Details of the Target

General Information of Target

Target ID LDTP03870
Target Name Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST)
Gene Name DDOST
Gene ID 1650
Synonyms
KIAA0115; OST48; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; DDOST 48 kDa subunit; Oligosaccharyl transferase 48 kDa subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGYFRCARAGSFGRRRKMEPSTAARAWALFWLLLPLLGAVCASGPRTLVLLDNLNVRETH
SLFFRSLKDRGFELTFKTADDPSLSLIKYGEFLYDNLIIFSPSVEDFGGNINVETISAFI
DGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENL
LKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKN
TLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVF
KEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRI
DPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYER
FIPSAYPYYASAFSMMLGLFIFSIVFLHMKEKEKSD
Target Bioclass
Transporter and channel
Family
DDOST 48 kDa subunit family
Subcellular location
Endoplasmic reticulum membrane
Function
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Required for the assembly of both SST3A- and SS3B-containing OST complexes.
Uniprot ID
P39656
Ensemble ID
ENST00000415136.6
HGNC ID
HGNC:2728
ChEMBL ID
CHEMBL4239

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y385(14.27)  LDD0260  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [5]
STPyne
 Probe Info  		K189(10.00); K374(1.08)  LDD0277  [6]
IPM
 Probe Info  		N.A.  LDD0241  [7]
Probe 1
 Probe Info  		Y289(36.76)  LDD3495  [8]
BTD
 Probe Info  		C145(1.38)  LDD2107  [9]
DBIA
 Probe Info  		C145(0.78)  LDD0533  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
m-APA
 Probe Info  		N.A.  LDD2231  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
NHS
 Probe Info  		K77(0.00); K189(0.00)  LDD0010  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
1c-yne
 Probe Info  		K189(0.00); K239(0.00)  LDD0228  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
Crotonaldehyde
 Probe Info  		C145(0.00); H314(0.00)  LDD0219  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		13.66  LDD0471  [18]
FFF probe12
 Probe Info  		6.08  LDD0487  [18]
FFF probe13
 Probe Info  		20.00  LDD0475  [18]
FFF probe14
 Probe Info  		13.75  LDD0477  [18]
FFF probe2
 Probe Info  		8.30  LDD0463  [18]
FFF probe3
 Probe Info  		14.44  LDD0464  [18]
FFF probe9
 Probe Info  		5.10  LDD0470  [18]
JN0003
 Probe Info  		10.14  LDD0469  [18]
STS-1
 Probe Info  		N.A.  LDD0137  [19]
STS-2
 Probe Info  		N.A.  LDD0138  [19]
A-DA
 Probe Info  		2.03  LDD0145  [20]
OEA-DA
 Probe Info  		8.06  LDD0046  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C145(0.91)  LDD1507  [22]
 LDCM0215  AC10 PaTu 8988t C145(0.59)  LDD1094  [10]
 LDCM0216  AC100 HCT 116 C145(0.78)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C145(0.66)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C145(0.58)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C145(0.43)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C145(0.60)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C145(0.53)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C145(0.55)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C145(0.45)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C145(0.60)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C145(0.67)  LDD0542  [10]
 LDCM0226  AC11 PaTu 8988t C145(0.55)  LDD1105  [10]
 LDCM0227  AC110 HCT 116 C145(0.62)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C145(0.58)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C145(0.50)  LDD0546  [10]
 LDCM0230  AC113 HEK-293T C145(1.28)  LDD0828  [10]
 LDCM0231  AC114 HEK-293T C145(1.01)  LDD0829  [10]
 LDCM0232  AC115 HEK-293T C145(0.88)  LDD0830  [10]
 LDCM0233  AC116 HEK-293T C145(0.73)  LDD0831  [10]
 LDCM0234  AC117 HEK-293T C145(0.86)  LDD0832  [10]
 LDCM0235  AC118 HEK-293T C145(0.77)  LDD0833  [10]
 LDCM0236  AC119 HEK-293T C145(0.77)  LDD0834  [10]
 LDCM0237  AC12 PaTu 8988t C145(0.56)  LDD1116  [10]
 LDCM0238  AC120 HEK-293T C145(0.83)  LDD0836  [10]
 LDCM0239  AC121 HEK-293T C145(0.79)  LDD0837  [10]
 LDCM0240  AC122 HEK-293T C145(0.62)  LDD0838  [10]
 LDCM0241  AC123 HEK-293T C145(0.67)  LDD0839  [10]
 LDCM0242  AC124 HEK-293T C145(0.83)  LDD0840  [10]
 LDCM0243  AC125 HEK-293T C145(0.49)  LDD0841  [10]
 LDCM0244  AC126 HEK-293T C145(0.44)  LDD0842  [10]
 LDCM0245  AC127 HEK-293T C145(0.43)  LDD0843  [10]
 LDCM0246  AC128 HCT 116 C145(0.66)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C145(1.66)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C145(0.95)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C145(1.52)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C145(1.72)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C145(1.23)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C145(1.07)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C145(1.18)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C145(1.15)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C145(1.18)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C145(1.17)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C145(1.62)  LDD0575  [10]
 LDCM0259  AC14 PaTu 8988t C145(0.86)  LDD1138  [10]
 LDCM0260  AC140 HCT 116 C145(1.10)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C145(1.20)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C145(1.77)  LDD0579  [10]
 LDCM0263  AC143 PaTu 8988t C145(1.07)  LDD1142  [10]
 LDCM0264  AC144 PaTu 8988t C145(1.25)  LDD1143  [10]
 LDCM0265  AC145 PaTu 8988t C145(1.10)  LDD1144  [10]
 LDCM0266  AC146 PaTu 8988t C145(1.32)  LDD1145  [10]
 LDCM0267  AC147 PaTu 8988t C145(1.11)  LDD1146  [10]
 LDCM0268  AC148 PaTu 8988t C145(1.00)  LDD1147  [10]
 LDCM0269  AC149 PaTu 8988t C145(0.97)  LDD1148  [10]
 LDCM0270  AC15 PaTu 8988t C145(0.71)  LDD1149  [10]
 LDCM0271  AC150 PaTu 8988t C145(1.03)  LDD1150  [10]
 LDCM0272  AC151 PaTu 8988t C145(0.39)  LDD1151  [10]
 LDCM0273  AC152 PaTu 8988t C145(0.97)  LDD1152  [10]
 LDCM0274  AC153 PaTu 8988t C145(0.67)  LDD1153  [10]
 LDCM0621  AC154 PaTu 8988t C145(0.53)  LDD2166  [10]
 LDCM0622  AC155 PaTu 8988t C145(0.72)  LDD2167  [10]
 LDCM0623  AC156 PaTu 8988t C145(1.20)  LDD2168  [10]
 LDCM0624  AC157 PaTu 8988t C145(0.68)  LDD2169  [10]
 LDCM0276  AC17 HEK-293T C145(0.69)  LDD0874  [10]
 LDCM0277  AC18 HEK-293T C145(0.78)  LDD0875  [10]
 LDCM0278  AC19 HEK-293T C145(1.09)  LDD0876  [10]
 LDCM0279  AC2 HEK-293T C145(0.96)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C145(0.61)  LDD0878  [10]
 LDCM0281  AC21 HEK-293T C145(0.72)  LDD0879  [10]
 LDCM0282  AC22 HEK-293T C145(0.73)  LDD0880  [10]
 LDCM0283  AC23 HEK-293T C145(0.61)  LDD0881  [10]
 LDCM0284  AC24 HEK-293T C145(0.78)  LDD0882  [10]
 LDCM0285  AC25 HCT 116 C145(0.97)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C145(0.91)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C145(1.01)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C145(0.81)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C145(0.65)  LDD0606  [10]
 LDCM0290  AC3 HEK-293T C145(1.07)  LDD1529  [22]
 LDCM0291  AC30 HCT 116 C145(0.61)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C145(0.74)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C145(0.69)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C145(1.04)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C145(0.98)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C145(1.38)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C145(1.44)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C145(1.85)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C145(1.28)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C145(0.97)  LDD0617  [10]
 LDCM0301  AC4 HEK-293T C145(0.99)  LDD1540  [22]
 LDCM0302  AC40 HCT 116 C145(0.85)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C145(1.20)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C145(0.86)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C145(1.04)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C145(1.48)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C145(1.15)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C145(1.24)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C145(1.00)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C145(1.60)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C145(0.40)  LDD0628  [10]
 LDCM0312  AC5 HEK-293T C145(1.03)  LDD1551  [22]
 LDCM0313  AC50 HCT 116 C145(0.49)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C145(1.89)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C145(1.11)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C145(0.67)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C145(0.57)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C145(0.46)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C145(0.26)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C145(0.76)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C145(0.72)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C145(0.53)  LDD0639  [10]
 LDCM0323  AC6 PaTu 8988t C145(0.88)  LDD1202  [10]
 LDCM0324  AC60 HCT 116 C145(1.08)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C145(1.14)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C145(0.56)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C145(0.88)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C145(0.55)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C145(0.86)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C145(1.06)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C145(0.29)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C145(0.81)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C145(0.71)  LDD0650  [10]
 LDCM0334  AC7 PaTu 8988t C145(0.82)  LDD1213  [10]
 LDCM0335  AC70 HCT 116 C145(0.46)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C145(0.90)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C145(0.68)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C145(0.35)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C145(0.38)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C145(0.25)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C145(0.64)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C145(0.78)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C145(1.24)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C145(0.85)  LDD0661  [10]
 LDCM0345  AC8 PaTu 8988t C145(1.03)  LDD1224  [10]
 LDCM0346  AC80 HCT 116 C145(0.61)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C145(0.58)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C145(0.23)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C145(0.34)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C145(0.36)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C145(0.70)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C145(1.09)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C145(1.24)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C145(0.88)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C145(0.61)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C145(1.82)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C145(0.31)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C145(0.40)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C145(0.84)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C145(0.69)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C145(1.19)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C145(0.70)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C145(0.45)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C145(0.29)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C145(0.65)  LDD0683  [10]
 LDCM0248  AKOS034007472 PaTu 8988t C145(0.79)  LDD1127  [10]
 LDCM0356  AKOS034007680 PaTu 8988t C145(0.67)  LDD1235  [10]
 LDCM0275  AKOS034007705 PaTu 8988t C145(0.73)  LDD1154  [10]
 LDCM0108  Chloroacetamide HeLa C145(0.00); H314(0.00); H313(0.00)  LDD0222  [17]
 LDCM0367  CL1 HEK-293T C145(1.39)  LDD0965  [10]
 LDCM0368  CL10 HEK-293T C145(0.84)  LDD0966  [10]
 LDCM0370  CL101 PaTu 8988t C145(0.87)  LDD1249  [10]
 LDCM0371  CL102 PaTu 8988t C145(0.79)  LDD1250  [10]
 LDCM0372  CL103 PaTu 8988t C145(0.44)  LDD1251  [10]
 LDCM0373  CL104 PaTu 8988t C145(0.75)  LDD1252  [10]
 LDCM0374  CL105 HEK-293T C145(1.01)  LDD0972  [10]
 LDCM0375  CL106 HEK-293T C145(0.98)  LDD0973  [10]
 LDCM0376  CL107 HEK-293T C145(1.06)  LDD0974  [10]
 LDCM0377  CL108 HEK-293T C145(0.88)  LDD0975  [10]
 LDCM0378  CL109 HEK-293T C145(0.90)  LDD0976  [10]
 LDCM0379  CL11 HEK-293T C145(0.78)  LDD0977  [10]
 LDCM0380  CL110 HEK-293T C145(0.79)  LDD0978  [10]
 LDCM0381  CL111 HEK-293T C145(0.91)  LDD0979  [10]
 LDCM0382  CL112 HCT 116 C145(0.84)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C145(0.69)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C145(0.60)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C145(0.78)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C145(0.87)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C145(0.50)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C145(0.96)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C145(0.82)  LDD0706  [10]
 LDCM0390  CL12 HEK-293T C145(1.03)  LDD0988  [10]
 LDCM0391  CL120 HCT 116 C145(1.20)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C145(0.86)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C145(1.24)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C145(0.62)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C145(0.55)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C145(1.25)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C145(0.35)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C145(0.96)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C145(0.58)  LDD0716  [10]
 LDCM0400  CL13 HEK-293T C145(1.07)  LDD0998  [10]
 LDCM0401  CL14 HEK-293T C145(1.13)  LDD0999  [10]
 LDCM0402  CL15 HEK-293T C145(0.73)  LDD1000  [10]
 LDCM0403  CL16 PaTu 8988t C145(0.62)  LDD1282  [10]
 LDCM0404  CL17 PaTu 8988t C145(0.68)  LDD1283  [10]
 LDCM0405  CL18 PaTu 8988t C145(0.61)  LDD1284  [10]
 LDCM0406  CL19 PaTu 8988t C145(0.43)  LDD1285  [10]
 LDCM0407  CL2 HEK-293T C145(1.14)  LDD1005  [10]
 LDCM0408  CL20 PaTu 8988t C145(0.24)  LDD1287  [10]
 LDCM0409  CL21 PaTu 8988t C145(0.18)  LDD1288  [10]
 LDCM0410  CL22 PaTu 8988t C145(0.33)  LDD1289  [10]
 LDCM0411  CL23 PaTu 8988t C145(0.48)  LDD1290  [10]
 LDCM0412  CL24 PaTu 8988t C145(0.92)  LDD1291  [10]
 LDCM0413  CL25 PaTu 8988t C145(0.94)  LDD1292  [10]
 LDCM0414  CL26 PaTu 8988t C145(0.35)  LDD1293  [10]
 LDCM0415  CL27 PaTu 8988t C145(0.75)  LDD1294  [10]
 LDCM0416  CL28 PaTu 8988t C145(0.24)  LDD1295  [10]
 LDCM0417  CL29 PaTu 8988t C145(0.23)  LDD1296  [10]
 LDCM0418  CL3 HEK-293T C145(1.52)  LDD1016  [10]
 LDCM0419  CL30 PaTu 8988t C145(0.76)  LDD1298  [10]
 LDCM0420  CL31 HEK-293T C145(1.23)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C145(0.99)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C145(1.11)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C145(1.33)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C145(1.63)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C145(1.59)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C145(0.93)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C145(0.97)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C145(1.18)  LDD1027  [10]
 LDCM0431  CL41 HEK-293T C145(0.93)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C145(1.09)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C145(1.31)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C145(1.43)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C145(1.10)  LDD1639  [22]
 LDCM0436  CL46 PaTu 8988t C145(0.83)  LDD1315  [10]
 LDCM0437  CL47 PaTu 8988t C145(0.86)  LDD1316  [10]
 LDCM0438  CL48 PaTu 8988t C145(0.90)  LDD1317  [10]
 LDCM0439  CL49 PaTu 8988t C145(0.95)  LDD1318  [10]
 LDCM0440  CL5 HEK-293T C145(1.23)  LDD1038  [10]
 LDCM0441  CL50 PaTu 8988t C145(0.60)  LDD1320  [10]
 LDCM0442  CL51 PaTu 8988t C145(0.80)  LDD1321  [10]
 LDCM0443  CL52 PaTu 8988t C145(0.81)  LDD1322  [10]
 LDCM0444  CL53 PaTu 8988t C145(1.14)  LDD1323  [10]
 LDCM0445  CL54 PaTu 8988t C145(0.96)  LDD1324  [10]
 LDCM0446  CL55 PaTu 8988t C145(0.74)  LDD1325  [10]
 LDCM0447  CL56 PaTu 8988t C145(0.81)  LDD1326  [10]
 LDCM0448  CL57 PaTu 8988t C145(0.68)  LDD1327  [10]
 LDCM0449  CL58 PaTu 8988t C145(0.88)  LDD1328  [10]
 LDCM0450  CL59 PaTu 8988t C145(0.90)  LDD1329  [10]
 LDCM0451  CL6 HEK-293T C145(0.92)  LDD1049  [10]
 LDCM0452  CL60 PaTu 8988t C145(0.81)  LDD1331  [10]
 LDCM0453  CL61 PaTu 8988t C145(1.11)  LDD1332  [10]
 LDCM0454  CL62 PaTu 8988t C145(1.13)  LDD1333  [10]
 LDCM0455  CL63 PaTu 8988t C145(1.07)  LDD1334  [10]
 LDCM0456  CL64 PaTu 8988t C145(0.98)  LDD1335  [10]
 LDCM0457  CL65 PaTu 8988t C145(1.01)  LDD1336  [10]
 LDCM0458  CL66 PaTu 8988t C145(0.81)  LDD1337  [10]
 LDCM0459  CL67 PaTu 8988t C145(0.73)  LDD1338  [10]
 LDCM0460  CL68 PaTu 8988t C145(0.68)  LDD1339  [10]
 LDCM0461  CL69 PaTu 8988t C145(0.58)  LDD1340  [10]
 LDCM0462  CL7 HEK-293T C145(1.17)  LDD1060  [10]
 LDCM0463  CL70 PaTu 8988t C145(0.86)  LDD1342  [10]
 LDCM0464  CL71 PaTu 8988t C145(1.00)  LDD1343  [10]
 LDCM0465  CL72 PaTu 8988t C145(1.20)  LDD1344  [10]
 LDCM0466  CL73 PaTu 8988t C145(0.83)  LDD1345  [10]
 LDCM0467  CL74 PaTu 8988t C145(1.34)  LDD1346  [10]
 LDCM0469  CL76 PaTu 8988t C145(1.22)  LDD1348  [10]
 LDCM0470  CL77 PaTu 8988t C145(0.85)  LDD1349  [10]
 LDCM0471  CL78 PaTu 8988t C145(0.96)  LDD1350  [10]
 LDCM0472  CL79 PaTu 8988t C145(1.18)  LDD1351  [10]
 LDCM0473  CL8 HEK-293T C145(1.11)  LDD1071  [10]
 LDCM0474  CL80 PaTu 8988t C145(1.55)  LDD1353  [10]
 LDCM0475  CL81 PaTu 8988t C145(0.64)  LDD1354  [10]
 LDCM0476  CL82 PaTu 8988t C145(0.88)  LDD1355  [10]
 LDCM0477  CL83 PaTu 8988t C145(0.81)  LDD1356  [10]
 LDCM0478  CL84 PaTu 8988t C145(0.53)  LDD1357  [10]
 LDCM0479  CL85 PaTu 8988t C145(1.06)  LDD1358  [10]
 LDCM0480  CL86 PaTu 8988t C145(1.03)  LDD1359  [10]
 LDCM0481  CL87 PaTu 8988t C145(0.44)  LDD1360  [10]
 LDCM0482  CL88 PaTu 8988t C145(0.64)  LDD1361  [10]
 LDCM0483  CL89 PaTu 8988t C145(0.58)  LDD1362  [10]
 LDCM0484  CL9 HEK-293T C145(1.13)  LDD1082  [10]
 LDCM0485  CL90 PaTu 8988t C145(0.57)  LDD1364  [10]
 LDCM0486  CL91 HEK-293T C145(1.16)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C145(1.13)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C145(1.12)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C145(1.12)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C145(0.97)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C145(1.12)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C145(0.94)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C145(0.99)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C145(0.98)  LDD1697  [22]
 LDCM0495  E2913 HEK-293T C145(1.09)  LDD1698  [22]
 LDCM0468  Fragment33 PaTu 8988t C145(0.78)  LDD1347  [10]
 LDCM0427  Fragment51 HEK-293T C145(0.98)  LDD1631  [22]
 LDCM0107  IAA HeLa C145(0.00); H314(0.00)  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C145(0.97)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C145(1.00)  LDD1497  [22]
 LDCM0024  KB05 IGR37 C145(3.15)  LDD3314  [23]
 LDCM0109  NEM HeLa C145(0.00); H314(0.00); H160(0.00)  LDD0223  [17]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C145(1.38)  LDD2107  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C145(1.35)  LDD2140  [9]
 LDCM0084  Ro 48-8071 A-549 2.03  LDD0145  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stimulator of interferon genes protein (STING1) STING family Q86WV6

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
21 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840