Details of the Target

General Information of Target

Target ID LDTP10775
Target Name Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2)
Gene Name ERGIC2
Gene ID 51290
Synonyms
ERV41; PTX1; Endoplasmic reticulum-Golgi intermediate compartment protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLLGAAAVAALGRGRAPASLGWQRKQVNWKACRWSSSGVIPNEKIRNIGISAHIDSGKT
TLTERVLYYTGRIAKMHEVKGKDGVGAVMDSMELERQRGITIQSAATYTMWKDVNINIID
TPGHVDFTIEVERALRVLDGAVLVLCAVGGVQCQTMTVNRQMKRYNVPFLTFINKLDRMG
SNPARALQQMRSKLNHNAAFMQIPMGLEGNFKGIVDLIEERAIYFDGDFGQIVRYGEIPA
ELRAAATDHRQELIECVANSDEQLGEMFLEEKIPSISDLKLAIRRATLKRSFTPVFLGSA
LKNKGVQPLLDAVLEYLPNPSEVQNYAILNKEDDSKEKTKILMNSSRDNSHPFVGLAFKL
EVGRFGQLTYVRSYQGELKKGDTIYNTRTRKKVRLQRLARMHADMMEDVEEVYAGDICAL
FGIDCASGDTFTDKANSGLSMESIHVPDPVISIAMKPSNKNDLEKFSKGIGRFTREDPTF
KVYFDTENKETVISGMGELHLEIYAQRLEREYGCPCITGKPKVAFRETITAPVPFDFTHK
KQSGGAGQYGKVIGVLEPLDPEDYTKLEFSDETFGSNIPKQFVPAVEKGFLDACEKGPLS
GHKLSGLRFVLQDGAHHMVDSNEISFIRAGEGALKQALANATLCILEPIMAVEVVAPNEF
QGQVIAGINRRHGVITGQDGVEDYFTLYADVPLNDMFGYSTELRSCTEGKGEYTMEYSRY
QPCLPSTQEDVINKYLEATGQLPVKKGKAKN
Target Bioclass
Other
Family
ERGIC family
Subcellular location
Endoplasmic reticulum-Golgi intermediate compartment membrane
Function Possible role in transport between endoplasmic reticulum and Golgi.
Uniprot ID
Q96RQ1
Ensemble ID
ENST00000360150.9
HGNC ID
HGNC:30208

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
m-APA
 Probe Info  		11.44  LDD0403  [2]
DBIA
 Probe Info  		C344(0.81); C345(0.81)  LDD1095  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]
PAL-AfBPP Probe
Click To Hide/Show 50 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		8.34  LDD1725  [7]
C040
 Probe Info  		11.55  LDD1740  [7]
C041
 Probe Info  		6.23  LDD1741  [7]
C055
 Probe Info  		99.73  LDD1752  [7]
C056
 Probe Info  		28.64  LDD1753  [7]
C091
 Probe Info  		35.75  LDD1782  [7]
C092
 Probe Info  		75.58  LDD1783  [7]
C094
 Probe Info  		99.73  LDD1785  [7]
C095
 Probe Info  		5.58  LDD1786  [7]
C100
 Probe Info  		6.77  LDD1789  [7]
C106
 Probe Info  		22.01  LDD1793  [7]
C107
 Probe Info  		11.79  LDD1794  [7]
C108
 Probe Info  		8.82  LDD1795  [7]
C112
 Probe Info  		22.78  LDD1799  [7]
C134
 Probe Info  		33.59  LDD1816  [7]
C143
 Probe Info  		15.89  LDD1825  [7]
C163
 Probe Info  		5.82  LDD1843  [7]
C166
 Probe Info  		7.78  LDD1846  [7]
C210
 Probe Info  		45.57  LDD1884  [7]
C213
 Probe Info  		17.39  LDD1887  [7]
C218
 Probe Info  		14.32  LDD1892  [7]
C219
 Probe Info  		6.87  LDD1893  [7]
C231
 Probe Info  		14.42  LDD1904  [7]
C233
 Probe Info  		22.78  LDD1906  [7]
C234
 Probe Info  		10.20  LDD1907  [7]
C235
 Probe Info  		17.03  LDD1908  [7]
C238
 Probe Info  		20.11  LDD1911  [7]
C243
 Probe Info  		14.83  LDD1916  [7]
C244
 Probe Info  		17.15  LDD1917  [7]
C246
 Probe Info  		19.70  LDD1919  [7]
C285
 Probe Info  		22.78  LDD1955  [7]
C288
 Probe Info  		8.00  LDD1958  [7]
C289
 Probe Info  		52.71  LDD1959  [7]
C290
 Probe Info  		6.02  LDD1960  [7]
C293
 Probe Info  		20.11  LDD1963  [7]
C296
 Probe Info  		11.55  LDD1966  [7]
C343
 Probe Info  		18.38  LDD2005  [7]
C349
 Probe Info  		13.00  LDD2010  [7]
C350
 Probe Info  		35.26  LDD2011  [7]
C353
 Probe Info  		6.59  LDD2014  [7]
C354
 Probe Info  		7.06  LDD2015  [7]
C362
 Probe Info  		35.51  LDD2023  [7]
C364
 Probe Info  		16.00  LDD2025  [7]
C366
 Probe Info  		7.36  LDD2027  [7]
C367
 Probe Info  		6.11  LDD2028  [7]
C386
 Probe Info  		8.17  LDD2045  [7]
C388
 Probe Info  		63.56  LDD2047  [7]
C403
 Probe Info  		20.25  LDD2061  [7]
VE-P
 Probe Info  		N.A.  LDD0396  [8]
OEA-DA
 Probe Info  		20.00  LDD0046  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 PaTu 8988t C344(0.81); C345(0.81)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C344(0.83); C345(0.83)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C344(0.79); C345(0.79)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C344(0.92); C345(0.92)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C344(0.78); C345(0.78)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C344(0.67); C345(0.67)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C344(1.01); C345(1.01)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C344(0.91); C345(0.91)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C344(1.20); C345(1.20)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C344(0.86); C345(0.86)  LDD1104  [3]
 LDCM0227  AC110 PaTu 8988t C344(0.83); C345(0.83)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C344(0.72); C345(0.72)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C344(0.77); C345(0.77)  LDD1108  [3]
 LDCM0230  AC113 PaTu 8988t C344(1.20); C345(1.20)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C344(1.48); C345(1.48)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C344(1.64); C345(1.64)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C344(0.99); C345(0.99)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C344(1.63); C345(1.63)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C344(1.17); C345(1.17)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C344(1.24); C345(1.24)  LDD1115  [3]
 LDCM0238  AC120 PaTu 8988t C344(1.20); C345(1.20)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C344(1.84); C345(1.84)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C344(1.16); C345(1.16)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C344(1.16); C345(1.16)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C344(1.32); C345(1.32)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C344(1.10); C345(1.10)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C344(0.90); C345(0.90)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C344(1.09); C345(1.09)  LDD1124  [3]
 LDCM0276  AC17 PaTu 8988t C344(1.07); C345(1.07)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C344(0.93); C345(0.93)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C344(1.01); C345(1.01)  LDD1157  [3]
 LDCM0280  AC20 PaTu 8988t C344(0.95); C345(0.95)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C344(0.91); C345(0.91)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C344(1.11); C345(1.11)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C344(1.12); C345(1.12)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C344(0.97); C345(0.97)  LDD1163  [3]
 LDCM0320  AC57 PaTu 8988t C344(1.19); C345(1.19)  LDD1199  [3]
 LDCM0321  AC58 PaTu 8988t C344(1.39); C345(1.39)  LDD1200  [3]
 LDCM0322  AC59 PaTu 8988t C344(1.19); C345(1.19)  LDD1201  [3]
 LDCM0324  AC60 PaTu 8988t C344(1.43); C345(1.43)  LDD1203  [3]
 LDCM0325  AC61 PaTu 8988t C344(1.35); C345(1.35)  LDD1204  [3]
 LDCM0326  AC62 PaTu 8988t C344(1.44); C345(1.44)  LDD1205  [3]
 LDCM0327  AC63 PaTu 8988t C344(1.23); C345(1.23)  LDD1206  [3]
 LDCM0328  AC64 PaTu 8988t C344(1.60); C345(1.60)  LDD1207  [3]
 LDCM0329  AC65 PaTu 8988t C344(1.01); C345(1.01)  LDD1208  [3]
 LDCM0330  AC66 PaTu 8988t C344(1.11); C345(1.11)  LDD1209  [3]
 LDCM0331  AC67 PaTu 8988t C344(1.52); C345(1.52)  LDD1210  [3]
 LDCM0365  AC98 PaTu 8988t C344(0.71); C345(0.71)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C344(0.92); C345(0.92)  LDD1245  [3]
 LDCM0156  Aniline NCI-H1299 11.44  LDD0403  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0374  CL105 PaTu 8988t C344(0.68); C345(0.68)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C344(0.92); C345(0.92)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C344(0.89); C345(0.89)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C344(0.78); C345(0.78)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C344(0.91); C345(0.91)  LDD1257  [3]
 LDCM0380  CL110 PaTu 8988t C344(1.13); C345(1.13)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C344(1.55); C345(1.55)  LDD1260  [3]
 LDCM0396  CL125 PaTu 8988t C344(1.18); C345(1.18)  LDD1275  [3]
 LDCM0397  CL126 PaTu 8988t C344(1.45); C345(1.45)  LDD1276  [3]
 LDCM0398  CL127 PaTu 8988t C344(1.21); C345(1.21)  LDD1277  [3]
 LDCM0399  CL128 PaTu 8988t C344(1.18); C345(1.18)  LDD1278  [3]
 LDCM0420  CL31 PaTu 8988t C344(0.94); C345(0.94)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C344(0.90); C345(0.90)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C344(1.57); C345(1.57)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C344(0.78); C345(0.78)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C344(0.99); C345(0.99)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C344(1.08); C345(1.08)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C344(0.92); C345(0.92)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C344(1.03); C345(1.03)  LDD1307  [3]
 LDCM0430  CL40 PaTu 8988t C344(0.98); C345(0.98)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C344(1.21); C345(1.21)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C344(0.84); C345(0.84)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C344(1.00); C345(1.00)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C344(0.94); C345(0.94)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C344(0.97); C345(0.97)  LDD1314  [3]
 LDCM0436  CL46 PaTu 8988t C344(0.80); C345(0.80)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C344(0.81); C345(0.81)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C344(0.82); C345(0.82)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C344(0.91); C345(0.91)  LDD1318  [3]
 LDCM0441  CL50 PaTu 8988t C344(0.91); C345(0.91)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C344(1.00); C345(1.00)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C344(0.87); C345(0.87)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C344(0.96); C345(0.96)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C344(0.98); C345(0.98)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C344(0.94); C345(0.94)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C344(0.46); C345(0.46)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C344(1.73); C345(1.73)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C344(1.15); C345(1.15)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C344(1.76); C345(1.76)  LDD1329  [3]
 LDCM0452  CL60 PaTu 8988t C344(1.22); C345(1.22)  LDD1331  [3]
 LDCM0453  CL61 PaTu 8988t C344(1.01); C345(1.01)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C344(0.83); C345(0.83)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C344(0.90); C345(0.90)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C344(1.13); C345(1.13)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C344(0.90); C345(0.90)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C344(0.99); C345(0.99)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C344(1.04); C345(1.04)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C344(1.03); C345(1.03)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C344(1.16); C345(1.16)  LDD1340  [3]
 LDCM0463  CL70 PaTu 8988t C344(0.99); C345(0.99)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C344(0.89); C345(0.89)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C344(0.94); C345(0.94)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C344(1.20); C345(1.20)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C344(0.84); C345(0.84)  LDD1346  [3]
 LDCM0468  Fragment33 PaTu 8988t C344(1.00); C345(1.00)  LDD1347  [3]
 LDCM0427  Fragment51 PaTu 8988t C344(0.88); C345(0.88)  LDD1306  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0109  NEM HeLa N.A.  LDD0224  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
9 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570