Details of the Target

General Information of Target

Target ID LDTP00857
Target Name Syntaxin-6 (STX6)
Gene Name STX6
Gene ID 10228
Synonyms
Syntaxin-6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWD
LEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNR
QALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSI
GVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAI
LFAVLLVVLILFLVL
Target Bioclass
Transporter and channel
Family
Syntaxin family
Subcellular location
Golgi apparatus membrane
Function
SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway.
Uniprot ID
O43752
Ensemble ID
ENST00000258301.6
HGNC ID
HGNC:11441

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
GAMG SNV: p.R55Q .
JURKAT SNV: p.R232W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		5.02  LDD0318  [1]
STPyne
 Probe Info  		K89(0.88)  LDD0277  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [3]
PAL-AfBPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		35.51  LDD1793  [4]
C107
 Probe Info  		16.00  LDD1794  [4]
C108
 Probe Info  		11.47  LDD1795  [4]
C169
 Probe Info  		42.81  LDD1849  [4]
C170
 Probe Info  		18.38  LDD1850  [4]
C173
 Probe Info  		5.82  LDD1853  [4]
C186
 Probe Info  		15.45  LDD1864  [4]
C187
 Probe Info  		23.75  LDD1865  [4]
C264
 Probe Info  		37.53  LDD1935  [4]
C265
 Probe Info  		17.27  LDD1936  [4]
C282
 Probe Info  		17.63  LDD1952  [4]
C284
 Probe Info  		22.47  LDD1954  [4]
C285
 Probe Info  		20.39  LDD1955  [4]
C287
 Probe Info  		29.86  LDD1957  [4]
C288
 Probe Info  		6.45  LDD1958  [4]
C289
 Probe Info  		43.71  LDD1959  [4]
C293
 Probe Info  		32.67  LDD1963  [4]
C296
 Probe Info  		31.56  LDD1966  [4]
C313
 Probe Info  		16.91  LDD1980  [4]
C314
 Probe Info  		27.47  LDD1981  [4]
C343
 Probe Info  		15.35  LDD2005  [4]
C346
 Probe Info  		13.09  LDD2007  [4]
C348
 Probe Info  		19.70  LDD2009  [4]
C349
 Probe Info  		16.34  LDD2010  [4]
C350
 Probe Info  		95.01  LDD2011  [4]
C362
 Probe Info  		83.29  LDD2023  [4]
C363
 Probe Info  		20.97  LDD2024  [4]
C364
 Probe Info  		23.59  LDD2025  [4]
C367
 Probe Info  		5.62  LDD2028  [4]
C399
 Probe Info  		7.06  LDD2058  [4]
C403
 Probe Info  		24.59  LDD2061  [4]
FFF probe11
 Probe Info  		20.00  LDD0472  [5]
FFF probe13
 Probe Info  		20.00  LDD0475  [5]
FFF probe3
 Probe Info  		18.91  LDD0465  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0109  NEM HeLa N.A.  LDD0227  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Stomatin (STOM) Band 7/mec-2 family P27105
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-4 (STX4) Syntaxin family Q12846
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 205 (TMEM205) TMEM205 family Q6UW68
Proton-transporting V-type ATPase complex assembly regulator TMEM9 (TMEM9) TMEM9 family Q9P0T7
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Translation initiation factor IF-3, mitochondrial (MTIF3) IF-3 family Q9H2K0
Transcription termination factor 2, mitochondrial (MTERF2) MTERF family Q49AM1
Beta-soluble NSF attachment protein (NAPB) SNAP family Q9H115
Synaptosomal-associated protein 29 (SNAP29) SNAP-25 family O95721
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) Tim17/Tim22/Tim23 family Q9NPL8
Lck-interacting transmembrane adapter 1 (LIME1) . Q9H400

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.