Details of the Target

General Information of Target

Target ID LDTP03364
Target Name Polypyrimidine tract-binding protein 1 (PTBP1)
Gene Name PTBP1
Gene ID 5725
Synonyms
PTB; Polypyrimidine tract-binding protein 1; PTB; 57 kDa RNA-binding protein PPTB-1; Heterogeneous nuclear ribonucleoprotein I; hnRNP I
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGIVPDIAVGTKRGSDELFSTCVTNGPFIMSSNSASAANGNDSKKFKGDSRSAGVPSRV
IHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVTPV
LRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNSVQSGNLALAASAAAVDAGMAMAGQ
SPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLS
LDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTRPDLPSGDSQPSLDQTMAAAFGAP
GIISASPYAGAGFPPTFAIPQAAGLSVPNVHGALAPLAIPSAAAAAAAAGRIAIPGLAGA
GNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNKKENALVQMADGNQAQLAMSHL
NGHKLHGKPIRITLSKHQNVQLPREGQEDQGLTKDYGNSPLHRFKKPGSKNFQNIFPPSA
TLHLSNIPPSVSEEDLKVLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIDLHNH
DLGENHHLRVSFSKSTI
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Nucleus
Function
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.
TTD ID
T24609
Uniprot ID
P26599
DrugMap ID
TTWMX0U
Ensemble ID
ENST00000349038.8
HGNC ID
HGNC:9583
ChEMBL ID
CHEMBL1293230

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 55 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.87  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0452  [2]
P2
 Probe Info  		1.72  LDD0449  [2]
P3
 Probe Info  		2.12  LDD0450  [2]
P8
 Probe Info  		1.96  LDD0451  [2]
A-EBA
 Probe Info  		2.88  LDD0215  [3]
CHEMBL5175495
 Probe Info  		7.16  LDD0196  [4]
CY-1
 Probe Info  		100.00  LDD0243  [5]
CY4
 Probe Info  		100.00  LDD0244  [5]
N1
 Probe Info  		100.00  LDD0242  [5]
W1
 Probe Info  		14.70  LDD0235  [6]
TH211
 Probe Info  		Y430(20.00); Y127(15.58); Y267(10.38); Y113(6.96)  LDD0257  [7]
TH214
 Probe Info  		Y430(6.46)  LDD0258  [7]
TH216
 Probe Info  		Y430(10.58)  LDD0259  [7]
YN-1
 Probe Info  		100.00  LDD0444  [8]
ONAyne
 Probe Info  		K137(0.00); K402(0.00)  LDD0273  [9]
OPA-S-S-alkyne
 Probe Info  		K271(2.72); K137(3.20); K428(3.97); K528(5.37)  LDD3494  [10]
Probe 1
 Probe Info  		Y127(21.35); Y247(7.32)  LDD3495  [11]
DBIA
 Probe Info  		C251(3.81)  LDD3337  [12]
THZ1-DTB
 Probe Info  		C251(1.06)  LDD0460  [13]
BTD
 Probe Info  		C250(1.32)  LDD2090  [14]
AHL-Pu-1
 Probe Info  		C251(2.30); C23(2.09)  LDD0169  [15]
HHS-482
 Probe Info  		Y127(0.86); Y430(1.01)  LDD0285  [16]
HHS-475
 Probe Info  		Y127(0.87); Y113(0.90); Y430(8.20)  LDD0264  [17]
HHS-465
 Probe Info  		Y127(8.07); Y267(10.00)  LDD2237  [18]
5E-2FA
 Probe Info  		H483(0.00); H236(0.00)  LDD2235  [19]
AMP probe
 Probe Info  		N.A.  LDD0200  [20]
ATP probe
 Probe Info  		K259(0.00); K218(0.00); K454(0.00); K137(0.00)  LDD0199  [20]
4-Iodoacetamidophenylacetylene
 Probe Info  		C23(0.00); C250(0.00); C251(0.00)  LDD0038  [21]
IA-alkyne
 Probe Info  		C250(0.00); C23(0.00)  LDD0032  [22]
IPIAA_L
 Probe Info  		C23(0.00); C250(0.00)  LDD0031  [23]
Lodoacetamide azide
 Probe Info  		C23(0.00); C250(0.00); C251(0.00)  LDD0037  [21]
ATP probe
 Probe Info  		K259(0.00); K428(0.00); K65(0.00); K137(0.00)  LDD0035  [24]
JW-RF-010
 Probe Info  		C23(0.00); C251(0.00); C250(0.00)  LDD0026  [25]
NAIA_4
 Probe Info  		N.A.  LDD2226  [26]
TFBX
 Probe Info  		C251(0.00); C250(0.00); C23(0.00)  LDD0027  [25]
1d-yne
 Probe Info  		K94(0.00); K65(0.00)  LDD0356  [27]
Compound 10
 Probe Info  		C23(0.00); C250(0.00)  LDD2216  [28]
Compound 11
 Probe Info  		C23(0.00); C250(0.00)  LDD2213  [28]
ENE
 Probe Info  		C23(0.00); C250(0.00)  LDD0006  [29]
IPM
 Probe Info  		N.A.  LDD0005  [29]
NHS
 Probe Info  		K259(0.00); K436(0.00); K137(0.00); K454(0.00)  LDD0010  [29]
OSF
 Probe Info  		N.A.  LDD0029  [30]
PF-06672131
 Probe Info  		N.A.  LDD0017  [31]
SF
 Probe Info  		Y267(0.00); K515(0.00); K454(0.00); K466(0.00)  LDD0028  [30]
STPyne
 Probe Info  		K436(0.00); K454(0.00); K259(0.00); K137(0.00)  LDD0009  [29]
VSF
 Probe Info  		N.A.  LDD0007  [29]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [32]
1c-yne
 Probe Info  		K374(0.00); K259(0.00); K218(0.00); K94(0.00)  LDD0228  [27]
Acrolein
 Probe Info  		C250(0.00); H236(0.00); H133(0.00); H411(0.00)  LDD0217  [33]
Crotonaldehyde
 Probe Info  		H436(0.00); H411(0.00); H400(0.00); C251(0.00)  LDD0219  [33]
Methacrolein
 Probe Info  		C250(0.00); H436(0.00); C251(0.00); H411(0.00)  LDD0218  [33]
AOyne
 Probe Info  		10.10  LDD0443  [34]
NAIA_5
 Probe Info  		N.A.  LDD2223  [26]
TPP-AC
 Probe Info  		N.A.  LDD0427  [35]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.39  LDD0475  [36]
FFF probe14
 Probe Info  		5.33  LDD0477  [36]
STS-2
 Probe Info  		N.A.  LDD0138  [37]
VE-P
 Probe Info  		N.A.  LDD0396  [38]
DA-2
 Probe Info  		N.A.  LDD0070  [39]
STS-1
 Probe Info  		N.A.  LDD0068  [40]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C250(0.75)  LDD2142  [14]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C250(0.59)  LDD2112  [14]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C250(0.94); C251(1.03)  LDD2117  [14]
 LDCM0026  4SU-RNA+native RNA HEK-293T C251(2.30); C23(2.09)  LDD0169  [15]
 LDCM0214  AC1 HEK-293T C23(1.08); C251(0.93); C250(1.08)  LDD1507  [41]
 LDCM0215  AC10 HEK-293T C23(1.06); C251(0.98); C250(0.91)  LDD1508  [41]
 LDCM0226  AC11 HEK-293T C23(1.01); C251(0.90); C250(0.92)  LDD1509  [41]
 LDCM0237  AC12 HEK-293T C23(1.02); C251(0.83); C250(1.09)  LDD1510  [41]
 LDCM0259  AC14 HEK-293T C23(0.94); C251(0.94); C250(0.96)  LDD1512  [41]
 LDCM0270  AC15 HEK-293T C23(0.91); C251(1.02); C250(1.01)  LDD1513  [41]
 LDCM0276  AC17 HEK-293T C23(1.09); C251(0.96); C250(1.04)  LDD1515  [41]
 LDCM0277  AC18 HEK-293T C23(1.04); C251(0.91); C250(1.01)  LDD1516  [41]
 LDCM0278  AC19 HEK-293T C23(1.00); C251(0.55); C250(0.89)  LDD1517  [41]
 LDCM0279  AC2 HEK-293T C23(1.02); C251(1.07); C250(0.97)  LDD1518  [41]
 LDCM0280  AC20 HEK-293T C23(0.98); C251(0.83); C250(0.98)  LDD1519  [41]
 LDCM0281  AC21 HEK-293T C23(1.00); C251(0.89); C250(0.90)  LDD1520  [41]
 LDCM0282  AC22 HEK-293T C23(1.03); C251(0.91); C250(1.02)  LDD1521  [41]
 LDCM0283  AC23 HEK-293T C23(0.92); C251(0.97); C250(0.88)  LDD1522  [41]
 LDCM0284  AC24 HEK-293T C23(0.95); C251(0.86); C250(0.90)  LDD1523  [41]
 LDCM0285  AC25 HEK-293T C23(1.05); C251(0.97); C250(0.88)  LDD1524  [41]
 LDCM0286  AC26 HEK-293T C23(1.04); C251(1.14); C250(0.96)  LDD1525  [41]
 LDCM0287  AC27 HEK-293T C23(1.03); C251(1.04); C250(0.87)  LDD1526  [41]
 LDCM0288  AC28 HEK-293T C23(0.95); C251(1.00); C250(0.97)  LDD1527  [41]
 LDCM0289  AC29 HEK-293T C23(1.00); C251(0.87); C250(1.36)  LDD1528  [41]
 LDCM0290  AC3 HEK-293T C23(1.16); C251(0.91); C250(1.08)  LDD1529  [41]
 LDCM0291  AC30 HEK-293T C23(0.98); C251(1.04); C250(1.00)  LDD1530  [41]
 LDCM0292  AC31 HEK-293T C23(0.90); C251(1.05); C250(0.89)  LDD1531  [41]
 LDCM0293  AC32 HEK-293T C23(0.97); C251(0.93); C250(1.04)  LDD1532  [41]
 LDCM0294  AC33 HEK-293T C23(1.08); C251(0.89); C250(1.01)  LDD1533  [41]
 LDCM0295  AC34 HEK-293T C23(1.05); C251(1.10); C250(1.03)  LDD1534  [41]
 LDCM0296  AC35 HEK-293T C23(1.06); C251(0.96); C250(1.01)  LDD1535  [41]
 LDCM0297  AC36 HEK-293T C23(1.04); C251(0.83); C250(1.06)  LDD1536  [41]
 LDCM0298  AC37 HEK-293T C23(1.02); C251(0.93); C250(1.07)  LDD1537  [41]
 LDCM0299  AC38 HEK-293T C23(0.94); C251(1.03); C250(0.91)  LDD1538  [41]
 LDCM0300  AC39 HEK-293T C23(0.89); C251(0.95); C250(0.80)  LDD1539  [41]
 LDCM0301  AC4 HEK-293T C23(1.05); C251(1.02); C250(1.11)  LDD1540  [41]
 LDCM0302  AC40 HEK-293T C23(1.00); C251(0.91); C250(0.89)  LDD1541  [41]
 LDCM0303  AC41 HEK-293T C23(0.99); C251(0.84); C250(1.13)  LDD1542  [41]
 LDCM0304  AC42 HEK-293T C23(1.06); C251(1.28); C250(0.98)  LDD1543  [41]
 LDCM0305  AC43 HEK-293T C23(1.06); C251(0.95); C250(1.19)  LDD1544  [41]
 LDCM0306  AC44 HEK-293T C23(1.02); C251(0.88); C250(1.05)  LDD1545  [41]
 LDCM0307  AC45 HEK-293T C23(1.06); C251(0.88); C250(0.91)  LDD1546  [41]
 LDCM0308  AC46 HEK-293T C23(0.95); C251(0.92); C250(1.08)  LDD1547  [41]
 LDCM0309  AC47 HEK-293T C23(0.93); C251(0.90); C250(1.21)  LDD1548  [41]
 LDCM0310  AC48 HEK-293T C23(0.99); C251(0.89); C250(0.97)  LDD1549  [41]
 LDCM0311  AC49 HEK-293T C23(1.05); C251(0.84); C250(1.12)  LDD1550  [41]
 LDCM0312  AC5 HEK-293T C23(1.09); C251(0.82); C250(0.94)  LDD1551  [41]
 LDCM0313  AC50 HEK-293T C23(1.06); C251(1.23); C250(0.97)  LDD1552  [41]
 LDCM0314  AC51 HEK-293T C23(1.05); C251(1.09); C250(1.00)  LDD1553  [41]
 LDCM0315  AC52 HEK-293T C23(0.98); C251(0.96); C250(0.94)  LDD1554  [41]
 LDCM0316  AC53 HEK-293T C23(0.99); C251(0.97); C250(0.94)  LDD1555  [41]
 LDCM0317  AC54 HEK-293T C23(0.98); C251(0.95); C250(1.01)  LDD1556  [41]
 LDCM0318  AC55 HEK-293T C23(0.89); C251(0.84); C250(0.80)  LDD1557  [41]
 LDCM0319  AC56 HEK-293T C23(1.05); C251(0.91); C250(0.93)  LDD1558  [41]
 LDCM0320  AC57 HEK-293T C23(1.12); C251(0.95); C250(0.98)  LDD1559  [41]
 LDCM0321  AC58 HEK-293T C23(1.05); C251(0.99); C250(0.98)  LDD1560  [41]
 LDCM0322  AC59 HEK-293T C23(1.09); C251(1.06); C250(0.82)  LDD1561  [41]
 LDCM0323  AC6 HEK-293T C23(1.03); C251(0.90); C250(1.08)  LDD1562  [41]
 LDCM0324  AC60 HEK-293T C23(1.08); C251(1.08); C250(1.02)  LDD1563  [41]
 LDCM0325  AC61 HEK-293T C23(1.15); C251(0.88); C250(0.88)  LDD1564  [41]
 LDCM0326  AC62 HEK-293T C23(1.03); C251(0.90); C250(0.84)  LDD1565  [41]
 LDCM0327  AC63 HEK-293T C23(0.98); C251(0.83); C250(0.97)  LDD1566  [41]
 LDCM0328  AC64 HEK-293T C23(1.12); C251(1.01); C250(0.91)  LDD1567  [41]
 LDCM0334  AC7 HEK-293T C23(1.04); C251(1.12); C250(0.74)  LDD1568  [41]
 LDCM0345  AC8 HEK-293T C23(1.05); C251(1.00); C250(0.73)  LDD1569  [41]
 LDCM0520  AKOS000195272 MDA-MB-231 C251(0.99)  LDD2113  [14]
 LDCM0248  AKOS034007472 HEK-293T C23(1.07); C251(0.92); C250(1.15)  LDD1511  [41]
 LDCM0356  AKOS034007680 HEK-293T C23(1.06); C251(0.94); C250(0.97)  LDD1570  [41]
 LDCM0275  AKOS034007705 HEK-293T C23(0.97); C251(1.02); C250(1.13)  LDD1514  [41]
 LDCM0156  Aniline NCI-H1299 12.10  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C23(2.35)  LDD2214  [42]
 LDCM0108  Chloroacetamide HeLa H520(0.00); C250(0.00); H411(0.00); H133(0.00)  LDD0222  [33]
 LDCM0632  CL-Sc Hep-G2 C23(2.18); C250(0.87); C23(0.04)  LDD2227  [26]
 LDCM0367  CL1 HEK-293T C23(1.04); C251(0.82); C250(1.18)  LDD1571  [41]
 LDCM0368  CL10 HEK-293T C23(0.62); C251(0.81); C250(0.95)  LDD1572  [41]
 LDCM0369  CL100 HEK-293T C23(1.07); C251(0.88); C250(0.69)  LDD1573  [41]
 LDCM0370  CL101 HEK-293T C23(1.10); C251(0.94); C250(1.10)  LDD1574  [41]
 LDCM0371  CL102 HEK-293T C23(1.00); C251(0.81); C250(0.87)  LDD1575  [41]
 LDCM0372  CL103 HEK-293T C23(1.00); C251(0.81); C250(0.78)  LDD1576  [41]
 LDCM0373  CL104 HEK-293T C23(0.97); C251(0.79); C250(0.91)  LDD1577  [41]
 LDCM0374  CL105 HEK-293T C23(1.01); C251(0.99); C250(0.90)  LDD1578  [41]
 LDCM0375  CL106 HEK-293T C23(0.98); C251(0.97); C250(0.66)  LDD1579  [41]
 LDCM0376  CL107 HEK-293T C23(0.97); C251(0.87); C250(0.67)  LDD1580  [41]
 LDCM0377  CL108 HEK-293T C23(0.98); C251(1.19); C250(0.79)  LDD1581  [41]
 LDCM0378  CL109 HEK-293T C23(0.99); C251(0.85); C250(0.91)  LDD1582  [41]
 LDCM0379  CL11 HEK-293T C23(0.54); C251(0.82); C250(0.76)  LDD1583  [41]
 LDCM0380  CL110 HEK-293T C23(1.00); C251(1.05); C250(0.77)  LDD1584  [41]
 LDCM0381  CL111 HEK-293T C23(0.91); C251(0.90); C250(0.70)  LDD1585  [41]
 LDCM0382  CL112 HEK-293T C23(1.06); C251(0.96); C250(0.97)  LDD1586  [41]
 LDCM0383  CL113 HEK-293T C23(1.03); C251(0.94); C250(0.90)  LDD1587  [41]
 LDCM0384  CL114 HEK-293T C23(0.97); C251(0.92); C250(0.87)  LDD1588  [41]
 LDCM0385  CL115 HEK-293T C23(1.03); C251(0.92); C250(0.74)  LDD1589  [41]
 LDCM0386  CL116 HEK-293T C23(1.05); C251(0.82); C250(0.90)  LDD1590  [41]
 LDCM0387  CL117 HEK-293T C23(1.08); C251(0.88); C250(1.06)  LDD1591  [41]
 LDCM0388  CL118 HEK-293T C23(1.01); C251(0.90); C250(0.87)  LDD1592  [41]
 LDCM0389  CL119 HEK-293T C23(1.01); C251(1.00); C250(0.66)  LDD1593  [41]
 LDCM0390  CL12 HEK-293T C23(0.64); C251(0.87); C250(0.76)  LDD1594  [41]
 LDCM0391  CL120 HEK-293T C23(1.00); C251(1.01); C250(0.73)  LDD1595  [41]
 LDCM0392  CL121 HEK-293T C23(1.06); C251(0.90); C250(0.96)  LDD1596  [41]
 LDCM0393  CL122 HEK-293T C23(1.00); C251(0.84); C250(0.92)  LDD1597  [41]
 LDCM0394  CL123 HEK-293T C23(0.93); C251(0.79); C250(0.79)  LDD1598  [41]
 LDCM0395  CL124 HEK-293T C23(0.98); C251(0.90); C250(0.82)  LDD1599  [41]
 LDCM0396  CL125 HEK-293T C23(1.30); C251(0.86); C250(0.97)  LDD1600  [41]
 LDCM0397  CL126 HEK-293T C23(1.05); C251(1.01); C250(0.94)  LDD1601  [41]
 LDCM0398  CL127 HEK-293T C23(1.03); C251(0.92); C250(0.97)  LDD1602  [41]
 LDCM0399  CL128 HEK-293T C23(1.12); C251(0.87); C250(0.77)  LDD1603  [41]
 LDCM0400  CL13 HEK-293T C23(1.19); C251(0.98); C250(1.15)  LDD1604  [41]
 LDCM0401  CL14 HEK-293T C23(0.96); C251(0.95); C250(1.13)  LDD1605  [41]
 LDCM0402  CL15 HEK-293T C23(0.87); C251(0.78); C250(0.64)  LDD1606  [41]
 LDCM0403  CL16 HEK-293T C23(0.97); C251(0.96); C250(0.81)  LDD1607  [41]
 LDCM0404  CL17 HEK-293T C23(0.82); C251(0.91); C250(1.10)  LDD1608  [41]
 LDCM0405  CL18 HEK-293T C23(0.96); C251(1.07); C250(1.15)  LDD1609  [41]
 LDCM0406  CL19 HEK-293T C23(0.84); C251(0.97); C250(1.01)  LDD1610  [41]
 LDCM0407  CL2 HEK-293T C23(1.04); C251(0.84); C250(0.88)  LDD1611  [41]
 LDCM0408  CL20 HEK-293T C23(0.76); C251(1.00); C250(1.05)  LDD1612  [41]
 LDCM0409  CL21 HEK-293T C23(0.59); C251(0.71); C250(0.79)  LDD1613  [41]
 LDCM0410  CL22 HEK-293T C23(0.67); C251(1.00); C250(1.07)  LDD1614  [41]
 LDCM0411  CL23 HEK-293T C23(0.48); C251(0.86); C250(0.98)  LDD1615  [41]
 LDCM0412  CL24 HEK-293T C23(0.59); C251(1.04); C250(0.89)  LDD1616  [41]
 LDCM0413  CL25 HEK-293T C23(1.09); C251(0.85); C250(1.23)  LDD1617  [41]
 LDCM0414  CL26 HEK-293T C23(0.98); C251(0.84); C250(0.28)  LDD1618  [41]
 LDCM0415  CL27 HEK-293T C23(0.95); C251(0.84); C250(0.69)  LDD1619  [41]
 LDCM0416  CL28 HEK-293T C23(0.96); C251(0.85); C250(0.91)  LDD1620  [41]
 LDCM0417  CL29 HEK-293T C23(0.85); C251(0.94); C250(0.94)  LDD1621  [41]
 LDCM0418  CL3 HEK-293T C23(1.01); C251(0.93); C250(0.80)  LDD1622  [41]
 LDCM0419  CL30 HEK-293T C23(0.84); C251(1.00); C250(0.98)  LDD1623  [41]
 LDCM0420  CL31 HEK-293T C23(0.83); C251(0.90); C250(1.08)  LDD1624  [41]
 LDCM0421  CL32 HEK-293T C23(0.76); C251(0.96); C250(0.68)  LDD1625  [41]
 LDCM0422  CL33 HEK-293T C23(0.50); C251(0.82); C250(0.56)  LDD1626  [41]
 LDCM0423  CL34 HEK-293T C23(0.61); C251(1.06); C250(0.50)  LDD1627  [41]
 LDCM0424  CL35 HEK-293T C23(0.46); C251(1.11); C250(0.33)  LDD1628  [41]
 LDCM0425  CL36 HEK-293T C23(0.53); C251(0.93); C250(0.71)  LDD1629  [41]
 LDCM0426  CL37 HEK-293T C23(1.11); C251(0.97); C250(1.01)  LDD1630  [41]
 LDCM0428  CL39 HEK-293T C23(0.92); C251(0.85); C250(0.83)  LDD1632  [41]
 LDCM0429  CL4 HEK-293T C23(0.98); C251(0.88); C250(0.82)  LDD1633  [41]
 LDCM0430  CL40 HEK-293T C23(0.91); C251(1.01); C250(1.11)  LDD1634  [41]
 LDCM0431  CL41 HEK-293T C23(0.95); C251(0.78); C250(1.04)  LDD1635  [41]
 LDCM0432  CL42 HEK-293T C23(0.88); C251(1.07); C250(1.06)  LDD1636  [41]
 LDCM0433  CL43 HEK-293T C23(0.79); C251(0.90); C250(1.05)  LDD1637  [41]
 LDCM0434  CL44 HEK-293T C23(0.80); C251(1.12); C250(0.90)  LDD1638  [41]
 LDCM0435  CL45 HEK-293T C23(0.64); C251(0.94); C250(1.08)  LDD1639  [41]
 LDCM0436  CL46 HEK-293T C23(0.64); C251(0.99); C250(0.74)  LDD1640  [41]
 LDCM0437  CL47 HEK-293T C23(0.49); C251(0.87); C250(0.63)  LDD1641  [41]
 LDCM0438  CL48 HEK-293T C23(0.53); C251(0.99); C250(0.89)  LDD1642  [41]
 LDCM0439  CL49 HEK-293T C23(1.20); C251(1.09); C250(1.18)  LDD1643  [41]
 LDCM0440  CL5 HEK-293T C23(1.06); C251(1.09); C250(1.15)  LDD1644  [41]
 LDCM0441  CL50 HEK-293T C23(0.91); C251(0.89); C250(0.48)  LDD1645  [41]
 LDCM0443  CL52 HEK-293T C23(0.97); C251(0.93); C250(0.76)  LDD1646  [41]
 LDCM0444  CL53 HEK-293T C23(0.91); C251(0.90); C250(1.03)  LDD1647  [41]
 LDCM0445  CL54 HEK-293T C23(0.85); C251(0.90); C250(0.96)  LDD1648  [41]
 LDCM0446  CL55 HEK-293T C23(0.79); C251(0.95); C250(1.08)  LDD1649  [41]
 LDCM0447  CL56 HEK-293T C23(0.77); C251(0.95); C250(0.73)  LDD1650  [41]
 LDCM0448  CL57 HEK-293T C23(0.58); C251(0.81); C250(0.23)  LDD1651  [41]
 LDCM0449  CL58 HEK-293T C23(0.61); C251(0.85); C250(0.69)  LDD1652  [41]
 LDCM0450  CL59 HEK-293T C23(0.48); C251(0.87); C250(0.42)  LDD1653  [41]
 LDCM0451  CL6 HEK-293T C23(0.99); C251(1.02); C250(1.03)  LDD1654  [41]
 LDCM0452  CL60 HEK-293T C23(0.55); C251(0.88); C250(0.91)  LDD1655  [41]
 LDCM0453  CL61 HEK-293T C23(1.25); C251(1.01); C250(1.18)  LDD1656  [41]
 LDCM0454  CL62 HEK-293T C23(0.99); C251(0.90); C250(0.51)  LDD1657  [41]
 LDCM0455  CL63 HEK-293T C23(0.96); C251(0.79); C250(0.80)  LDD1658  [41]
 LDCM0456  CL64 HEK-293T C23(0.95); C251(0.80); C250(0.78)  LDD1659  [41]
 LDCM0457  CL65 HEK-293T C23(0.96); C251(0.91); C250(1.06)  LDD1660  [41]
 LDCM0458  CL66 HEK-293T C23(0.97); C251(1.08); C250(1.22)  LDD1661  [41]
 LDCM0459  CL67 HEK-293T C23(0.85); C251(1.04); C250(1.14)  LDD1662  [41]
 LDCM0460  CL68 HEK-293T C23(0.77); C251(0.81); C250(0.81)  LDD1663  [41]
 LDCM0461  CL69 HEK-293T C23(0.63); C251(0.87); C250(1.09)  LDD1664  [41]
 LDCM0462  CL7 HEK-293T C23(0.92); C251(0.96); C250(1.06)  LDD1665  [41]
 LDCM0463  CL70 HEK-293T C23(0.67); C251(0.92); C250(0.78)  LDD1666  [41]
 LDCM0464  CL71 HEK-293T C23(0.50); C251(0.88); C250(0.44)  LDD1667  [41]
 LDCM0465  CL72 HEK-293T C23(0.60); C251(0.88); C250(0.79)  LDD1668  [41]
 LDCM0466  CL73 HEK-293T C23(1.15); C251(0.73); C250(0.99)  LDD1669  [41]
 LDCM0467  CL74 HEK-293T C23(1.06); C251(1.01); C250(0.33)  LDD1670  [41]
 LDCM0469  CL76 HEK-293T C23(0.95); C251(0.88); C250(0.75)  LDD1672  [41]
 LDCM0470  CL77 HEK-293T C23(0.96); C251(0.83); C250(0.95)  LDD1673  [41]
 LDCM0471  CL78 HEK-293T C23(0.92); C251(1.04); C250(1.02)  LDD1674  [41]
 LDCM0472  CL79 HEK-293T C23(0.83); C251(0.95); C250(1.01)  LDD1675  [41]
 LDCM0473  CL8 HEK-293T C23(0.69); C251(0.88); C250(0.89)  LDD1676  [41]
 LDCM0474  CL80 HEK-293T C23(0.80); C251(1.03); C250(0.71)  LDD1677  [41]
 LDCM0475  CL81 HEK-293T C23(0.66); C251(1.16); C250(1.00)  LDD1678  [41]
 LDCM0476  CL82 HEK-293T C23(0.71); C251(0.96); C250(0.61)  LDD1679  [41]
 LDCM0477  CL83 HEK-293T C23(0.54); C251(0.98); C250(0.37)  LDD1680  [41]
 LDCM0478  CL84 HEK-293T C23(0.68); C251(0.94); C250(0.72)  LDD1681  [41]
 LDCM0479  CL85 HEK-293T C23(1.45); C251(0.98); C250(1.16)  LDD1682  [41]
 LDCM0480  CL86 HEK-293T C23(1.14); C251(1.02); C250(0.80)  LDD1683  [41]
 LDCM0481  CL87 HEK-293T C23(1.07); C251(0.80); C250(1.01)  LDD1684  [41]
 LDCM0482  CL88 HEK-293T C23(1.14); C251(0.93); C250(0.75)  LDD1685  [41]
 LDCM0483  CL89 HEK-293T C23(1.08); C251(0.93); C250(1.10)  LDD1686  [41]
 LDCM0484  CL9 HEK-293T C23(0.68); C251(0.97); C250(1.02)  LDD1687  [41]
 LDCM0485  CL90 HEK-293T C23(0.84); C251(0.80); C250(1.04)  LDD1688  [41]
 LDCM0486  CL91 HEK-293T C23(0.90); C251(1.07); C250(1.12)  LDD1689  [41]
 LDCM0487  CL92 HEK-293T C23(0.89); C251(0.90); C250(1.00)  LDD1690  [41]
 LDCM0488  CL93 HEK-293T C23(0.72); C251(0.84); C250(1.00)  LDD1691  [41]
 LDCM0489  CL94 HEK-293T C23(0.79); C251(0.93); C250(0.82)  LDD1692  [41]
 LDCM0490  CL95 HEK-293T C23(0.61); C251(0.80); C250(0.63)  LDD1693  [41]
 LDCM0491  CL96 HEK-293T C23(0.86); C251(0.93); C250(0.77)  LDD1694  [41]
 LDCM0492  CL97 HEK-293T C23(1.08); C251(0.94); C250(1.15)  LDD1695  [41]
 LDCM0493  CL98 HEK-293T C23(1.03); C251(0.97); C250(0.78)  LDD1696  [41]
 LDCM0494  CL99 HEK-293T C23(1.05); C251(1.04); C250(0.63)  LDD1697  [41]
 LDCM0495  E2913 HEK-293T C23(0.97); C251(0.74); C250(0.70)  LDD1698  [41]
 LDCM0625  F8 Ramos C23(1.33)  LDD2187  [43]
 LDCM0572  Fragment10 Ramos C23(1.04)  LDD2189  [43]
 LDCM0573  Fragment11 Ramos 4.32  LDD2190  [43]
 LDCM0574  Fragment12 Ramos 0.44; C23(0.77)  LDD2191  [43]
 LDCM0575  Fragment13 Ramos C23(0.91)  LDD2192  [43]
 LDCM0576  Fragment14 Ramos C23(0.78)  LDD2193  [43]
 LDCM0579  Fragment20 Ramos 0.18; C23(0.67)  LDD2194  [43]
 LDCM0580  Fragment21 Ramos C23(0.79)  LDD2195  [43]
 LDCM0582  Fragment23 Ramos C23(0.90)  LDD2196  [43]
 LDCM0578  Fragment27 Ramos C23(0.88)  LDD2197  [43]
 LDCM0586  Fragment28 Ramos C23(0.69)  LDD2198  [43]
 LDCM0588  Fragment30 Ramos 0.10; C23(0.79)  LDD2199  [43]
 LDCM0589  Fragment31 Ramos C23(0.89)  LDD2200  [43]
 LDCM0590  Fragment32 Ramos C23(1.09)  LDD2201  [43]
 LDCM0468  Fragment33 HEK-293T C23(0.98); C251(0.85); C250(0.89)  LDD1671  [41]
 LDCM0596  Fragment38 Ramos C23(0.73)  LDD2203  [43]
 LDCM0566  Fragment4 Ramos C23(0.73)  LDD2184  [43]
 LDCM0427  Fragment51 HEK-293T C23(0.96); C251(0.90); C250(0.66)  LDD1631  [41]
 LDCM0610  Fragment52 Ramos C23(0.70)  LDD2204  [43]
 LDCM0614  Fragment56 Ramos C23(0.79)  LDD2205  [43]
 LDCM0569  Fragment7 Ramos C23(0.85)  LDD2186  [43]
 LDCM0571  Fragment9 Ramos 0.07; C23(0.88)  LDD2188  [43]
 LDCM0116  HHS-0101 DM93 Y127(0.87); Y113(0.90); Y430(8.20)  LDD0264  [17]
 LDCM0117  HHS-0201 DM93 Y127(0.64); Y113(0.84); Y430(8.71)  LDD0265  [17]
 LDCM0118  HHS-0301 DM93 Y430(0.69); Y127(0.74); Y113(0.84)  LDD0266  [17]
 LDCM0119  HHS-0401 DM93 Y127(0.66); Y113(1.03); Y430(5.37)  LDD0267  [17]
 LDCM0120  HHS-0701 DM93 Y430(0.53); Y127(0.84); Y113(1.37)  LDD0268  [17]
 LDCM0107  IAA HeLa H236(0.00); C250(0.00); H411(0.00); H436(0.00)  LDD0221  [33]
 LDCM0123  JWB131 DM93 Y127(0.86); Y430(1.01)  LDD0285  [16]
 LDCM0124  JWB142 DM93 Y127(0.84); Y430(1.01)  LDD0286  [16]
 LDCM0125  JWB146 DM93 Y127(0.95); Y430(0.98)  LDD0287  [16]
 LDCM0126  JWB150 DM93 Y127(2.71); Y430(3.01)  LDD0288  [16]
 LDCM0127  JWB152 DM93 Y127(1.71); Y430(2.04)  LDD0289  [16]
 LDCM0128  JWB198 DM93 Y127(1.38); Y430(1.14)  LDD0290  [16]
 LDCM0129  JWB202 DM93 Y127(0.71); Y430(1.28)  LDD0291  [16]
 LDCM0130  JWB211 DM93 Y127(0.95); Y430(1.03)  LDD0292  [16]
 LDCM0022  KB02 HEK-293T C23(1.14); C251(1.03); C250(1.05)  LDD1492  [41]
 LDCM0023  KB03 HEK-293T C23(1.06); C251(0.97); C250(0.92)  LDD1497  [41]
 LDCM0024  KB05 MSTO-211H C251(3.81)  LDD3337  [12]
 LDCM0109  NEM HeLa H236(0.00); H133(0.00); H436(0.00); H411(0.00)  LDD0223  [33]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C250(1.32)  LDD2090  [14]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C250(1.00)  LDD2099  [14]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C251(0.88)  LDD2101  [14]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C250(0.55); C251(0.54)  LDD2106  [14]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C251(0.97)  LDD2107  [14]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C251(1.17)  LDD2110  [14]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C251(0.62)  LDD2114  [14]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C251(0.57)  LDD2115  [14]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C250(0.87); C251(0.89)  LDD2123  [14]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C250(1.05); C251(0.76)  LDD2125  [14]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C250(0.95)  LDD2129  [14]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C250(1.02)  LDD2135  [14]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C251(1.00)  LDD2136  [14]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C250(0.83); C251(0.86)  LDD2137  [14]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C250(1.04)  LDD2146  [14]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C251(0.53)  LDD2148  [14]
 LDCM0627  NUDT7-COV-1 HEK-293T C23(1.53); C23(1.06)  LDD2206  [44]
 LDCM0628  OTUB2-COV-1 HEK-293T C23(1.06); C250(0.96); C23(0.88); C23(0.80)  LDD2207  [44]
 LDCM0131  RA190 MM1.R C23(1.38); C250(1.20); C251(1.20)  LDD0304  [45]
 LDCM0021  THZ1 HeLa S3 C251(1.06)  LDD0460  [13]
 LDCM0110  W12 Hep-G2 K485(0.93)  LDD0237  [6]
 LDCM0112  W16 Hep-G2 C23(0.62)  LDD0239  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Splicing factor, proline- and glutamine-rich (SFPQ) . P23246
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
KH domain-containing RNA-binding protein QKI (QKI) . Q96PU8
Poly(rC)-binding protein 1 (PCBP1) . Q15365
RNA-binding protein 10 (RBM10) . P98175
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
11 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
13 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
14 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
15 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
16 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
17 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
18 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
19 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
20 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
21 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
22 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
23 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
24 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
25 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD036569
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Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD044402
42 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
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Mass spectrometry data entry: PXD027578
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