Details of the Target

General Information of Target

Target ID LDTP04183
Target Name Lanosterol synthase (LSS)
Gene Name LSS
Gene ID 4047
Synonyms
OSC; Lanosterol synthase; EC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC; hOSC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP
AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM
SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE
HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL
SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM
AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS
QLYPERALAGHP
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Terpene cyclase/mutase family
Subcellular location
Endoplasmic reticulum membrane
Function
Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
TTD ID
T56175
Uniprot ID
P48449
DrugMap ID
TT7O8ZA
Ensemble ID
ENST00000356396.8
HGNC ID
HGNC:6708
ChEMBL ID
CHEMBL3593

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.H510R DBIA    Probe Info 
CFPAC1 SNV: p.Y264C DBIA    Probe Info 
HT SNV: p.G630R .
NCIH661 SNV: p.R31S .
SKMEL24 Deletion: p.G673del DBIA    Probe Info 
SW1783 SNV: p.R507C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.26  LDD0402  [1]
TH211
 Probe Info  		Y503(6.22)  LDD0260  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
YN-4
 Probe Info  		100.00  LDD0445  [3]
STPyne
 Probe Info  		K506(5.73)  LDD0277  [4]
Probe 1
 Probe Info  		Y14(173.10); Y38(21.12); Y54(31.53); Y430(15.05)  LDD3495  [5]
Dasatinib-CA-4PAP
 Probe Info  		5.39  LDD0270  [6]
BTD
 Probe Info  		C616(0.43)  LDD2100  [7]
AHL-Pu-1
 Probe Info  		C700(3.91)  LDD0170  [8]
DBIA
 Probe Info  		C616(10.46)  LDD0204  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C616(0.00); C471(0.00); C609(0.00); C484(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C609(0.00); C616(0.00); C484(0.00)  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C616(0.00); C471(0.00); C609(0.00); C567(0.00)  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD0025  [13]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
TFBX
 Probe Info  		C700(0.00); C6(0.00)  LDD0027  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
ENE
 Probe Info  		N.A.  LDD0006  [16]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [17]
Acrolein
 Probe Info  		C567(0.00); C471(0.00)  LDD0217  [18]
Crotonaldehyde
 Probe Info  		C567(0.00); C609(0.00); C616(0.00)  LDD0219  [18]
Methacrolein
 Probe Info  		C567(0.00); C609(0.00)  LDD0218  [18]
W1
 Probe Info  		N.A.  LDD0236  [19]
NAIA_5
 Probe Info  		C567(0.00); C616(0.00); C471(0.00); C484(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
PARPYnD
 Probe Info  		4.35  LDD0374  [20]
C006
 Probe Info  		6.32  LDD1715  [21]
C017
 Probe Info  		7.46  LDD1725  [21]
C044
 Probe Info  		5.70  LDD1743  [21]
C072
 Probe Info  		7.67  LDD1768  [21]
C107
 Probe Info  		6.28  LDD1794  [21]
C138
 Probe Info  		5.21  LDD1820  [21]
C140
 Probe Info  		8.28  LDD1822  [21]
C143
 Probe Info  		16.91  LDD1825  [21]
C145
 Probe Info  		11.79  LDD1827  [21]
C166
 Probe Info  		8.00  LDD1846  [21]
C185
 Probe Info  		6.11  LDD1863  [21]
C225
 Probe Info  		7.41  LDD1898  [21]
C229
 Probe Info  		7.01  LDD1902  [21]
C233
 Probe Info  		9.00  LDD1906  [21]
C235
 Probe Info  		16.91  LDD1908  [21]
C258
 Probe Info  		5.46  LDD1931  [21]
C260
 Probe Info  		5.70  LDD1932  [21]
C288
 Probe Info  		6.82  LDD1958  [21]
C290
 Probe Info  		7.67  LDD1960  [21]
C342
 Probe Info  		5.28  LDD2004  [21]
C356
 Probe Info  		8.88  LDD2017  [21]
C360
 Probe Info  		5.13  LDD2021  [21]
C373
 Probe Info  		7.41  LDD2033  [21]
C426
 Probe Info  		13.09  LDD2081  [21]
FFF probe11
 Probe Info  		17.05  LDD0471  [22]
FFF probe13
 Probe Info  		10.12  LDD0476  [22]
FFF probe14
 Probe Info  		20.00  LDD0477  [22]
FFF probe3
 Probe Info  		15.36  LDD0464  [22]
FFF probe9
 Probe Info  		20.00  LDD0485  [22]
JN0003
 Probe Info  		20.00  LDD0484  [22]
STS-1
 Probe Info  		N.A.  LDD0136  [23]
STS-2
 Probe Info  		N.A.  LDD0138  [23]
A-DA
 Probe Info  		2.34  LDD0141  [24]
OEA-DA
 Probe Info  		14.95  LDD0046  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C567(1.18)  LDD2117  [7]
 LDCM0025  4SU-RNA DM93 C700(3.91)  LDD0170  [8]
 LDCM0214  AC1 HCT 116 C609(1.25); C616(1.00)  LDD0531  [26]
 LDCM0215  AC10 HCT 116 C609(1.22)  LDD0532  [26]
 LDCM0216  AC100 HCT 116 C567(1.18); C609(1.37); C616(1.23)  LDD0533  [26]
 LDCM0217  AC101 HCT 116 C567(0.86); C609(1.01); C616(0.90)  LDD0534  [26]
 LDCM0218  AC102 HCT 116 C567(0.75); C609(1.25); C616(0.59)  LDD0535  [26]
 LDCM0219  AC103 HCT 116 C567(1.12); C609(1.61); C616(0.58)  LDD0536  [26]
 LDCM0220  AC104 HCT 116 C567(1.84); C609(1.18); C616(0.64)  LDD0537  [26]
 LDCM0221  AC105 HCT 116 C567(0.64); C609(1.31); C616(0.67)  LDD0538  [26]
 LDCM0222  AC106 HCT 116 C567(0.70); C609(1.07); C616(0.79)  LDD0539  [26]
 LDCM0223  AC107 HCT 116 C567(0.74); C609(0.70); C616(0.65)  LDD0540  [26]
 LDCM0224  AC108 HCT 116 C567(0.70); C609(1.39); C616(0.85)  LDD0541  [26]
 LDCM0225  AC109 HCT 116 C567(0.90); C609(2.53); C616(1.28)  LDD0542  [26]
 LDCM0226  AC11 HCT 116 C609(1.47)  LDD0543  [26]
 LDCM0227  AC110 HCT 116 C567(1.18); C609(1.20); C616(0.79)  LDD0544  [26]
 LDCM0228  AC111 HCT 116 C567(0.63); C609(1.59); C616(0.78)  LDD0545  [26]
 LDCM0229  AC112 HCT 116 C567(1.03); C609(1.02); C616(0.75)  LDD0546  [26]
 LDCM0230  AC113 HCT 116 C609(1.47); C700(1.31)  LDD0547  [26]
 LDCM0231  AC114 HCT 116 C609(1.16); C700(1.23)  LDD0548  [26]
 LDCM0232  AC115 HCT 116 C609(1.39); C700(1.06)  LDD0549  [26]
 LDCM0233  AC116 HCT 116 C609(2.00); C700(1.55)  LDD0550  [26]
 LDCM0234  AC117 HCT 116 C609(1.10); C700(1.26)  LDD0551  [26]
 LDCM0235  AC118 HCT 116 C609(1.46); C700(1.19)  LDD0552  [26]
 LDCM0236  AC119 HCT 116 C609(1.23); C700(1.77)  LDD0553  [26]
 LDCM0237  AC12 HCT 116 C609(1.26)  LDD0554  [26]
 LDCM0238  AC120 HCT 116 C609(1.46); C700(1.45)  LDD0555  [26]
 LDCM0239  AC121 HCT 116 C609(1.13); C700(1.38)  LDD0556  [26]
 LDCM0240  AC122 HCT 116 C609(1.33); C700(1.23)  LDD0557  [26]
 LDCM0241  AC123 HCT 116 C609(1.16); C700(0.86)  LDD0558  [26]
 LDCM0242  AC124 HCT 116 C609(1.43); C700(1.23)  LDD0559  [26]
 LDCM0243  AC125 HCT 116 C609(1.72); C700(0.91)  LDD0560  [26]
 LDCM0244  AC126 HCT 116 C609(1.42); C700(0.92)  LDD0561  [26]
 LDCM0245  AC127 HCT 116 C609(1.26); C700(1.21)  LDD0562  [26]
 LDCM0246  AC128 HEK-293T C449(0.95); C471(0.87); C700(0.96)  LDD0844  [26]
 LDCM0247  AC129 HEK-293T C449(1.06); C471(0.99); C700(1.07)  LDD0845  [26]
 LDCM0249  AC130 HEK-293T C449(2.18); C471(1.10); C700(0.97)  LDD0847  [26]
 LDCM0250  AC131 HEK-293T C449(0.92); C471(0.97); C700(0.95)  LDD0848  [26]
 LDCM0251  AC132 HEK-293T C449(1.37); C471(0.83); C700(1.04)  LDD0849  [26]
 LDCM0252  AC133 HEK-293T C449(1.17); C471(1.04); C700(1.20)  LDD0850  [26]
 LDCM0253  AC134 HEK-293T C449(1.25); C471(1.02); C700(1.26)  LDD0851  [26]
 LDCM0254  AC135 HEK-293T C449(0.99); C471(1.03); C700(1.05)  LDD0852  [26]
 LDCM0255  AC136 HEK-293T C449(1.00); C471(0.98); C700(0.99)  LDD0853  [26]
 LDCM0256  AC137 HEK-293T C449(1.14); C471(1.31); C700(1.11)  LDD0854  [26]
 LDCM0257  AC138 HEK-293T C449(1.24); C471(1.56); C700(1.25)  LDD0855  [26]
 LDCM0258  AC139 HEK-293T C449(1.37); C471(1.40); C700(1.34)  LDD0856  [26]
 LDCM0259  AC14 HCT 116 C609(0.97)  LDD0576  [26]
 LDCM0260  AC140 HEK-293T C449(1.17); C471(1.13); C700(0.99)  LDD0858  [26]
 LDCM0261  AC141 HEK-293T C449(1.08); C471(1.18); C700(1.38)  LDD0859  [26]
 LDCM0262  AC142 HEK-293T C449(1.10); C471(1.05); C700(1.27)  LDD0860  [26]
 LDCM0263  AC143 HCT 116 C616(1.11); C567(1.12)  LDD0580  [26]
 LDCM0264  AC144 HCT 116 C616(0.89); C567(0.89)  LDD0581  [26]
 LDCM0265  AC145 HCT 116 C567(0.76); C616(0.90)  LDD0582  [26]
 LDCM0266  AC146 HCT 116 C567(0.85); C616(1.08)  LDD0583  [26]
 LDCM0267  AC147 HCT 116 C567(0.77); C616(1.01)  LDD0584  [26]
 LDCM0268  AC148 HCT 116 C567(0.43); C616(1.25)  LDD0585  [26]
 LDCM0269  AC149 HCT 116 C567(0.69); C616(1.24)  LDD0586  [26]
 LDCM0270  AC15 HCT 116 C609(1.03)  LDD0587  [26]
 LDCM0271  AC150 HCT 116 C616(0.94); C567(1.15)  LDD0588  [26]
 LDCM0272  AC151 HCT 116 C567(0.79); C616(1.07)  LDD0589  [26]
 LDCM0273  AC152 HCT 116 C567(0.69); C616(1.18)  LDD0590  [26]
 LDCM0274  AC153 HCT 116 C567(0.31); C616(0.93)  LDD0591  [26]
 LDCM0621  AC154 HCT 116 C567(0.73); C616(0.91)  LDD2158  [26]
 LDCM0622  AC155 HCT 116 C567(0.84); C616(0.98)  LDD2159  [26]
 LDCM0623  AC156 HCT 116 C567(1.02); C616(1.03)  LDD2160  [26]
 LDCM0624  AC157 HCT 116 C567(0.90); C616(0.85)  LDD2161  [26]
 LDCM0276  AC17 HCT 116 C609(0.94); C567(0.97); C616(1.06); C700(1.51)  LDD0593  [26]
 LDCM0277  AC18 HCT 116 C567(0.80); C609(0.85); C616(1.01); C700(1.13)  LDD0594  [26]
 LDCM0278  AC19 HCT 116 C567(0.90); C609(0.91); C616(1.07); C700(1.35)  LDD0595  [26]
 LDCM0279  AC2 HCT 116 C609(0.88); C616(1.02)  LDD0596  [26]
 LDCM0280  AC20 HCT 116 C609(0.77); C567(0.83); C616(0.98); C700(1.15)  LDD0597  [26]
 LDCM0281  AC21 HCT 116 C609(0.81); C700(0.84); C567(0.85); C616(1.04)  LDD0598  [26]
 LDCM0282  AC22 HCT 116 C609(0.87); C567(0.91); C616(1.12); C700(1.20)  LDD0599  [26]
 LDCM0283  AC23 HCT 116 C567(0.70); C609(0.76); C700(0.91); C616(1.09)  LDD0600  [26]
 LDCM0284  AC24 HCT 116 C609(0.79); C700(0.79); C567(0.83); C616(1.05)  LDD0601  [26]
 LDCM0285  AC25 HCT 116 C700(0.71); C609(1.37)  LDD0602  [26]
 LDCM0286  AC26 HCT 116 C700(0.72); C609(1.27)  LDD0603  [26]
 LDCM0287  AC27 HCT 116 C700(0.83); C609(1.10)  LDD0604  [26]
 LDCM0288  AC28 HCT 116 C700(0.89); C609(1.12)  LDD0605  [26]
 LDCM0289  AC29 HCT 116 C609(1.13); C700(1.67)  LDD0606  [26]
 LDCM0290  AC3 HCT 116 C616(1.32); C609(1.51)  LDD0607  [26]
 LDCM0291  AC30 HCT 116 C700(1.07); C609(1.21)  LDD0608  [26]
 LDCM0292  AC31 HCT 116 C700(0.87); C609(1.42)  LDD0609  [26]
 LDCM0293  AC32 HCT 116 C700(0.64); C609(1.20)  LDD0610  [26]
 LDCM0294  AC33 HCT 116 C700(0.71); C609(1.05)  LDD0611  [26]
 LDCM0295  AC34 HCT 116 C609(0.56); C700(1.16)  LDD0612  [26]
 LDCM0296  AC35 HCT 116 C609(0.93)  LDD0613  [26]
 LDCM0297  AC36 HCT 116 C609(0.92)  LDD0614  [26]
 LDCM0298  AC37 HCT 116 C609(1.18)  LDD0615  [26]
 LDCM0299  AC38 HCT 116 C609(1.25)  LDD0616  [26]
 LDCM0300  AC39 HCT 116 C609(1.29)  LDD0617  [26]
 LDCM0301  AC4 HCT 116 C616(1.25); C609(1.51)  LDD0618  [26]
 LDCM0302  AC40 HCT 116 C609(1.15)  LDD0619  [26]
 LDCM0303  AC41 HCT 116 C609(1.05)  LDD0620  [26]
 LDCM0304  AC42 HCT 116 C609(0.98)  LDD0621  [26]
 LDCM0305  AC43 HCT 116 C609(1.18)  LDD0622  [26]
 LDCM0306  AC44 HCT 116 C609(1.29)  LDD0623  [26]
 LDCM0307  AC45 HCT 116 C609(1.12)  LDD0624  [26]
 LDCM0308  AC46 HCT 116 C609(1.06); C567(1.18)  LDD0625  [26]
 LDCM0309  AC47 HCT 116 C567(0.95); C609(1.19)  LDD0626  [26]
 LDCM0310  AC48 HCT 116 C567(1.24); C609(1.34)  LDD0627  [26]
 LDCM0311  AC49 HCT 116 C567(0.36); C609(0.71)  LDD0628  [26]
 LDCM0312  AC5 HCT 116 C616(0.97); C609(1.42)  LDD0629  [26]
 LDCM0313  AC50 HCT 116 C567(0.44); C609(0.88)  LDD0630  [26]
 LDCM0314  AC51 HCT 116 C609(1.10); C567(1.25)  LDD0631  [26]
 LDCM0315  AC52 HCT 116 C609(0.92); C567(1.31)  LDD0632  [26]
 LDCM0316  AC53 HCT 116 C567(0.75); C609(1.05)  LDD0633  [26]
 LDCM0317  AC54 HCT 116 C567(0.87); C609(0.98)  LDD0634  [26]
 LDCM0318  AC55 HCT 116 C567(0.40); C609(0.76)  LDD0635  [26]
 LDCM0319  AC56 HCT 116 C567(0.22); C609(0.52)  LDD0636  [26]
 LDCM0320  AC57 HCT 116 C700(1.37); C609(2.69)  LDD0637  [26]
 LDCM0321  AC58 HCT 116 C700(1.22); C609(2.50)  LDD0638  [26]
 LDCM0322  AC59 HCT 116 C700(1.05); C609(1.55)  LDD0639  [26]
 LDCM0323  AC6 HCT 116 C609(1.33)  LDD0640  [26]
 LDCM0324  AC60 HCT 116 C700(1.39); C609(2.14)  LDD0641  [26]
 LDCM0325  AC61 HCT 116 C700(1.04); C609(2.08)  LDD0642  [26]
 LDCM0326  AC62 HCT 116 C700(1.26); C609(2.81)  LDD0643  [26]
 LDCM0327  AC63 HCT 116 C700(1.37); C609(2.43)  LDD0644  [26]
 LDCM0328  AC64 HCT 116 C700(1.36); C609(2.84)  LDD0645  [26]
 LDCM0329  AC65 HCT 116 C700(1.32); C609(2.60)  LDD0646  [26]
 LDCM0330  AC66 HCT 116 C700(0.96); C609(1.86)  LDD0647  [26]
 LDCM0331  AC67 HCT 116 C700(0.87); C609(2.30)  LDD0648  [26]
 LDCM0332  AC68 HCT 116 C609(0.77); C700(0.85); C567(0.96)  LDD0649  [26]
 LDCM0333  AC69 HCT 116 C567(0.83); C700(0.89); C609(0.89)  LDD0650  [26]
 LDCM0334  AC7 HCT 116 C609(1.14)  LDD0651  [26]
 LDCM0335  AC70 HCT 116 C700(0.50); C567(0.58); C609(0.90)  LDD0652  [26]
 LDCM0336  AC71 HCT 116 C700(0.86); C609(0.96); C567(1.04)  LDD0653  [26]
 LDCM0337  AC72 HCT 116 C700(0.89); C567(0.93); C609(1.07)  LDD0654  [26]
 LDCM0338  AC73 HCT 116 C567(0.37); C700(0.47); C609(0.68)  LDD0655  [26]
 LDCM0339  AC74 HCT 116 C567(0.40); C700(0.52); C609(0.63)  LDD0656  [26]
 LDCM0340  AC75 HCT 116 C567(0.29); C700(0.37); C609(0.59)  LDD0657  [26]
 LDCM0341  AC76 HCT 116 C567(0.81); C700(0.91); C609(1.39)  LDD0658  [26]
 LDCM0342  AC77 HCT 116 C700(0.68); C567(0.72); C609(1.29)  LDD0659  [26]
 LDCM0343  AC78 HCT 116 C700(0.79); C567(0.96); C609(1.09)  LDD0660  [26]
 LDCM0344  AC79 HCT 116 C609(0.81); C700(0.90); C567(1.02)  LDD0661  [26]
 LDCM0345  AC8 HCT 116 C609(1.06)  LDD0662  [26]
 LDCM0346  AC80 HCT 116 C567(0.78); C700(0.92); C609(0.95)  LDD0663  [26]
 LDCM0347  AC81 HCT 116 C609(0.85); C700(0.88); C567(0.91)  LDD0664  [26]
 LDCM0348  AC82 HCT 116 C567(0.30); C700(0.34); C609(0.53)  LDD0665  [26]
 LDCM0349  AC83 HCT 116 C616(0.87); C609(1.38); C700(2.05)  LDD0666  [26]
 LDCM0350  AC84 HCT 116 C616(0.94); C609(1.42); C700(3.46)  LDD0667  [26]
 LDCM0351  AC85 HCT 116 C616(1.02); C609(1.18); C700(2.56)  LDD0668  [26]
 LDCM0352  AC86 HCT 116 C616(0.96); C609(1.54); C700(2.50)  LDD0669  [26]
 LDCM0353  AC87 HCT 116 C609(0.77); C616(1.01); C700(2.11)  LDD0670  [26]
 LDCM0354  AC88 HCT 116 C609(0.94); C616(1.07); C700(3.08)  LDD0671  [26]
 LDCM0355  AC89 HCT 116 C616(1.06); C609(1.37); C700(2.58)  LDD0672  [26]
 LDCM0357  AC90 HCT 116 C616(0.92); C609(1.47); C700(2.87)  LDD0674  [26]
 LDCM0358  AC91 HCT 116 C616(0.95); C609(1.31); C700(2.53)  LDD0675  [26]
 LDCM0359  AC92 HCT 116 C609(0.92); C616(0.93); C700(2.33)  LDD0676  [26]
 LDCM0360  AC93 HCT 116 C616(0.98); C609(1.14); C700(2.27)  LDD0677  [26]
 LDCM0361  AC94 HCT 116 C616(0.87); C609(1.12); C700(2.23)  LDD0678  [26]
 LDCM0362  AC95 HCT 116 C609(0.67); C616(1.00); C700(3.75)  LDD0679  [26]
 LDCM0363  AC96 HCT 116 C616(1.14); C609(1.48); C700(2.31)  LDD0680  [26]
 LDCM0364  AC97 HCT 116 C616(0.99); C609(1.35); C700(2.38)  LDD0681  [26]
 LDCM0365  AC98 HCT 116 C616(0.14); C567(0.29); C609(0.51)  LDD0682  [26]
 LDCM0366  AC99 HCT 116 C616(0.65); C567(0.93); C609(1.17)  LDD0683  [26]
 LDCM0248  AKOS034007472 HCT 116 C609(0.92)  LDD0565  [26]
 LDCM0356  AKOS034007680 HCT 116 C609(1.37)  LDD0673  [26]
 LDCM0275  AKOS034007705 HCT 116 C609(1.24)  LDD0592  [26]
 LDCM0156  Aniline NCI-H1299 13.30  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C700(1.10)  LDD2171  [26]
 LDCM0083  Avasimibe A-549 2.28  LDD0143  [24]
 LDCM0147  AZ0108 MDA-MB-468 2.03  LDD0376  [20]
 LDCM0103  BDHI 10 Jurkat C616(10.46)  LDD0205  [9]
 LDCM0102  BDHI 8 Jurkat C616(10.46)  LDD0204  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C6(20.00)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C616(1.15)  LDD0684  [26]
 LDCM0368  CL10 HCT 116 C616(1.31)  LDD0685  [26]
 LDCM0369  CL100 HCT 116 C616(0.91); C609(1.17)  LDD0686  [26]
 LDCM0370  CL101 HCT 116 C609(0.85)  LDD0687  [26]
 LDCM0371  CL102 HCT 116 C609(1.21)  LDD0688  [26]
 LDCM0372  CL103 HCT 116 C609(1.35)  LDD0689  [26]
 LDCM0373  CL104 HCT 116 C609(0.86)  LDD0690  [26]
 LDCM0374  CL105 HCT 116 C567(0.72); C609(1.05); C700(1.08); C616(1.18)  LDD0691  [26]
 LDCM0375  CL106 HCT 116 C567(0.64); C616(0.88); C609(0.92); C700(1.11)  LDD0692  [26]
 LDCM0376  CL107 HCT 116 C567(0.71); C616(1.02); C609(1.35); C700(1.36)  LDD0693  [26]
 LDCM0377  CL108 HCT 116 C567(0.72); C616(1.11); C609(1.18); C700(1.41)  LDD0694  [26]
 LDCM0378  CL109 HCT 116 C567(0.76); C609(1.03); C616(1.06); C700(1.29)  LDD0695  [26]
 LDCM0379  CL11 HCT 116 C616(1.13)  LDD0696  [26]
 LDCM0380  CL110 HCT 116 C567(0.73); C609(0.83); C616(1.00); C700(1.10)  LDD0697  [26]
 LDCM0381  CL111 HCT 116 C609(0.79); C567(0.84); C700(1.10); C616(1.15)  LDD0698  [26]
 LDCM0382  CL112 HCT 116 C700(0.88); C609(1.50)  LDD0699  [26]
 LDCM0383  CL113 HCT 116 C700(0.90); C609(1.01)  LDD0700  [26]
 LDCM0384  CL114 HCT 116 C609(1.11); C700(1.27)  LDD0701  [26]
 LDCM0385  CL115 HCT 116 C700(0.82); C609(1.11)  LDD0702  [26]
 LDCM0386  CL116 HCT 116 C700(0.60); C609(0.87)  LDD0703  [26]
 LDCM0387  CL117 HCT 116 C609(0.91)  LDD0704  [26]
 LDCM0388  CL118 HCT 116 C609(1.08)  LDD0705  [26]
 LDCM0389  CL119 HCT 116 C609(1.00)  LDD0706  [26]
 LDCM0390  CL12 HCT 116 C616(1.10)  LDD0707  [26]
 LDCM0391  CL120 HCT 116 C609(1.25)  LDD0708  [26]
 LDCM0392  CL121 HCT 116 C567(0.86); C609(2.14)  LDD0709  [26]
 LDCM0393  CL122 HCT 116 C567(0.89); C609(1.39)  LDD0710  [26]
 LDCM0394  CL123 HCT 116 C567(0.69); C609(1.41)  LDD0711  [26]
 LDCM0395  CL124 HCT 116 C567(0.49); C609(1.13)  LDD0712  [26]
 LDCM0396  CL125 HCT 116 C700(1.57); C609(1.95)  LDD0713  [26]
 LDCM0397  CL126 HCT 116 C700(1.59); C609(2.39)  LDD0714  [26]
 LDCM0398  CL127 HCT 116 C700(1.35); C609(1.86)  LDD0715  [26]
 LDCM0399  CL128 HCT 116 C700(1.16); C609(1.58)  LDD0716  [26]
 LDCM0400  CL13 HCT 116 C616(1.11)  LDD0717  [26]
 LDCM0401  CL14 HCT 116 C616(1.14)  LDD0718  [26]
 LDCM0402  CL15 HCT 116 C616(1.02)  LDD0719  [26]
 LDCM0403  CL16 HCT 116 C609(0.91)  LDD0720  [26]
 LDCM0404  CL17 HCT 116 C609(1.01)  LDD0721  [26]
 LDCM0405  CL18 HCT 116 C609(1.60)  LDD0722  [26]
 LDCM0406  CL19 HCT 116 C609(0.98)  LDD0723  [26]
 LDCM0407  CL2 HCT 116 C616(0.75)  LDD0724  [26]
 LDCM0408  CL20 HCT 116 C609(0.86)  LDD0725  [26]
 LDCM0409  CL21 HCT 116 C609(1.21)  LDD0726  [26]
 LDCM0410  CL22 HCT 116 C609(0.50)  LDD0727  [26]
 LDCM0411  CL23 HCT 116 C609(0.73)  LDD0728  [26]
 LDCM0412  CL24 HCT 116 C609(1.07)  LDD0729  [26]
 LDCM0413  CL25 HCT 116 C609(1.17)  LDD0730  [26]
 LDCM0414  CL26 HCT 116 C609(0.96)  LDD0731  [26]
 LDCM0415  CL27 HCT 116 C609(1.01)  LDD0732  [26]
 LDCM0416  CL28 HCT 116 C609(0.97)  LDD0733  [26]
 LDCM0417  CL29 HCT 116 C609(0.88)  LDD0734  [26]
 LDCM0418  CL3 HCT 116 C616(1.13)  LDD0735  [26]
 LDCM0419  CL30 HCT 116 C609(0.76)  LDD0736  [26]
 LDCM0420  CL31 HCT 116 C567(2.47)  LDD0737  [26]
 LDCM0421  CL32 HCT 116 C567(1.25)  LDD0738  [26]
 LDCM0422  CL33 HCT 116 C567(1.49)  LDD0739  [26]
 LDCM0423  CL34 HCT 116 C567(0.92)  LDD0740  [26]
 LDCM0424  CL35 HCT 116 C567(0.99)  LDD0741  [26]
 LDCM0425  CL36 HCT 116 C567(0.85)  LDD0742  [26]
 LDCM0426  CL37 HCT 116 C567(1.10)  LDD0743  [26]
 LDCM0428  CL39 HCT 116 C567(0.75)  LDD0745  [26]
 LDCM0429  CL4 HCT 116 C616(0.94)  LDD0746  [26]
 LDCM0430  CL40 HCT 116 C567(1.09)  LDD0747  [26]
 LDCM0431  CL41 HCT 116 C567(1.99)  LDD0748  [26]
 LDCM0432  CL42 HCT 116 C567(0.52)  LDD0749  [26]
 LDCM0433  CL43 HCT 116 C567(0.75)  LDD0750  [26]
 LDCM0434  CL44 HCT 116 C567(0.83)  LDD0751  [26]
 LDCM0435  CL45 HCT 116 C567(1.17)  LDD0752  [26]
 LDCM0436  CL46 HCT 116 C609(2.03)  LDD0753  [26]
 LDCM0437  CL47 HCT 116 C609(1.58)  LDD0754  [26]
 LDCM0438  CL48 HCT 116 C609(1.50)  LDD0755  [26]
 LDCM0439  CL49 HCT 116 C609(1.85)  LDD0756  [26]
 LDCM0440  CL5 HCT 116 C616(1.22)  LDD0757  [26]
 LDCM0441  CL50 HCT 116 C609(1.55)  LDD0758  [26]
 LDCM0442  CL51 HCT 116 C609(1.27)  LDD0759  [26]
 LDCM0443  CL52 HCT 116 C609(2.36)  LDD0760  [26]
 LDCM0444  CL53 HCT 116 C609(1.31)  LDD0761  [26]
 LDCM0445  CL54 HCT 116 C609(2.08)  LDD0762  [26]
 LDCM0446  CL55 HCT 116 C609(1.22)  LDD0763  [26]
 LDCM0447  CL56 HCT 116 C609(1.28)  LDD0764  [26]
 LDCM0448  CL57 HCT 116 C609(1.54)  LDD0765  [26]
 LDCM0449  CL58 HCT 116 C609(1.49)  LDD0766  [26]
 LDCM0450  CL59 HCT 116 C609(2.13)  LDD0767  [26]
 LDCM0451  CL6 HCT 116 C616(1.10)  LDD0768  [26]
 LDCM0452  CL60 HCT 116 C609(1.87)  LDD0769  [26]
 LDCM0453  CL61 HCT 116 C609(2.16)  LDD0770  [26]
 LDCM0454  CL62 HCT 116 C609(2.38)  LDD0771  [26]
 LDCM0455  CL63 HCT 116 C609(2.10)  LDD0772  [26]
 LDCM0456  CL64 HCT 116 C609(2.05)  LDD0773  [26]
 LDCM0457  CL65 HCT 116 C609(1.66)  LDD0774  [26]
 LDCM0458  CL66 HCT 116 C609(2.09)  LDD0775  [26]
 LDCM0459  CL67 HCT 116 C609(1.06)  LDD0776  [26]
 LDCM0460  CL68 HCT 116 C609(1.44)  LDD0777  [26]
 LDCM0461  CL69 HCT 116 C609(1.84)  LDD0778  [26]
 LDCM0462  CL7 HCT 116 C616(1.10)  LDD0779  [26]
 LDCM0463  CL70 HCT 116 C609(1.15)  LDD0780  [26]
 LDCM0464  CL71 HCT 116 C609(1.68)  LDD0781  [26]
 LDCM0465  CL72 HCT 116 C609(1.34)  LDD0782  [26]
 LDCM0466  CL73 HCT 116 C609(1.19)  LDD0783  [26]
 LDCM0467  CL74 HCT 116 C609(1.39)  LDD0784  [26]
 LDCM0469  CL76 HCT 116 C609(1.13); C616(1.15)  LDD0786  [26]
 LDCM0470  CL77 HCT 116 C609(0.89); C616(0.75)  LDD0787  [26]
 LDCM0471  CL78 HCT 116 C609(0.67); C616(1.01)  LDD0788  [26]
 LDCM0472  CL79 HCT 116 C609(0.99); C616(0.83)  LDD0789  [26]
 LDCM0473  CL8 HCT 116 C616(0.83)  LDD0790  [26]
 LDCM0474  CL80 HCT 116 C609(1.02); C616(0.81)  LDD0791  [26]
 LDCM0475  CL81 HCT 116 C609(0.97); C616(0.75)  LDD0792  [26]
 LDCM0476  CL82 HCT 116 C609(1.09); C616(0.45)  LDD0793  [26]
 LDCM0477  CL83 HCT 116 C609(1.34); C616(0.57)  LDD0794  [26]
 LDCM0478  CL84 HCT 116 C609(1.49); C616(0.29)  LDD0795  [26]
 LDCM0479  CL85 HCT 116 C609(1.14); C616(1.10)  LDD0796  [26]
 LDCM0480  CL86 HCT 116 C609(1.07); C616(1.20)  LDD0797  [26]
 LDCM0481  CL87 HCT 116 C609(0.82); C616(0.86)  LDD0798  [26]
 LDCM0482  CL88 HCT 116 C609(0.86); C616(0.56)  LDD0799  [26]
 LDCM0483  CL89 HCT 116 C609(0.99); C616(0.27)  LDD0800  [26]
 LDCM0484  CL9 HCT 116 C616(1.20)  LDD0801  [26]
 LDCM0485  CL90 HCT 116 C609(0.45); C616(0.95)  LDD0802  [26]
 LDCM0486  CL91 HCT 116 C609(1.03); C616(0.90)  LDD0803  [26]
 LDCM0487  CL92 HCT 116 C609(0.57); C616(0.88)  LDD0804  [26]
 LDCM0488  CL93 HCT 116 C609(0.59); C616(1.00)  LDD0805  [26]
 LDCM0489  CL94 HCT 116 C609(0.72); C616(0.84)  LDD0806  [26]
 LDCM0490  CL95 HCT 116 C609(0.76); C616(0.88)  LDD0807  [26]
 LDCM0491  CL96 HCT 116 C609(0.81); C616(0.99)  LDD0808  [26]
 LDCM0492  CL97 HCT 116 C609(0.67); C616(0.93)  LDD0809  [26]
 LDCM0493  CL98 HCT 116 C609(1.52); C616(1.04)  LDD0810  [26]
 LDCM0494  CL99 HCT 116 C609(1.20); C616(1.24)  LDD0811  [26]
 LDCM0189  Compound 16 HEK-293T 11.30  LDD0492  [22]
 LDCM0184  Compound 20 HEK-293T 9.30  LDD0503  [22]
 LDCM0191  Compound 21 HEK-293T 4.90  LDD0493  [22]
 LDCM0190  Compound 34 HEK-293T 12.82  LDD0497  [22]
 LDCM0192  Compound 35 HEK-293T 6.67  LDD0491  [22]
 LDCM0193  Compound 36 HEK-293T 7.19  LDD0494  [22]
 LDCM0194  Compound 37 HEK-293T 8.16  LDD0498  [22]
 LDCM0195  Compound 38 HEK-293T 6.85  LDD0499  [22]
 LDCM0196  Compound 39 HEK-293T 10.87  LDD0496  [22]
 LDCM0197  Compound 40 HEK-293T 11.05  LDD0495  [22]
 LDCM0097  Dasatinib K562 5.39  LDD0270  [6]
 LDCM0495  E2913 HEK-293T C609(0.97); C471(1.08); C567(1.01); C484(0.96)  LDD1698  [27]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C471(0.94)  LDD1702  [7]
 LDCM0625  F8 Ramos C616(0.40); C700(1.15)  LDD2187  [28]
 LDCM0572  Fragment10 Ramos C616(1.51); C700(0.45)  LDD2189  [28]
 LDCM0573  Fragment11 Ramos C616(2.55); C700(0.17); C471(2.17)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C616(1.50); C700(0.50)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C616(1.02)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C700(1.23); C471(0.98)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C616(2.32); C700(0.31)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C616(1.19)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C700(0.85)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C616(0.94)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C471(0.47)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C616(1.05); C700(5.58)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C616(1.54)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C616(1.34); C700(0.52)  LDD2201  [28]
 LDCM0468  Fragment33 HCT 116 C609(1.35)  LDD0785  [26]
 LDCM0596  Fragment38 Ramos C616(1.21)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C616(0.98); C700(0.81); C471(0.71)  LDD2184  [28]
 LDCM0427  Fragment51 HCT 116 C567(0.80)  LDD0744  [26]
 LDCM0610  Fragment52 Ramos C616(1.10); C700(0.71)  LDD2204  [28]
 LDCM0569  Fragment7 Ramos C616(1.39); C700(0.98); C471(0.84)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C616(2.02); C700(0.47)  LDD2188  [28]
 LDCM0022  KB02 HEK-293T C609(0.96); C471(0.91); C616(1.16); C567(0.91)  LDD1492  [27]
 LDCM0023  KB03 HEK-293T C609(1.01); C471(1.02); C616(1.05); C567(1.02)  LDD1497  [27]
 LDCM0024  KB05 G361 C567(1.02)  LDD3311  [29]
 LDCM0109  NEM HeLa H664(0.00); H473(0.00)  LDD0227  [18]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C616(0.43)  LDD2100  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C567(0.96); C700(1.13)  LDD2137  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C616(0.59)  LDD2141  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C616(0.18)  LDD2145  [7]
 LDCM0148  Olaparib MDA-MB-468 1.80  LDD0377  [20]
 LDCM0628  OTUB2-COV-1 HEK-293T C6(1.73)  LDD2207  [30]
 LDCM0084  Ro 48-8071 A-549 20.00  LDD0144  [24]
 LDCM0081  Rofecoxib A-549 2.34  LDD0141  [24]
 LDCM0021  THZ1 HCT 116 C700(1.10)  LDD2173  [26]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Calcium and integrin-binding protein 1 (CIB1) . Q99828
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein kish-B (TMEM167B) KISH family Q9NRX6
Protein YIF1A (YIF1A) YIF1 family O95070

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lanosterol Small molecular drug DB03696
R048-8071 Small molecular drug DB02016

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
25 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
26 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
29 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.