Details of the Probe

General Information of Probe

Probe ID
LDPC0029
Probe Name
OSF
Probe Type
ABPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 257.242
Lipid-water partition coefficient (xlogp) 0.6427
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C10H8FNO4S
Canonical SMILES
C#CCNC(=O)c1ccc(OS(=O)(=O)F)cc1
InChI
InChI=1S/C10H8FNO4S/c1-2-7-12-10(13)8-3-5-9(6-4-8)16-17(11,14)15/h1,3-6H,7H2,(H,12,13)
InChIKey
DUCQRZOXEFQXMZ-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

63 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) LDTP10954 Y168  LDD0029 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 H267; Y227  LDD0029 
Actin, cytoplasmic 1 (ACTB) LDTP04876 Y198; Y53; Y306; H40  LDD0029 
Adenosylhomocysteinase (AHCY) LDTP03242 Y39  LDD0029 
Adenylosuccinate lyase (ADSL) LDTP03551 H159  LDD0029 
Alpha-enolase (ENO1) LDTP02159 Y44; H68; H190  LDD0029 
Aspartate aminotransferase, mitochondrial (GOT2) LDTP01783 H423  LDD0029 
ATP synthase subunit beta, mitochondrial (ATP5F1B) LDTP02150 H417; Y418  LDD0029 
ATP-citrate synthase (ACLY) LDTP04561 Y531  LDD0029 
ATPase family AAA domain-containing protein 3B (ATAD3B) LDTP07154 H299  LDD0029 
Calcyclin-binding protein (CACYBP) LDTP12163 Y71  LDD0029 
Citrate synthase, mitochondrial (CS) LDTP01205 Y381  LDD0029 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 H29  LDD0029 
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) LDTP00194 Y194  LDD0029 
DNA topoisomerase 1 (TOP1) LDTP02567 H399  LDD0029 
DNA-dependent protein kinase catalytic subunit (PRKDC) LDTP05136 H3716  LDD0029 
Elongation factor 1-alpha 1 (EEF1A1) LDTP05071 H7; H95; H26; Y141  LDD0029 
Eukaryotic initiation factor 4A-I (EIF4A1) LDTP04878 H358; Y70  LDD0029 
Exosome complex exonuclease RRP44 (DIS3) LDTP13887 Y106  LDD0029 
Fatty acid synthase (FASN) LDTP04243 Y2034; H1056  LDD0029 
Fructose-bisphosphate aldolase A (ALDOA) LDTP02008 Y3; H21; H246  LDD0029 
Gamma-enolase (ENO2) LDTP02328 Y44  LDD0029 
Glutathione S-transferase A4 (GSTA4) LDTP00575 Y9  LDD0029 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 H49  LDD0029 
Glutathione S-transferase P (GSTP1) LDTP02333 Y8  LDD0029 
Heat shock cognate 71 kDa protein (HSPA8) LDTP02541 Y107; Y41; Y525  LDD0029 
Heat shock protein HSP 90-alpha (HSP90AA1) LDTP02225 Y492; Y61; H450  LDD0029 
Heme oxygenase 1 (HMOX1) LDTP02359 Y134  LDD0029 
Heme oxygenase 2 (HMOX2) LDTP03540 Y154  LDD0029 
Histone deacetylase 11 (HDAC11) LDTP10208 Y209  LDD0029 
L-lactate dehydrogenase B chain (LDHB) LDTP02179 Y240  LDD0029 
Mitochondrial disaggregase (CLPB) LDTP11683 Y305  LDD0029 
Ornithine aminotransferase, mitochondrial (OAT) LDTP02021 Y55; H53  LDD0029 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 Y215  LDD0029 
Peptidyl-prolyl cis-trans isomerase A (PPIA) LDTP05028 H126  LDD0029 
Peptidyl-prolyl cis-trans isomerase B (PPIB) LDTP03216 H166  LDD0029 
Peptidyl-prolyl cis-trans isomerase D (PPID) LDTP05573 H146  LDD0029 
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF) LDTP03534 H168  LDD0029 
Peroxiredoxin-1 (PRDX1) LDTP05503 H10  LDD0029 
Peroxisomal carnitine O-octanoyltransferase (CROT) LDTP13453 Y439  LDD0029 
Phenylalanine--tRNA ligase beta subunit (FARSB) LDTP12586 H496; H297  LDD0029 
Phosphoglycerate kinase 1 (PGK1) LDTP01787 Y196  LDD0029 
Phosphoglycerate mutase 1 (PGAM1) LDTP02963 H107  LDD0029 
Probable ATP-dependent RNA helicase DDX6 (DDX6) LDTP03348 H420  LDD0029 
Proteasome subunit alpha type-1 (PSMA1) LDTP03330 H59  LDD0029 
Proteasome subunit alpha type-2 (PSMA2) LDTP03331 Y57  LDD0029 
Proteasome subunit alpha type-7 (PSMA7) LDTP00449 Y118; Y110  LDD0029 
Proteasome subunit beta type-5 (PSMB5) LDTP03419 H237; Y228; Y149; Y236  LDD0029 
Pyruvate kinase PKM (PKM) LDTP02733 Y370; H274  LDD0029 
Serine hydroxymethyltransferase, mitochondrial (SHMT2) LDTP03689 Y96  LDD0029 
Serine palmitoyltransferase 2 (SPTLC2) LDTP00598 Y176  LDD0029 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 H207  LDD0029 
sn-1-specific diacylglycerol lipase ABHD11 (ABHD11) LDTP09225 H296  LDD0029 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 H685  LDD0029 
Spliceosome RNA helicase DDX39B (DDX39B) LDTP05991 Y39; H373  LDD0029 
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) LDTP06455 Y122  LDD0029 
Threonine--tRNA ligase 1, cytoplasmic (TARS1) LDTP03365 Y298; H68  LDD0029 
Thymidine kinase 2, mitochondrial (TK2) LDTP00190 Y99  LDD0029 
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) LDTP03912 H598  LDD0029 
Tubulin alpha-1A chain (TUBA1A) LDTP07907 Y357; Y108; Y224; H107  LDD0029 
Tubulin alpha-1B chain (TUBA1B) LDTP05074 Y272; H107; Y161; H266  LDD0029 
Ubiquitin thioesterase OTUB1 (OTUB1) LDTP10318 H247  LDD0029 
Uroporphyrinogen decarboxylase (UROD) LDTP02135 H339  LDD0029 
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⏷ Show the Full List of 63 Enzyme
12 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein epsilon (YWHAE) LDTP04969 Y131  LDD0029 
14-3-3 protein zeta/delta (YWHAZ) LDTP05043 Y128  LDD0029 
ADP/ATP translocase 2 (SLC25A5) LDTP02087 Y81; H40  LDD0029 
AP-1 complex subunit gamma-1 (AP1G1) LDTP00855 H188  LDD0029 
Calnexin (CANX) LDTP03405 H128  LDD0029 
Clathrin interactor 1 (CLINT1) LDTP06177 H104  LDD0029 
Eukaryotic translation initiation factor 5A-1-like (EIF5AL1) LDTP17347 H57  LDD0029 
Fatty acid-binding protein 5 (FABP5) LDTP05292 Y131  LDD0029 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 Y56; H625; Y484; H442  LDD0029 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 Y164  LDD0029 
Prohibitin 1 (PHB1) LDTP03717 Y249  LDD0029 
Signal recognition particle 9 kDa protein (SRP9) LDTP04259 Y4  LDD0029 
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⏷ Show the Full List of 12 Transporter and channel
6 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Enhancer of rudimentary homolog (ERH) LDTP05194 Y92  LDD0029 
High mobility group protein B1 (HMGB1) LDTP02343 H31; H117  LDD0029 
High mobility group protein B2 (HMGB2) LDTP03363 H31  LDD0029 
Myc-associated zinc finger protein (MAZ) LDTP04734 Y292  LDD0029 
Nucleolar transcription factor 1 (UBTF) LDTP02897 H134  LDD0029 
Protein polybromo-1 (PBRM1) LDTP08216 Y555  LDD0029 
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⏷ Show the Full List of 6 Transcription factor
93 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
10 kDa heat shock protein, mitochondrial (HSPE1) LDTP04931 Y76  LDD0029 
Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) LDTP03871 H8  LDD0029 
Beta-actin-like protein 2 (ACTBL2) LDTP14951 H41; Y189  LDD0029 
Caprin-1 (CAPRIN1) LDTP06121 H7  LDD0029 
Cohesin subunit SA-2 (STAG2) LDTP08842 Y893; Y892  LDD0029 
Crooked neck-like protein 1 (CRNKL1) LDTP11540 Y223  LDD0029 
DnaJ homolog subfamily C member 7 (DNAJC7) LDTP10920 H408  LDD0029 
Elongation factor 1-delta (EEF1D) LDTP03499 Y26  LDD0029 
Emerin (EMD) LDTP04356 H23  LDD0029 
Endoplasmin (HSP90B1) LDTP02734 Y678; Y539; Y727  LDD0029 
Eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX) LDTP04129 Y106  LDD0029 
Eukaryotic translation initiation factor 3 subunit E (EIF3E) LDTP04853 H12  LDD0029 
Eukaryotic translation initiation factor 4E (EIF4E) LDTP02156 H37  LDD0029 
General transcription factor IIF subunit 1 (GTF2F1) LDTP03729 Y14  LDD0029 
Heat shock 70 kDa protein 1B (HSPA1B) LDTP02435 Y525; Y41; Y107  LDD0029 
Heat shock protein 75 kDa, mitochondrial (TRAP1) LDTP05697 H322; Y317  LDD0029 
Hepatoma-derived growth factor-related protein 2 (HDGFL2) LDTP08081 H3  LDD0029 
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) LDTP02364 Y341; Y357; Y366; Y347  LDD0029 
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) LDTP04495 Y360; Y373  LDD0029 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 H99; H194  LDD0029 
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) LDTP04952 Y449; Y280; H415  LDD0029 
Heterogeneous nuclear ribonucleoprotein L (HNRNPL) LDTP02750 Y47; H438  LDD0029 
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) LDTP00756 Y435; Y434; Y436; Y431  LDD0029 
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) LDTP05259 H357; H517; H631  LDD0029 
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) LDTP03182 Y234; Y336; Y331  LDD0029 
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) LDTP02227 Y139; Y137  LDD0029 
Histone H1.3 (H1-3) LDTP02844 Y72  LDD0029 
Histone H2A type 3 (H2AC25) LDTP07973 H125  LDD0029 
Histone H2A.V (H2AZ2) LDTP07908 H113  LDD0029 
Histone H2B type 1-J (H2BC11) LDTP02172 Y84; H83; H110  LDD0029 
Histone H2B type 1-K (H2BC12) LDTP01054 Y84; H83; Y41; H110  LDD0029 
Histone H3.3 (H3-3A; H3-3B) LDTP05198 Y42  LDD0029 
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) LDTP05004 Y89  LDD0029 
Lamin-B2 (LMNB2) LDTP05400 H157  LDD0029 
Large ribosomal subunit protein eL13 (RPL13) LDTP03354 H87  LDD0029 
Large ribosomal subunit protein eL14 (RPL14) LDTP04389 Y14  LDD0029 
Large ribosomal subunit protein eL15 (RPL15) LDTP04919 H181  LDD0029 
Large ribosomal subunit protein eL21 (RPL21) LDTP04107 H70; Y65  LDD0029 
Large ribosomal subunit protein eL24 (RPL24) LDTP05186 Y14  LDD0029 
Large ribosomal subunit protein eL28 (RPL28) LDTP04108 Y77  LDD0029 
Large ribosomal subunit protein eL29 (RPL29) LDTP04140 H101  LDD0029 
Large ribosomal subunit protein eL32 (RPL32) LDTP05025 H80  LDD0029 
Large ribosomal subunit protein eL33 (RPL35A) LDTP02940 Y34  LDD0029 
Large ribosomal subunit protein eL34 (RPL34) LDTP04233 Y32; Y34  LDD0029 
Large ribosomal subunit protein eL6 (RPL6) LDTP05378 Y115; H128  LDD0029 
Large ribosomal subunit protein uL1 (RPL10A) LDTP05024 H19  LDD0029 
Large ribosomal subunit protein uL13 (RPL13A) LDTP03899 Y137; Y149  LDD0029 
Large ribosomal subunit protein uL14 (RPL23) LDTP05008 H77  LDD0029 
Large ribosomal subunit protein uL15 (RPL27A) LDTP04105 H49  LDD0029 
Large ribosomal subunit protein uL18 (RPL5) LDTP04106 Y31  LDD0029 
Large ribosomal subunit protein uL2 (RPL8) LDTP05027 Y133  LDD0029 
Large ribosomal subunit protein uL24 (RPL26) LDTP04914 Y74; H96  LDD0029 
Large ribosomal subunit protein uL3 (RPL3) LDTP03865 H55  LDD0029 
Large ribosomal subunit protein uL30 (RPL7) LDTP02944 Y82  LDD0029 
Mesencephalic astrocyte-derived neurotrophic factor (MANF) LDTP04676 H99; H98  LDD0029 
Nuclear autoantigenic sperm protein (NASP) LDTP04241 H545  LDD0029 
Nucleolin (NCL) LDTP02990 Y473; Y462; Y433  LDD0029 
Nucleophosmin (NPM1) LDTP02164 Y271  LDD0029 
Polyadenylate-binding protein 3 (PABPC3) LDTP11862 Y364  LDD0029 
Polypyrimidine tract-binding protein 1 (PTBP1) LDTP03364 Y127  LDD0029 
Programmed cell death protein 5 (PDCD5) LDTP00417 Y73  LDD0029 
Putative cytochrome b-c1 complex subunit Rieske-like protein 1 (UQCRFS1P1) LDTP16876 Y100  LDD0029 
Putative heat shock protein HSP 90-beta 4 (HSP90AB4P) LDTP17159 Y32  LDD0029 
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) LDTP04117 H1234  LDD0029 
Ribosomal protein uL16-like (RPL10L) LDTP10525 H92  LDD0029 
Ribosomal protein uL24-like (RPL26L1) LDTP20031 Y74; H96  LDD0029 
RNA-binding motif protein, X chromosome (RBMX) LDTP03850 Y357; Y304; Y234; Y335  LDD0029 
RNA-binding protein FUS (FUS) LDTP03775 Y325  LDD0029 
Serine/arginine-rich splicing factor 8 (SRSF8) LDTP11117 Y44  LDD0029 
Single-stranded DNA-binding protein, mitochondrial (SSBP1) LDTP05437 H34  LDD0029 
Small ribosomal subunit protein eS10 (RPS10) LDTP04111 H84  LDD0029 
Small ribosomal subunit protein eS12 (RPS12) LDTP03321 H28; Y127  LDD0029 
Small ribosomal subunit protein eS24 (RPS24) LDTP05012 H63  LDD0029 
Small ribosomal subunit protein eS25 (RPS25) LDTP05013 Y109  LDD0029 
Small ribosomal subunit protein eS26 (RPS26) LDTP05014 H17  LDD0029 
Small ribosomal subunit protein eS27 (RPS27) LDTP03987 H9  LDD0029 
Small ribosomal subunit protein eS4, X isoform (RPS4X) LDTP04997 H138  LDD0029 
Small ribosomal subunit protein eS7 (RPS7) LDTP04958 H91  LDD0029 
Small ribosomal subunit protein eS8 (RPS8) LDTP04964 Y188  LDD0029 
Small ribosomal subunit protein uS10 (RPS20) LDTP04880 H92  LDD0029 
Small ribosomal subunit protein uS12 (RPS23) LDTP04971 H31; H46; H110  LDD0029 
Small ribosomal subunit protein uS13 (RPS18) LDTP04972 Y40; H42  LDD0029 
Small ribosomal subunit protein uS15 (RPS13) LDTP04974 Y38; H58; Y18  LDD0029 
Small ribosomal subunit protein uS5 (RPS2) LDTP02809 Y266; H136  LDD0029 
Small ribosomal subunit protein uS7 (RPS5) LDTP04110 Y48; H51  LDD0029 
Small ribosomal subunit protein uS9 (RPS16) LDTP04966 Y95; Y96  LDD0029 
T-complex protein 1 subunit beta (CCT2) LDTP05113 H337  LDD0029 
T-complex protein 1 subunit theta (CCT8) LDTP04390 H303  LDD0029 
Tight junction protein ZO-2 (TJP2) LDTP13192 H788  LDD0029 
Transgelin-2 (TAGLN2) LDTP03846 Y8  LDD0029 
Tropomyosin alpha-4 chain (TPM4) LDTP05068 H117  LDD0029 
Tubulin beta chain (TUBB) LDTP02205 Y50; H105; Y310; H264  LDD0029 
Tubulin beta-4B chain (TUBB4B) LDTP05076 Y159; H105; H264; Y310  LDD0029 
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⏷ Show the Full List of 93 Other

Full Information of The Labelling Profiles of This Probe

Qualitation: Labeling site identification
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
100 uM
In Vitro Experiment Model
Model Type
Cell lysate
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cell lysate (HEK-293T)
Interaction Atlas ID
 LDD0029 
Download The Altas

References

1 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931