Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C186  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 115 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 67.2
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 45.9
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 39.7
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 36.8
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 36.0
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 35.8
 LDTP02505  Lysosomal protective protein (CTSA) 32.2
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 30.5
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 30.5
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 30.5
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 29.7
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 28.6
 LDTP13147  Cathepsin Z (CTSZ) 28.4
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 28.1
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 28.1
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 27.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 27.5
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 26.7
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 26.2
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 25.8
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 23.4
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 21.6
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 21.6
 LDTP04884  Proteasome subunit alpha type-6 (PSMA6) 21.6
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 21.0
 LDTP00316  Ribonuclease T2 (RNASET2) 21.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 20.3
 LDTP09095  Diacylglycerol lipase-beta (DAGLB) 20.1
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 19.8
 LDTP02539  Lysosomal acid phosphatase (ACP2) 18.8
 LDTP02141  Alpha-galactosidase A (GLA) 18.3
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 18.1
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 17.6
 LDTP04456  Ubiquitin carboxyl-terminal hydrolase 11 (USP11) 17.6
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 17.4
 LDTP05905  Acid ceramidase (ASAH1) 17.1
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 17.0
 LDTP10888  Legumain (LGMN) 16.4
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 16.2
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) 15.3
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 15.1
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 15.1
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 15.0
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 15.0
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 14.7
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 14.6
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 14.3
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 14.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 14.3
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 14.3
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 14.2
 LDTP01372  Carboxypeptidase D (CPD) 14.1
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 13.9
 LDTP02260  Beta-glucuronidase (GUSB) 13.8
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 13.8
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 13.7
 LDTP03145  Catechol O-methyltransferase (COMT) 13.6
 LDTP00886  Nardilysin (NRDC) 13.5
 LDTP17305  Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) 13.5
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 13.3
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 13.2
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 13.1
 LDTP10329  Ceramide synthase 2 (CERS2) 12.8
 LDTP05422  Copper-transporting ATPase 1 (ATP7A) 12.8
 LDTP10981  Mitochondrial intermediate peptidase (MIPEP) 12.8
 LDTP02359  Heme oxygenase 1 (HMOX1) 12.6
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 12.5
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 12.5
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 12.1
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 11.9
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 11.8
 LDTP10930  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) 11.8
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 11.7
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 11.7
 LDTP02837  Beta-galactosidase (GLB1) 11.6
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 11.4
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 11.2
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 11.0
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 10.9
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 10.8
 LDTP03540  Heme oxygenase 2 (HMOX2) 10.7
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 10.7
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) 10.7
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 10.6
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 10.3
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 10.3
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 10.2
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 10.1
 LDTP05193  ADP-ribosylation factor 5 (ARF5) 10.0
 LDTP03787  Choline kinase alpha (CHKA) 10.0
 LDTP02942  ADP-ribosylation factor 4 (ARF4) 9.8
 LDTP06617  Ceramide glucosyltransferase (UGCG) 9.8
 LDTP12763  Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) 9.7
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 9.6
 LDTP06721  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) 9.4
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 9.4
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 9.4
 LDTP09251  Atlastin-2 (ATL2) 9.2
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 9.2
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 8.9
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 8.9
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 8.8
 LDTP11127  ADP-dependent glucokinase (ADPGK) 8.8
 LDTP13491  E3 ubiquitin-protein ligase AMFR (AMFR) 8.8
 LDTP07989  Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) 8.8
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 8.7
 LDTP12470  GTP-binding protein SAR1a (SAR1A) 8.6
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 8.4
 LDTP11237  DNA-directed RNA polymerase III subunit RPC3 (POLR3C) 8.3
 LDTP11437  Peroxisomal trans-2-enoyl-CoA reductase (PECR) 8.3
 LDTP11438  Signal peptidase complex catalytic subunit SEC11C (SEC11C) 8.3
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 8.1
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 7.9
 LDTP13574  E3 ubiquitin-protein ligase HECTD1 (HECTD1) 7.9
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 7.8
Transporter and channel
Click to Show/Hide to Show 76 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 76.1
 LDTP16813  Tetraspanin-3 (TSPAN3) 52.3
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 50.9
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 48.8
 LDTP11615  Protein tweety homolog 3 (TTYH3) 48.2
 LDTP15948  Transmembrane protein 126A (TMEM126A) 44.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 39.4
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 37.0
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 33.1
 LDTP07236  Protein GPR107 (GPR107) 28.6
 LDTP08881  Transmembrane protein 199 (TMEM199) 28.2
 LDTP20002  Transmembrane protein 160 (TMEM160) 24.3
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 23.9
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 23.8
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 22.5
 LDTP02215  Prosaposin (PSAP) 22.2
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 22.0
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 21.7
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 21.6
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 21.3
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 19.3
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 19.0
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 18.1
 LDTP12451  Integral membrane protein 2C (ITM2C) 16.8
 LDTP02071  Amyloid-beta precursor protein (APP) 16.1
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 15.8
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 15.8
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 15.8
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 15.6
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 15.5
 LDTP00857  Syntaxin-6 (STX6) 15.5
 LDTP13833  Integral membrane protein 2B (ITM2B) 15.2
 LDTP02586  Cation-independent mannose-6-phosphate receptor (IGF2R) 14.8
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 14.1
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 13.8
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 13.1
 LDTP16163  Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial (COX16) 13.0
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 12.6
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 12.6
 LDTP01574  Importin-7 (IPO7) 12.0
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 12.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 11.9
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 11.5
 LDTP11245  Derlin-1 (DERL1) 10.6
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 10.5
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 10.4
 LDTP00592  Surfeit locus protein 4 (SURF4) 10.2
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 10.1
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 9.9
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 9.8
 LDTP01969  Transferrin receptor protein 1 (TFRC) 9.7
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 9.3
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 9.1
 LDTP05811  Syntaxin-3 (STX3) 8.8
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 8.6
 LDTP10065  Transmembrane protein 230 (TMEM230) 8.6
 LDTP01748  Mitochondrial import receptor subunit TOM40 homolog (TOMM40) 8.5
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 8.3
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 8.3
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 8.2
 LDTP16190  Protein FAM8A1 (FAM8A1) 8.2
 LDTP11250  MICOS complex subunit MIC26 (APOO) 8.2
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 8.2
 LDTP08981  Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) 8.1
 LDTP06499  V-type proton ATPase subunit S1 (ATP6AP1) 8.1
 LDTP10621  Sideroflexin-2 (SFXN2) 8.1
 LDTP10885  Sortilin (SORT1) 8.1
 LDTP09789  Transmembrane 9 superfamily member 4 (TM9SF4) 8.1
 LDTP06855  Anoctamin-6 (ANO6) 8.0
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 7.8
 LDTP17682  Zinc transporter ZIP11 (SLC39A11) 7.8
 LDTP07531  Sideroflexin-4 (SFXN4) 7.7
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 7.6
 LDTP11213  Nucleoporin NDC1 (NDC1) 7.6
 LDTP10731  Sodium-coupled neutral amino acid symporter 2 (SLC38A2) 7.6
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 7.6
Immunoglobulin
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09907  Neogenin (NEO1) 16.8
 LDTP02040  HLA class I histocompatibility antigen, A alpha chain (HLA-A) 11.2
 LDTP02491  HLA class I histocompatibility antigen, C alpha chain (HLA-C) 8.8
 LDTP05572  Leukocyte surface antigen CD47 (CD47) 7.9
 LDTP14203  Junctional adhesion molecule A (F11R) 7.6
Other
Click to Show/Hide to Show 65 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 37.5
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 27.3
 LDTP14458  Tetraspanin-6 (TSPAN6) 27.3
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 27.1
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 25.3
 LDTP02927  Ganglioside GM2 activator (GM2A) 23.3
 LDTP19859  Small integral membrane protein 12 (SMIM12) 22.6
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 22.5
 LDTP08594  Negative elongation factor C/D (NELFCD) 19.4
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 19.2
 LDTP06543  DNA damage-binding protein 1 (DDB1) 18.4
 LDTP18883  Protein CEBPZOS (CEBPZOS) 18.0
 LDTP05160  Nucleobindin-2 (NUCB2) 16.8
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 16.2
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 15.5
 LDTP00986  Syntaxin-10 (STX10) 15.2
 LDTP14259  Testis-expressed protein 264 (TEX264) 14.9
 LDTP16577  DENN domain-containing protein 11 (DENND11) 14.8
 LDTP14939  Membralin (TMEM259) 14.8
 LDTP10056  Protein FAM162A (FAM162A) 14.4
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 14.2
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 13.9
 LDTP01522  Reticulon-3 (RTN3) 13.8
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 13.5
 LDTP04382  Kinetochore-associated protein 1 (KNTC1) 13.4
 LDTP11239  Protein misato homolog 1 (MSTO1) 13.1
 LDTP03352  Splicing factor U2AF 65 kDa subunit (U2AF2) 13.0
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 12.7
 LDTP05898  Sequestosome-1 (SQSTM1) 12.7
 LDTP00859  Synaptogyrin-2 (SYNGR2) 12.6
 LDTP01494  Protein YIF1A (YIF1A) 12.2
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 12.0
 LDTP07031  Collectin-12 (COLEC12) 11.9
 LDTP19924  Protein PBDC1 (PBDC1) 11.9
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 11.9
 LDTP09143  Divergent protein kinase domain 2A (DIPK2A) 11.8
 LDTP10191  Gamma-tubulin complex component 3 (TUBGCP3) 11.2
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 11.0
 LDTP13863  DnaJ homolog subfamily C member 16 (DNAJC16) 10.9
 LDTP06097  Reticulocalbin-2 (RCN2) 10.9
 LDTP09920  Golgi apparatus protein 1 (GLG1) 10.3
 LDTP16006  Optic atrophy 3 protein (OPA3) 10.3
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 10.3
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 10.1
 LDTP00887  Calumenin (CALU) 10.0
 LDTP07574  Superkiller complex protein 3 (SKIC3) 9.8
 LDTP12412  Reticulon-4 (RTN4) 9.7
 LDTP13086  Syntaxin-18 (STX18) 9.7
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 9.3
 LDTP10847  Protein Niban 2 (NIBAN2) 9.0
 LDTP12001  BCAS3 microtubule associated cell migration factor (BCAS3) 8.9
 LDTP13114  C-type mannose receptor 2 (MRC2) 8.9
 LDTP13982  Mitochondrial fission 1 protein (FIS1) 8.8
 LDTP01711  Protein ecdysoneless homolog (ECD) 8.7
 LDTP16080  Protein FAM114A2 (FAM114A2) 8.6
 LDTP19963  TraB domain-containing protein (TRABD) 8.6
 LDTP07221  Myomegalin (PDE4DIP) 8.3
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 8.2
 LDTP04207  Heat shock 70 kDa protein 13 (HSPA13) 8.1
 LDTP00199  HCLS1-associated protein X-1 (HAX1) 8.0
 LDTP06479  Tubulin-specific chaperone E (TBCE) 7.9
 LDTP09773  Protein FAM3C (FAM3C) 7.9
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 7.8
 LDTP05233  55 kDa erythrocyte membrane protein (MPP1) 7.8
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 7.8

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587