Details of the Probe

General Information of Probe

Probe ID
LDPC0130
Probe Name
1oxF11yne
Probe Type
ABPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 341.4
Lipid-water partition coefficient (xlogp) 1.3
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C18H19N3O4
IUPAC Name
prop-2-ynyl (3aR,6aS)-2-(3-phenyloxaziridine-2-carbonyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate
Canonical SMILES
C#CCOC(=O)N1CC2CN(CC2C1)C(=O)N3C(O3)C4=CC=CC=C4
InChI
InChI=1S/C18H19N3O4/c1-2-8-24-18(23)20-11-14-9-19(10-15(14)12-20)17(22)21-16(25-21)13-6-4-3-5-7-13/h1,3-7,14-16H,8-12H2/t14-,15+,16?,21?
InChIKey
HGRIMRFBQDCUTJ-MEWABEDBSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

46 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
26S proteasome non-ATPase regulatory subunit 2 (PSMD2) LDTP05782 N.A.  LDD0193 
26S proteasome non-ATPase regulatory subunit 2 (PSMD2) LDTP05782 N.A.  LDD0193 
26S proteasome non-ATPase regulatory subunit 3 (PSMD3) LDTP00714 N.A.  LDD0193 
26S proteasome non-ATPase regulatory subunit 3 (PSMD3) LDTP00714 N.A.  LDD0193 
26S proteasome non-ATPase regulatory subunit 7 (PSMD7) LDTP04441 N.A.  LDD0193 
26S proteasome non-ATPase regulatory subunit 7 (PSMD7) LDTP04441 N.A.  LDD0193 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 N.A.  LDD0193 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 N.A.  LDD0193 
ADP-ribosylation factor 4 (ARF4) LDTP02942 N.A.  LDD0193 
ADP-ribosylation factor 4 (ARF4) LDTP02942 N.A.  LDD0193 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 N.A.  LDD0193 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 N.A.  LDD0193 
ATP-dependent 6-phosphofructokinase, platelet type (PFKP) LDTP05314 N.A.  LDD0193 
ATP-dependent 6-phosphofructokinase, platelet type (PFKP) LDTP05314 N.A.  LDD0193 
ATP-dependent RNA helicase A (DHX9) LDTP05550 N.A.  LDD0193 
ATP-dependent RNA helicase A (DHX9) LDTP05550 N.A.  LDD0193 
ATP-dependent RNA helicase DHX15 (DHX15) LDTP00684 N.A.  LDD0193 
ATP-dependent RNA helicase DHX15 (DHX15) LDTP00684 N.A.  LDD0193 
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) LDTP03829 N.A.  LDD0193 
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) LDTP03829 N.A.  LDD0193 
DNA replication licensing factor MCM7 (MCM7) LDTP03682 N.A.  LDD0193 
DNA replication licensing factor MCM7 (MCM7) LDTP03682 N.A.  LDD0193 
Elongation factor 1-alpha 2 (EEF1A2) LDTP05460 N.A.  LDD0193 
Elongation factor 1-alpha 2 (EEF1A2) LDTP05460 N.A.  LDD0193 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 N.A.  LDD0193 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 N.A.  LDD0193 
Heat shock protein HSP 90-alpha (HSP90AA1) LDTP02225 N.A.  LDD0193 
Heat shock protein HSP 90-alpha (HSP90AA1) LDTP02225 N.A.  LDD0193 
Multifunctional protein CAD (CAD) LDTP03401 N.A.  LDD0193 
Multifunctional protein CAD (CAD) LDTP03401 N.A.  LDD0193 
Peroxiredoxin-1 (PRDX1) LDTP05503 N.A.  LDD0193 
Peroxiredoxin-1 (PRDX1) LDTP05503 N.A.  LDD0193 
Pyruvate kinase PKM (PKM) LDTP02733 N.A.  LDD0193 
Pyruvate kinase PKM (PKM) LDTP02733 N.A.  LDD0193 
Ras-related protein Rab-3D (RAB3D) LDTP01659 N.A.  LDD0193 
Ras-related protein Rab-3D (RAB3D) LDTP01659 N.A.  LDD0193 
Ribose-phosphate pyrophosphokinase 2 (PRPS2) LDTP02592 N.A.  LDD0193 
Ribose-phosphate pyrophosphokinase 2 (PRPS2) LDTP02592 N.A.  LDD0193 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 N.A.  LDD0193 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 N.A.  LDD0193 
sn-1-specific diacylglycerol lipase ABHD11 (ABHD11) LDTP09225 N.A.  LDD0193 
sn-1-specific diacylglycerol lipase ABHD11 (ABHD11) LDTP09225 N.A.  LDD0193 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 N.A.  LDD0193 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 N.A.  LDD0193 
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) LDTP09962 N.A.  LDD0193 
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) LDTP09962 N.A.  LDD0193 
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⏷ Show the Full List of 46 Enzyme
16 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ATP synthase subunit alpha, mitochondrial (ATP5F1A) LDTP03327 N.A.  LDD0193 
ATP synthase subunit alpha, mitochondrial (ATP5F1A) LDTP03327 N.A.  LDD0193 
Calcium load-activated calcium channel (TMCO1) LDTP13599 N.A.  LDD0193 
Calcium load-activated calcium channel (TMCO1) LDTP13599 N.A.  LDD0193 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST) LDTP03870 N.A.  LDD0193 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST) LDTP03870 N.A.  LDD0193 
Exportin-1 (XPO1) LDTP00501 N.A.  LDD0193 
Exportin-1 (XPO1) LDTP00501 N.A.  LDD0193 
Exportin-2 (CSE1L) LDTP04662 N.A.  LDD0193 
Exportin-2 (CSE1L) LDTP04662 N.A.  LDD0193 
Filamin-A (FLNA) LDTP03107 N.A.  LDD0193 
Filamin-A (FLNA) LDTP03107 N.A.  LDD0193 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 N.A.  LDD0193 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 N.A.  LDD0193 
Small ribosomal subunit protein RACK1 (RACK1) LDTP05057 N.A.  LDD0193 
Small ribosomal subunit protein RACK1 (RACK1) LDTP05057 N.A.  LDD0193 
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⏷ Show the Full List of 16 Transporter and channel
52 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Actin-related protein 2 (ACTR2) LDTP04903 N.A.  LDD0193 
Actin-related protein 2 (ACTR2) LDTP04903 N.A.  LDD0193 
AP-1 complex subunit sigma-2 (AP1S2) LDTP04739 N.A.  LDD0193 
AP-1 complex subunit sigma-2 (AP1S2) LDTP04739 N.A.  LDD0193 
Coatomer subunit beta (COPB1) LDTP04570 N.A.  LDD0193 
Coatomer subunit beta (COPB1) LDTP04570 N.A.  LDD0193 
DNA mismatch repair protein Msh2 (MSH2) LDTP04028 N.A.  LDD0193 
DNA mismatch repair protein Msh2 (MSH2) LDTP04028 N.A.  LDD0193 
Elongation factor 1-gamma (EEF1G) LDTP03367 N.A.  LDD0193 
Elongation factor 1-gamma (EEF1G) LDTP03367 N.A.  LDD0193 
Endoplasmin (HSP90B1) LDTP02734 N.A.  LDD0193 
Endoplasmin (HSP90B1) LDTP02734 N.A.  LDD0193 
Eukaryotic peptide chain release factor subunit 1 (ETF1) LDTP04993 N.A.  LDD0193 
Eukaryotic peptide chain release factor subunit 1 (ETF1) LDTP04993 N.A.  LDD0193 
Glutamate-rich WD repeat-containing protein 1 (GRWD1) LDTP11058 N.A.  LDD0193 
Glutamate-rich WD repeat-containing protein 1 (GRWD1) LDTP11058 N.A.  LDD0193 
Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3) LDTP02306 N.A.  LDD0193 
Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3) LDTP02306 N.A.  LDD0193 
Heat shock 70 kDa protein 1A (HSPA1A) LDTP02434 N.A.  LDD0193 
Heat shock 70 kDa protein 1A (HSPA1A) LDTP02434 N.A.  LDD0193 
Heat shock 70 kDa protein 4 (HSPA4) LDTP03695 N.A.  LDD0193 
Heat shock 70 kDa protein 4 (HSPA4) LDTP03695 N.A.  LDD0193 
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) LDTP00756 N.A.  LDD0193 
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) LDTP00756 N.A.  LDD0193 
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) LDTP03182 N.A.  LDD0193 
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) LDTP03182 N.A.  LDD0193 
Keratin, type I cytoskeletal 19 (KRT19) LDTP02304 N.A.  LDD0193 
Keratin, type I cytoskeletal 19 (KRT19) LDTP02304 N.A.  LDD0193 
Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) LDTP03997 N.A.  LDD0193 
Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) LDTP03997 N.A.  LDD0193 
Polyubiquitin-B (UBB) LDTP02412 N.A.  LDD0193 
Polyubiquitin-B (UBB) LDTP02412 N.A.  LDD0193 
Prelamin-A/C (LMNA) LDTP01932 N.A.  LDD0193 
Prelamin-A/C (LMNA) LDTP01932 N.A.  LDD0193 
Rab GDP dissociation inhibitor alpha (GDI1) LDTP03574 N.A.  LDD0193 
Rab GDP dissociation inhibitor alpha (GDI1) LDTP03574 N.A.  LDD0193 
Splicing factor 3B subunit 3 (SF3B3) LDTP06376 N.A.  LDD0193 
Splicing factor 3B subunit 3 (SF3B3) LDTP06376 N.A.  LDD0193 
Splicing factor 3B subunit 6 (SF3B6) LDTP13970 N.A.  LDD0193 
Splicing factor 3B subunit 6 (SF3B6) LDTP13970 N.A.  LDD0193 
Stalled ribosome sensor GCN1 (GCN1) LDTP09821 N.A.  LDD0193 
Stalled ribosome sensor GCN1 (GCN1) LDTP09821 N.A.  LDD0193 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 N.A.  LDD0193 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 N.A.  LDD0193 
T-complex protein 1 subunit beta (CCT2) LDTP05113 N.A.  LDD0193 
T-complex protein 1 subunit beta (CCT2) LDTP05113 N.A.  LDD0193 
UV excision repair protein RAD23 homolog B (RAD23B) LDTP04627 N.A.  LDD0193 
UV excision repair protein RAD23 homolog B (RAD23B) LDTP04627 N.A.  LDD0193 
Vacuolar protein sorting-associated protein 45 (VPS45) LDTP12541 N.A.  LDD0193 
Vacuolar protein sorting-associated protein 45 (VPS45) LDTP12541 N.A.  LDD0193 
Vesicle-trafficking protein SEC22b (SEC22B) LDTP01206 N.A.  LDD0193 
Vesicle-trafficking protein SEC22b (SEC22B) LDTP01206 N.A.  LDD0193 
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⏷ Show the Full List of 52 Other

Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs DMSO
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
500 uM
Quantitative Method
ReDiMe
In Vitro Experiment Model
Model Type
Cell lysate
Derived Tissue
Breast
Disease Model
Invasive breast carcinoma [ICD-11:2C60]
Model Name
Human invasive breast carcinoma cell lysate (MCF-7)
Interaction Atlas ID
 LDD0193 
Download The Altas

References

1 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.