Details of the Target

General Information of Target

Target ID LDTP05944
Target Name Myotubularin-related protein 2 (MTMR2)
Gene Name MTMR2
Gene ID 8898
Synonyms
KIAA1073; Myotubularin-related protein 2; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; EC 3.1.3.95; Phosphatidylinositol-3-phosphate phosphatase; EC 3.1.3.64
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEKSSSCESLGSQPAAARPPSVDSLSSASTSHSENSVHTKSASVVSSDSISTSADNFSPD
LRVLRESNKLAEMEEPPLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSMERD
PPFVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLM
KYAFPVSNNLPLFAFEYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTY
PALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDE
KYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMR
ESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDG
WDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVF
LQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSL
WSYINSQLEDFTNPLYGSYSNHVLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKEL
LAKRAELQKKVEELQREISNRSTSSSERASSPAQCVTPVQTVV
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Subcellular location
Cytoplasm
Function
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Stabilizes SBF2/MTMR13 at the membranes. Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein.
Uniprot ID
Q13614
Ensemble ID
ENST00000346299.10
HGNC ID
HGNC:7450

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT Insertion: p.S27RfsTer47 DBIA    Probe Info 
ICC9 Insertion: . DBIA    Probe Info 
LS123 Insertion: p.S27RfsTer47 DBIA    Probe Info 
MSTO211H SNV: p.Q278K .
NCIN87 SNV: p.L213V DBIA    Probe Info 
SW1271 SNV: p.A321V DBIA    Probe Info 
SW480 SNV: p.G11S .
VMRCRCW SNV: p.I369F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K137(9.92); K166(0.18)  LDD0277  [1]
m-APA
 Probe Info  		15.00  LDD0403  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [3]
DBIA
 Probe Info  		C95(1.18)  LDD0080  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C95(0.00); C155(0.00); C417(0.00); C237(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C95(0.00); C155(0.00); C417(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C284(0.00); C486(0.00); C417(0.00); C237(0.00)  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
NAIA_5
 Probe Info  		C284(0.00); C486(0.00); C237(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C313
 Probe Info  		13.83  LDD1980  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C95(0.72)  LDD0813  [4]
 LDCM0216  AC100 HCT 116 C95(0.98)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C95(0.66)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C95(0.97)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C95(0.84)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C95(1.23)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C95(0.95)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C95(0.98)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C95(1.01)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C95(0.86)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C95(1.14)  LDD0542  [4]
 LDCM0226  AC11 HEK-293T C95(0.80)  LDD0824  [4]
 LDCM0227  AC110 HCT 116 C95(0.92)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C95(1.50)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C95(1.24)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C95(0.94)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C95(1.26)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C95(0.86)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C95(0.80)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C95(0.88)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C95(0.82)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C95(0.83)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C95(0.87)  LDD0835  [4]
 LDCM0238  AC120 HCT 116 C95(1.94)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C95(1.47)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C95(0.92)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C95(1.05)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C95(0.81)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C95(1.22)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C95(1.30)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C95(0.80)  LDD0562  [4]
 LDCM0259  AC14 HEK-293T C95(0.80)  LDD0857  [4]
 LDCM0270  AC15 HEK-293T C95(0.79)  LDD0868  [4]
 LDCM0276  AC17 HEK-293T C155(0.91)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C155(0.87)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C155(1.01)  LDD0876  [4]
 LDCM0280  AC20 HEK-293T C155(0.87)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C155(0.87)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C155(1.02)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C155(1.03)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C155(0.84)  LDD0882  [4]
 LDCM0285  AC25 HCT 116 C95(0.72)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C95(0.67)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C95(0.86)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C95(0.57)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C95(0.84)  LDD0606  [4]
 LDCM0291  AC30 HCT 116 C95(0.79)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C95(0.78)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C95(0.72)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C95(1.07)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C95(1.42)  LDD0612  [4]
 LDCM0308  AC46 HCT 116 C95(0.69)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C95(0.71)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C95(0.91)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C95(1.07)  LDD0628  [4]
 LDCM0313  AC50 HCT 116 C95(1.10)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C95(0.73)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C95(1.00)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C95(1.03)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C95(1.10)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C95(0.81)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C95(1.09)  LDD0636  [4]
 LDCM0323  AC6 HEK-293T C95(0.85)  LDD0921  [4]
 LDCM0332  AC68 HEK-293T C155(0.91)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C155(0.83)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C95(0.74)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C155(1.01)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C155(1.03)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C155(0.88)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C155(0.93)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C155(1.06)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C155(0.94)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C155(0.97)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C155(1.00)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C155(0.98)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C155(1.00)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C95(0.79)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C155(0.96)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C155(1.43)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C155(1.03)  LDD0946  [4]
 LDCM0349  AC83 HCT 116 C95(0.61)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C95(0.71)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C95(0.85)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C95(0.78)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C95(1.49)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C95(1.49)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C95(1.31)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C95(2.07)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C95(1.07)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C95(0.44)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C95(1.37)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C95(0.58)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C95(1.27)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C95(0.35)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C95(1.43)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C95(0.94)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C95(0.88)  LDD0683  [4]
 LDCM0248  AKOS034007472 HEK-293T C95(0.74)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C95(0.65)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C95(0.87)  LDD0873  [4]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0632  CL-Sc Hep-G2 C95(20.00)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C95(1.71)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C95(2.16)  LDD0685  [4]
 LDCM0370  CL101 HEK-293T C95(0.79)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C95(0.88)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C95(0.90)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C95(0.63)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C155(0.78)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C155(0.92)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C155(0.83)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C155(0.85)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C155(1.02)  LDD0976  [4]
 LDCM0379  CL11 HCT 116 C95(1.35)  LDD0696  [4]
 LDCM0380  CL110 HEK-293T C155(1.00)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C155(0.98)  LDD0979  [4]
 LDCM0382  CL112 HCT 116 C95(0.86)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C95(1.34)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C95(1.30)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C95(1.29)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C95(1.19)  LDD0703  [4]
 LDCM0390  CL12 HCT 116 C95(2.16)  LDD0707  [4]
 LDCM0392  CL121 HCT 116 C95(1.00)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C95(0.92)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C95(1.02)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C95(0.87)  LDD0712  [4]
 LDCM0400  CL13 HCT 116 C95(1.78)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C95(2.32)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C95(1.46)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C95(0.91)  LDD1001  [4]
 LDCM0404  CL17 HCT 116 C95(0.67)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C95(0.78)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C95(0.78)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C95(1.32)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C95(1.01)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C95(0.88)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C95(2.05)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C95(1.45)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C95(1.09)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C95(0.64)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C95(1.05)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C95(0.86)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C95(0.79)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C95(0.81)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C95(2.11)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C95(0.92)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C95(0.69)  LDD0737  [4]
 LDCM0429  CL4 HCT 116 C95(2.23)  LDD0746  [4]
 LDCM0436  CL46 HCT 116 C95(0.90)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C95(0.98)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C95(1.05)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C95(1.00)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C95(1.12)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C95(1.10)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C95(1.00)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C95(1.03)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C95(1.29)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C95(1.10)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C95(1.09)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C95(0.96)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C95(0.93)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C95(1.07)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C95(1.13)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C95(0.70)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C95(1.10)  LDD0769  [4]
 LDCM0453  CL61 HEK-293T C155(0.94); C95(0.94)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C155(0.99); C95(0.89)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C155(0.83); C95(0.98)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C155(0.86); C95(1.02)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C155(0.88); C95(0.92)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C155(0.96); C95(0.87)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C155(1.03); C95(1.00)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C155(1.30); C95(0.92)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C155(1.10); C95(0.84)  LDD1059  [4]
 LDCM0462  CL7 HCT 116 C95(1.00)  LDD0779  [4]
 LDCM0463  CL70 HEK-293T C155(1.09); C95(0.78)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C155(1.07); C95(0.76)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C155(1.20); C95(1.26)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C155(1.25); C95(0.87)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C155(1.41); C95(1.05)  LDD1065  [4]
 LDCM0473  CL8 HCT 116 C95(1.73)  LDD0790  [4]
 LDCM0484  CL9 HCT 116 C95(1.21)  LDD0801  [4]
 LDCM0625  F8 Ramos C95(1.03)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C95(0.98)  LDD2189  [9]
 LDCM0574  Fragment12 Ramos C95(0.76)  LDD2191  [9]
 LDCM0579  Fragment20 Ramos C95(0.86)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C95(0.98)  LDD2195  [9]
 LDCM0586  Fragment28 Ramos C95(0.93)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C95(1.07)  LDD2199  [9]
 LDCM0590  Fragment32 Ramos C95(0.87)  LDD2201  [9]
 LDCM0468  Fragment33 HEK-293T C155(1.05); C95(0.90)  LDD1066  [4]
 LDCM0596  Fragment38 Ramos C95(0.63)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C95(0.66)  LDD2184  [9]
 LDCM0614  Fragment56 Ramos C95(0.88)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C95(0.68)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C95(0.68)  LDD2188  [9]
 LDCM0022  KB02 HCT 116 C95(1.18)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C95(1.03)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C95(1.27)  LDD0082  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myotubularin-related protein 12 (MTMR12) Protein-tyrosine phosphatase family Q9C0I1
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578