Details of the Target

General Information of Target

Target ID LDTP04746
Target Name NADH dehydrogenase 1 alpha subcomplex subunit 6 (NDUFA6)
Gene Name NDUFA6
Gene ID 4700
Synonyms
LYRM6; NADHB14; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Complex I-B14; CI-B14; LYR motif-containing protein 6; NADH-ubiquinone oxidoreductase B14 subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGSGVRQATSTASTFVKPIFSRDMNEAKRRVRELYRAWYREVPNTVHQFQLDITVKMGR
DKVREMFMKNAHVTDPRVVDLLVIKGKIELEETIKVWKQRTHVMRFFHETEAPRPKDFLS
KFYVGHDP
Target Bioclass
Enzyme
Family
Complex I LYR family
Subcellular location
Mitochondrion inner membrane
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Uniprot ID
P56556
Ensemble ID
ENST00000498737.8
HGNC ID
HGNC:7690
ChEMBL ID
CHEMBL2363065

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K18(1.49); K85(8.12)  LDD0277  [1]
5E-2FA
 Probe Info  		N.A.  LDD2235  [2]
ATP probe
 Probe Info  		K85(0.00); K87(0.00)  LDD0199  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [2]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]
Crotonaldehyde
 Probe Info  		H108(0.00); H72(0.00)  LDD0219  [4]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		8.88  LDD1838  [5]
C313
 Probe Info  		15.03  LDD1980  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0107  IAA HeLa H108(0.00); H72(0.00)  LDD0221  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587