Details of the Probe

General Information of Probe

Probe ID
LDPC0605
Probe Name
C386
Synonyms
Z4282860593
Probe Type
PAL-AfBPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 323.4
Lipid-water partition coefficient (xlogp) 3.2
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C17H23F2N3O
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-1-(7,7-difluoro-2,3,4,4a,5,6,8,8a-octahydroquinolin-1-yl)propan-1-one
Canonical SMILES
C#CCCC1(N=N1)CCC(=O)N2CCCC3C2CC(CC3)(F)F
InChI
InChI=1S/C17H23F2N3O/c1-2-3-8-17(20-21-17)10-7-15(23)22-11-4-5-13-6-9-16(18,19)12-14(13)22/h1,13-14H,3-12H2
InChIKey
JREPVURJXRGSMS-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

96 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) LDTP06325 7.46  LDD2045 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 10.63  LDD2045 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 8.11  LDD2045 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 17.51  LDD2045 
Acid ceramidase (ASAH1) LDTP05905 25.81  LDD2045 
Acyl-coenzyme A thioesterase 8 (ACOT8) LDTP00415 7.01  LDD2045 
Adenosine deaminase (ADA) LDTP01803 6.96  LDD2045 
ADP-dependent glucokinase (ADPGK) LDTP11127 7.06  LDD2045 
ADP-ribosylation factor-like protein 5B (ARL5B) LDTP15758 6.92  LDD2045 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 7.84  LDD2045 
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) LDTP00186 6.63  LDD2045 
Alpha-galactosidase A (GLA) LDTP02141 7.94  LDD2045 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 6.54  LDD2045 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 11.31  LDD2045 
Beta-1,4-glucuronyltransferase 1 (B4GAT1) LDTP00783 9.06  LDD2045 
Beta-galactosidase (GLB1) LDTP02837 30.48  LDD2045 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 12.21  LDD2045 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 7.41  LDD2045 
Calcyclin-binding protein (CACYBP) LDTP12163 15.45  LDD2045 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 8.34  LDD2045 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 7.11  LDD2045 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 8.34  LDD2045 
Ceramide synthase 1 (CERS1) LDTP03394 8.22  LDD2045 
Ceramide synthase 2 (CERS2) LDTP10329 9.19  LDD2045 
Choline kinase alpha (CHKA) LDTP03787 8.11  LDD2045 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 8.63  LDD2045 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 13.64  LDD2045 
Cytochrome b5 type B (CYB5B) LDTP00697 16.11  LDD2045 
DCN1-like protein 5 (DCUN1D5) LDTP11199 6.96  LDD2045 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 13.00  LDD2045 
Dehydrogenase/reductase SDR family member 1 (DHRS1) LDTP10550 9.65  LDD2045 
Delta(24)-sterol reductase (DHCR24) LDTP06375 15.35  LDD2045 
Dihydrofolate reductase (DHFR) LDTP01769 23.10  LDD2045 
E3 ubiquitin-protein ligase RNF14 (RNF14) LDTP13154 6.77  LDD2045 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 8.82  LDD2045 
Endoplasmic reticulum protein SC65 (P3H4) LDTP09874 11.79  LDD2045 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 9.00  LDD2045 
Epoxide hydrolase 1 (EPHX1) LDTP02175 12.64  LDD2045 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 11.79  LDD2045 
Heme oxygenase 1 (HMOX1) LDTP02359 9.19  LDD2045 
Heme oxygenase 2 (HMOX2) LDTP03540 20.53  LDD2045 
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A) LDTP01018 7.26  LDD2045 
Histone-lysine N-methyltransferase NSD2 (NSD2) LDTP01759 8.11  LDD2045 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 6.73  LDD2045 
Kinesin-like protein KIF11 (KIF11) LDTP04519 7.41  LDD2045 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 13.74  LDD2045 
Lathosterol oxidase (SC5D) LDTP01329 7.21  LDD2045 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 9.51  LDD2045 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 18.13  LDD2045 
Long-chain-fatty-acid--CoA ligase 6 (ACSL6) LDTP13486 7.36  LDD2045 
Lysine-specific histone demethylase 2 (KDM1B) LDTP09043 15.67  LDD2045 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 7.01  LDD2045 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 10.41  LDD2045 
Lysosomal acid phosphatase (ACP2) LDTP02539 7.16  LDD2045 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 15.24  LDD2045 
Lysosomal protective protein (CTSA) LDTP02505 8.75  LDD2045 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 12.55  LDD2045 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 14.22  LDD2045 
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) LDTP01004 6.96  LDD2045 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 31.12  LDD2045 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 14.93  LDD2045 
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) LDTP01168 7.06  LDD2045 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 11.71  LDD2045 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 8.82  LDD2045 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 25.99  LDD2045 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 42.22  LDD2045 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 6.73  LDD2045 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 13.55  LDD2045 
Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) LDTP01562 10.06  LDD2045 
Phospholipase A2 group XV (PLA2G15) LDTP09088 8.46  LDD2045 
Polyamine-transporting ATPase 13A2 (ATP13A2) LDTP12386 9.25  LDD2045 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 41.36  LDD2045 
Prenylcysteine oxidase-like (PCYOX1L) LDTP15480 7.67  LDD2045 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 9.06  LDD2045 
Prolyl 3-hydroxylase 1 (P3H1) LDTP06750 8.57  LDD2045 
Prostaglandin reductase 3 (PTGR3) LDTP15422 7.11  LDD2045 
Proteasome subunit alpha type-6 (PSMA6) LDTP04884 6.77  LDD2045 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 18.51  LDD2045 
Proteasome subunit beta type-6 (PSMB6) LDTP03418 18.00  LDD2045 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 9.92  LDD2045 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 6.92  LDD2045 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 14.12  LDD2045 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 8.11  LDD2045 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 16.34  LDD2045 
Ribonuclease T2 (RNASET2) LDTP00316 7.16  LDD2045 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 30.06  LDD2045 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 8.34  LDD2045 
Serine palmitoyltransferase 1 (SPTLC1) LDTP00597 7.06  LDD2045 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 11.63  LDD2045 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 12.04  LDD2045 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 8.57  LDD2045 
Thimet oligopeptidase (THOP1) LDTP04542 7.16  LDD2045 
TLC domain-containing protein 1 (TLCD1) LDTP10182 9.32  LDD2045 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 9.85  LDD2045 
Ubiquitin thioesterase OTUB1 (OTUB1) LDTP10318 6.77  LDD2045 
Very-long-chain enoyl-CoA reductase (TECR) LDTP12867 9.58  LDD2045 
------------------------------------------------------------------------------------
⏷ Show the Full List of 96 Enzyme
47 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Acetyl-coenzyme A transporter 1 (SLC33A1) LDTP00262 9.99  LDD2045 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 8.94  LDD2045 
ATP synthase subunit a (MT-ATP6) LDTP01804 8.34  LDD2045 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 12.91  LDD2045 
BRI3-binding protein (BRI3BP) LDTP15648 7.62  LDD2045 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 29.86  LDD2045 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 6.82  LDD2045 
Gasdermin-E (GSDME) LDTP00970 12.30  LDD2045 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 6.50  LDD2045 
Importin subunit alpha-5 (KPNA1) LDTP04502 6.50  LDD2045 
Lysosomal cobalamin transport escort protein LMBD1 (LMBRD1) LDTP12636 7.73  LDD2045 
Lysosome membrane protein 2 (SCARB2) LDTP06034 29.24  LDD2045 
Metaxin-1 (MTX1) LDTP05900 11.55  LDD2045 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 7.73  LDD2045 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 8.88  LDD2045 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 45.57  LDD2045 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 44.32  LDD2045 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 14.22  LDD2045 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 8.11  LDD2045 
Mpv17-like protein 2 (MPV17L2) LDTP14952 11.31  LDD2045 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 9.32  LDD2045 
Nucleoporin NDC1 (NDC1) LDTP11213 7.67  LDD2045 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 17.15  LDD2045 
Prosaposin (PSAP) LDTP02215 10.85  LDD2045 
Protein GPR107 (GPR107) LDTP07236 15.14  LDD2045 
Protein RFT1 homolog (RFT1) LDTP10073 7.46  LDD2045 
Protein tweety homolog 3 (TTYH3) LDTP11615 11.71  LDD2045 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 12.04  LDD2045 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 7.73  LDD2045 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 11.96  LDD2045 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 26.35  LDD2045 
Signal recognition particle subunit SRP68 (SRP68) LDTP13262 13.45  LDD2045 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 7.41  LDD2045 
Solute carrier family 25 member 44 (SLC25A44) LDTP15733 13.64  LDD2045 
Solute carrier family 35 member F1 (SLC35F1) LDTP15000 6.92  LDD2045 
Surfeit locus protein 4 (SURF4) LDTP00592 9.25  LDD2045 
Tetraspanin-3 (TSPAN3) LDTP16813 11.63  LDD2045 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 10.27  LDD2045 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 14.62  LDD2045 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 9.58  LDD2045 
Transmembrane protein 126A (TMEM126A) LDTP15948 9.06  LDD2045 
Transmembrane protein 160 (TMEM160) LDTP20002 9.99  LDD2045 
Transmembrane protein 199 (TMEM199) LDTP08881 13.27  LDD2045 
Transmembrane protein 59 (TMEM59) LDTP11406 8.00  LDD2045 
V-type proton ATPase subunit S1 (ATP6AP1) LDTP06499 7.01  LDD2045 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 37.01  LDD2045 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 28.64  LDD2045 
------------------------------------------------------------------------------------
⏷ Show the Full List of 47 Transporter and channel
1 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Membrane progestin receptor alpha (PAQR7) LDTP15303 6.96  LDD2045 
------------------------------------------------------------------------------------
2 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
HLA class I histocompatibility antigen, alpha chain F (HLA-F) LDTP03538 17.39  LDD2045 
IgG receptor FcRn large subunit p51 (FCGRT) LDTP04720 6.77  LDD2045 
------------------------------------------------------------------------------------
63 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 10.63  LDD2045 
Apolipoprotein L2 (APOL2) LDTP11076 21.56  LDD2045 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 10.41  LDD2045 
cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) LDTP02511 7.21  LDD2045 
Capping protein-inhibiting regulator of actin dynamics (CRACD) LDTP07839 9.25  LDD2045 
Centrosomal protein 43 (CEP43) LDTP01652 9.58  LDD2045 
Cerebellar degeneration-related protein 2-like (CDR2L) LDTP08346 6.68  LDD2045 
Clustered mitochondria protein homolog (CLUH) LDTP14486 12.30  LDD2045 
CYFIP-related Rac1 interactor B (CYRIB) LDTP12642 14.42  LDD2045 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 13.18  LDD2045 
DENN domain-containing protein 11 (DENND11) LDTP16577 7.62  LDD2045 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 8.06  LDD2045 
Dynactin subunit 3 (DCTN3) LDTP01359 6.54  LDD2045 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 7.73  LDD2045 
Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) LDTP10775 8.17  LDD2045 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 18.25  LDD2045 
Eukaryotic translation initiation factor 3 subunit L (EIF3L) LDTP13813 10.34  LDD2045 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 10.41  LDD2045 
Galectin-3-binding protein (LGALS3BP) LDTP05558 7.31  LDD2045 
Ganglioside GM2 activator (GM2A) LDTP02927 7.16  LDD2045 
Golgi apparatus protein 1 (GLG1) LDTP09920 6.68  LDD2045 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 11.79  LDD2045 
HAUS augmin-like complex subunit 1 (HAUS1) LDTP10184 7.41  LDD2045 
HAUS augmin-like complex subunit 5 (HAUS5) LDTP01466 8.69  LDD2045 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 6.59  LDD2045 
Large proline-rich protein BAG6 (BAG6) LDTP04094 12.21  LDD2045 
LYR motif-containing protein 2 (LYRM2) LDTP18467 8.22  LDD2045 
MAGUK p55 subfamily member 2 (MPP2) LDTP06068 6.68  LDD2045 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 7.16  LDD2045 
Membralin (TMEM259) LDTP14939 14.42  LDD2045 
MICOS complex subunit MIC19 (CHCHD3) LDTP12764 6.73  LDD2045 
Microtubule nucleation factor SSNA1 (SSNA1) LDTP00871 8.17  LDD2045 
Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9) LDTP14126 6.82  LDD2045 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 24.25  LDD2045 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 7.57  LDD2045 
Neudesin (NENF) LDTP13630 11.31  LDD2045 
Neuferricin (CYB5D2) LDTP15623 8.94  LDD2045 
Nucleobindin-1 (NUCB1) LDTP05375 13.45  LDD2045 
Nucleobindin-2 (NUCB2) LDTP05160 36.50  LDD2045 
Nucleosome assembly protein 1-like 1 (NAP1L1) LDTP04684 19.84  LDD2045 
Nucleosome assembly protein 1-like 4 (NAP1L4) LDTP10965 15.56  LDD2045 
Nurim (NRM) LDTP08606 6.54  LDD2045 
Optic atrophy 3 protein (OPA3) LDTP16006 12.82  LDD2045 
p53 and DNA damage-regulated protein 1 (PDRG1) LDTP16099 83.29  LDD2045 
Phosducin-like protein 3 (PDCL3) LDTP11825 9.38  LDD2045 
Protein CEBPZOS (CEBPZOS) LDTP18883 9.78  LDD2045 
Protein CutA (CUTA) LDTP01075 7.21  LDD2045 
Protein FAM114A2 (FAM114A2) LDTP16080 9.00  LDD2045 
Protein FAM162A (FAM162A) LDTP10056 7.06  LDD2045 
Reticulocalbin-2 (RCN2) LDTP06097 7.16  LDD2045 
Reticulon-3 (RTN3) LDTP01522 9.85  LDD2045 
RNA-binding protein FXR1 (FXR1) LDTP04395 7.84  LDD2045 
SHC SH2 domain-binding protein 1 (SHCBP1) LDTP17808 8.06  LDD2045 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 8.11  LDD2045 
Syntaxin-18 (STX18) LDTP13086 7.46  LDD2045 
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) LDTP14263 15.56  LDD2045 
Tetraspanin-6 (TSPAN6) LDTP14458 13.55  LDD2045 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 6.82  LDD2045 
Thioredoxin domain-containing protein 15 (TXNDC15) LDTP10442 8.22  LDD2045 
TraB domain-containing protein (TRABD) LDTP19963 6.82  LDD2045 
Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) LDTP15634 33.59  LDD2045 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 31.78  LDD2045 
Vacuolar protein sorting-associated protein 26C (VPS26C) LDTP00494 8.57  LDD2045 
------------------------------------------------------------------------------------
⏷ Show the Full List of 63 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD2045 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587