Details of the Probe

General Information of Probe

Probe ID
LDPC0520
Probe Name
C290
Synonyms
Z4282859658
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 381.9
Lipid-water partition coefficient (xlogp) 2.4
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C17H20ClN3O3S
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-N-[(3-chloro-5-ethylsulfonylphenyl)methyl]propanamide
Canonical SMILES
CCS(=O)(=O)C1=CC(=CC(=C1)CNC(=O)CCC2(N=N2)CCC#C)Cl
InChI
InChI=1S/C17H20ClN3O3S/c1-3-5-7-17(20-21-17)8-6-16(22)19-12-13-9-14(18)11-15(10-13)25(23,24)4-2/h1,9-11H,4-8,12H2,2H3,(H,19,22)
InChIKey
BGQZTSPVRUSSIW-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

84 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) LDTP06325 4.96  LDD1960 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 25.63  LDD1960 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 10.34  LDD1960 
Adipocyte plasma membrane-associated protein (APMAP) LDTP12293 14.32  LDD1960 
ADP-dependent glucokinase (ADPGK) LDTP11127 5.98  LDD1960 
ADP-ribosylation factor-like protein 10 (ARL10) LDTP19745 8.06  LDD1960 
Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) LDTP04253 5.43  LDD1960 
Antigen peptide transporter 1 (TAP1) LDTP05408 5.66  LDD1960 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 9.78  LDD1960 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 5.70  LDD1960 
Beta-1,4-glucuronyltransferase 1 (B4GAT1) LDTP00783 6.15  LDD1960 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 9.19  LDD1960 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 8.94  LDD1960 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 6.23  LDD1960 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 10.27  LDD1960 
Ceramide synthase 2 (CERS2) LDTP10329 9.06  LDD1960 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 6.92  LDD1960 
Cytochrome b5 type B (CYB5B) LDTP00697 11.08  LDD1960 
DCN1-like protein 4 (DCUN1D4) LDTP09799 10.63  LDD1960 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 11.88  LDD1960 
Delta(24)-sterol reductase (DHCR24) LDTP06375 19.70  LDD1960 
Deoxyhypusine hydroxylase (DOHH) LDTP11225 6.02  LDD1960 
Dihydrofolate reductase (DHFR) LDTP01769 6.11  LDD1960 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 6.11  LDD1960 
Dolichyldiphosphatase 1 (DOLPP1) LDTP15328 6.36  LDD1960 
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) LDTP05369 5.03  LDD1960 
E3 ubiquitin-protein ligase TRIM21 (TRIM21) LDTP03001 5.03  LDD1960 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 6.11  LDD1960 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 13.00  LDD1960 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 6.54  LDD1960 
Epoxide hydrolase 1 (EPHX1) LDTP02175 6.59  LDD1960 
Ethanolamine kinase 1 (ETNK1) LDTP12197 15.67  LDD1960 
Exonuclease 1 (EXO1) LDTP13751 8.40  LDD1960 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 6.77  LDD1960 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 6.82  LDD1960 
Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2) LDTP04032 12.04  LDD1960 
Helicase MOV-10 (MOV10) LDTP12233 7.62  LDD1960 
Heme oxygenase 2 (HMOX2) LDTP03540 7.78  LDD1960 
Histone-lysine N-methyltransferase 2A (KMT2A) LDTP05396 6.02  LDD1960 
Isochorismatase domain-containing protein 1 (ISOC1) LDTP19851 8.51  LDD1960 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 5.98  LDD1960 
Lanosterol synthase (LSS) LDTP04183 7.67  LDD1960 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 8.28  LDD1960 
Long-chain-fatty-acid--CoA ligase 6 (ACSL6) LDTP13486 9.38  LDD1960 
Lysine-specific histone demethylase 2 (KDM1B) LDTP09043 8.11  LDD1960 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 15.03  LDD1960 
Lysophospholipid acyltransferase 5 (LPCAT3) LDTP07504 6.06  LDD1960 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 12.04  LDD1960 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 4.99  LDD1960 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 9.65  LDD1960 
Mitochondrial cardiolipin hydrolase (PLD6) LDTP08790 11.47  LDD1960 
Mitochondrial-processing peptidase subunit alpha (PMPCA) LDTP05632 6.45  LDD1960 
N-alpha-acetyltransferase 35, NatC auxiliary subunit (NAA35) LDTP07259 5.70  LDD1960 
N-alpha-acetyltransferase 40 (NAA40) LDTP08265 5.62  LDD1960 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 13.27  LDD1960 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 10.34  LDD1960 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 21.26  LDD1960 
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) LDTP01168 4.96  LDD1960 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 11.96  LDD1960 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 40.50  LDD1960 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 16.34  LDD1960 
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) LDTP05029 8.11  LDD1960 
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) LDTP06307 8.17  LDD1960 
Phospholipase A2 group XV (PLA2G15) LDTP09088 9.06  LDD1960 
Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) LDTP08859 15.67  LDD1960 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 19.56  LDD1960 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 7.06  LDD1960 
Prolyl endopeptidase-like (PREPL) LDTP06849 8.88  LDD1960 
Prostaglandin reductase 3 (PTGR3) LDTP15422 8.22  LDD1960 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 15.03  LDD1960 
Protein farnesyltransferase subunit beta (FNTB) LDTP04247 5.03  LDD1960 
Protein O-GlcNAcase (OGA) LDTP00988 10.13  LDD1960 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 10.13  LDD1960 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 11.24  LDD1960 
Rab-like protein 3 (RABL3) LDTP06986 5.03  LDD1960 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 7.01  LDD1960 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 14.22  LDD1960 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 5.17  LDD1960 
Thioredoxin domain-containing protein 12 (TXNDC12) LDTP01707 6.15  LDD1960 
TLC domain-containing protein 1 (TLCD1) LDTP10182 5.31  LDD1960 
Translation initiation factor IF-2, mitochondrial (MTIF2) LDTP04093 8.57  LDD1960 
tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) LDTP08687 5.66  LDD1960 
Ubiquitin carboxyl-terminal hydrolase 47 (USP47) LDTP10495 11.71  LDD1960 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 5.66  LDD1960 
------------------------------------------------------------------------------------
⏷ Show the Full List of 84 Enzyme
61 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Acetyl-coenzyme A transporter 1 (SLC33A1) LDTP00262 7.41  LDD1960 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 5.90  LDD1960 
ATP synthase subunit a (MT-ATP6) LDTP01804 21.26  LDD1960 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 12.13  LDD1960 
BRI3-binding protein (BRI3BP) LDTP15648 6.45  LDD1960 
Calcium uptake protein 1, mitochondrial (MICU1) LDTP11041 5.82  LDD1960 
Calcium uptake protein 2, mitochondrial (MICU2) LDTP08673 6.92  LDD1960 
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial (COX16) LDTP16163 9.58  LDD1960 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 5.39  LDD1960 
Derlin-1 (DERL1) LDTP11245 5.28  LDD1960 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 11.08  LDD1960 
Growth hormone-inducible transmembrane protein (GHITM) LDTP11869 5.17  LDD1960 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 5.13  LDD1960 
Lysosomal-associated transmembrane protein 4A (LAPTM4A) LDTP06275 7.57  LDD1960 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 6.82  LDD1960 
Metaxin-1 (MTX1) LDTP05900 11.55  LDD1960 
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) LDTP11095 4.92  LDD1960 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 7.41  LDD1960 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 6.54  LDD1960 
Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) LDTP04956 5.28  LDD1960 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 9.85  LDD1960 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 20.97  LDD1960 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 7.57  LDD1960 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 5.74  LDD1960 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 7.11  LDD1960 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 23.26  LDD1960 
Monocarboxylate transporter 1 (SLC16A1) LDTP04592 7.26  LDD1960 
Mpv17-like protein 2 (MPV17L2) LDTP14952 13.45  LDD1960 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 6.06  LDD1960 
Nucleoporin NDC1 (NDC1) LDTP11213 6.11  LDD1960 
Peroxisomal membrane protein 11A (PEX11A) LDTP01160 6.11  LDD1960 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 5.90  LDD1960 
Protein ARV1 (ARV1) LDTP11812 5.28  LDD1960 
Protein GPR107 (GPR107) LDTP07236 21.11  LDD1960 
Protein GPR108 (GPR108) LDTP12383 8.88  LDD1960 
Protein spinster homolog 1 (SPNS1) LDTP11844 5.24  LDD1960 
Protein YIPF3 (YIPF3) LDTP11626 4.92  LDD1960 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 7.46  LDD1960 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 12.04  LDD1960 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 24.25  LDD1960 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 6.68  LDD1960 
Solute carrier family 25 member 44 (SLC25A44) LDTP15733 11.47  LDD1960 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 8.00  LDD1960 
StAR-related lipid transfer protein 7, mitochondrial (STARD7) LDTP18459 6.41  LDD1960 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 6.06  LDD1960 
Tetraspanin-3 (TSPAN3) LDTP16813 5.06  LDD1960 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 11.47  LDD1960 
Translocator protein (TSPO) LDTP03546 10.20  LDD1960 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 8.11  LDD1960 
Transmembrane 9 superfamily member 2 (TM9SF2) LDTP15845 6.68  LDD1960 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 9.19  LDD1960 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 5.10  LDD1960 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 5.50  LDD1960 
Transmembrane protein 126A (TMEM126A) LDTP15948 14.32  LDD1960 
Transmembrane protein 160 (TMEM160) LDTP20002 15.78  LDD1960 
Transmembrane protein 199 (TMEM199) LDTP08881 8.82  LDD1960 
Transmembrane protein 205 (TMEM205) LDTP07667 5.24  LDD1960 
Transmembrane protein 87A (TMEM87A) LDTP15481 10.63  LDD1960 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 6.77  LDD1960 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 16.34  LDD1960 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 15.03  LDD1960 
------------------------------------------------------------------------------------
⏷ Show the Full List of 61 Transporter and channel
43 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 7.31  LDD1960 
Apolipoprotein L2 (APOL2) LDTP11076 6.73  LDD1960 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 14.12  LDD1960 
Centrosomal protein 43 (CEP43) LDTP01652 5.50  LDD1960 
Clustered mitochondria protein homolog (CLUH) LDTP14486 15.24  LDD1960 
Cobalamin trafficking protein CblD (MMADHC) LDTP11871 6.59  LDD1960 
Dymeclin (DYM) LDTP08000 14.72  LDD1960 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 5.82  LDD1960 
Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) LDTP10775 6.02  LDD1960 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 6.87  LDD1960 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 9.06  LDD1960 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 5.46  LDD1960 
Gem-associated protein 8 (GEMIN8) LDTP12746 7.06  LDD1960 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 6.19  LDD1960 
HAUS augmin-like complex subunit 1 (HAUS1) LDTP10184 11.31  LDD1960 
Hepatoma-derived growth factor (HDGF) LDTP04483 5.94  LDD1960 
Hepatoma-derived growth factor-related protein 2 (HDGFL2) LDTP08081 11.55  LDD1960 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 4.96  LDD1960 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 6.06  LDD1960 
HIG1 domain family member 1A, mitochondrial (HIGD1A) LDTP13797 5.35  LDD1960 
Large proline-rich protein BAG6 (BAG6) LDTP04094 8.51  LDD1960 
Large ribosomal subunit protein mL55 (MRPL55) LDTP15269 9.13  LDD1960 
Lipid droplet assembly factor 1 (LDAF1) LDTP10116 4.99  LDD1960 
Mdm2-binding protein (MTBP) LDTP15714 7.11  LDD1960 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 7.67  LDD1960 
Neuferricin (CYB5D2) LDTP15623 4.92  LDD1960 
Nucleobindin-1 (NUCB1) LDTP05375 8.00  LDD1960 
Nucleobindin-2 (NUCB2) LDTP05160 18.64  LDD1960 
Optic atrophy 3 protein (OPA3) LDTP16006 17.03  LDD1960 
Peroxisomal membrane protein 11C (PEX11G) LDTP10381 16.56  LDD1960 
Protein CutA (CUTA) LDTP01075 7.73  LDD1960 
Protein FAM114A2 (FAM114A2) LDTP16080 7.73  LDD1960 
Protein unc-119 homolog B (UNC119B) LDTP00105 14.93  LDD1960 
Protein YIF1B (YIF1B) LDTP06948 6.19  LDD1960 
Reticulocalbin-2 (RCN2) LDTP06097 5.78  LDD1960 
Reticulon-3 (RTN3) LDTP01522 8.63  LDD1960 
Retinol-binding protein 1 (RBP1) LDTP02345 5.43  LDD1960 
RNA-binding protein with multiple splicing (RBPMS) LDTP09970 5.10  LDD1960 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 5.06  LDD1960 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 5.86  LDD1960 
Tudor and KH domain-containing protein (TDRKH) LDTP13922 4.99  LDD1960 
Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) LDTP15634 8.57  LDD1960 
UPF0449 protein C19orf25 (C19orf25) LDTP13214 8.57  LDD1960 
------------------------------------------------------------------------------------
⏷ Show the Full List of 43 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1960 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587