Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C346  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 84 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 50.6
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 44.0
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 39.1
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 36.8
 LDTP12415  Adenosine 5'-monophosphoramidase HINT3 (HINT3) 34.3
 LDTP02713  Macrophage migration inhibitory factor (MIF) 30.7
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 30.3
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 29.9
 LDTP02223  Cathepsin B (CTSB) 27.1
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 25.1
 LDTP06227  Prostaglandin reductase 1 (PTGR1) 24.8
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 24.4
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 23.6
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 21.7
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 21.6
 LDTP02505  Lysosomal protective protein (CTSA) 21.3
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 21.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.5
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 20.3
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 19.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 18.9
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 18.6
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 18.4
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 18.3
 LDTP01759  Histone-lysine N-methyltransferase NSD2 (NSD2) 18.1
 LDTP02539  Lysosomal acid phosphatase (ACP2) 18.0
 LDTP10322  Abasic site processing protein HMCES (HMCES) 17.5
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 17.4
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 17.3
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 17.1
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 16.7
 LDTP12490  Sphingosine kinase 2 (SPHK2) 16.7
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 16.2
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 16.0
 LDTP00316  Ribonuclease T2 (RNASET2) 15.9
 LDTP10329  Ceramide synthase 2 (CERS2) 15.8
 LDTP12003  Ribosomal oxygenase 1 (RIOX1) 15.8
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 15.7
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 15.5
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 15.3
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 15.0
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 15.0
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 14.9
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 14.9
 LDTP02141  Alpha-galactosidase A (GLA) 14.8
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 14.7
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 14.7
 LDTP05905  Acid ceramidase (ASAH1) 14.4
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 14.1
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 13.8
 LDTP02837  Beta-galactosidase (GLB1) 13.7
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 13.6
 LDTP08564  E3 ubiquitin-protein ligase UBR1 (UBR1) 13.6
 LDTP02359  Heme oxygenase 1 (HMOX1) 13.4
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 13.3
 LDTP10780  Trimethylguanosine synthase (TGS1) 13.3
 LDTP09819  Unconventional myosin-XVIIIa (MYO18A) 13.2
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 13.1
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 12.9
 LDTP10709  Pseudouridylate synthase 7 homolog (PUS7) 12.7
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 12.6
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 12.3
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 12.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 11.9
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 11.7
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 11.5
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) 11.5
 LDTP10785  Ubiquitin carboxyl-terminal hydrolase 28 (USP28) 11.4
 LDTP10215  Carboxymethylenebutenolidase homolog (CMBL) 11.3
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 11.2
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 11.2
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 11.2
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 11.2
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 11.1
 LDTP00697  Cytochrome b5 type B (CYB5B) 11.0
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 10.9
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 10.9
 LDTP01300  Cartilage-associated protein (CRTAP) 10.9
 LDTP04581  Holocytochrome c-type synthase (HCCS) 10.8
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 10.7
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 10.7
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 10.5
 LDTP11823  Peptidyl-prolyl cis-trans isomerase-like 3 (PPIL3) 10.4
 LDTP06069  DNA polymerase alpha subunit B (POLA2) 10.3
Transporter and channel
Click to Show/Hide to Show 38 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 52.7
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 31.1
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 26.2
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 24.6
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 24.4
 LDTP12383  Protein GPR108 (GPR108) 24.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 20.0
 LDTP05900  Metaxin-1 (MTX1) 19.7
 LDTP02215  Prosaposin (PSAP) 19.0
 LDTP10885  Sortilin (SORT1) 17.6
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 17.5
 LDTP07667  Transmembrane protein 205 (TMEM205) 17.0
 LDTP03380  Stomatin (STOM) 16.6
 LDTP11615  Protein tweety homolog 3 (TTYH3) 16.2
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 15.7
 LDTP01804  ATP synthase subunit a (MT-ATP6) 15.2
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 14.7
 LDTP11406  Transmembrane protein 59 (TMEM59) 14.6
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 14.1
 LDTP03546  Translocator protein (TSPO) 14.1
 LDTP15967  Tetraspanin-10 (TSPAN10) 13.4
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 13.3
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 13.2
 LDTP00857  Syntaxin-6 (STX6) 13.1
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 12.9
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 12.8
 LDTP07236  Protein GPR107 (GPR107) 12.8
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 12.6
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 12.3
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 12.2
 LDTP20002  Transmembrane protein 160 (TMEM160) 11.4
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 11.3
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 11.2
 LDTP15948  Transmembrane protein 126A (TMEM126A) 10.9
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 10.6
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 10.5
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 10.2
 LDTP15481  Transmembrane protein 87A (TMEM87A) 10.2
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02870  Y-box-binding protein 3 (YBX3) 11.2
Other
Click to Show/Hide to Show 64 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 87.4
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 42.2
 LDTP16078  Heme-binding protein 1 (HEBP1) 34.3
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 31.3
 LDTP00105  Protein unc-119 homolog B (UNC119B) 30.5
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 26.0
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) 24.6
 LDTP05160  Nucleobindin-2 (NUCB2) 21.9
 LDTP15623  Neuferricin (CYB5D2) 21.3
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 18.5
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 18.4
 LDTP02927  Ganglioside GM2 activator (GM2A) 16.4
 LDTP02297  Vimentin (VIM) 16.4
 LDTP13630  Neudesin (NENF) 16.2
 LDTP05226  RNA-binding protein 3 (RBM3) 16.2
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 15.7
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 15.6
 LDTP06097  Reticulocalbin-2 (RCN2) 14.6
 LDTP15283  Nucleolar protein 9 (NOP9) 14.4
 LDTP05375  Nucleobindin-1 (NUCB1) 14.0
 LDTP03775  RNA-binding protein FUS (FUS) 13.6
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 13.6
 LDTP06915  Borealin (CDCA8) 13.4
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 13.3
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 13.2
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 13.1
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 13.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 12.9
 LDTP11328  Splicing factor 3B subunit 5 (SF3B5) 12.9
 LDTP02351  Tropomyosin alpha-1 chain (TPM1) 12.4
 LDTP09215  Torsin-1A-interacting protein 2 (TOR1AIP2) 12.3
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 12.2
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 12.2
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 12.1
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 11.9
 LDTP01075  Protein CutA (CUTA) 11.9
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 11.8
 LDTP02180  Neurofilament light polypeptide (NEFL) 11.8
 LDTP12629  T-complex protein 11-like protein 1 (TCP11L1) 11.8
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 11.6
 LDTP06515  Coiled-coil domain-containing protein 6 (CCDC6) 11.6
 LDTP10700  KH domain-containing RNA-binding protein QKI (QKI) 11.6
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 11.5
 LDTP01246  KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) 11.4
 LDTP13851  Exocyst complex component 6B (EXOC6B) 11.3
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 11.3
 LDTP14458  Tetraspanin-6 (TSPAN6) 11.2
 LDTP00887  Calumenin (CALU) 11.2
 LDTP05113  T-complex protein 1 subunit beta (CCT2) 11.1
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 11.0
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 10.9
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 10.9
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 10.6
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 10.6
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 10.5
 LDTP09054  Golgi membrane protein 1 (GOLM1) 10.5
 LDTP06291  ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) 10.4
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 10.3
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 10.3
 LDTP09410  Protein bicaudal D homolog 2 (BICD2) 10.3
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 10.3
 LDTP06952  DBIRD complex subunit ZNF326 (ZNF326) 10.3
 LDTP01582  Pre-mRNA-splicing factor SLU7 (SLU7) 10.3
 LDTP06068  MAGUK p55 subfamily member 2 (MPP2) 10.2

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587