Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C088  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 9.4
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 9.2
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 7.8
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 7.6
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 7.3
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 6.8
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 6.1
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 14.3
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 5.7
Other
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 12.0
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 6.9

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587