Details of the Target

General Information of Target

Target ID LDTP09225
Target Name sn-1-specific diacylglycerol lipase ABHD11 (ABHD11)
Gene Name ABHD11
Gene ID 83451
Synonyms
WBSCR21; sn-1-specific diacylglycerol lipase ABHD11; EC 3.1.1.116; Alpha/beta hydrolase domain-containing protein 11; Abhydrolase domain-containing protein 11; Williams-Beuren syndrome chromosomal region 21 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRWTRAWRLPREGLGPHGPSFARVPVAPSSSSGGRGGAEPRPLPLSYRLLDGEAALPAV
VFLHGLFGSKTNFNSIAKILAQQTGRRVLTVDARNHGDSPHSPDMSYEIMSQDLQDLLPQ
LGLVPCVVVGHSMGGKTAMLLALQRPELVERLIAVDISPVESTGVSHFATYVAAMRAINI
ADELPRSRARKLADEQLSSVIQDMAVRQHLLTNLVEVDGRFVWRVNLDALTQHLDKILAF
PQRQESYLGPTLFLLGGNSQFVHPSHHPEIMRLFPRAQMQTVPNAGHWIHADRPQDFIAA
IRGFLV
Target Bioclass
Enzyme
Family
AB hydrolase superfamily
Function
Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol. 1,2-diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn-glycerols. The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols. Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts. In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs).
Uniprot ID
Q8NFV4
Ensemble ID
ENST00000222800.8
HGNC ID
HGNC:16407
ChEMBL ID
CHEMBL2189134

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		3.04  LDD0066  [1]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [2]
STPyne
 Probe Info  		K87(1.85)  LDD0277  [3]
Acrolein
 Probe Info  		N.A.  LDD0227  [4]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [5]
OSF
 Probe Info  		N.A.  LDD0029  [6]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		26.72  LDD1838  [7]
C269
 Probe Info  		46.21  LDD1939  [7]
C363
 Probe Info  		19.70  LDD2024  [7]
C383
 Probe Info  		16.68  LDD2042  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0227  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Lysine-specific demethylase hairless (HR) . O43593
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein ZIC 1 (ZIC1) GLI C2H2-type zinc-finger protein family Q15915
Homeobox protein prophet of Pit-1 (PROP1) Paired homeobox family O75360
Pituitary homeobox 1 (PITX1) Paired homeobox family P78337
Homeobox protein VENTX (VENTX) . O95231
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Docking protein 6 (DOK6) DOK family, Type B subfamily Q6PKX4
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
YTH domain-containing family protein 1 (YTHDF1) YTHDF family Q9BYJ9
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
Cleavage stimulation factor subunit 2 (CSTF2) . P33240
Grancalcin (GCA) . P28676
MORN repeat-containing protein 3 (MORN3) . Q6PF18
Proline-rich protein 35 (PRR35) . P0CG20

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587