDTP02944 C186(1.08)  LDD0460 
Large ribosomal subunit protein uL4 (RPL4) LDTP03815 C125(1.16); C208(0.99)  LDD0460 
Large ribosomal subunit protein uL5 (RPL11) LDTP05026 C25(1.10)  LDD0460 
Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) LDTP03997 C1277(1.01); C484(1.02)  LDD0460 
Luc7-like protein 3 (LUC7L3) LDTP01534 C43(1.03)  LDD0460 
MICOS complex subunit MIC13 (MICOS13) LDTP07274 C60(1.08)  LDD0460 
Microtubule-associated protein 4 (MAP4) LDTP03404 C126(1.85)  LDD0460 
Microtubule-associated protein RP/EB family member 1 (MAPRE1) LDTP06444 C228(1.10)  LDD0460 
Nck-associated protein 1 (NCKAP1) LDTP13839 C622(1.13)  LDD0460 
Nuclear migration protein nudC (NUDC) LDTP13817 C188(1.01)  LDD0460 
Nuclear transport factor 2 (NUTF2) LDTP04951 C114(1.09)  LDD0460 
Perilipin-3 (PLIN3) LDTP01021 C341(1.05)  LDD0460 
Phosphatidylethanolamine-binding protein 1 (PEBP1) LDTP03520 C168(1.03)  LDD0460 
Pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1IP) LDTP04586 C81(1.03)  LDD0460 
Plastin-3 (PLS3) LDTP02692 C566(1.09); C104(1.02)  LDD0460 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 C109(1.06); C54(1.05)  LDD0460 
Poly(rC)-binding protein 2 (PCBP2) LDTP06367 C109(1.08); C217(1.12)  LDD0460 
Polyadenylate-binding protein 1 (PABPC1) LDTP02595 C128(1.08)  LDD0460 
Polypyrimidine tract-binding protein 1 (PTBP1) LDTP03364 C251(1.06)  LDD0460 
Pre-mRNA-splicing factor SYF1 (XAB2) LDTP12269 C587(1.06)  LDD0460 
Proliferating cell nuclear antigen (PCNA) LDTP02596 C135(1.06)  LDD0460 
Proteasome activator complex subunit 1 (PSME1) LDTP05484 C106(1.13); C101(1.08)  LDD0460 
Proteasome activator complex subunit 2 (PSME2) LDTP13519 C91(1.09)  LDD0460 
Proteasome assembly chaperone 2 (PSMG2) LDTP10035 C178(1.13)  LDD0460 
Protein diaphanous homolog 1 (DIAPH1) LDTP01011 C796(1.07)  LDD0460 
Protein kinase C and casein kinase substrate in neurons protein 3 (PACSIN3) LDTP13479 C42(1.08)  LDD0460 
Protein S100-A11 (S100A11) LDTP03620 C13(1.09); C91(1.07)  LDD0460 
Putative annexin A2-like protein (ANXA2P2) LDTP00114 C133(1.10)  LDD0460 
Rab GDP dissociation inhibitor alpha (GDI1) LDTP03574 C202(1.04)  LDD0460 
Rab GDP dissociation inhibitor beta (GDI2) LDTP04355 C414(1.12); C202(1.06)  LDD0460 
Reticulon-4 (RTN4) LDTP12412 C1110(1.18)  LDD0460 
Rho GDP-dissociation inhibitor 1 (ARHGDIA) LDTP04510 C79(1.15)  LDD0460 
Ribonuclease inhibitor (RNH1) LDTP02656 C96(1.03)  LDD0460 
Ribosomal L1 domain-containing protein 1 (RSL1D1) LDTP01379 C96(1.10)  LDD0460 
Serine-threonine kinase receptor-associated protein (STRAP) LDTP13991 C305(1.16)  LDD0460 
Serpin B5 (SERPINB5) LDTP03825 C34(1.10)  LDD0460 
Serpin B6 (SERPINB6) LDTP03719 C100(1.13)  LDD0460 
Small ribosomal subunit protein eS12 (RPS12) LDTP03321 C92(1.08)  LDD0460 
Small ribosomal subunit protein eS4, X isoform (RPS4X) LDTP04997 C181(1.07); C41(1.10)  LDD0460 
Small ribosomal subunit protein eS6 (RPS6) LDTP05002 C12(1.08)  LDD0460 
Small ribosomal subunit protein eS8 (RPS8) LDTP04964 C72(1.04); C71(1.05)  LDD0460 
Small ribosomal subunit protein uS12 (RPS23) LDTP04971 C90(1.04)  LDD0460 
Small ribosomal subunit protein uS17 (RPS11) LDTP04975 C131(1.04)  LDD0460 
Small ribosomal subunit protein uS2 (RPSA) LDTP02312 C163(1.03); C148(1.05)  LDD0460 
Small ribosomal subunit protein uS5 (RPS2) LDTP02809 C229(1.11); C222(1.02)  LDD0460 
Small ribosomal subunit protein uS7 (RPS5) LDTP04110 C155(1.21); C172(1.09); C66(1.01)  LDD0460 
Sorcin (SRI) LDTP03554 C194(1.14); C163(1.00)  LDD0460 
Spartin (SPART) LDTP08735 C499(1.08)  LDD0460 
Splicing factor 3B subunit 1 (SF3B1) LDTP01251 C1035(1.00)  LDD0460 
Splicing factor 3B subunit 3 (SF3B3) LDTP06376 C427(1.00)  LDD0460 
Stalled ribosome sensor GCN1 (GCN1) LDTP09821 C1482(1.08)  LDD0460 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 C317(1.07)  LDD0460 
T-complex protein 1 subunit alpha (TCP1) LDTP02934 C385(1.05); C147(0.98)  LDD0460 
T-complex protein 1 subunit beta (CCT2) LDTP05113 C412(1.07)  LDD0460 
T-complex protein 1 subunit epsilon (CCT5) LDTP04201 C253(1.11); C429(1.10); C302(1.09); C440(1.06)  LDD0460 
T-complex protein 1 subunit eta (CCT7) LDTP10990 C326(1.18); C450(1.07); C345(1.07); C29(0.97)  LDD0460 
T-complex protein 1 subunit gamma (CCT3) LDTP04249 C182(1.12); C366(1.12); C213(1.06); C455(1.08)  LDD0460 
T-complex protein 1 subunit theta (CCT8) LDTP04390 C244(1.11); C148(1.07); C149(1.05)  LDD0460 
T-complex protein 1 subunit zeta (CCT6A) LDTP03888 C499(1.06); C406(1.07)  LDD0460 
TAR DNA-binding protein 43 (TARDBP) LDTP05767 C39(1.05)  LDD0460 
Transgelin-2 (TAGLN2) LDTP03846 C63(1.10); C38(1.05); C124(0.96)  LDD0460 
Translation initiation factor eIF2 assembly protein (CDC123) LDTP16826 C151(1.08)  LDD0460 
Translationally-controlled tumor protein (TPT1) LDTP02683 C28(1.02)  LDD0460 
Tubulin beta 8B (TUBB8B) LDTP00119 C303(1.20); C127(1.08); C354(1.05); C129(1.02)  LDD0460 
Tubulin beta chain (TUBB) LDTP02205 C12(1.04)  LDD0460 
Tubulin beta-2A chain (TUBB2A) LDTP05998 C129(1.00)  LDD0460 
Tubulin beta-3 chain (TUBB3) LDTP05904 C211(1.03); C201(1.04)  LDD0460 
Tubulin beta-4A chain (TUBB4A) LDTP02037 C239(1.11); C211(1.04); C239(0.99); C201(1.03)  LDD0460 
U2 small nuclear ribonucleoprotein A' (SNRPA1) LDTP02365 C89(1.03)  LDD0460 
Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) LDTP08018 C513(1.12)  LDD0460 
Zinc finger protein-like 1 (ZFPL1) LDTP01510 C230(0.96)  LDD0460 
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⏷ Show the Full List of 122 Other

Competitor(s) Related To This Probe

Competitor ID Name Concentration Cell-system Ref
 LDCM0021  THZ1 5 uM Human cervical adenocarcinoma cell lysate (HeLa S3) [1]
 LDCM0178  THZ531 5 uM Human cervical adenocarcinoma cell lysate (HeLa S3) [1]

Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
2 uM
Quantitative Method
iTRAQ
Competitor Name
THZ1
 Competitor Info 
Competitor Concentration
5 uM
In Vitro Experiment Model
Model Type
Cell lysate
Derived Tissue
Cervix uteri
Disease Model
Cervical cancer [ICD11: 2C77]
Model Name
Human cervical adenocarcinoma cell lysate (HeLa S3)
Interaction Atlas ID
 LDD0460 
Download The Altas
  
Experiment 2 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
2 uM
Quantitative Method
iTRAQ
Competitor Name
THZ531
 Competitor Info 
Competitor Concentration
5 uM
In Vitro Experiment Model
Model Type
Cell lysate
Derived Tissue
Cervix uteri
Disease Model
Cervical cancer [ICD11: 2C77]
Model Name
Human cervical adenocarcinoma cell lysate (HeLa S3)
Interaction Atlas ID
 LDD0461 
Download The Altas

References

1 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.