Details of the Target

General Information of Target

Target ID LDTP16322
Target Name Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B)
Gene Name TIMM8B
Gene ID 26521
Synonyms
DDP2; DDPL; TIM8B; Mitochondrial import inner membrane translocase subunit Tim8 B; DDP-like protein; Deafness dystonia protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEQAGTRPAATEHPRLRRPMPWLLLLPLLLLLLLLLPGPAASQLRYSVPEEQAPGALVGN
VARALGLELRRLGPGCLRINHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLS
LEVLAHNPVAVSAVEVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGAN
SVQTYELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGT
AQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYT
SDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVND
NAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLNGFGNSYT
LVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQE
NNLPGVLLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYE
KFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPA
GYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTV
VVRDNGEPSLSASVAITVAVVDRVSKILPDTQRHVKSPRTYSEITLYLIIALSTVSFIFL
LTIIILSIIKCYRYTAYGTACCGGFCGVRERSPAELYKQANNNIDARIPHGLKVQPHFIE
VRGNGSLTKTYCYKACLTAGSGSDTFMFYNTGAQTGPGPSGAQAAVTDSRNLTGQSGQNA
GNLIILKNEAVSQNEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVS
SATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEP
TNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Target Bioclass
Other
Family
Small Tim family
Subcellular location
Mitochondrion inner membrane
Function
Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Uniprot ID
Q9Y5J9
Ensemble ID
ENST00000504148.3
HGNC ID
HGNC:11818

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K80(10.95)  LDD2217  [1]
OPA-S-S-alkyne
 Probe Info  		K80(1.18)  LDD3494  [2]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0175  [5]
IPM
 Probe Info  		C55(0.00); C40(0.00); C59(0.00)  LDD2156  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		12.13  LDD1713  [10]
C004
 Probe Info  		6.68  LDD1714  [10]
C055
 Probe Info  		14.22  LDD1752  [10]
C056
 Probe Info  		24.59  LDD1753  [10]
C063
 Probe Info  		12.04  LDD1760  [10]
C087
 Probe Info  		9.19  LDD1779  [10]
C106
 Probe Info  		27.67  LDD1793  [10]
C108
 Probe Info  		8.57  LDD1795  [10]
C112
 Probe Info  		32.00  LDD1799  [10]
C134
 Probe Info  		29.86  LDD1816  [10]
C161
 Probe Info  		12.73  LDD1841  [10]
C194
 Probe Info  		8.88  LDD1870  [10]
C201
 Probe Info  		38.32  LDD1877  [10]
C206
 Probe Info  		16.56  LDD1881  [10]
C210
 Probe Info  		55.33  LDD1884  [10]
C218
 Probe Info  		12.73  LDD1892  [10]
C220
 Probe Info  		12.47  LDD1894  [10]
C228
 Probe Info  		15.24  LDD1901  [10]
C231
 Probe Info  		12.47  LDD1904  [10]
C232
 Probe Info  		51.63  LDD1905  [10]
C238
 Probe Info  		13.64  LDD1911  [10]
C284
 Probe Info  		21.11  LDD1954  [10]
C285
 Probe Info  		23.10  LDD1955  [10]
C289
 Probe Info  		51.63  LDD1959  [10]
C293
 Probe Info  		20.97  LDD1963  [10]
C296
 Probe Info  		13.45  LDD1966  [10]
C313
 Probe Info  		17.88  LDD1980  [10]
C314
 Probe Info  		14.83  LDD1981  [10]
C338
 Probe Info  		13.09  LDD2001  [10]
C348
 Probe Info  		12.91  LDD2009  [10]
C349
 Probe Info  		10.85  LDD2010  [10]
C350
 Probe Info  		44.94  LDD2011  [10]
C382
 Probe Info  		9.13  LDD2041  [10]
C383
 Probe Info  		15.14  LDD2042  [10]
C388
 Probe Info  		66.72  LDD2047  [10]
C403
 Probe Info  		21.11  LDD2061  [10]
C407
 Probe Info  		20.53  LDD2064  [10]
C429
 Probe Info  		11.47  LDD2084  [10]
C431
 Probe Info  		15.78  LDD2086  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [3]

References

1 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587