Details of the Target

General Information of Target

Target ID LDTP10208
Target Name Histone deacetylase 11 (HDAC11)
Gene Name HDAC11
Gene ID 79885
Synonyms
Histone deacetylase 11; HD11; EC 3.5.1.98
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASTVVAVGLTIAAAGFAGRYVLQAMKHMEPQVKQVFQSLPKSAFSGGYYRGGFEPKMTK
REAALILGVSPTANKGKIRDAHRRIMLLNHPDKGGSPYIAAKINEAKDLLEGQAKK
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Histone deacetylase family
Subcellular location
Nucleus
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
TTD ID
T97903
Uniprot ID
Q96DB2
DrugMap ID
TT8K17W
Ensemble ID
ENST00000295757.8
HGNC ID
HGNC:19086
ChEMBL ID
CHEMBL3310

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R131Q .
AN3CA Deletion: p.V98LfsTer14 .
HCT15 SNV: p.R206H .
MEWO SNV: p.S245F .
SNGM SNV: p.L101P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OSF
 Probe Info  		N.A.  LDD0029  [1]
SF
 Probe Info  		N.A.  LDD0028  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nurim (NRM) Nurim family Q8IXM6

The Drug(s) Related To This Target

Approved
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Decitabine Small molecular drug DB01262
Phenylbutyric Acid Small molecular drug DB06819
Propanoic Acid Small molecular drug DB03766
Romidepsin Small molecular drug DB06176
Valproic Acid Small molecular drug DB00313
Vorinostat Small molecular drug DB02546
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abexinostat Small molecular drug DB12565
Patented
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid29671355-compound-21 Small molecular drug D0LP1K
Pmid29671355-compound-23 Small molecular drug D00HXJ
Pmid29671355-compound-25 Small molecular drug D0RA0D
Pmid29671355-compound-36 Small molecular drug D04JWR
Pmid29671355-compound-43 Small molecular drug D0BP8I
Pmid29671355-compound-44 Small molecular drug D0N2DK
Pmid29671355-compound-62 Small molecular drug D07WAT

References

1 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931