Details of the Target

General Information of Target

Target ID LDTP02180
Target Name Neurofilament light polypeptide (NEFL)
Gene Name NEFL
Gene ID 4747
Synonyms
NF68; NFL; Neurofilament light polypeptide; NF-L; 68 kDa neurofilament protein; Neurofilament triplet L protein
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSSFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSS
SGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEA
ELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEE
EVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQY
AQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRA
AKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRT
TKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFG
RSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEE
KDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAK
KKD
Target Bioclass
Other
Family
Intermediate filament family
Subcellular location
Cell projection, axon
Function
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
Uniprot ID
P07196
Ensemble ID
ENST00000610854.2
HGNC ID
HGNC:7739

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.88  LDD0318  [1]
AZ-9
 Probe Info  		E371(10.00); D374(10.00)  LDD2208  [2]
HHS-465
 Probe Info  		Y389(0.63)  LDD2237  [3]
DBIA
 Probe Info  		C322(1.71)  LDD0080  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
PAL-AfBPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		12.64  LDD1752  [7]
C056
 Probe Info  		20.82  LDD1753  [7]
C063
 Probe Info  		13.45  LDD1760  [7]
C087
 Probe Info  		18.64  LDD1779  [7]
C106
 Probe Info  		21.41  LDD1793  [7]
C108
 Probe Info  		8.22  LDD1795  [7]
C112
 Probe Info  		22.94  LDD1799  [7]
C158
 Probe Info  		13.64  LDD1838  [7]
C161
 Probe Info  		10.63  LDD1841  [7]
C196
 Probe Info  		9.99  LDD1872  [7]
C201
 Probe Info  		24.93  LDD1877  [7]
C210
 Probe Info  		59.30  LDD1884  [7]
C232
 Probe Info  		39.40  LDD1905  [7]
C238
 Probe Info  		12.82  LDD1911  [7]
C244
 Probe Info  		19.29  LDD1917  [7]
C246
 Probe Info  		14.22  LDD1919  [7]
C249
 Probe Info  		14.83  LDD1922  [7]
C265
 Probe Info  		14.03  LDD1936  [7]
C269
 Probe Info  		9.32  LDD1939  [7]
C284
 Probe Info  		24.59  LDD1954  [7]
C289
 Probe Info  		27.28  LDD1959  [7]
C313
 Probe Info  		19.29  LDD1980  [7]
C314
 Probe Info  		12.38  LDD1981  [7]
C317
 Probe Info  		6.36  LDD1983  [7]
C326
 Probe Info  		6.92  LDD1990  [7]
C346
 Probe Info  		11.79  LDD2007  [7]
C347
 Probe Info  		5.43  LDD2008  [7]
C362
 Probe Info  		38.32  LDD2023  [7]
C363
 Probe Info  		18.13  LDD2024  [7]
C364
 Probe Info  		17.51  LDD2025  [7]
C383
 Probe Info  		13.93  LDD2042  [7]
C388
 Probe Info  		37.79  LDD2047  [7]
C390
 Probe Info  		34.30  LDD2049  [7]
C391
 Probe Info  		37.79  LDD2050  [7]
C407
 Probe Info  		19.29  LDD2064  [7]
C429
 Probe Info  		12.82  LDD2084  [7]
C431
 Probe Info  		15.45  LDD2086  [7]
STS-2
 Probe Info  		N.A.  LDD0139  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C322(0.96)  LDD1508  [9]
 LDCM0237  AC12 HEK-293T C322(0.97)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C322(0.97)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C322(1.07)  LDD1513  [9]
 LDCM0277  AC18 HEK-293T C322(0.98)  LDD1516  [9]
 LDCM0279  AC2 HEK-293T C322(1.01)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C322(1.08)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C322(0.96)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C322(0.95)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C322(0.89)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C322(0.93)  LDD1523  [9]
 LDCM0286  AC26 HEK-293T C322(1.16)  LDD1525  [9]
 LDCM0288  AC28 HEK-293T C322(1.00)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C322(0.97)  LDD1528  [9]
 LDCM0291  AC30 HEK-293T C322(1.03)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C322(0.93)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C322(1.00)  LDD1532  [9]
 LDCM0295  AC34 HEK-293T C322(0.99)  LDD1534  [9]
 LDCM0297  AC36 HEK-293T C322(1.01)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C322(0.96)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C322(0.98)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C322(0.89)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C322(1.04)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C322(0.98)  LDD1541  [9]
 LDCM0304  AC42 HEK-293T C322(1.04)  LDD1543  [9]
 LDCM0306  AC44 HEK-293T C322(1.03)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C322(1.01)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C322(1.00)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C322(0.98)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C322(0.95)  LDD1549  [9]
 LDCM0312  AC5 HEK-293T C322(0.90)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C322(0.93)  LDD1552  [9]
 LDCM0315  AC52 HEK-293T C322(1.00)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C322(1.06)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C322(1.00)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C322(0.97)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C322(1.05)  LDD1558  [9]
 LDCM0321  AC58 HEK-293T C322(1.10)  LDD1560  [9]
 LDCM0323  AC6 HEK-293T C322(0.97)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C322(1.02)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C322(1.06)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C322(1.06)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C322(1.12)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C322(1.00)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C322(0.94)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C322(0.95)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C322(1.07)  LDD1511  [9]
 LDCM0275  AKOS034007705 HEK-293T C322(1.00)  LDD1514  [9]
 LDCM0367  CL1 HEK-293T C322(0.89)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C322(1.01)  LDD1572  [9]
 LDCM0370  CL101 HEK-293T C322(1.06)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C322(1.09)  LDD1575  [9]
 LDCM0374  CL105 HEK-293T C322(1.00)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C322(0.96)  LDD1579  [9]
 LDCM0378  CL109 HEK-293T C322(1.08)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C322(1.07)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C322(1.04)  LDD1584  [9]
 LDCM0383  CL113 HEK-293T C322(1.00)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C322(1.07)  LDD1588  [9]
 LDCM0387  CL117 HEK-293T C322(0.98)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C322(1.01)  LDD1592  [9]
 LDCM0390  CL12 HEK-293T C322(1.06)  LDD1594  [9]
 LDCM0392  CL121 HEK-293T C322(1.03)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C322(1.07)  LDD1597  [9]
 LDCM0396  CL125 HEK-293T C322(1.02)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C322(1.06)  LDD1601  [9]
 LDCM0400  CL13 HEK-293T C322(1.12)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C322(1.06)  LDD1605  [9]
 LDCM0405  CL18 HEK-293T C322(1.04)  LDD1609  [9]
 LDCM0407  CL2 HEK-293T C322(1.16)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C322(1.17)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C322(0.88)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C322(1.11)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C322(0.97)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C322(1.10)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C322(1.04)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C322(1.03)  LDD1618  [9]
 LDCM0419  CL30 HEK-293T C322(0.98)  LDD1623  [9]
 LDCM0421  CL32 HEK-293T C322(0.99)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C322(0.96)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C322(1.15)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C322(0.93)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C322(0.99)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C322(1.05)  LDD1630  [9]
 LDCM0432  CL42 HEK-293T C322(1.08)  LDD1636  [9]
 LDCM0434  CL44 HEK-293T C322(1.10)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C322(1.00)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C322(1.11)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C322(1.10)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C322(1.09)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C322(1.07)  LDD1643  [9]
 LDCM0441  CL50 HEK-293T C322(1.12)  LDD1645  [9]
 LDCM0445  CL54 HEK-293T C322(1.22)  LDD1648  [9]
 LDCM0447  CL56 HEK-293T C322(1.08)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C322(0.95)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C322(1.05)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C322(1.03)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C322(1.21)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C322(1.11)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C322(1.13)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C322(0.98)  LDD1657  [9]
 LDCM0458  CL66 HEK-293T C322(1.12)  LDD1661  [9]
 LDCM0460  CL68 HEK-293T C322(1.21)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C322(0.98)  LDD1664  [9]
 LDCM0463  CL70 HEK-293T C322(1.02)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C322(1.10)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C322(0.98)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C322(0.89)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C322(1.08)  LDD1670  [9]
 LDCM0471  CL78 HEK-293T C322(1.02)  LDD1674  [9]
 LDCM0473  CL8 HEK-293T C322(0.89)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C322(1.06)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C322(1.05)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C322(1.15)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C322(1.06)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C322(1.06)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C322(1.04)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C322(0.89)  LDD1683  [9]
 LDCM0484  CL9 HEK-293T C322(1.08)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C322(1.19)  LDD1688  [9]
 LDCM0487  CL92 HEK-293T C322(1.07)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C322(1.17)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C322(1.14)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C322(0.95)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C322(1.06)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C322(1.03)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C322(1.09)  LDD1696  [9]
 LDCM0427  Fragment51 HEK-293T C322(0.96)  LDD1631  [9]
 LDCM0022  KB02 HCT 116 C322(1.71)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C322(1.53)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C322(1.86)  LDD0082  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SMYD1 (SMYD1) Class V-like SAM-binding methyltransferase superfamily Q8NB12
FAST kinase domain-containing protein 1, mitochondrial (FASTKD1) FAST kinase family Q53R41
Glucose-fructose oxidoreductase domain-containing protein 1 (GFOD1) Gfo/Idh/MocA family Q9NXC2
Eyes absent homolog 3 (EYA3) EYA family Q99504
Peptidoglycan recognition protein 3 (PGLYRP3) N-acetylmuramoyl-L-alanine amidase 2 family Q96LB9
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (AGA) Ntn-hydrolase family P20933
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Protein phosphatase PTC7 homolog (PPTC7) PP2C family Q8NI37
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
Serine/threonine-protein kinase PAK 5 (PAK5) STE Ser/Thr protein kinase family Q9P286
Myotubularin-related protein 2 (MTMR2) Protein-tyrosine phosphatase family Q13614
G/T mismatch-specific thymine DNA glycosylase (TDG) TDG/mug family Q13569
G2/M phase-specific E3 ubiquitin-protein ligase (G2E3) . Q7L622
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
V-type proton ATPase subunit B, brain isoform (ATP6V1B2) ATPase alpha/beta chains family P21281
Voltage-dependent anion-selective channel protein 2 (VDAC2) Eukaryotic mitochondrial porin family P45880
Membrane protein MLC1 (MLC1) . Q15049
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 9 (ZSCAN9) Krueppel C2H2-type zinc-finger protein family O15535
Zinc finger protein 436 (ZNF436) Krueppel C2H2-type zinc-finger protein family Q9C0F3
Zinc finger protein 57 (ZNF57) Krueppel C2H2-type zinc-finger protein family Q68EA5
Zinc finger protein 572 (ZNF572) Krueppel C2H2-type zinc-finger protein family Q7Z3I7
Zinc finger protein with KRAB and SCAN domains 8 (ZKSCAN8) Krueppel C2H2-type zinc-finger protein family Q15776
Visual system homeobox 2 (VSX2) Paired homeobox family P58304
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytokine receptor-like factor 3 (CRLF3) Cytokine receptor-like factor 3 family Q8IUI8
Other
Click To Hide/Show 46 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A8 (ANXA8) Annexin family P13928
Coiled-coil domain-containing protein 172 (CCDC172) CCDC172 family P0C7W6
Cytoplasmic FMR1-interacting protein 1 (CYFIP1) CYFIP family Q7L576
Dynein light chain Tctex-type 1 (DYNLT1) Dynein light chain Tctex-type family P63172
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8L2) EPS8 family Q9H6S3
Protein pelota homolog (PELO) Eukaryotic release factor 1 family Q9BRX2
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgi reassembly-stacking protein 1 (GORASP1) GORASP family Q9BQQ3
Desmin (DES) Intermediate filament family P17661
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cytoskeletal 13 (KRT13) Intermediate filament family P13646
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 18 (KRT18) Intermediate filament family P05783
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Neurofilament medium polypeptide (NEFM) Intermediate filament family P07197
Syncoilin (SYNC) Intermediate filament family Q9H7C4
Vimentin (VIM) Intermediate filament family P08670
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Protein Mis18-beta (OIP5) Mis18 family O43482
Rhophilin-1 (RHPN1) RHPN family Q8TCX5
Protein S100-P (S100P) S-100 family P25815
Ski-like protein (SKIL) SKI family P12757
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Synaptotagmin-3 (SYT3) Synaptotagmin family Q9BQG1
Protein TASOR 2 (TASOR2) TASOR family Q5VWN6
T-complex protein 10A homolog 1 (TCP10L) TCP10 family Q8TDR4
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) . Q9NP61
BAG family molecular chaperone regulator 3 (BAG3) . O95817
C-type lectin domain family 11 member A (CLEC11A) . Q9Y240
Chromatin complexes subunit BAP18 (BAP18) . Q8IXM2
Coiled-coil domain-containing protein 13 (CCDC13) . Q8IYE1
Fibronectin type 3 and ankyrin repeat domains protein 1 (FANK1) . Q8TC84
FMR1-interacting protein NUFIP2 (NUFIP2) . Q7Z417
Methyl-CpG-binding protein 2 (MECP2) . P51608
Nebulette (NEBL) . O76041
Necdin (NDN) . Q99608
Phostensin (PPP1R18) . Q6NYC8
Retinoic acid-induced protein 2 (RAI2) . Q9Y5P3
RING1 and YY1-binding protein (RYBP) . Q8N488
RNA-binding protein 14 (RBM14) . Q96PK6
Sperm-associated microtubule inner protein 4 (SPMIP4) . Q8N865
Telomeric repeat-binding factor 1 (TERF1) . P54274
Uncharacterized protein C8orf48 (C8orf48) . Q96LL4
Uncharacterized protein KIAA0408 (KIAA0408) . Q6ZU52

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402