Details of the Target

General Information of Target

Target ID LDTP12628
Target Name Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10)
Gene Name ABHD10
Gene ID 55347
Synonyms
Palmitoyl-protein thioesterase ABHD10, mitochondrial; EC 3.1.2.22; Acyl-protein thioesterase ABHD10; Alpha/beta hydrolase domain-containing protein 10; Abhydrolase domain-containing protein 10; Mycophenolic acid acyl-glucuronide esterase, mitochondrial; EC 3.1.1.93
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQPPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASR
SLPRVLTAARKLAGATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLC
PAGALSFNAFKTVMDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGS
AKAAVDAMTRHLAVEWGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLG
NKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFPNGVKGLPDFASFSAKL
Target Bioclass
Enzyme
Family
AB hydrolase superfamily
Subcellular location
Mitochondrion
Function
Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate.
Uniprot ID
Q9NUJ1
Ensemble ID
ENST00000273359.8
HGNC ID
HGNC:25656

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.R44Q .
HT115 SNV: p.L290I .
HT1197 SNV: p.M88L DBIA    Probe Info 
KMCH1 SNV: p.A10S DBIA    Probe Info 
TOV21G SNV: p.H28N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y215(20.00); Y87(20.00); Y84(9.40)  LDD0260  [1]
TH214
 Probe Info  		Y84(20.00); Y87(13.20)  LDD0258  [1]
TH216
 Probe Info  		Y87(20.00)  LDD0259  [1]
STPyne
 Probe Info  		K248(5.56)  LDD0277  [2]
Probe 1
 Probe Info  		Y112(18.61)  LDD3495  [3]
BTD
 Probe Info  		C107(4.73)  LDD1700  [4]
Jackson_1
 Probe Info  		4.93  LDD0121  [5]
HHS-482
 Probe Info  		Y215(1.13); Y84(1.09); Y87(1.17)  LDD0285  [6]
HHS-475
 Probe Info  		Y87(0.92); Y84(1.02); Y215(2.16)  LDD0264  [7]
HHS-465
 Probe Info  		Y215(2.58)  LDD2237  [8]
DBIA
 Probe Info  		C229(0.61); C239(0.61); C100(0.67)  LDD0531  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		K248(0.00); K223(0.00)  LDD0199  [11]
m-APA
 Probe Info  		N.A.  LDD2231  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C100(0.00); C107(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C100(0.00); C107(0.00); C239(0.00); C229(0.00)  LDD0036  [12]
Lodoacetamide azide
 Probe Info  		C100(0.00); C239(0.00); C229(0.00); C107(0.00)  LDD0037  [12]
NHS
 Probe Info  		N.A.  LDD0010  [13]
OSF
 Probe Info  		N.A.  LDD0029  [14]
SF
 Probe Info  		N.A.  LDD0028  [14]
TFBX
 Probe Info  		C107(0.00); C100(0.00)  LDD0148  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
1d-yne
 Probe Info  		N.A.  LDD0357  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
Crotonaldehyde
 Probe Info  		C107(0.00); C100(0.00)  LDD0219  [17]
Methacrolein
 Probe Info  		C107(0.00); C100(0.00)  LDD0218  [17]
AOyne
 Probe Info  		10.60  LDD0443  [18]
NAIA_5
 Probe Info  		C100(0.00); C107(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 123 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		16.11  LDD1713  [20]
C004
 Probe Info  		6.23  LDD1714  [20]
C006
 Probe Info  		9.92  LDD1715  [20]
C007
 Probe Info  		5.43  LDD1716  [20]
C025
 Probe Info  		13.55  LDD1731  [20]
C040
 Probe Info  		13.74  LDD1740  [20]
C055
 Probe Info  		22.16  LDD1752  [20]
C056
 Probe Info  		74.54  LDD1753  [20]
C064
 Probe Info  		10.41  LDD1761  [20]
C067
 Probe Info  		16.00  LDD1763  [20]
C070
 Probe Info  		13.83  LDD1766  [20]
C082
 Probe Info  		4.96  LDD1774  [20]
C085
 Probe Info  		4.92  LDD1777  [20]
C087
 Probe Info  		8.00  LDD1779  [20]
C088
 Probe Info  		9.19  LDD1780  [20]
C094
 Probe Info  		41.93  LDD1785  [20]
C098
 Probe Info  		9.00  LDD1787  [20]
C107
 Probe Info  		7.73  LDD1794  [20]
C108
 Probe Info  		11.55  LDD1795  [20]
C112
 Probe Info  		31.34  LDD1799  [20]
C130
 Probe Info  		7.52  LDD1812  [20]
C132
 Probe Info  		8.22  LDD1814  [20]
C135
 Probe Info  		19.56  LDD1817  [20]
C139
 Probe Info  		18.64  LDD1821  [20]
C140
 Probe Info  		12.38  LDD1822  [20]
C142
 Probe Info  		26.72  LDD1824  [20]
C143
 Probe Info  		14.03  LDD1825  [20]
C145
 Probe Info  		17.88  LDD1827  [20]
C147
 Probe Info  		7.26  LDD1829  [20]
C153
 Probe Info  		21.41  LDD1834  [20]
C158
 Probe Info  		64.00  LDD1838  [20]
C161
 Probe Info  		24.59  LDD1841  [20]
C163
 Probe Info  		10.56  LDD1843  [20]
C165
 Probe Info  		26.54  LDD1845  [20]
C166
 Probe Info  		8.88  LDD1846  [20]
C167
 Probe Info  		62.68  LDD1847  [20]
C177
 Probe Info  		8.28  LDD1856  [20]
C178
 Probe Info  		14.72  LDD1857  [20]
C183
 Probe Info  		12.64  LDD1861  [20]
C187
 Probe Info  		27.28  LDD1865  [20]
C195
 Probe Info  		28.84  LDD1871  [20]
C197
 Probe Info  		12.47  LDD1873  [20]
C198
 Probe Info  		24.08  LDD1874  [20]
C201
 Probe Info  		46.53  LDD1877  [20]
C206
 Probe Info  		35.51  LDD1881  [20]
C213
 Probe Info  		26.72  LDD1887  [20]
C216
 Probe Info  		13.27  LDD1890  [20]
C218
 Probe Info  		37.79  LDD1892  [20]
C220
 Probe Info  		23.92  LDD1894  [20]
C228
 Probe Info  		25.81  LDD1901  [20]
C233
 Probe Info  		45.25  LDD1906  [20]
C235
 Probe Info  		24.42  LDD1908  [20]
C236
 Probe Info  		5.46  LDD1909  [20]
C238
 Probe Info  		14.52  LDD1911  [20]
C242
 Probe Info  		11.47  LDD1915  [20]
C246
 Probe Info  		18.77  LDD1919  [20]
C249
 Probe Info  		20.11  LDD1922  [20]
C252
 Probe Info  		17.03  LDD1925  [20]
C265
 Probe Info  		32.22  LDD1936  [20]
C269
 Probe Info  		6.54  LDD1939  [20]
C271
 Probe Info  		6.11  LDD1941  [20]
C277
 Probe Info  		9.51  LDD1947  [20]
C278
 Probe Info  		62.25  LDD1948  [20]
C282
 Probe Info  		17.27  LDD1952  [20]
C284
 Probe Info  		23.43  LDD1954  [20]
C286
 Probe Info  		8.28  LDD1956  [20]
C288
 Probe Info  		9.45  LDD1958  [20]
C290
 Probe Info  		16.34  LDD1960  [20]
C293
 Probe Info  		18.51  LDD1963  [20]
C296
 Probe Info  		16.34  LDD1966  [20]
C297
 Probe Info  		7.36  LDD1967  [20]
C305
 Probe Info  		13.55  LDD1974  [20]
C307
 Probe Info  		5.43  LDD1975  [20]
C314
 Probe Info  		15.67  LDD1981  [20]
C322
 Probe Info  		14.72  LDD1988  [20]
C326
 Probe Info  		7.57  LDD1990  [20]
C333
 Probe Info  		37.01  LDD1996  [20]
C335
 Probe Info  		10.27  LDD1998  [20]
C337
 Probe Info  		5.17  LDD2000  [20]
C338
 Probe Info  		22.94  LDD2001  [20]
C339
 Probe Info  		5.58  LDD2002  [20]
C342
 Probe Info  		6.82  LDD2004  [20]
C343
 Probe Info  		11.39  LDD2005  [20]
C346
 Probe Info  		14.93  LDD2007  [20]
C348
 Probe Info  		28.64  LDD2009  [20]
C349
 Probe Info  		14.42  LDD2010  [20]
C350
 Probe Info  		46.85  LDD2011  [20]
C353
 Probe Info  		9.65  LDD2014  [20]
C355
 Probe Info  		24.25  LDD2016  [20]
C356
 Probe Info  		14.32  LDD2017  [20]
C361
 Probe Info  		25.99  LDD2022  [20]
C362
 Probe Info  		99.73  LDD2023  [20]
C363
 Probe Info  		16.80  LDD2024  [20]
C364
 Probe Info  		17.63  LDD2025  [20]
C366
 Probe Info  		5.46  LDD2027  [20]
C367
 Probe Info  		10.20  LDD2028  [20]
C376
 Probe Info  		23.10  LDD2036  [20]
C382
 Probe Info  		13.18  LDD2041  [20]
C386
 Probe Info  		42.22  LDD2045  [20]
C387
 Probe Info  		17.88  LDD2046  [20]
C388
 Probe Info  		99.73  LDD2047  [20]
C390
 Probe Info  		45.57  LDD2049  [20]
C397
 Probe Info  		10.27  LDD2056  [20]
C399
 Probe Info  		7.89  LDD2058  [20]
C403
 Probe Info  		36.25  LDD2061  [20]
C409
 Probe Info  		4.92  LDD2066  [20]
C413
 Probe Info  		14.83  LDD2069  [20]
C429
 Probe Info  		17.15  LDD2084  [20]
C430
 Probe Info  		14.62  LDD2085  [20]
C431
 Probe Info  		29.04  LDD2086  [20]
FFF probe11
 Probe Info  		20.00  LDD0471  [21]
FFF probe13
 Probe Info  		20.00  LDD0475  [21]
FFF probe14
 Probe Info  		20.00  LDD0477  [21]
FFF probe15
 Probe Info  		18.75  LDD0478  [21]
FFF probe2
 Probe Info  		6.59  LDD0463  [21]
FFF probe3
 Probe Info  		13.90  LDD0464  [21]
FFF probe4
 Probe Info  		20.00  LDD0466  [21]
JN0003
 Probe Info  		20.00  LDD0469  [21]
A-DA
 Probe Info  		4.98  LDD0330  [22]
AEA-DA
 Probe Info  		11.68  LDD0333  [22]
BD-F
 Probe Info  		S122(0.00); G120(0.00); D119(0.00)  LDD0024  [23]
Photonaproxen
 Probe Info  		Y84(0.00); F80(0.00)  LDD0157  [24]
OEA-DA
 Probe Info  		20.00  LDD0046  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C100(0.48)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C100(0.67)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C100(0.99); C107(0.84)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C107(1.13)  LDD2152  [4]
 LDCM0214  AC1 HCT 116 C229(0.61); C239(0.61); C100(0.67)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C229(0.57); C239(0.57); C100(0.61)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C229(2.01); C239(2.01); C100(0.96); C107(1.00)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C229(0.65); C239(0.65); C100(0.91); C107(0.77)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C229(0.68); C239(0.68); C100(0.97); C107(0.85)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C229(0.55); C239(0.55); C100(0.86); C107(0.58)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C229(0.67); C239(0.67); C100(1.03); C107(0.91)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C229(0.58); C239(0.58); C100(0.93); C107(0.58)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C229(0.54); C239(0.54); C100(1.05); C107(0.51)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C229(0.58); C239(0.56); C100(0.95); C107(0.54)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C229(0.59); C239(0.62); C100(0.94); C107(0.56)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C229(0.73); C239(0.77); C100(1.01); C107(0.83)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C229(0.57); C239(0.57); C100(0.60)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C229(0.67); C239(0.67); C100(0.92); C107(0.72)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C229(0.62); C239(0.62); C100(0.71); C107(0.58)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C229(0.47); C239(0.47); C100(0.83); C107(0.77)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C229(1.11); C239(1.11); C100(1.39); C107(1.03)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C229(0.87); C239(0.87); C100(0.87); C107(0.71)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C229(0.66); C239(0.68); C100(0.91); C107(0.61)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C229(0.59); C239(0.60); C100(0.90); C107(0.64)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C229(0.84); C239(0.80); C100(1.35); C107(0.88)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C229(0.74); C239(0.71); C100(1.05); C107(0.79)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C229(0.66); C239(0.70); C100(1.01); C107(0.85)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C229(0.86); C239(0.86); C100(0.94)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C229(0.85); C239(0.83); C100(1.11); C107(1.35)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C229(0.93); C239(0.89); C100(1.43); C107(1.07)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C229(0.63); C239(0.67); C100(0.90); C107(0.57)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C229(1.04); C239(0.93); C100(1.71); C107(0.98)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C229(1.01); C239(0.98); C100(1.02); C107(1.08)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C229(0.77); C239(0.81); C100(0.90); C107(0.77)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C229(0.86); C239(0.85); C100(0.81); C107(0.54)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C229(0.84); C239(0.82); C100(0.94); C107(0.59)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C229(1.42); C239(1.42); C100(1.60); C107(0.48)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C229(1.72); C239(1.72); C100(1.32); C107(0.78)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C229(0.89); C239(0.89); C100(1.21); C107(0.47)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C229(1.78); C239(1.78); C100(1.18); C107(0.82)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C229(0.87); C239(0.87); C100(0.99); C107(0.98)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C229(0.87); C239(0.87); C100(1.18); C107(0.64)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C229(0.93); C239(0.93); C100(0.79); C107(0.52)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C229(0.73); C239(0.73); C100(0.89); C107(0.55)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C229(0.82); C239(0.82); C100(0.86); C107(0.99)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C229(0.83); C239(0.83); C100(0.90); C107(0.94)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C229(0.53); C239(0.53); C100(0.45); C107(0.68)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C229(0.82); C239(0.82); C100(0.58); C107(0.58)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C229(0.97); C239(0.97); C100(0.63)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C229(0.70); C239(0.70); C100(0.48); C107(0.60)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C229(0.63); C239(0.63); C100(0.45); C107(0.65)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C229(0.60); C239(0.60); C100(0.88); C107(0.76)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C229(0.82); C239(0.82); C107(0.88)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C107(0.44); C229(0.62); C239(0.62)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C229(0.83); C239(0.83); C107(0.96)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C107(0.35); C229(0.48); C239(0.48)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C107(0.42); C229(0.61); C239(0.61)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C107(0.28); C229(0.50); C239(0.50)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C107(0.31); C229(0.47); C239(0.47)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C100(0.66); C229(0.85); C239(0.85)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C229(0.71); C239(0.71); C107(0.85)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C229(0.81); C239(0.81); C107(1.11)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C229(0.54); C239(0.54); C107(0.55)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C107(0.17); C229(0.37); C239(0.37)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C229(0.72); C239(0.72); C107(0.53)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C229(0.78); C239(0.78); C107(0.57)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C229(1.08); C239(1.08); C107(0.92)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C229(1.14); C239(1.14); C107(0.79)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C100(1.08); C239(1.47); C229(1.48)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C100(0.63); C229(0.71); C239(0.75)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C100(1.14); C229(1.64); C239(1.68)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C229(0.66); C239(0.66); C100(0.81)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C100(0.87); C239(1.46); C229(1.47)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C100(0.94); C229(1.18); C239(1.20)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C100(1.20); C239(1.28); C229(1.29)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C100(1.01); C229(1.41); C239(1.45)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C100(1.14); C229(2.01); C239(2.01)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C107(0.60); C229(0.87); C239(0.87); C100(0.99)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C229(0.65); C239(0.65); C100(0.77); C107(0.82)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C229(0.69); C239(0.69); C100(0.76); C107(0.83)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C229(0.65); C239(0.65); C100(0.72); C107(0.78)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C229(0.60); C239(0.60); C100(0.64); C107(0.94)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C229(0.65); C239(0.65); C100(0.75)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C229(0.60); C239(0.60); C100(0.63); C107(0.78)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C229(0.60); C239(0.60); C107(0.68); C100(0.69)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C229(0.39); C239(0.39); C100(0.50); C107(0.58)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C107(0.56); C229(0.57); C239(0.57); C100(0.63)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C100(0.59); C107(0.62); C229(0.65); C239(0.65)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C107(1.07); C100(1.30); C229(1.35); C239(1.35)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C100(1.08); C229(1.08); C239(1.08); C107(1.12)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C229(0.97); C239(0.97); C100(1.31); C107(1.42)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C107(0.96); C100(1.04); C229(1.31); C239(1.31)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C229(0.72); C239(0.72); C100(0.93); C107(1.12)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C229(0.58); C239(0.58); C100(0.68)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C229(0.81); C239(0.81); C100(1.03); C107(1.10)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C229(0.78); C239(0.78); C107(1.00); C100(1.14)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C229(0.76); C239(0.76); C107(0.77); C100(1.05)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C107(0.51); C229(0.59); C239(0.59); C100(0.86)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C229(0.76); C239(0.76); C107(1.01); C100(1.24)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C229(0.57); C239(0.57); C107(0.98); C100(1.12)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C229(0.82); C239(0.84); C107(1.00); C100(1.28)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C229(0.76); C239(0.81); C100(0.87); C107(1.06)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C229(0.45); C239(0.49); C100(0.76); C107(0.90)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C229(0.58); C239(0.61); C100(0.74); C107(0.94)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C229(0.49); C239(0.49); C100(0.66)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C100(0.73); C229(0.73); C239(0.76); C107(0.97)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C107(0.93); C229(0.94); C239(0.96); C100(1.28)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C229(0.74); C239(0.78); C100(0.79); C107(1.00)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C229(0.76); C239(0.81); C100(0.88); C107(0.94)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C229(0.72); C239(0.76); C107(0.98); C100(0.99)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C229(0.64); C239(0.68); C100(0.71); C107(0.96)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C229(0.40); C239(0.43); C100(0.48); C107(0.75)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C100(0.71); C107(0.71); C229(0.74); C239(0.74)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C107(0.52); C229(0.71); C239(0.71); C100(0.73)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C100(0.60); C229(0.68); C239(0.68); C107(0.78)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C229(0.62); C239(0.62); C100(0.65)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C100(0.47); C229(0.57); C239(0.57); C107(0.65)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C229(0.48); C239(0.48); C107(0.56); C100(0.59)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C107(0.44); C100(0.52); C229(0.65); C239(0.65)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C100(0.53); C107(0.63); C229(0.75); C239(0.75)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C107(0.51); C100(0.56); C229(0.62); C239(0.62)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C229(0.53); C239(0.53); C100(0.64); C107(0.69)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C107(0.54); C100(0.62); C229(0.64); C239(0.64)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C107(0.28); C100(0.38); C229(0.38); C239(0.38)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C229(0.48); C239(0.48); C100(0.71); C107(0.84)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C100(0.43); C229(0.51); C239(0.51); C107(0.71)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C229(0.71); C239(0.71); C100(0.80)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C229(0.39); C239(0.39); C100(0.53); C107(0.67)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C229(0.74); C239(0.74); C100(0.75); C107(0.90)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C100(0.67); C229(0.69); C239(0.69); C107(0.80)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C100(0.38); C229(0.39); C239(0.39); C107(0.58)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C100(0.25); C229(0.47); C239(0.47); C107(0.71)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C100(0.30); C229(0.32); C239(0.32); C107(0.67)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C100(0.63); C229(0.66); C239(0.66); C107(0.90)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C229(0.52); C239(0.52); C100(0.56); C107(0.79)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C100(0.52); C229(0.61); C239(0.61); C107(0.85)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C229(0.57); C239(0.57); C100(0.74); C107(0.87)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C229(0.68); C239(0.68); C100(0.74)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C100(0.69); C107(0.84); C229(0.84); C239(0.84)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C229(0.63); C239(0.63); C100(0.76); C107(0.86)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C100(0.17); C229(0.43); C239(0.43); C107(0.55)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C107(0.36); C229(0.47); C239(0.47); C100(0.55)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C229(0.44); C239(0.44); C107(0.51); C100(0.59)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C229(0.50); C239(0.50); C100(0.64); C107(0.73)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C107(0.78); C229(0.80); C239(0.80); C100(0.89)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C229(0.99); C239(0.99); C100(1.02); C107(1.07)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C100(0.82); C229(0.97); C239(0.97); C107(1.18)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C107(0.53); C100(0.69); C229(0.76); C239(0.76)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C107(1.07); C100(1.51); C229(1.69); C239(1.69)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C107(0.46); C229(0.64); C239(0.64); C100(0.67)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C107(0.51); C100(0.68); C229(0.71); C239(0.71)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C100(0.83); C229(0.93); C239(0.93); C107(1.05)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C229(0.86); C239(0.86); C100(0.88); C107(0.95)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C107(0.60); C100(0.69); C229(0.88); C239(0.88)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C107(0.46); C100(0.70); C229(0.78); C239(0.78)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C100(0.61); C229(0.73); C239(0.73); C107(0.74)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C229(0.24); C239(0.24); C107(0.34); C100(0.73)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C229(0.70); C239(0.70); C100(0.85); C107(0.87)  LDD0683  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C107(0.92)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C229(0.73); C239(0.73); C100(0.94)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C229(0.59); C239(0.59); C100(0.74)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C100(0.35); C229(0.63); C239(0.63)  LDD0592  [9]
 LDCM0020  ARS-1620 HCC44 C100(1.01); C107(0.71)  LDD2171  [9]
 LDCM0108  Chloroacetamide HeLa C100(0.00); C107(0.00); H227(0.00)  LDD0222  [17]
 LDCM0071  Cisar_cp14 MDA-MB-231 4.93  LDD0121  [5]
 LDCM0367  CL1 HCT 116 C100(0.97); C229(1.32); C239(1.32)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C229(0.36); C239(0.36); C100(0.66)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C229(0.55); C239(0.55); C100(0.70)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C100(0.60); C229(1.32); C239(1.32)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C100(0.84); C229(1.89); C239(1.89)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C100(0.84); C229(1.29); C239(1.29)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C100(0.77); C229(1.37); C239(1.37)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C229(0.77); C100(0.77); C239(0.79)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C100(0.34); C229(0.50); C239(0.56)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C229(0.64); C239(0.66); C100(0.67)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C100(0.62); C229(0.67); C239(0.68)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C100(0.63); C229(0.97); C239(1.00)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C229(0.49); C239(0.49); C100(0.69)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C100(0.54); C229(0.76); C239(0.77)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C100(0.78); C229(1.14); C239(1.14)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C107(0.72); C229(0.77); C239(0.77); C100(0.88)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C100(0.55); C229(0.57); C239(0.57); C107(0.58)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C100(0.55); C229(0.67); C239(0.67); C107(0.71)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C100(0.64); C229(0.67); C239(0.67); C107(0.73)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C229(0.54); C239(0.54); C100(0.69); C107(0.74)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C107(0.65); C100(0.67); C229(0.82); C239(0.82)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C107(0.75); C229(0.75); C239(0.75); C100(1.02)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C107(0.71); C229(0.79); C239(0.79); C100(0.96)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C229(0.50); C239(0.50); C100(0.79)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C107(0.66); C229(0.76); C239(0.76); C100(1.10)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C239(0.72); C100(0.75); C229(0.83); C107(0.98)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C229(0.51); C239(0.56); C100(0.75); C107(1.05)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C229(0.73); C239(0.78); C107(0.88); C100(0.97)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C229(0.53); C239(0.61); C100(0.93); C107(0.98)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C100(0.85); C229(0.90); C239(0.90); C107(1.22)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C229(0.73); C239(0.73); C100(0.77); C107(0.87)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C100(0.68); C229(0.84); C239(0.84); C107(0.96)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C229(0.74); C239(0.74); C107(0.77); C100(0.90)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C229(0.50); C239(0.50); C100(0.68)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C229(0.77); C239(0.77); C100(0.91)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C100(0.65); C229(0.92); C239(0.92)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C100(0.62); C229(0.73); C239(0.73); C107(0.86)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C100(0.72); C229(0.72); C239(0.72); C107(0.73)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C107(0.47); C229(0.55); C239(0.55); C100(0.62)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C107(0.58); C229(0.60); C239(0.60); C100(0.67)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C100(1.14); C229(1.26); C239(1.26)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C107(0.56); C229(0.65); C239(0.65); C100(0.69)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C107(0.40); C229(0.60); C239(0.60); C100(0.63)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C107(0.34); C229(0.48); C239(0.48); C100(0.58)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C100(0.69); C229(0.79); C239(0.79); C107(0.83)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C229(0.56); C239(0.56); C100(0.59); C107(0.63)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C229(0.52); C239(0.52); C100(0.59); C107(0.56)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C229(0.64); C239(0.64); C100(0.54); C107(0.73)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C229(0.61); C239(0.61); C100(0.70); C107(0.64)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C229(0.53); C239(0.53); C100(0.55); C107(0.57)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C229(0.54); C239(0.54); C100(0.70); C107(0.47)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C229(0.96); C239(0.96); C100(1.00)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C229(0.75); C239(0.75); C100(0.74); C107(0.78)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C229(0.88); C239(0.88); C107(0.70)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C229(0.50); C239(0.50); C107(0.50)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C229(0.58); C239(0.58); C107(0.51)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C229(0.47); C239(0.47); C107(0.39)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C229(0.69); C239(0.69); C107(0.52)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C229(0.89); C239(0.89); C107(0.52)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C229(0.67); C239(0.67); C107(0.38)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C229(0.65); C239(0.65); C107(0.62)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C229(0.99); C239(0.99); C100(0.94)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C229(0.72); C239(0.72); C107(0.54)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C229(0.82); C239(0.82); C107(0.56)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C229(0.56); C239(0.56); C107(0.35)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C229(0.64); C239(0.64); C107(0.47)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C229(0.55); C239(0.55); C107(0.43)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C229(0.43); C239(0.43); C107(0.31)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C229(3.33); C239(3.33); C100(1.11)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C229(2.78); C239(2.78); C100(1.40)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C229(4.45); C239(4.45); C100(1.00)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C229(3.89); C239(3.89); C100(1.11)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C229(1.19); C239(1.19); C100(1.04)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C229(2.57); C239(2.57); C100(1.33)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C229(2.73); C239(2.73); C100(0.99)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C229(2.03); C239(2.03); C100(1.00)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C229(4.28); C239(4.28); C100(0.99)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C229(3.97); C239(3.97); C100(1.28)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C229(4.57); C239(4.57); C100(0.91)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C229(1.46); C239(1.46); C100(1.02)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C229(2.42); C239(2.42); C100(1.03)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C229(3.19); C239(3.19); C100(1.06)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C229(2.10); C239(2.10); C100(1.28)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C229(0.70); C239(0.70); C100(0.76)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C229(2.56); C239(2.56); C100(0.88)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C229(0.79); C239(0.79); C100(0.97); C107(0.81)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C229(0.82); C239(0.82); C100(0.89); C107(0.80)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C229(0.65); C239(0.65); C100(0.59); C107(0.69)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C229(0.64); C239(0.64); C100(0.47); C107(0.61)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C229(0.83); C239(0.83); C100(0.75); C107(0.86)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C229(0.47); C239(0.47); C100(0.45); C107(0.57)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C229(0.72); C239(0.72); C100(0.53); C107(0.81)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C229(0.53); C239(0.53); C100(0.46); C107(0.87)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C229(0.58); C239(0.58); C100(0.75); C107(0.60)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C229(0.50); C239(0.50); C100(0.87)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C229(0.54); C239(0.54); C100(0.56); C107(0.67)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C229(0.57); C239(0.57); C100(0.57); C107(0.67)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C229(0.61); C239(0.61); C100(0.95); C107(0.83)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C229(0.73); C239(0.73); C100(0.77); C107(0.77)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C229(0.69); C239(0.69); C100(0.67); C107(0.78)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C229(0.73); C239(0.73); C107(0.83)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C229(0.94); C239(0.94); C107(0.74)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C229(0.74); C239(0.74); C107(0.95)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C229(0.81); C239(0.81); C107(0.86)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C229(0.61); C239(0.61); C100(0.74)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C229(0.74); C239(0.74); C107(0.73)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C229(0.91); C239(0.91); C107(1.01)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C229(0.70); C239(0.70); C107(0.84)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C229(0.64); C239(0.64); C107(0.81)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C229(0.56); C239(0.56); C107(0.75)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C229(0.83); C239(0.83); C107(1.01)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C229(1.02); C239(1.02); C107(1.04)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C229(0.85); C239(0.85); C107(1.13)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C229(0.70); C239(0.70); C107(0.85)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C229(0.49); C239(0.49); C107(0.56)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C229(0.72); C239(0.72); C100(0.81)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C229(1.31); C239(1.31); C107(1.03)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C229(0.76); C239(0.76); C100(0.77)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C229(0.92); C239(0.92); C100(0.79)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C229(1.06); C239(1.06); C100(0.72)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C229(0.90); C239(0.90); C100(0.70)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C229(0.79); C239(0.79); C100(0.76)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C229(0.67); C239(0.67); C100(0.75)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C229(0.65); C239(0.65); C100(0.62)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C229(0.51); C239(0.51); C100(0.64)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C229(0.59); C239(0.59); C100(0.67)  LDD0811  [9]
 LDCM0185  Compound 17 HEK-293T 13.09  LDD0504  [21]
 LDCM0191  Compound 21 HEK-293T 4.05  LDD0493  [21]
 LDCM0187  Compound 32 HEK-293T 17.84  LDD0507  [21]
 LDCM0188  Compound 33 HEK-293T 4.98  LDD0505  [21]
 LDCM0190  Compound 34 HEK-293T 4.66  LDD0497  [21]
 LDCM0192  Compound 35 HEK-293T 4.32  LDD0509  [21]
 LDCM0193  Compound 36 HEK-293T 3.12  LDD0494  [21]
 LDCM0194  Compound 37 HEK-293T 5.52  LDD0498  [21]
 LDCM0195  Compound 38 HEK-293T 3.78  LDD0499  [21]
 LDCM0197  Compound 40 HEK-293T 4.33  LDD0495  [21]
 LDCM0495  E2913 HEK-293T C239(0.97); C229(0.90); C239(0.90)  LDD1698  [25]
 LDCM0468  Fragment33 HCT 116 C229(0.54); C239(0.54); C100(0.88); C107(0.89)  LDD0785  [9]
 LDCM0427  Fragment51 HCT 116 C229(0.66); C239(0.66); C107(0.39)  LDD0744  [9]
 LDCM0116  HHS-0101 DM93 Y87(0.92); Y84(1.02); Y215(2.16)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y84(1.16); Y87(1.51); Y215(5.94)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y87(0.65); Y84(0.66); Y215(1.97)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y84(1.12); Y87(1.79); Y215(4.63)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y84(2.13); Y87(2.67); Y215(14.77)  LDD0268  [7]
 LDCM0107  IAA HeLa C100(0.00); H227(0.00); C107(0.00)  LDD0221  [17]
 LDCM0123  JWB131 DM93 Y215(1.13); Y84(1.09); Y87(1.17)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y215(1.20); Y84(1.00); Y87(0.52)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y215(1.28); Y84(2.60); Y87(1.30)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y215(1.57); Y84(2.18); Y87(2.46)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y215(1.87); Y84(2.57); Y87(3.19)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y215(1.74); Y84(1.01); Y87(1.15)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y84(11.46); Y87(1.25)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y215(2.47); Y84(3.65); Y87(4.58)  LDD0292  [6]
 LDCM0022  KB02 HEK-293T C239(1.02); C100(0.96); C229(0.92); C239(0.92)  LDD1492  [25]
 LDCM0023  KB03 HEK-293T C239(1.06); C100(1.02); C229(1.00); C239(1.00)  LDD1497  [25]
 LDCM0024  KB05 G361 C100(1.61); C107(1.64)  LDD3311  [26]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C100(1.09); C107(1.28)  LDD2093  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C100(1.42); C107(1.16)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C100(0.33)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C107(1.22)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C100(0.47)  LDD2104  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C100(0.44)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C107(0.75)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C100(0.46)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C100(0.69); C107(0.56)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C107(1.07)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C100(0.47); C107(0.53)  LDD2115  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C100(1.01); C107(1.62)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C107(0.94)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C107(0.73)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C100(1.33); C107(0.95)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C100(1.34); C107(1.12)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C107(0.47)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C100(1.47); C107(1.03)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C107(0.96)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C100(0.96); C107(0.97)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C107(4.73)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C100(0.95); C107(0.96)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C100(0.50)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C107(1.41)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C100(0.05); C107(0.11)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C100(0.93); C107(0.95)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C100(0.45); C107(0.47)  LDD2148  [4]
 LDCM0136  SR-4559 HEK-293T 4.98  LDD0330  [22]
 LDCM0021  THZ1 HCT 116 C100(1.01); C107(0.71)  LDD2173  [9]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
23 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
24 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840