Details of the Target

General Information of Target

Target ID LDTP16163
Target Name Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial (COX16)
Gene Name COX16
Gene ID 51241
Synonyms
C14orf112; Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial; hCOX16
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASVVLALRTRTAVTSLLSPTPATALAVRYASKKSGGSSKNLGGKSSGRRQGIKKMEGHY
VHAGNIIATQRHFRWHPGAHVGVGKNKCLYALEEGIVRYTKEVYVPHPRNTEAVDLITRL
PKGAVLYKTFVHVVPAKPEGTFKLVAML
Target Bioclass
Transporter and channel
Family
COX16 family
Subcellular location
Mitochondrion inner membrane
Function
Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6. Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines.
Uniprot ID
Q9P0S2
Ensemble ID
ENST00000389912.7
HGNC ID
HGNC:20213

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C159
 Probe Info  		20.11  LDD1839  [1]
C160
 Probe Info  		14.62  LDD1840  [1]
C161
 Probe Info  		39.40  LDD1841  [1]
C186
 Probe Info  		13.00  LDD1864  [1]
C285
 Probe Info  		99.73  LDD1955  [1]
C286
 Probe Info  		6.63  LDD1956  [1]
C287
 Probe Info  		43.71  LDD1957  [1]
C288
 Probe Info  		26.72  LDD1958  [1]
C289
 Probe Info  		99.73  LDD1959  [1]
C290
 Probe Info  		9.58  LDD1960  [1]
C373
 Probe Info  		5.31  LDD2033  [1]
C399
 Probe Info  		6.77  LDD2058  [1]
C403
 Probe Info  		22.47  LDD2061  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM25C (FAM25C) FAM25 family B3EWG5

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587