Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name A-DA  Probe Info 
Probe concentration 5 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Ro 48-8071  Competitor Info 
Competitor Concentration 50 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Lung
Disease Model Lung adenocarcinoma [ICD-11:2C25]
Model Name Human lung adenocarcinoma cells (A-549)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 72 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07963  Fatty acid 2-hydroxylase (FA2H) 20.0
 LDTP04183  Lanosterol synthase (LSS) 20.0
 LDTP08617  Patatin-like phospholipase domain-containing protein 6 (PNPLA6) 20.0
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 19.6
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 15.0
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 12.9
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 12.1
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 11.7
 LDTP10077  Patatin-like phospholipase domain-containing protein 2 (PNPLA2) 10.5
 LDTP12293  Adipocyte plasma membrane-associated protein (APMAP) 8.8
 LDTP11124  Ferroptosis suppressor protein 1 (AIFM2) 7.5
 LDTP09542  1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5) 7.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 6.9
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 5.1
 LDTP08859  Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) 5.0
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 5.0
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 4.9
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 4.6
 LDTP00697  Cytochrome b5 type B (CYB5B) 4.2
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 4.2
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 4.1
 LDTP12147  UDP-glucuronosyltransferase 1A7 (UGT1A7) 4.0
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 3.6
 LDTP09063  Estradiol 17-beta-dehydrogenase 11 (HSD17B11) 3.5
 LDTP06988  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) 3.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 3.4
 LDTP03736  Prostaglandin G/H synthase 2 (PTGS2) 3.3
 LDTP06142  Squalene monooxygenase (SQLE) 3.3
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 3.3
 LDTP08017  Endoplasmic reticulum metallopeptidase 1 (ERMP1) 3.2
 LDTP01349  Short-chain dehydrogenase/reductase 3 (DHRS3) 3.1
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 3.1
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 3.0
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 3.0
 LDTP06334  Serum paraoxonase/lactonase 3 (PON3) 2.9
 LDTP06885  Glycerol-3-phosphate acyltransferase 3 (GPAT3) 2.9
 LDTP06617  Ceramide glucosyltransferase (UGCG) 2.9
 LDTP07591  Neutral cholesterol ester hydrolase 1 (NCEH1) 2.8
 LDTP08722  Retinol dehydrogenase 10 (RDH10) 2.8
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 2.7
 LDTP08900  Dehydrogenase/reductase SDR family member on chromosome X (DHRSX) 2.7
 LDTP07504  Lysophospholipid acyltransferase 5 (LPCAT3) 2.7
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 2.6
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 2.5
 LDTP06455  Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) 2.5
 LDTP10329  Ceramide synthase 2 (CERS2) 2.5
 LDTP05971  Mannosyl-oligosaccharide glucosidase (MOGS) 2.5
 LDTP14264  Choline/ethanolaminephosphotransferase 1 (CEPT1) 2.5
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 2.5
 LDTP03842  Squalene synthase (FDFT1) 2.5
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 2.4
 LDTP14231  GTP-binding protein SAR1b (SAR1B) 2.4
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 2.4
 LDTP08232  Glycerol-3-phosphate acyltransferase 4 (GPAT4) 2.4
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 2.3
 LDTP01634  Fatty acid CoA ligase Acsl3 (ACSL3) 2.3
 LDTP09505  GPI ethanolamine phosphate transferase 3 (PIGO) 2.3
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 2.3
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 2.2
 LDTP03145  Catechol O-methyltransferase (COMT) 2.2
 LDTP04203  Phosphatidylserine synthase 1 (PTDSS1) 2.2
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 2.2
 LDTP12470  GTP-binding protein SAR1a (SAR1A) 2.1
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 2.1
 LDTP04036  Aldehyde dehydrogenase family 3 member B1 (ALDH3B1) 2.1
 LDTP11127  ADP-dependent glucokinase (ADPGK) 2.1
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 2.1
 LDTP00032  2-hydroxyacyl-CoA lyase 2 (ILVBL) 2.1
 LDTP02198  Cathepsin D (CTSD) 2.1
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 2.0
 LDTP01770  NADH-cytochrome b5 reductase 3 (CYB5R3) 2.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 2.0
Transporter and channel
Click to Show/Hide to Show 28 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 20.0
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 20.0
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 20.0
 LDTP05394  Caveolin-1 (CAV1) 6.9
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 6.7
 LDTP07236  Protein GPR107 (GPR107) 6.5
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 5.3
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 4.8
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 4.6
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 3.4
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 3.3
 LDTP02215  Prosaposin (PSAP) 3.1
 LDTP11213  Nucleoporin NDC1 (NDC1) 2.8
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 2.7
 LDTP08881  Transmembrane protein 199 (TMEM199) 2.5
 LDTP11245  Derlin-1 (DERL1) 2.4
 LDTP13599  Calcium load-activated calcium channel (TMCO1) 2.4
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 2.4
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 2.2
 LDTP09180  Zinc transporter 7 (SLC30A7) 2.1
 LDTP03405  Calnexin (CANX) 2.1
 LDTP10343  Vacuole membrane protein 1 (VMP1) 2.1
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 2.1
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 2.1
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 2.1
 LDTP03870  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST) 2.0
 LDTP04932  Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) 2.0
 LDTP13243  Translocation protein SEC63 homolog (SEC63) 2.0
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 3.9
Immunoglobulin
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 4.3
 LDTP14205  Neuroplastin (NPTN) 3.0
Other
Click to Show/Hide to Show 20 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 20.0
 LDTP16080  Protein FAM114A2 (FAM114A2) 20.0
 LDTP10889  Perilipin-2 (PLIN2) 9.2
 LDTP01021  Perilipin-3 (PLIN3) 8.9
 LDTP00759  Tumor protein D54 (TPD52L2) 8.4
 LDTP01522  Reticulon-3 (RTN3) 4.5
 LDTP10185  FAS-associated factor 2 (FAF2) 4.1
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 3.1
 LDTP10357  RUS family member 1 (RUSF1) 2.9
 LDTP12412  Reticulon-4 (RTN4) 2.8
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 2.6
 LDTP15887  Lipase maturation factor 2 (LMF2) 2.4
 LDTP03342  Integrin alpha-3 (ITGA3) 2.4
 LDTP00729  Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) 2.4
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) 2.3
 LDTP07012  Torsin-1A-interacting protein 1 (TOR1AIP1) 2.3
 LDTP11140  Peroxiredoxin-like 2A (PRXL2A) 2.3
 LDTP11906  Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) 2.2
 LDTP06948  Protein YIF1B (YIF1B) 2.1
 LDTP08224  Protein LYRIC (MTDH) 2.1

References

1 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.