Details of the Probe

General Information of Probe

Probe ID
LDPC0492
Probe Name
C260
Synonyms
Z3433407567
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 353.8
Lipid-water partition coefficient (xlogp) 2.3
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C15H16ClN3O3S
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-2-(2-chlorophenyl)sulfonylacetamide
Canonical SMILES
C#CCCC1(N=N1)CCNC(=O)CS(=O)(=O)C2=CC=CC=C2Cl
InChI
InChI=1S/C15H16ClN3O3S/c1-2-3-8-15(18-19-15)9-10-17-14(20)11-23(21,22)13-7-5-4-6-12(13)16/h1,4-7H,3,8-11H2,(H,17,20)
InChIKey
OXKOJDHECRKWCW-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

24 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 5.54  LDD1932 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 5.21  LDD1932 
Cytochrome b5 type B (CYB5B) LDTP00697 5.54  LDD1932 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 14.32  LDD1932 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 5.39  LDD1932 
Delta(24)-sterol reductase (DHCR24) LDTP06375 5.21  LDD1932 
Dihydrofolate reductase (DHFR) LDTP01769 7.16  LDD1932 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 5.70  LDD1932 
Glyoxalase domain-containing protein 4 (GLOD4) LDTP16040 26.72  LDD1932 
Heme oxygenase 1 (HMOX1) LDTP02359 4.92  LDD1932 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 6.11  LDD1932 
Lanosterol synthase (LSS) LDTP04183 5.70  LDD1932 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 4.96  LDD1932 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 26.72  LDD1932 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 10.63  LDD1932 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 14.32  LDD1932 
Phospholipase A2 group XV (PLA2G15) LDTP09088 12.91  LDD1932 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 6.59  LDD1932 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 10.27  LDD1932 
Protein O-GlcNAcase (OGA) LDTP00988 9.00  LDD1932 
Protein phosphatase 1L (PPM1L) LDTP07057 5.17  LDD1932 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 4.92  LDD1932 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 6.02  LDD1932 
RAC-beta serine/threonine-protein kinase (AKT2) LDTP03608 5.94  LDD1932 
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⏷ Show the Full List of 24 Enzyme
19 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ATP synthase subunit a (MT-ATP6) LDTP01804 15.14  LDD1932 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 5.06  LDD1932 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 11.16  LDD1932 
Metaxin-1 (MTX1) LDTP05900 11.39  LDD1932 
MFS-type transporter SLC18B1 (SLC18B1) LDTP07462 8.94  LDD1932 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 18.90  LDD1932 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 6.63  LDD1932 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 5.43  LDD1932 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 15.14  LDD1932 
Protein GPR107 (GPR107) LDTP07236 10.20  LDD1932 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 10.41  LDD1932 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 5.86  LDD1932 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 8.34  LDD1932 
Surfeit locus protein 4 (SURF4) LDTP00592 5.39  LDD1932 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 6.28  LDD1932 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 4.92  LDD1932 
Transmembrane protein 126A (TMEM126A) LDTP15948 6.50  LDD1932 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 5.17  LDD1932 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 5.98  LDD1932 
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⏷ Show the Full List of 19 Transporter and channel
2 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Chromatin accessibility complex protein 1 (CHRAC1) LDTP12507 5.21  LDD1932 
PHD finger protein 14 (PHF14) LDTP01447 5.86  LDD1932 
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8 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Apolipoprotein L2 (APOL2) LDTP11076 8.22  LDD1932 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 5.28  LDD1932 
Clustered mitochondria protein homolog (CLUH) LDTP14486 5.66  LDD1932 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 7.01  LDD1932 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 9.92  LDD1932 
Eukaryotic translation initiation factor 4E (EIF4E) LDTP02156 5.66  LDD1932 
Mdm2-binding protein (MTBP) LDTP15714 5.86  LDD1932 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 9.99  LDD1932 
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⏷ Show the Full List of 8 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1932 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587