Details of the Target

General Information of Target

Target ID	LDTP10913
Target Name	Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A)
Gene Name	TIMM17A
Gene ID	10440
Synonyms	MIMT17; TIM17; TIM17A; TIMM17; Mitochondrial import inner membrane translocase subunit Tim17-A; Inner membrane preprotein translocase Tim17a
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MASNSWNASSSPGEAREDGPEGLDKGLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIIL SDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKAMNLDQVSKD KALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKP FAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDP DTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFW ADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVY RIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVST SEHGAQHHVYKLVKD
Target Bioclass	Transporter and channel
Family	Tim17/Tim22/Tim23 family
Subcellular location	Mitochondrion inner membrane
Function	Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Uniprot ID	Q99595
Ensemble ID	ENST00000367287.5
HGNC ID	HGNC:17315

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 12 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
FBPP2 Probe Info	11.69	LDD0318	[1]
BTD Probe Info	C9(0.66)	LDD2089	[2]
Acrolein Probe Info	N.A.	LDD0222	[3]
DBIA Probe Info	C17(0.77)	LDD0531	[4]
IA-alkyne Probe Info	N.A.	LDD0162	[5]
TFBX Probe Info	N.A.	LDD0027	[6]
WYneN Probe Info	N.A.	LDD0021	[7]
IPM Probe Info	N.A.	LDD0005	[7]
Phosphinate-6 Probe Info	N.A.	LDD0018	[8]
Crotonaldehyde Probe Info	N.A.	LDD0219	[3]
AOyne Probe Info	15.00	LDD0443	[9]
NAIA_5 Probe Info	N.A.	LDD2223	[10]

PAL-AfBPP Probe

Click To Hide/Show 230 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C004 Probe Info	9.78	LDD1714	[11]
C007 Probe Info	6.68	LDD1716	[11]
C008 Probe Info	8.17	LDD1717	[11]
C010 Probe Info	8.00	LDD1719	[11]
C011 Probe Info	19.43	LDD1720	[11]
C017 Probe Info	37.53	LDD1725	[11]
C022 Probe Info	38.59	LDD1728	[11]
C026 Probe Info	32.67	LDD1732	[11]
C039 Probe Info	12.47	LDD1739	[11]
C040 Probe Info	61.39	LDD1740	[11]
C041 Probe Info	35.75	LDD1741	[11]
C044 Probe Info	6.15	LDD1743	[11]
C049 Probe Info	18.51	LDD1747	[11]
C051 Probe Info	9.99	LDD1749	[11]
C052 Probe Info	9.06	LDD1750	[11]
C053 Probe Info	10.70	LDD1751	[11]
C055 Probe Info	99.73	LDD1752	[11]
C056 Probe Info	99.73	LDD1753	[11]
C059 Probe Info	21.26	LDD1756	[11]
C060 Probe Info	22.32	LDD1757	[11]
C063 Probe Info	99.73	LDD1760	[11]
C064 Probe Info	27.47	LDD1761	[11]
C065 Probe Info	11.24	LDD1762	[11]
C067 Probe Info	13.45	LDD1763	[11]
C070 Probe Info	62.68	LDD1766	[11]
C071 Probe Info	13.09	LDD1767	[11]
C072 Probe Info	28.64	LDD1768	[11]
C075 Probe Info	6.19	LDD1770	[11]
C082 Probe Info	31.34	LDD1774	[11]
C083 Probe Info	7.16	LDD1775	[11]
C085 Probe Info	21.26	LDD1777	[11]
C087 Probe Info	42.81	LDD1779	[11]
C088 Probe Info	14.32	LDD1780	[11]
C089 Probe Info	7.67	LDD1781	[11]
C091 Probe Info	99.73	LDD1782	[11]
C092 Probe Info	99.73	LDD1783	[11]
C093 Probe Info	5.82	LDD1784	[11]
C094 Probe Info	99.73	LDD1785	[11]
C095 Probe Info	23.75	LDD1786	[11]
C098 Probe Info	8.00	LDD1787	[11]
C099 Probe Info	9.32	LDD1788	[11]
C100 Probe Info	25.81	LDD1789	[11]
C102 Probe Info	5.50	LDD1790	[11]
C106 Probe Info	79.34	LDD1793	[11]
C107 Probe Info	36.25	LDD1794	[11]
C108 Probe Info	43.41	LDD1795	[11]
C110 Probe Info	5.13	LDD1797	[11]
C112 Probe Info	99.73	LDD1799	[11]
C117 Probe Info	8.00	LDD1804	[11]
C122 Probe Info	6.82	LDD1808	[11]
C129 Probe Info	46.21	LDD1811	[11]
C130 Probe Info	37.27	LDD1812	[11]
C134 Probe Info	99.73	LDD1816	[11]
C135 Probe Info	99.73	LDD1817	[11]
C138 Probe Info	8.11	LDD1820	[11]
C139 Probe Info	85.04	LDD1821	[11]
C140 Probe Info	83.87	LDD1822	[11]
C141 Probe Info	99.73	LDD1823	[11]
C143 Probe Info	99.73	LDD1825	[11]
C145 Probe Info	31.12	LDD1827	[11]
C147 Probe Info	28.64	LDD1829	[11]
C153 Probe Info	99.73	LDD1834	[11]
C156 Probe Info	14.93	LDD1836	[11]
C158 Probe Info	11.39	LDD1838	[11]
C159 Probe Info	99.73	LDD1839	[11]
C160 Probe Info	99.73	LDD1840	[11]
C161 Probe Info	99.73	LDD1841	[11]
C163 Probe Info	36.00	LDD1843	[11]
C164 Probe Info	10.41	LDD1844	[11]
C165 Probe Info	68.59	LDD1845	[11]
C166 Probe Info	34.54	LDD1846	[11]
C169 Probe Info	98.36	LDD1849	[11]
C170 Probe Info	17.88	LDD1850	[11]
C172 Probe Info	5.90	LDD1852	[11]
C173 Probe Info	9.65	LDD1853	[11]
C174 Probe Info	8.69	LDD1854	[11]
C176 Probe Info	6.68	LDD1855	[11]
C177 Probe Info	29.45	LDD1856	[11]
C178 Probe Info	99.73	LDD1857	[11]
C182 Probe Info	11.55	LDD1860	[11]
C183 Probe Info	18.13	LDD1861	[11]
C185 Probe Info	8.17	LDD1863	[11]
C186 Probe Info	39.40	LDD1864	[11]
C187 Probe Info	99.73	LDD1865	[11]
C191 Probe Info	45.57	LDD1868	[11]
C193 Probe Info	39.67	LDD1869	[11]
C194 Probe Info	69.55	LDD1870	[11]
C196 Probe Info	65.34	LDD1872	[11]
C197 Probe Info	25.99	LDD1873	[11]
C198 Probe Info	99.73	LDD1874	[11]
C199 Probe Info	14.32	LDD1875	[11]
C210 Probe Info	99.73	LDD1884	[11]
C211 Probe Info	35.51	LDD1885	[11]
C213 Probe Info	31.56	LDD1887	[11]
C215 Probe Info	10.41	LDD1889	[11]
C216 Probe Info	18.38	LDD1890	[11]
C217 Probe Info	16.22	LDD1891	[11]
C218 Probe Info	99.73	LDD1892	[11]
C219 Probe Info	64.00	LDD1893	[11]
C220 Probe Info	99.73	LDD1894	[11]
C225 Probe Info	9.65	LDD1898	[11]
C226 Probe Info	11.16	LDD1899	[11]
C228 Probe Info	31.34	LDD1901	[11]
C238 Probe Info	67.18	LDD1911	[11]
C239 Probe Info	10.13	LDD1912	[11]
C240 Probe Info	36.00	LDD1913	[11]
C243 Probe Info	81.01	LDD1916	[11]
C244 Probe Info	57.28	LDD1917	[11]
C245 Probe Info	23.92	LDD1918	[11]
C246 Probe Info	66.26	LDD1919	[11]
C249 Probe Info	50.91	LDD1922	[11]
C251 Probe Info	29.04	LDD1924	[11]
C252 Probe Info	99.73	LDD1925	[11]
C255 Probe Info	14.72	LDD1928	[11]
C257 Probe Info	7.26	LDD1930	[11]
C258 Probe Info	43.11	LDD1931	[11]
C260 Probe Info	18.90	LDD1932	[11]
C261 Probe Info	11.39	LDD1933	[11]
C264 Probe Info	72.00	LDD1935	[11]
C265 Probe Info	54.57	LDD1936	[11]
C266 Probe Info	15.78	LDD1937	[11]
C269 Probe Info	9.85	LDD1939	[11]
C270 Probe Info	32.90	LDD1940	[11]
C271 Probe Info	8.75	LDD1941	[11]
C272 Probe Info	8.06	LDD1942	[11]
C273 Probe Info	18.38	LDD1943	[11]
C274 Probe Info	6.19	LDD1944	[11]
C277 Probe Info	50.21	LDD1947	[11]
C278 Probe Info	99.73	LDD1948	[11]
C280 Probe Info	18.90	LDD1950	[11]
C282 Probe Info	77.71	LDD1952	[11]
C284 Probe Info	86.82	LDD1954	[11]
C285 Probe Info	39.40	LDD1955	[11]
C286 Probe Info	8.06	LDD1956	[11]
C287 Probe Info	33.13	LDD1957	[11]
C288 Probe Info	13.00	LDD1958	[11]
C289 Probe Info	53.82	LDD1959	[11]
C290 Probe Info	9.85	LDD1960	[11]
C292 Probe Info	10.78	LDD1962	[11]
C293 Probe Info	91.77	LDD1963	[11]
C296 Probe Info	69.55	LDD1966	[11]
C297 Probe Info	8.69	LDD1967	[11]
C299 Probe Info	62.25	LDD1968	[11]
C301 Probe Info	8.46	LDD1970	[11]
C303 Probe Info	9.32	LDD1972	[11]
C304 Probe Info	17.63	LDD1973	[11]
C305 Probe Info	42.52	LDD1974	[11]
C307 Probe Info	12.30	LDD1975	[11]
C310 Probe Info	31.78	LDD1977	[11]
C313 Probe Info	70.52	LDD1980	[11]
C314 Probe Info	65.34	LDD1981	[11]
C317 Probe Info	12.21	LDD1983	[11]
C320 Probe Info	15.24	LDD1986	[11]
C322 Probe Info	45.57	LDD1988	[11]
C326 Probe Info	59.71	LDD1990	[11]
C327 Probe Info	20.53	LDD1991	[11]
C333 Probe Info	18.25	LDD1996	[11]
C337 Probe Info	11.31	LDD2000	[11]
C338 Probe Info	93.05	LDD2001	[11]
C339 Probe Info	76.64	LDD2002	[11]
C340 Probe Info	6.28	LDD2003	[11]
C342 Probe Info	7.73	LDD2004	[11]
C343 Probe Info	64.45	LDD2005	[11]
C346 Probe Info	52.71	LDD2007	[11]
C347 Probe Info	7.57	LDD2008	[11]
C348 Probe Info	64.00	LDD2009	[11]
C349 Probe Info	75.58	LDD2010	[11]
C350 Probe Info	99.73	LDD2011	[11]
C353 Probe Info	14.72	LDD2014	[11]
C354 Probe Info	18.64	LDD2015	[11]
C355 Probe Info	99.73	LDD2016	[11]
C356 Probe Info	99.73	LDD2017	[11]
C357 Probe Info	54.95	LDD2018	[11]
C360 Probe Info	25.63	LDD2021	[11]
C361 Probe Info	76.64	LDD2022	[11]
C362 Probe Info	83.87	LDD2023	[11]
C363 Probe Info	38.32	LDD2024	[11]
C364 Probe Info	40.22	LDD2025	[11]
C366 Probe Info	28.84	LDD2027	[11]
C367 Probe Info	5.94	LDD2028	[11]
C373 Probe Info	29.24	LDD2033	[11]
C376 Probe Info	26.17	LDD2036	[11]
C378 Probe Info	19.70	LDD2037	[11]
C380 Probe Info	16.45	LDD2039	[11]
C382 Probe Info	60.13	LDD2041	[11]
C383 Probe Info	99.73	LDD2042	[11]
C385 Probe Info	6.68	LDD2044	[11]
C386 Probe Info	45.57	LDD2045	[11]
C387 Probe Info	10.41	LDD2046	[11]
C388 Probe Info	99.73	LDD2047	[11]
C389 Probe Info	11.55	LDD2048	[11]
C397 Probe Info	19.84	LDD2056	[11]
C399 Probe Info	49.87	LDD2058	[11]
C400 Probe Info	5.62	LDD2059	[11]
C403 Probe Info	90.51	LDD2061	[11]
C405 Probe Info	21.71	LDD2063	[11]
C407 Probe Info	99.73	LDD2064	[11]
C408 Probe Info	28.05	LDD2065	[11]
C409 Probe Info	49.18	LDD2066	[11]
C413 Probe Info	99.73	LDD2069	[11]
C414 Probe Info	15.14	LDD2070	[11]
C416 Probe Info	16.22	LDD2071	[11]
C418 Probe Info	20.25	LDD2073	[11]
C419 Probe Info	69.07	LDD2074	[11]
C420 Probe Info	69.55	LDD2075	[11]
C421 Probe Info	12.91	LDD2076	[11]
C422 Probe Info	52.71	LDD2077	[11]
C423 Probe Info	44.63	LDD2078	[11]
C424 Probe Info	65.34	LDD2079	[11]
C426 Probe Info	99.73	LDD2081	[11]
C428 Probe Info	16.11	LDD2083	[11]
C429 Probe Info	99.73	LDD2084	[11]
C430 Probe Info	38.85	LDD2085	[11]
C431 Probe Info	99.73	LDD2086	[11]
C432 Probe Info	11.55	LDD2087	[11]
C433 Probe Info	32.67	LDD2088	[11]
FFF probe11 Probe Info	20.00	LDD0471	[12]
FFF probe12 Probe Info	20.00	LDD0473	[12]
FFF probe13 Probe Info	20.00	LDD0475	[12]
FFF probe14 Probe Info	20.00	LDD0477	[12]
FFF probe15 Probe Info	20.00	LDD0478	[12]
FFF probe2 Probe Info	20.00	LDD0463	[12]
FFF probe3 Probe Info	20.00	LDD0464	[12]
FFF probe4 Probe Info	20.00	LDD0466	[12]
FFF probe6 Probe Info	20.00	LDD0482	[12]
FFF probe9 Probe Info	20.00	LDD0485	[12]
JN0003 Probe Info	20.00	LDD0469	[12]
A-DA Probe Info	6.69	LDD0145	[13]
BD-F Probe Info	I126(0.00); G120(0.00)	LDD0024	[14]
OEA-DA Probe Info	20.00	LDD0046	[15]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0548	1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one	MDA-MB-231	C9(0.92)	LDD2142	[2]
LDCM0519	1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one	MDA-MB-231	C9(1.53)	LDD2112	[2]
LDCM0524	2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide	MDA-MB-231	C9(0.92)	LDD2117	[2]
LDCM0558	2-Cyano-N-phenylacetamide	MDA-MB-231	C9(1.08)	LDD2152	[2]
LDCM0510	3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile	MDA-MB-231	C9(1.18)	LDD2103	[2]
LDCM0539	3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile	MDA-MB-231	C9(0.74)	LDD2132	[2]
LDCM0214	AC1	HCT 116	C17(0.77)	LDD0531	[4]
LDCM0215	AC10	HEK-293T	C17(1.38)	LDD0813	[4]
LDCM0226	AC11	HEK-293T	C17(1.08)	LDD0824	[4]
LDCM0230	AC113	HCT 116	C17(0.90)	LDD0547	[4]
LDCM0231	AC114	HCT 116	C17(0.65)	LDD0548	[4]
LDCM0232	AC115	HCT 116	C17(0.56)	LDD0549	[4]
LDCM0233	AC116	HCT 116	C17(0.59)	LDD0550	[4]
LDCM0234	AC117	HCT 116	C17(0.75)	LDD0551	[4]
LDCM0235	AC118	HCT 116	C17(0.68)	LDD0552	[4]
LDCM0236	AC119	HCT 116	C17(0.66)	LDD0553	[4]
LDCM0237	AC12	HEK-293T	C17(1.26)	LDD0835	[4]
LDCM0238	AC120	HCT 116	C17(0.71)	LDD0555	[4]
LDCM0239	AC121	HCT 116	C17(0.78)	LDD0556	[4]
LDCM0240	AC122	HCT 116	C17(0.60)	LDD0557	[4]
LDCM0241	AC123	HCT 116	C17(0.81)	LDD0558	[4]
LDCM0242	AC124	HCT 116	C17(0.74)	LDD0559	[4]
LDCM0243	AC125	HCT 116	C17(0.84)	LDD0560	[4]
LDCM0244	AC126	HCT 116	C17(0.59)	LDD0561	[4]
LDCM0245	AC127	HCT 116	C17(0.62)	LDD0562	[4]
LDCM0259	AC14	HEK-293T	C17(1.35)	LDD0857	[4]
LDCM0263	AC143	HCT 116	C17(0.98)	LDD0580	[4]
LDCM0264	AC144	HCT 116	C17(0.66)	LDD0581	[4]
LDCM0265	AC145	HCT 116	C17(0.87)	LDD0582	[4]
LDCM0266	AC146	HCT 116	C17(0.61)	LDD0583	[4]
LDCM0267	AC147	HCT 116	C17(0.73)	LDD0584	[4]
LDCM0268	AC148	HCT 116	C17(0.72)	LDD0585	[4]
LDCM0269	AC149	HCT 116	C17(0.63)	LDD0586	[4]
LDCM0270	AC15	HEK-293T	C17(1.86)	LDD0868	[4]
LDCM0271	AC150	HCT 116	C17(0.75)	LDD0588	[4]
LDCM0272	AC151	HCT 116	C17(0.84)	LDD0589	[4]
LDCM0273	AC152	HCT 116	C17(0.69)	LDD0590	[4]
LDCM0274	AC153	HCT 116	C17(0.67)	LDD0591	[4]
LDCM0621	AC154	HCT 116	C17(0.75)	LDD2158	[4]
LDCM0622	AC155	HCT 116	C17(0.66)	LDD2159	[4]
LDCM0623	AC156	HCT 116	C17(0.99)	LDD2160	[4]
LDCM0624	AC157	HCT 116	C17(0.96)	LDD2161	[4]
LDCM0276	AC17	HCT 116	C17(0.96)	LDD0593	[4]
LDCM0277	AC18	HCT 116	C17(0.73)	LDD0594	[4]
LDCM0278	AC19	HCT 116	C17(0.85)	LDD0595	[4]
LDCM0279	AC2	HCT 116	C17(0.89)	LDD0596	[4]
LDCM0280	AC20	HCT 116	C17(0.94)	LDD0597	[4]
LDCM0281	AC21	HCT 116	C17(0.89)	LDD0598	[4]
LDCM0282	AC22	HCT 116	C17(1.08)	LDD0599	[4]
LDCM0283	AC23	HCT 116	C17(1.00)	LDD0600	[4]
LDCM0284	AC24	HCT 116	C17(1.05)	LDD0601	[4]
LDCM0285	AC25	HCT 116	C17(0.98)	LDD0602	[4]
LDCM0286	AC26	HCT 116	C17(0.73)	LDD0603	[4]
LDCM0287	AC27	HCT 116	C17(0.69)	LDD0604	[4]
LDCM0288	AC28	HCT 116	C17(0.77)	LDD0605	[4]
LDCM0289	AC29	HCT 116	C17(0.84)	LDD0606	[4]
LDCM0290	AC3	HCT 116	C17(0.96)	LDD0607	[4]
LDCM0291	AC30	HCT 116	C17(0.71)	LDD0608	[4]
LDCM0292	AC31	HCT 116	C17(0.57)	LDD0609	[4]
LDCM0293	AC32	HCT 116	C17(0.60)	LDD0610	[4]
LDCM0294	AC33	HCT 116	C17(0.65)	LDD0611	[4]
LDCM0295	AC34	HCT 116	C17(0.71)	LDD0612	[4]
LDCM0296	AC35	HEK-293T	C17(0.80)	LDD0894	[4]
LDCM0297	AC36	HEK-293T	C17(1.21)	LDD0895	[4]
LDCM0298	AC37	HEK-293T	C17(1.15)	LDD0896	[4]
LDCM0299	AC38	HEK-293T	C17(1.15)	LDD0897	[4]
LDCM0300	AC39	HEK-293T	C17(1.32)	LDD0898	[4]
LDCM0301	AC4	HCT 116	C17(0.78)	LDD0618	[4]
LDCM0302	AC40	HEK-293T	C17(1.16)	LDD0900	[4]
LDCM0303	AC41	HEK-293T	C17(1.09)	LDD0901	[4]
LDCM0304	AC42	HEK-293T	C17(1.18)	LDD0902	[4]
LDCM0305	AC43	HEK-293T	C17(1.36)	LDD0903	[4]
LDCM0306	AC44	HEK-293T	C17(1.35)	LDD0904	[4]
LDCM0307	AC45	HEK-293T	C17(1.14)	LDD0905	[4]
LDCM0308	AC46	HCT 116	C17(0.91)	LDD0625	[4]
LDCM0309	AC47	HCT 116	C17(0.89)	LDD0626	[4]
LDCM0310	AC48	HCT 116	C17(0.69)	LDD0627	[4]
LDCM0311	AC49	HCT 116	C17(1.13)	LDD0628	[4]
LDCM0312	AC5	HCT 116	C17(0.81)	LDD0629	[4]
LDCM0313	AC50	HCT 116	C17(0.91)	LDD0630	[4]
LDCM0314	AC51	HCT 116	C17(0.95)	LDD0631	[4]
LDCM0315	AC52	HCT 116	C17(0.97)	LDD0632	[4]
LDCM0316	AC53	HCT 116	C17(0.95)	LDD0633	[4]
LDCM0317	AC54	HCT 116	C17(1.05)	LDD0634	[4]
LDCM0318	AC55	HCT 116	C17(0.97)	LDD0635	[4]
LDCM0319	AC56	HCT 116	C17(1.13)	LDD0636	[4]
LDCM0320	AC57	HEK-293T	C17(1.00)	LDD1559	[16]
LDCM0321	AC58	HEK-293T	C17(1.08)	LDD1560	[16]
LDCM0322	AC59	HEK-293T	C17(0.95)	LDD1561	[16]
LDCM0323	AC6	HEK-293T	C17(1.44)	LDD0921	[4]
LDCM0324	AC60	HEK-293T	C17(1.04)	LDD1563	[16]
LDCM0325	AC61	HEK-293T	C17(1.01)	LDD1564	[16]
LDCM0326	AC62	HEK-293T	C17(0.98)	LDD1565	[16]
LDCM0327	AC63	HEK-293T	C17(1.09)	LDD1566	[16]
LDCM0328	AC64	HEK-293T	C17(0.98)	LDD1567	[16]
LDCM0332	AC68	HCT 116	C17(0.69)	LDD0649	[4]
LDCM0333	AC69	HCT 116	C17(0.70)	LDD0650	[4]
LDCM0334	AC7	HEK-293T	C17(1.32)	LDD0932	[4]
LDCM0335	AC70	HCT 116	C17(0.60)	LDD0652	[4]
LDCM0336	AC71	HCT 116	C17(0.89)	LDD0653	[4]
LDCM0337	AC72	HCT 116	C17(0.76)	LDD0654	[4]
LDCM0338	AC73	HCT 116	C17(0.63)	LDD0655	[4]
LDCM0339	AC74	HCT 116	C17(0.67)	LDD0656	[4]
LDCM0340	AC75	HCT 116	C17(0.68)	LDD0657	[4]
LDCM0341	AC76	HCT 116	C17(0.69)	LDD0658	[4]
LDCM0342	AC77	HCT 116	C17(0.78)	LDD0659	[4]
LDCM0343	AC78	HCT 116	C17(0.57)	LDD0660	[4]
LDCM0344	AC79	HCT 116	C17(1.02)	LDD0661	[4]
LDCM0345	AC8	HEK-293T	C17(1.64)	LDD0943	[4]
LDCM0346	AC80	HCT 116	C17(0.79)	LDD0663	[4]
LDCM0347	AC81	HCT 116	C17(0.60)	LDD0664	[4]
LDCM0348	AC82	HCT 116	C17(0.71)	LDD0665	[4]
LDCM0248	AKOS034007472	HEK-293T	C17(1.17)	LDD0846	[4]
LDCM0356	AKOS034007680	HEK-293T	C17(1.86)	LDD0954	[4]
LDCM0275	AKOS034007705	HEK-293T	C17(1.40)	LDD0873	[4]
LDCM0498	BS-3668	MDA-MB-231	C9(0.53)	LDD2091	[2]
LDCM0108	Chloroacetamide	HeLa	N.A.	LDD0222	[3]
LDCM0367	CL1	HCT 116	C17(2.05)	LDD0684	[4]
LDCM0368	CL10	HCT 116	C17(1.08)	LDD0685	[4]
LDCM0369	CL100	HCT 116	C17(0.83)	LDD0686	[4]
LDCM0370	CL101	HEK-293T	C17(1.83)	LDD0968	[4]
LDCM0371	CL102	HEK-293T	C17(1.93)	LDD0969	[4]
LDCM0372	CL103	HEK-293T	C17(1.63)	LDD0970	[4]
LDCM0373	CL104	HEK-293T	C17(1.37)	LDD0971	[4]
LDCM0374	CL105	HCT 116	C17(0.72)	LDD0691	[4]
LDCM0375	CL106	HCT 116	C17(0.60)	LDD0692	[4]
LDCM0376	CL107	HCT 116	C17(0.69)	LDD0693	[4]
LDCM0377	CL108	HCT 116	C17(0.75)	LDD0694	[4]
LDCM0378	CL109	HCT 116	C17(0.77)	LDD0695	[4]
LDCM0379	CL11	HCT 116	C17(1.02)	LDD0696	[4]
LDCM0380	CL110	HCT 116	C17(0.73)	LDD0697	[4]
LDCM0381	CL111	HCT 116	C17(0.83)	LDD0698	[4]
LDCM0382	CL112	HCT 116	C17(1.11)	LDD0699	[4]
LDCM0383	CL113	HCT 116	C17(0.65)	LDD0700	[4]
LDCM0384	CL114	HCT 116	C17(0.87)	LDD0701	[4]
LDCM0385	CL115	HCT 116	C17(0.76)	LDD0702	[4]
LDCM0386	CL116	HCT 116	C17(0.64)	LDD0703	[4]
LDCM0387	CL117	HEK-293T	C17(0.90)	LDD0985	[4]
LDCM0388	CL118	HEK-293T	C17(1.28)	LDD0986	[4]
LDCM0389	CL119	HEK-293T	C17(1.36)	LDD0987	[4]
LDCM0390	CL12	HCT 116	C17(0.92)	LDD0707	[4]
LDCM0391	CL120	HEK-293T	C17(1.31)	LDD0989	[4]
LDCM0392	CL121	HCT 116	C17(0.54)	LDD0709	[4]
LDCM0393	CL122	HCT 116	C17(0.88)	LDD0710	[4]
LDCM0394	CL123	HCT 116	C17(1.09)	LDD0711	[4]
LDCM0395	CL124	HCT 116	C17(1.03)	LDD0712	[4]
LDCM0396	CL125	HEK-293T	C17(0.97)	LDD1600	[16]
LDCM0397	CL126	HEK-293T	C17(1.17)	LDD1601	[16]
LDCM0398	CL127	HEK-293T	C17(1.12)	LDD1602	[16]
LDCM0399	CL128	HEK-293T	C17(1.07)	LDD1603	[16]
LDCM0400	CL13	HCT 116	C17(0.91)	LDD0717	[4]
LDCM0401	CL14	HCT 116	C17(1.55)	LDD0718	[4]
LDCM0402	CL15	HCT 116	C17(0.93)	LDD0719	[4]
LDCM0403	CL16	HCT 116	C17(1.00)	LDD0720	[4]
LDCM0404	CL17	HCT 116	C17(0.73)	LDD0721	[4]
LDCM0405	CL18	HCT 116	C17(0.57)	LDD0722	[4]
LDCM0406	CL19	HCT 116	C17(0.63)	LDD0723	[4]
LDCM0407	CL2	HCT 116	C17(1.74)	LDD0724	[4]
LDCM0408	CL20	HCT 116	C17(0.70)	LDD0725	[4]
LDCM0409	CL21	HCT 116	C17(0.70)	LDD0726	[4]
LDCM0410	CL22	HCT 116	C17(0.72)	LDD0727	[4]
LDCM0411	CL23	HCT 116	C17(0.85)	LDD0728	[4]
LDCM0412	CL24	HCT 116	C17(0.76)	LDD0729	[4]
LDCM0413	CL25	HCT 116	C17(0.66)	LDD0730	[4]
LDCM0414	CL26	HCT 116	C17(0.76)	LDD0731	[4]
LDCM0415	CL27	HCT 116	C17(0.66)	LDD0732	[4]
LDCM0416	CL28	HCT 116	C17(0.61)	LDD0733	[4]
LDCM0417	CL29	HCT 116	C17(0.68)	LDD0734	[4]
LDCM0418	CL3	HCT 116	C17(1.45)	LDD0735	[4]
LDCM0419	CL30	HCT 116	C17(0.88)	LDD0736	[4]
LDCM0420	CL31	HCT 116	C17(0.91)	LDD0737	[4]
LDCM0421	CL32	HCT 116	C17(0.88)	LDD0738	[4]
LDCM0422	CL33	HCT 116	C17(0.60)	LDD0739	[4]
LDCM0423	CL34	HCT 116	C17(0.63)	LDD0740	[4]
LDCM0424	CL35	HCT 116	C17(0.67)	LDD0741	[4]
LDCM0425	CL36	HCT 116	C17(0.66)	LDD0742	[4]
LDCM0426	CL37	HCT 116	C17(0.78)	LDD0743	[4]
LDCM0428	CL39	HCT 116	C17(0.58)	LDD0745	[4]
LDCM0429	CL4	HCT 116	C17(1.20)	LDD0746	[4]
LDCM0430	CL40	HCT 116	C17(0.51)	LDD0747	[4]
LDCM0431	CL41	HCT 116	C17(0.81)	LDD0748	[4]
LDCM0432	CL42	HCT 116	C17(0.68)	LDD0749	[4]
LDCM0433	CL43	HCT 116	C17(0.77)	LDD0750	[4]
LDCM0434	CL44	HCT 116	C17(0.65)	LDD0751	[4]
LDCM0435	CL45	HCT 116	C17(0.79)	LDD0752	[4]
LDCM0436	CL46	HCT 116	C17(1.79)	LDD0753	[4]
LDCM0437	CL47	HCT 116	C17(1.55)	LDD0754	[4]
LDCM0438	CL48	HCT 116	C17(1.54)	LDD0755	[4]
LDCM0439	CL49	HCT 116	C17(1.33)	LDD0756	[4]
LDCM0440	CL5	HCT 116	C17(1.31)	LDD0757	[4]
LDCM0441	CL50	HCT 116	C17(1.35)	LDD0758	[4]
LDCM0442	CL51	HCT 116	C17(1.22)	LDD0759	[4]
LDCM0443	CL52	HCT 116	C17(1.40)	LDD0760	[4]
LDCM0444	CL53	HCT 116	C17(1.35)	LDD0761	[4]
LDCM0445	CL54	HCT 116	C17(1.50)	LDD0762	[4]
LDCM0446	CL55	HCT 116	C17(1.70)	LDD0763	[4]
LDCM0447	CL56	HCT 116	C17(1.17)	LDD0764	[4]
LDCM0448	CL57	HCT 116	C17(1.20)	LDD0765	[4]
LDCM0449	CL58	HCT 116	C17(1.29)	LDD0766	[4]
LDCM0450	CL59	HCT 116	C17(1.34)	LDD0767	[4]
LDCM0451	CL6	HCT 116	C17(0.99)	LDD0768	[4]
LDCM0452	CL60	HCT 116	C17(1.53)	LDD0769	[4]
LDCM0453	CL61	HCT 116	C17(0.84)	LDD0770	[4]
LDCM0454	CL62	HCT 116	C17(0.85)	LDD0771	[4]
LDCM0455	CL63	HCT 116	C17(0.67)	LDD0772	[4]
LDCM0456	CL64	HCT 116	C17(0.73)	LDD0773	[4]
LDCM0457	CL65	HCT 116	C17(0.75)	LDD0774	[4]
LDCM0458	CL66	HCT 116	C17(0.66)	LDD0775	[4]
LDCM0459	CL67	HCT 116	C17(0.73)	LDD0776	[4]
LDCM0460	CL68	HCT 116	C17(0.67)	LDD0777	[4]
LDCM0461	CL69	HCT 116	C17(0.78)	LDD0778	[4]
LDCM0462	CL7	HCT 116	C17(0.97)	LDD0779	[4]
LDCM0463	CL70	HCT 116	C17(0.63)	LDD0780	[4]
LDCM0464	CL71	HCT 116	C17(0.75)	LDD0781	[4]
LDCM0465	CL72	HCT 116	C17(0.81)	LDD0782	[4]
LDCM0466	CL73	HCT 116	C17(1.14)	LDD0783	[4]
LDCM0467	CL74	HCT 116	C17(0.86)	LDD0784	[4]
LDCM0469	CL76	HEK-293T	C17(1.14)	LDD1067	[4]
LDCM0470	CL77	HEK-293T	C17(1.15)	LDD1068	[4]
LDCM0471	CL78	HEK-293T	C17(2.14)	LDD1069	[4]
LDCM0472	CL79	HEK-293T	C17(1.43)	LDD1070	[4]
LDCM0473	CL8	HCT 116	C17(1.20)	LDD0790	[4]
LDCM0474	CL80	HEK-293T	C17(1.19)	LDD1072	[4]
LDCM0475	CL81	HEK-293T	C17(1.42)	LDD1073	[4]
LDCM0476	CL82	HEK-293T	C17(1.10)	LDD1074	[4]
LDCM0477	CL83	HEK-293T	C17(1.08)	LDD1075	[4]
LDCM0478	CL84	HEK-293T	C17(1.52)	LDD1076	[4]
LDCM0479	CL85	HEK-293T	C17(1.51)	LDD1077	[4]
LDCM0480	CL86	HEK-293T	C17(1.77)	LDD1078	[4]
LDCM0481	CL87	HEK-293T	C17(1.59)	LDD1079	[4]
LDCM0482	CL88	HEK-293T	C17(1.39)	LDD1080	[4]
LDCM0483	CL89	HEK-293T	C17(1.72)	LDD1081	[4]
LDCM0484	CL9	HCT 116	C17(1.26)	LDD0801	[4]
LDCM0485	CL90	HEK-293T	C17(1.38)	LDD1083	[4]
LDCM0486	CL91	HCT 116	C17(0.93)	LDD0803	[4]
LDCM0487	CL92	HCT 116	C17(1.14)	LDD0804	[4]
LDCM0488	CL93	HCT 116	C17(1.15)	LDD0805	[4]
LDCM0489	CL94	HCT 116	C17(0.89)	LDD0806	[4]
LDCM0490	CL95	HCT 116	C17(0.86)	LDD0807	[4]
LDCM0491	CL96	HCT 116	C17(0.76)	LDD0808	[4]
LDCM0492	CL97	HCT 116	C17(0.85)	LDD0809	[4]
LDCM0493	CL98	HCT 116	C17(0.81)	LDD0810	[4]
LDCM0494	CL99	HCT 116	C17(0.79)	LDD0811	[4]
LDCM0495	E2913	HEK-293T	C17(1.07)	LDD1698	[16]
LDCM0213	Electrophilic fragment 2	MDA-MB-231	C9(17.58)	LDD1702	[2]
LDCM0468	Fragment33	HCT 116	C17(0.78)	LDD0785	[4]
LDCM0427	Fragment51	HCT 116	C17(0.60)	LDD0744	[4]
LDCM0022	KB02	HEK-293T	C17(0.99)	LDD1492	[16]
LDCM0023	KB03	HEK-293T	C17(0.88)	LDD1497	[16]
LDCM0024	KB05	MKN45	C17(3.63)	LDD3332	[17]
LDCM0509	N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide	MDA-MB-231	C9(1.08)	LDD2102	[2]
LDCM0109	NEM	HeLa	N.A.	LDD0224	[3]
LDCM0496	Nucleophilic fragment 11a	MDA-MB-231	C9(0.66)	LDD2089	[2]
LDCM0497	Nucleophilic fragment 11b	MDA-MB-231	C9(1.63)	LDD2090	[2]
LDCM0499	Nucleophilic fragment 12b	MDA-MB-231	C9(1.03)	LDD2092	[2]
LDCM0501	Nucleophilic fragment 13b	MDA-MB-231	C9(1.10)	LDD2094	[2]
LDCM0505	Nucleophilic fragment 15b	MDA-MB-231	C9(1.90)	LDD2098	[2]
LDCM0506	Nucleophilic fragment 16a	MDA-MB-231	C9(0.90)	LDD2099	[2]
LDCM0507	Nucleophilic fragment 16b	MDA-MB-231	C9(2.98)	LDD2100	[2]
LDCM0511	Nucleophilic fragment 18b	MDA-MB-231	C9(1.20)	LDD2104	[2]
LDCM0512	Nucleophilic fragment 19a	MDA-MB-231	C9(1.28)	LDD2105	[2]
LDCM0513	Nucleophilic fragment 19b	MDA-MB-231	C9(1.26)	LDD2106	[2]
LDCM0514	Nucleophilic fragment 20a	MDA-MB-231	C9(1.11)	LDD2107	[2]
LDCM0515	Nucleophilic fragment 20b	MDA-MB-231	C9(0.87)	LDD2108	[2]
LDCM0516	Nucleophilic fragment 21a	MDA-MB-231	C9(0.95)	LDD2109	[2]
LDCM0517	Nucleophilic fragment 21b	MDA-MB-231	C9(1.82)	LDD2110	[2]
LDCM0518	Nucleophilic fragment 22a	MDA-MB-231	C9(1.14)	LDD2111	[2]
LDCM0521	Nucleophilic fragment 23b	MDA-MB-231	C9(1.00)	LDD2114	[2]
LDCM0526	Nucleophilic fragment 26a	MDA-MB-231	C9(2.27)	LDD2119	[2]
LDCM0527	Nucleophilic fragment 26b	MDA-MB-231	C9(0.89)	LDD2120	[2]
LDCM0530	Nucleophilic fragment 28a	MDA-MB-231	C9(1.01)	LDD2123	[2]
LDCM0532	Nucleophilic fragment 29a	MDA-MB-231	C9(0.87)	LDD2125	[2]
LDCM0534	Nucleophilic fragment 30a	MDA-MB-231	C9(1.08)	LDD2127	[2]
LDCM0542	Nucleophilic fragment 37	MDA-MB-231	C9(0.94)	LDD2135	[2]
LDCM0543	Nucleophilic fragment 38	MDA-MB-231	C9(1.73)	LDD2136	[2]
LDCM0544	Nucleophilic fragment 39	MDA-MB-231	C9(0.92)	LDD2137	[2]
LDCM0546	Nucleophilic fragment 40	MDA-MB-231	C9(0.89)	LDD2140	[2]
LDCM0547	Nucleophilic fragment 41	MDA-MB-231	C9(0.88)	LDD2141	[2]
LDCM0549	Nucleophilic fragment 43	MDA-MB-231	C9(0.82)	LDD2143	[2]
LDCM0550	Nucleophilic fragment 5a	MDA-MB-231	C9(2.86)	LDD2144	[2]
LDCM0552	Nucleophilic fragment 6a	MDA-MB-231	C9(1.04)	LDD2146	[2]
LDCM0559	Nucleophilic fragment 9b	MDA-MB-231	C9(2.27)	LDD2153	[2]
LDCM0084	Ro 48-8071	A-549	6.69	LDD0145	[13]

References

1	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
2	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
3	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
7	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8	DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22. Mass spectrometry data entry: PXD033004
9	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
11	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
12	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13	A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
14	Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b. Mass spectrometry data entry: PXD025652
15	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
16	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
17	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840

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Prof. Feng Zhu

Prof. Feng Ni