General Information of Experiment

Probe Name 1oxF11yne  Probe Info 
Probe concentration 500 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
ReDiMe
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Invasive breast carcinoma [ICD-11:2C60]
Model Name Human invasive breast carcinoma cell lysate (MCF-7)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 23 Protein Related to This Bioclass
Target ID Target Name
 LDTP05782  26S proteasome non-ATPase regulatory subunit 2 (PSMD2)
 LDTP00714  26S proteasome non-ATPase regulatory subunit 3 (PSMD3)
 LDTP04441  26S proteasome non-ATPase regulatory subunit 7 (PSMD7)
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2)
 LDTP02942  ADP-ribosylation factor 4 (ARF4)
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1)
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP)
 LDTP05550  ATP-dependent RNA helicase A (DHX9)
 LDTP00684  ATP-dependent RNA helicase DHX15 (DHX15)
 LDTP03829  Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST)
 LDTP03682  DNA replication licensing factor MCM7 (MCM7)
 LDTP05460  Elongation factor 1-alpha 2 (EEF1A2)
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1)
 LDTP03401  Multifunctional protein CAD (CAD)
 LDTP05503  Peroxiredoxin-1 (PRDX1)
 LDTP02733  Pyruvate kinase PKM (PKM)
 LDTP01659  Ras-related protein Rab-3D (RAB3D)
 LDTP02592  Ribose-phosphate pyrophosphokinase 2 (PRPS2)
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3)
 LDTP09225  sn-1-specific diacylglycerol lipase ABHD11 (ABHD11)
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1)
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7)
Transporter and channel
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A)
 LDTP13599  Calcium load-activated calcium channel (TMCO1)
 LDTP03870  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST)
 LDTP00501  Exportin-1 (XPO1)
 LDTP04662  Exportin-2 (CSE1L)
 LDTP03107  Filamin-A (FLNA)
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1)
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1)
Other
Click to Show/Hide to Show 26 Protein Related to This Bioclass
Target ID Target Name
 LDTP04903  Actin-related protein 2 (ACTR2)
 LDTP04739  AP-1 complex subunit sigma-2 (AP1S2)
 LDTP04570  Coatomer subunit beta (COPB1)
 LDTP04028  DNA mismatch repair protein Msh2 (MSH2)
 LDTP03367  Elongation factor 1-gamma (EEF1G)
 LDTP02734  Endoplasmin (HSP90B1)
 LDTP04993  Eukaryotic peptide chain release factor subunit 1 (ETF1)
 LDTP11058  Glutamate-rich WD repeat-containing protein 1 (GRWD1)
 LDTP02306  Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3)
 LDTP02434  Heat shock 70 kDa protein 1A (HSPA1A)
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4)
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR)
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
 LDTP02304  Keratin, type I cytoskeletal 19 (KRT19)
 LDTP03997  Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC)
 LDTP02412  Polyubiquitin-B (UBB)
 LDTP01932  Prelamin-A/C (LMNA)
 LDTP03574  Rab GDP dissociation inhibitor alpha (GDI1)
 LDTP06376  Splicing factor 3B subunit 3 (SF3B3)
 LDTP13970  Splicing factor 3B subunit 6 (SF3B6)
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1)
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9)
 LDTP05113  T-complex protein 1 subunit beta (CCT2)
 LDTP04627  UV excision repair protein RAD23 homolog B (RAD23B)
 LDTP12541  Vacuolar protein sorting-associated protein 45 (VPS45)
 LDTP01206  Vesicle-trafficking protein SEC22b (SEC22B)

References

1 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.