Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C313  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 73 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 53.8
 LDTP01803  Adenosine deaminase (ADA) 47.2
 LDTP10981  Mitochondrial intermediate peptidase (MIPEP) 44.6
 LDTP06617  Ceramide glucosyltransferase (UGCG) 43.4
 LDTP03145  Catechol O-methyltransferase (COMT) 38.1
 LDTP02359  Heme oxygenase 1 (HMOX1) 36.8
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 34.5
 LDTP06227  Prostaglandin reductase 1 (PTGR1) 32.7
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 32.0
 LDTP19851  Isochorismatase domain-containing protein 1 (ISOC1) 29.4
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 29.2
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 27.3
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 26.0
 LDTP12691  Pyridoxine-5'-phosphate oxidase (PNPO) 24.4
 LDTP12197  Ethanolamine kinase 1 (ETNK1) 23.9
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 23.1
 LDTP04114  E3 ubiquitin-protein ligase NEDD4 (NEDD4) 22.8
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 22.2
 LDTP03677  Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1) 20.7
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 20.4
 LDTP12105  L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) 20.3
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 20.1
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 19.8
 LDTP09074  UDP-glucuronic acid decarboxylase 1 (UXS1) 19.7
 LDTP03540  Heme oxygenase 2 (HMOX2) 18.8
 LDTP12109  Ribitol 5-phosphate transferase FKRP (FKRP) 18.8
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 18.5
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 18.4
 LDTP09285  Atypical kinase COQ8A, mitochondrial (COQ8A) 18.3
 LDTP00697  Cytochrome b5 type B (CYB5B) 18.0
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 17.8
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 17.5
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 17.0
 LDTP06023  Calcium/calmodulin-dependent protein kinase type 1 (CAMK1) 16.8
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 16.8
 LDTP00645  Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) 16.4
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 16.2
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 16.0
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 15.2
 LDTP04746  NADH dehydrogenase 1 alpha subcomplex subunit 6 (NDUFA6) 15.0
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 14.8
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 14.7
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 14.7
 LDTP13154  E3 ubiquitin-protein ligase RNF14 (RNF14) 14.6
 LDTP03608  RAC-beta serine/threonine-protein kinase (AKT2) 14.5
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 14.5
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 14.4
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) 14.0
 LDTP06614  NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5) 13.9
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 13.9
 LDTP06427  Translin (TSN) 13.9
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 13.8
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 13.8
 LDTP05944  Myotubularin-related protein 2 (MTMR2) 13.8
 LDTP10329  Ceramide synthase 2 (CERS2) 13.7
 LDTP07503  Endoplasmic reticulum aminopeptidase 2 (ERAP2) 13.7
 LDTP00773  Serine protease HTRA2, mitochondrial (HTRA2) 13.7
 LDTP11127  ADP-dependent glucokinase (ADPGK) 13.6
 LDTP03787  Choline kinase alpha (CHKA) 13.6
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 13.5
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 13.5
 LDTP17305  Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) 13.3
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 12.9
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 12.8
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 12.5
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 12.5
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 12.4
 LDTP12763  Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) 12.3
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 12.2
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 12.2
 LDTP13972  Oligoribonuclease, mitochondrial (REXO2) 12.2
 LDTP11535  Ras-related protein Rab-34 (RAB34) 12.2
 LDTP13862  GDP-fucose protein O-fucosyltransferase 2 (POFUT2) 12.1
Transporter and channel
Click to Show/Hide to Show 41 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 75.1
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 70.5
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 40.8
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 30.5
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 26.5
 LDTP15948  Transmembrane protein 126A (TMEM126A) 26.5
 LDTP05900  Metaxin-1 (MTX1) 24.3
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 22.2
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 21.9
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 21.7
 LDTP15648  BRI3-binding protein (BRI3BP) 21.6
 LDTP01804  ATP synthase subunit a (MT-ATP6) 21.4
 LDTP07236  Protein GPR107 (GPR107) 21.0
 LDTP20002  Transmembrane protein 160 (TMEM160) 20.5
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 19.2
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 19.0
 LDTP02215  Prosaposin (PSAP) 18.3
 LDTP01217  Metaxin-2 (MTX2) 17.5
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 17.1
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 17.1
 LDTP00857  Syntaxin-6 (STX6) 16.9
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 16.8
 LDTP08881  Transmembrane protein 199 (TMEM199) 16.3
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 15.3
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 15.1
 LDTP02071  Amyloid-beta precursor protein (APP) 14.6
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 14.6
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 14.3
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 14.1
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 13.6
 LDTP07156  Protein wntless homolog (WLS) 13.6
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 13.5
 LDTP08029  Nucleoporin p54 (NUP54) 13.3
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 13.3
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 12.7
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 12.6
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 12.6
 LDTP11615  Protein tweety homolog 3 (TTYH3) 12.4
 LDTP00592  Surfeit locus protein 4 (SURF4) 12.3
 LDTP10885  Sortilin (SORT1) 12.1
 LDTP13243  Translocation protein SEC63 homolog (SEC63) 12.1
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05065  Y-box-binding protein 1 (YBX1) 18.9
 LDTP09694  Paraspeckle component 1 (PSPC1) 13.9
 LDTP10195  G-protein coupled receptor-associated sorting protein 2 (GPRASP2) 12.3
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02040  HLA class I histocompatibility antigen, A alpha chain (HLA-A) 12.9
Other
Click to Show/Hide to Show 114 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 67.2
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 55.3
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 49.2
 LDTP01932  Prelamin-A/C (LMNA) 49.2
 LDTP01279  Protein CREG1 (CREG1) 39.9
 LDTP08594  Negative elongation factor C/D (NELFCD) 38.9
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 33.4
 LDTP06004  Nuclear nucleic acid-binding protein C1D (C1D) 30.7
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 29.7
 LDTP18467  LYR motif-containing protein 2 (LYRM2) 28.8
 LDTP11076  Apolipoprotein L2 (APOL2) 28.2
 LDTP02297  Vimentin (VIM) 28.2
 LDTP09069  Kinetochore protein Spc24 (SPC24) 28.1
 LDTP10255  Protein Hook homolog 2 (HOOK2) 28.1
 LDTP05012  Small ribosomal subunit protein eS24 (RPS24) 27.5
 LDTP04979  U6 snRNA-associated Sm-like protein LSm3 (LSM3) 25.3
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 25.1
 LDTP05226  RNA-binding protein 3 (RBM3) 24.8
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 24.1
 LDTP05160  Nucleobindin-2 (NUCB2) 23.9
 LDTP02940  Large ribosomal subunit protein eL33 (RPL35A) 23.8
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 23.6
 LDTP02181  Neurofilament medium polypeptide (NEFM) 23.4
 LDTP03303  Adenomatous polyposis coli protein (APC) 22.8
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 22.2
 LDTP10203  RalBP1-associated Eps domain-containing protein 1 (REPS1) 22.0
 LDTP01359  Dynactin subunit 3 (DCTN3) 21.6
 LDTP10056  Protein FAM162A (FAM162A) 21.4
 LDTP06097  Reticulocalbin-2 (RCN2) 21.4
 LDTP05277  Protein SET (SET) 20.8
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 20.5
 LDTP01075  Protein CutA (CUTA) 20.5
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 20.4
 LDTP02180  Neurofilament light polypeptide (NEFL) 19.3
 LDTP09297  Large ribosomal subunit protein mL64 (GADD45GIP1) 19.2
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 18.6
 LDTP03775  RNA-binding protein FUS (FUS) 18.5
 LDTP02351  Tropomyosin alpha-1 chain (TPM1) 18.4
 LDTP16322  Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) 17.9
 LDTP00887  Calumenin (CALU) 17.8
 LDTP06515  Coiled-coil domain-containing protein 6 (CCDC6) 17.6
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 17.5
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 17.4
 LDTP00417  Programmed cell death protein 5 (PDCD5) 17.4
 LDTP14458  Tetraspanin-6 (TSPAN6) 17.3
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 17.0
 LDTP13630  Neudesin (NENF) 16.9
 LDTP08000  Dymeclin (DYM) 16.8
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 16.4
 LDTP10213  Anaphase-promoting complex subunit 16 (ANAPC16) 16.3
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 16.3
 LDTP14259  Testis-expressed protein 264 (TEX264) 16.3
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 16.2
 LDTP12395  Large ribosomal subunit protein mL40 (MRPL40) 16.1
 LDTP16080  Protein FAM114A2 (FAM114A2) 16.0
 LDTP14126  Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9) 15.8
 LDTP03926  Centrin-2 (CETN2) 15.7
 LDTP11044  Polyadenylate-binding protein-interacting protein 2 (PAIP2) 15.7
 LDTP16193  Craniofacial development protein 1 (CFDP1) 15.5
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 15.1
 LDTP00913  Mitochondrial import inner membrane translocase subunit Tim8 A (TIMM8A) 15.1
 LDTP08073  Tetratricopeptide repeat protein 21B (TTC21B) 15.1
 LDTP09183  Periphilin-1 (PPHLN1) 14.9
 LDTP01711  Protein ecdysoneless homolog (ECD) 14.8
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 14.6
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 14.6
 LDTP13114  C-type mannose receptor 2 (MRC2) 14.5
 LDTP01246  KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) 14.4
 LDTP10469  Engulfment and cell motility protein 2 (ELMO2) 14.2
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 14.2
 LDTP05400  Lamin-B2 (LMNB2) 14.2
 LDTP00716  RNA binding protein fox-1 homolog 2 (RBFOX2) 14.2
 LDTP05318  RNA-binding protein EWS (EWSR1) 14.2
 LDTP13309  Prefoldin subunit 2 (PFDN2) 14.0
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 14.0
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 13.9
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 13.9
 LDTP11695  Kinesin light chain 2 (KLC2) 13.9
 LDTP15398  Protein FAM177A1 (FAM177A1) 13.9
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 13.7
 LDTP13519  Proteasome activator complex subunit 2 (PSME2) 13.7
 LDTP02526  Clusterin (CLU) 13.6
 LDTP11825  Phosducin-like protein 3 (PDCL3) 13.6
 LDTP05089  Immunoglobulin-binding protein 1 (IGBP1) 13.5
 LDTP00573  Prefoldin subunit 6 (PFDN6) 13.5
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 13.5
 LDTP13086  Syntaxin-18 (STX18) 13.5
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) 13.4
 LDTP12925  CCR4-NOT transcription complex subunit 2 (CNOT2) 13.4
 LDTP15623  Neuferricin (CYB5D2) 13.4
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 13.4
 LDTP17652  Uncharacterized protein KIAA2013 (KIAA2013) 13.4
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 13.2
 LDTP09410  Protein bicaudal D homolog 2 (BICD2) 13.2
 LDTP00864  Alpha-endosulfine (ENSA) 13.1
 LDTP09920  Golgi apparatus protein 1 (GLG1) 13.1
 LDTP00862  Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) 13.0
 LDTP12764  MICOS complex subunit MIC19 (CHCHD3) 12.9
 LDTP11682  Polyadenylate-binding protein-interacting protein 1 (PAIP1) 12.9
 LDTP11910  Golgi phosphoprotein 3-like (GOLPH3L) 12.8
 LDTP04206  Nestin (NES) 12.8
 LDTP04111  Small ribosomal subunit protein eS10 (RPS10) 12.7
 LDTP12412  Reticulon-4 (RTN4) 12.6
 LDTP10403  DDRGK domain-containing protein 1 (DDRGK1) 12.5
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 12.5
 LDTP09994  BLOC-2 complex member HPS3 (HPS3) 12.4
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 12.4
 LDTP09719  Progesterone-induced-blocking factor 1 (PIBF1) 12.4
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) 12.3
 LDTP19963  TraB domain-containing protein (TRABD) 12.3
 LDTP02165  Tropomyosin alpha-3 chain (TPM3) 12.2
 LDTP13626  Ubiquilin-1 (UBQLN1) 12.2
 LDTP10857  c-Myc-binding protein (MYCBP) 12.1
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 12.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587