Details of the Probe

General Information of Probe

Probe ID
LDPC0646
Probe Name
C431
Synonyms
Z4282860081
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 378.5
Lipid-water partition coefficient (xlogp) 3.3
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C22H26N4O2
IUPAC Name
3-(3-but-3-ynyldiazirin-3-yl)-1-[2-(2-methoxy-1-methylindol-3-yl)pyrrolidin-1-yl]propan-1-one
Canonical SMILES
CN1C2=CC=CC=C2C(=C1OC)C3CCCN3C(=O)CCC4(N=N4)CCC#C
InChI
InChI=1S/C22H26N4O2/c1-4-5-13-22(23-24-22)14-12-19(27)26-15-8-11-18(26)20-16-9-6-7-10-17(16)25(2)21(20)28-3/h1,6-7,9-10,18H,5,8,11-15H2,2-3H3
InChIKey
BHRRGHMCKTXYFE-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

127 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) LDTP12639 18.00  LDD2086 
2-hydroxyacyl-CoA lyase 2 (ILVBL) LDTP00032 26.17  LDD2086 
2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8) LDTP06657 13.93  LDD2086 
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 14.72  LDD2086 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 22.78  LDD2086 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 17.88  LDD2086 
Acid ceramidase (ASAH1) LDTP05905 47.18  LDD2086 
ADP-dependent glucokinase (ADPGK) LDTP11127 27.47  LDD2086 
ADP-ribosylation factor-like protein 1 (ARL1) LDTP03900 18.51  LDD2086 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 32.67  LDD2086 
Alpha-galactosidase A (GLA) LDTP02141 16.11  LDD2086 
Alpha-ketoglutarate-dependent dioxygenase FTO (FTO) LDTP11595 19.29  LDD2086 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 19.43  LDD2086 
Atlastin-2 (ATL2) LDTP09251 15.14  LDD2086 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 16.11  LDD2086 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 20.39  LDD2086 
Beta-galactosidase (GLB1) LDTP02837 29.86  LDD2086 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 13.93  LDD2086 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 21.11  LDD2086 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 46.21  LDD2086 
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1) LDTP06023 13.64  LDD2086 
Calcyclin-binding protein (CACYBP) LDTP12163 13.93  LDD2086 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 16.11  LDD2086 
Catechol O-methyltransferase (COMT) LDTP03145 17.51  LDD2086 
Ceramide synthase 1 (CERS1) LDTP03394 27.86  LDD2086 
Ceramide synthase 2 (CERS2) LDTP10329 30.48  LDD2086 
Copper-transporting ATPase 2 (ATP7B) LDTP03779 15.56  LDD2086 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 63.56  LDD2086 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 74.03  LDD2086 
Cytochrome b5 type B (CYB5B) LDTP00697 99.73  LDD2086 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 21.56  LDD2086 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 58.08  LDD2086 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 21.41  LDD2086 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 14.93  LDD2086 
Delta(24)-sterol reductase (DHCR24) LDTP06375 18.13  LDD2086 
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) LDTP05724 19.97  LDD2086 
Deoxyhypusine hydroxylase (DOHH) LDTP11225 23.75  LDD2086 
Deoxyhypusine synthase (DHPS) LDTP04248 14.83  LDD2086 
Dephospho-CoA kinase domain-containing protein (DCAKD) LDTP18087 16.11  LDD2086 
Dihydrofolate reductase (DHFR) LDTP01769 52.71  LDD2086 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 20.11  LDD2086 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 16.22  LDD2086 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 16.56  LDD2086 
Endoplasmic reticulum protein SC65 (P3H4) LDTP09874 27.10  LDD2086 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 23.26  LDD2086 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 30.91  LDD2086 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 20.39  LDD2086 
Ferrochelatase, mitochondrial (FECH) LDTP03198 17.63  LDD2086 
Glyoxalase domain-containing protein 4 (GLOD4) LDTP16040 25.11  LDD2086 
Heme A synthase COX15 (COX15) LDTP07931 15.89  LDD2086 
Heme oxygenase 1 (HMOX1) LDTP02359 70.52  LDD2086 
Heme oxygenase 2 (HMOX2) LDTP03540 92.41  LDD2086 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 19.97  LDD2086 
Hexokinase-2 (HK2) LDTP04531 20.11  LDD2086 
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A) LDTP01018 28.64  LDD2086 
Histone-lysine N-methyltransferase NSD2 (NSD2) LDTP01759 15.78  LDD2086 
Holocytochrome c-type synthase (HCCS) LDTP04581 34.54  LDD2086 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 38.59  LDD2086 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 29.86  LDD2086 
Long-chain-fatty-acid--CoA ligase 6 (ACSL6) LDTP13486 14.83  LDD2086 
Lysine-specific histone demethylase 2 (KDM1B) LDTP09043 21.56  LDD2086 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 35.51  LDD2086 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 16.22  LDD2086 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 22.32  LDD2086 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 26.54  LDD2086 
Lysosomal acid phosphatase (ACP2) LDTP02539 17.88  LDD2086 
Lysosomal alpha-glucosidase (GAA) LDTP02486 18.25  LDD2086 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 38.32  LDD2086 
Lysosomal protective protein (CTSA) LDTP02505 71.01  LDD2086 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 53.82  LDD2086 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 34.06  LDD2086 
Minor histocompatibility antigen H13 (HM13) LDTP09396 30.27  LDD2086 
Mitochondrial-processing peptidase subunit alpha (PMPCA) LDTP05632 16.34  LDD2086 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 13.64  LDD2086 
N-alpha-acetyltransferase 40 (NAA40) LDTP08265 18.13  LDD2086 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 14.83  LDD2086 
NAD-capped RNA hydrolase NUDT12 (NUDT12) LDTP11081 20.97  LDD2086 
NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) LDTP08385 14.32  LDD2086 
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) LDTP12959 32.45  LDD2086 
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) LDTP01743 16.91  LDD2086 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 79.89  LDD2086 
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) LDTP14276 15.56  LDD2086 
NADH-ubiquinone oxidoreductase chain 5 (MT-ND5) LDTP01986 14.83  LDD2086 
NADPH--cytochrome P450 reductase (POR) LDTP02848 20.68  LDD2086 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 15.35  LDD2086 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 99.73  LDD2086 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 29.04  LDD2086 
Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) LDTP10101 20.97  LDD2086 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 25.81  LDD2086 
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) LDTP05029 77.71  LDD2086 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 31.12  LDD2086 
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) LDTP06307 13.64  LDD2086 
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) LDTP13220 21.26  LDD2086 
Phospholipase A2 group XV (PLA2G15) LDTP09088 16.00  LDD2086 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 23.59  LDD2086 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 68.59  LDD2086 
Presequence protease, mitochondrial (PITRM1) LDTP07003 16.68  LDD2086 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 16.80  LDD2086 
Prolyl endopeptidase-like (PREPL) LDTP06849 13.64  LDD2086 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 16.00  LDD2086 
Prostaglandin reductase 3 (PTGR3) LDTP15422 19.03  LDD2086 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 21.11  LDD2086 
Proteasome subunit beta type-3 (PSMB3) LDTP04284 28.64  LDD2086 
Proteasome subunit beta type-6 (PSMB6) LDTP03418 57.28  LDD2086 
Protein disulfide-isomerase (P4HB) LDTP02188 19.84  LDD2086 
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) LDTP09031 14.52  LDD2086 
Protein SCO1 homolog, mitochondrial (SCO1) LDTP01335 15.78  LDD2086 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 28.84  LDD2086 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 14.22  LDD2086 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 35.75  LDD2086 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 99.73  LDD2086 
Ribonuclease T2 (RNASET2) LDTP00316 18.25  LDD2086 
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) LDTP03592 13.74  LDD2086 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 25.11  LDD2086 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 16.45  LDD2086 
Serine palmitoyltransferase 1 (SPTLC1) LDTP00597 16.68  LDD2086 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) LDTP03523 13.93  LDD2086 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 16.80  LDD2086 
Sphingolipid delta(4)-desaturase DES1 (DEGS1) LDTP00544 15.24  LDD2086 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 20.11  LDD2086 
Squalene monooxygenase (SQLE) LDTP06142 20.68  LDD2086 
Sterol O-acyltransferase 1 (SOAT1) LDTP03769 14.42  LDD2086 
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) LDTP03139 19.43  LDD2086 
Thioredoxin domain-containing protein 12 (TXNDC12) LDTP01707 15.03  LDD2086 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 43.11  LDD2086 
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) LDTP12954 22.47  LDD2086 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 31.78  LDD2086 
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⏷ Show the Full List of 127 Enzyme
84 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 23.92  LDD2086 
Annexin A1 (ANXA1) LDTP02010 14.22  LDD2086 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 20.39  LDD2086 
ATP synthase subunit a (MT-ATP6) LDTP01804 76.11  LDD2086 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 35.02  LDD2086 
Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) LDTP03064 17.75  LDD2086 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 24.76  LDD2086 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 15.89  LDD2086 
Derlin-1 (DERL1) LDTP11245 18.64  LDD2086 
ER membrane protein complex subunit 2 (EMC2) LDTP06271 14.72  LDD2086 
Erlin-1 (ERLIN1) LDTP01234 14.52  LDD2086 
Erlin-2 (ERLIN2) LDTP01455 15.35  LDD2086 
Essential MCU regulator, mitochondrial (SMDT1) LDTP11927 91.14  LDD2086 
Golgi SNAP receptor complex member 1 (GOSR1) LDTP01542 20.82  LDD2086 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 13.93  LDD2086 
Integral membrane protein 2C (ITM2C) LDTP12451 22.16  LDD2086 
Intraflagellar transport protein 56 (IFT56) LDTP00010 16.00  LDD2086 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 19.43  LDD2086 
Lysosome membrane protein 2 (SCARB2) LDTP06034 35.26  LDD2086 
Major facilitator superfamily domain-containing protein 3 (MFSD3) LDTP18153 33.36  LDD2086 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 22.32  LDD2086 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 21.71  LDD2086 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 39.67  LDD2086 
Metal transporter CNNM4 (CNNM4) LDTP07537 13.93  LDD2086 
Metaxin-1 (MTX1) LDTP05900 14.72  LDD2086 
Metaxin-3 (MTX3) LDTP14970 19.03  LDD2086 
MFS-type transporter SLC18B1 (SLC18B1) LDTP07462 40.79  LDD2086 
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) LDTP11095 28.05  LDD2086 
Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) LDTP07472 16.56  LDD2086 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 17.39  LDD2086 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 15.56  LDD2086 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 67.18  LDD2086 
Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) LDTP04956 99.73  LDD2086 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 99.73  LDD2086 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 99.73  LDD2086 
Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) LDTP14099 51.98  LDD2086 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 57.28  LDD2086 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 18.38  LDD2086 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 22.78  LDD2086 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 42.52  LDD2086 
Monocarboxylate transporter 1 (SLC16A1) LDTP04592 16.34  LDD2086 
Mpv17-like protein 2 (MPV17L2) LDTP14952 24.08  LDD2086 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 18.25  LDD2086 
Nucleoporin NDC1 (NDC1) LDTP11213 24.76  LDD2086 
Nucleoporin Nup37 (NUP37) LDTP09203 21.11  LDD2086 
Occludin (OCLN) LDTP06581 20.11  LDD2086 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 20.97  LDD2086 
Peroxisomal biogenesis factor 19 (PEX19) LDTP03905 14.03  LDD2086 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 18.90  LDD2086 
Peroxisomal membrane protein PEX14 (PEX14) LDTP01200 13.64  LDD2086 
Prosaposin (PSAP) LDTP02215 68.59  LDD2086 
Protein ERGIC-53 (LMAN1) LDTP04237 19.97  LDD2086 
Protein FAM8A1 (FAM8A1) LDTP16190 32.90  LDD2086 
Protein GPR107 (GPR107) LDTP07236 86.22  LDD2086 
Protein GPR108 (GPR108) LDTP12383 16.68  LDD2086 
Protein spinster homolog 1 (SPNS1) LDTP11844 16.56  LDD2086 
Protein tweety homolog 3 (TTYH3) LDTP11615 56.89  LDD2086 
Proton-coupled zinc antiporter SLC30A5 (SLC30A5) LDTP09294 24.25  LDD2086 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 22.01  LDD2086 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 27.28  LDD2086 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 13.64  LDD2086 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 13.83  LDD2086 
Signal recognition particle subunit SRP68 (SRP68) LDTP13262 14.72  LDD2086 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 17.15  LDD2086 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 47.84  LDD2086 
Surfeit locus protein 4 (SURF4) LDTP00592 17.63  LDD2086 
Synaptojanin-2-binding protein (SYNJ2BP) LDTP04789 24.42  LDD2086 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 44.94  LDD2086 
Translocator protein (TSPO) LDTP03546 24.25  LDD2086 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 73.52  LDD2086 
Transmembrane 9 superfamily member 2 (TM9SF2) LDTP15845 14.12  LDD2086 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 20.82  LDD2086 
Transmembrane protein 126A (TMEM126A) LDTP15948 61.39  LDD2086 
Transmembrane protein 160 (TMEM160) LDTP20002 99.73  LDD2086 
Transmembrane protein 199 (TMEM199) LDTP08881 70.03  LDD2086 
Transmembrane protein 205 (TMEM205) LDTP07667 16.00  LDD2086 
Transmembrane protein 33 (TMEM33) LDTP04787 15.56  LDD2086 
Transmembrane protein 41B (TMEM41B) LDTP06944 28.05  LDD2086 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 20.25  LDD2086 
Vacuole membrane protein 1 (VMP1) LDTP10343 28.25  LDD2086 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 56.10  LDD2086 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 65.34  LDD2086 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 24.25  LDD2086 
Zinc transporter 7 (SLC30A7) LDTP09180 23.10  LDD2086 
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⏷ Show the Full List of 84 Transporter and channel
1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 14.62  LDD2086 
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4 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Basigin (BSG) LDTP03772 15.78  LDD2086 
HLA class I histocompatibility antigen, C alpha chain (HLA-C) LDTP02491 16.45  LDD2086 
IgG receptor FcRn large subunit p51 (FCGRT) LDTP04720 15.03  LDD2086 
Leukocyte surface antigen CD47 (CD47) LDTP05572 13.74  LDD2086 
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115 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adapter molecule crk (CRK) LDTP04091 45.25  LDD2086 
Anaphase-promoting complex subunit 16 (ANAPC16) LDTP10213 15.45  LDD2086 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 23.92  LDD2086 
Annexin A7 (ANXA7) LDTP03030 13.64  LDD2086 
Ataxin-10 (ATXN10) LDTP13091 14.03  LDD2086 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 13.93  LDD2086 
Calcium-binding protein 39 (CAB39) LDTP13955 15.67  LDD2086 
Calumenin (CALU) LDTP00887 19.97  LDD2086 
Centrin-2 (CETN2) LDTP03926 20.39  LDD2086 
Centrosomal protein 43 (CEP43) LDTP01652 14.72  LDD2086 
Cold-inducible RNA-binding protein (CIRBP) LDTP06022 16.56  LDD2086 
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) LDTP12379 15.78  LDD2086 
CYFIP-related Rac1 interactor B (CYRIB) LDTP12642 19.70  LDD2086 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 99.73  LDD2086 
Cytoplasmic 60S subunit biogenesis factor ZNF622 (ZNF622) LDTP10027 14.03  LDD2086 
DDRGK domain-containing protein 1 (DDRGK1) LDTP10403 16.22  LDD2086 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 23.92  LDD2086 
Dynactin subunit 3 (DCTN3) LDTP01359 17.51  LDD2086 
Dysbindin (DTNBP1) LDTP10279 14.32  LDD2086 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 26.17  LDD2086 
Emerin (EMD) LDTP04356 16.00  LDD2086 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 91.14  LDD2086 
Endothelial protein C receptor (PROCR) LDTP13669 16.68  LDD2086 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 99.73  LDD2086 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 72.00  LDD2086 
Galectin-3-binding protein (LGALS3BP) LDTP05558 15.78  LDD2086 
Ganglioside GM2 activator (GM2A) LDTP02927 23.59  LDD2086 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 44.32  LDD2086 
H/ACA ribonucleoprotein complex subunit 1 (GAR1) LDTP12796 46.53  LDD2086 
HEAT repeat-containing protein 3 (HEATR3) LDTP15253 19.97  LDD2086 
Heat shock 70 kDa protein 13 (HSPA13) LDTP04207 21.71  LDD2086 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 14.93  LDD2086 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 16.11  LDD2086 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 15.78  LDD2086 
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) LDTP04714 13.74  LDD2086 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 14.32  LDD2086 
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) LDTP00991 13.55  LDD2086 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 13.93  LDD2086 
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA) LDTP01259 16.56  LDD2086 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 15.56  LDD2086 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 32.45  LDD2086 
Large ribosomal subunit protein mL46 (MRPL46) LDTP15976 15.78  LDD2086 
Large ribosomal subunit protein mL55 (MRPL55) LDTP15269 44.63  LDD2086 
Large ribosomal subunit protein uL10m (MRPL10) LDTP08154 19.70  LDD2086 
LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) LDTP15240 21.41  LDD2086 
m-AAA protease-interacting protein 1, mitochondrial (MAIP1) LDTP09644 19.03  LDD2086 
Matrix-remodeling-associated protein 7 (MXRA7) LDTP17003 15.67  LDD2086 
MAU2 chromatid cohesion factor homolog (MAU2) LDTP14304 36.25  LDD2086 
Mdm2-binding protein (MTBP) LDTP15714 16.00  LDD2086 
MICOS complex subunit MIC13 (MICOS13) LDTP07274 17.88  LDD2086 
MICOS complex subunit MIC19 (CHCHD3) LDTP12764 15.45  LDD2086 
Microtubule nucleation factor SSNA1 (SSNA1) LDTP00871 29.86  LDD2086 
Midasin (MDN1) LDTP12619 14.62  LDD2086 
MIF4G domain-containing protein (MIF4GD) LDTP00155 14.22  LDD2086 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 29.04  LDD2086 
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) LDTP16322 15.78  LDD2086 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 99.73  LDD2086 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 82.14  LDD2086 
Mitochondrial import receptor subunit TOM6 homolog (TOMM6) LDTP10113 60.13  LDD2086 
Mitochondrial intermembrane space import and assembly protein 40 (CHCHD4) LDTP08874 13.83  LDD2086 
Mortality factor 4-like protein 1 (MORF4L1) LDTP13162 14.52  LDD2086 
Neuferricin (CYB5D2) LDTP15623 30.06  LDD2086 
Neurofilament light polypeptide (NEFL) LDTP02180 15.45  LDD2086 
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) LDTP13622 14.12  LDD2086 
Nucleobindin-1 (NUCB1) LDTP05375 71.51  LDD2086 
Nucleobindin-2 (NUCB2) LDTP05160 99.73  LDD2086 
Nurim (NRM) LDTP08606 32.67  LDD2086 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 16.91  LDD2086 
Optic atrophy 3 protein (OPA3) LDTP16006 34.06  LDD2086 
Oxysterol-binding protein-related protein 3 (OSBPL3) LDTP11930 13.64  LDD2086 
Phosducin-like protein 3 (PDCL3) LDTP11825 19.97  LDD2086 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 58.89  LDD2086 
Polyamine-modulated factor 1 (PMF1) LDTP07508 24.25  LDD2086 
PRELI domain-containing protein 1, mitochondrial (PRELID1) LDTP13807 29.04  LDD2086 
Programmed cell death protein 5 (PDCD5) LDTP00417 18.77  LDD2086 
Protein CEBPZOS (CEBPZOS) LDTP18883 24.42  LDD2086 
Protein CUSTOS (CUSTOS) LDTP18134 16.00  LDD2086 
Protein FAM114A2 (FAM114A2) LDTP16080 32.22  LDD2086 
Protein FAM162A (FAM162A) LDTP10056 28.25  LDD2086 
Protein FAM177A1 (FAM177A1) LDTP15398 22.78  LDD2086 
Protein FAM89A (FAM89A) LDTP19867 16.91  LDD2086 
Protein flightless-1 homolog (FLII) LDTP05734 14.83  LDD2086 
Protein jagunal homolog 1 (JAGN1) LDTP08904 22.78  LDD2086 
Protein LYRIC (MTDH) LDTP08224 13.93  LDD2086 
Protein PBDC1 (PBDC1) LDTP19924 16.00  LDD2086 
Protein SET (SET) LDTP05277 13.55  LDD2086 
Protein SYS1 homolog (SYS1) LDTP08796 22.32  LDD2086 
Protein unc-119 homolog B (UNC119B) LDTP00105 20.53  LDD2086 
Protein UXT (UXT) LDTP13125 26.17  LDD2086 
Protein YIF1A (YIF1A) LDTP01494 16.91  LDD2086 
Ran guanine nucleotide release factor (RANGRF) LDTP12287 80.45  LDD2086 
Reticulocalbin-2 (RCN2) LDTP06097 39.40  LDD2086 
Reticulon-3 (RTN3) LDTP01522 72.00  LDD2086 
Reticulon-4 (RTN4) LDTP12412 26.91  LDD2086 
RNA-binding protein 10 (RBM10) LDTP05224 18.51  LDD2086 
RNA-binding protein FUS (FUS) LDTP03775 16.11  LDD2086 
RNA-binding protein FXR1 (FXR1) LDTP04395 22.01  LDD2086 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 27.28  LDD2086 
Small integral membrane protein 12 (SMIM12) LDTP19859 32.90  LDD2086 
Small ribosomal subunit protein mS33 (MRPS33) LDTP18561 16.68  LDD2086 
Synaptogyrin-2 (SYNGR2) LDTP00859 21.71  LDD2086 
Syntaxin-18 (STX18) LDTP13086 26.35  LDD2086 
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) LDTP14263 15.45  LDD2086 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 19.43  LDD2086 
TBC1 domain family member 9B (TBC1D9B) LDTP15057 19.29  LDD2086 
Tetraspanin-6 (TSPAN6) LDTP14458 71.51  LDD2086 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 27.10  LDD2086 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 29.24  LDD2086 
TraB domain-containing protein (TRABD) LDTP19963 19.70  LDD2086 
Transmembrane protein 43 (TMEM43) LDTP11210 14.62  LDD2086 
Type-1 angiotensin II receptor-associated protein (AGTRAP) LDTP07632 13.93  LDD2086 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 61.39  LDD2086 
UPF0488 protein C8orf33 (C8orf33) LDTP12025 14.52  LDD2086 
Vimentin (VIM) LDTP02297 14.52  LDD2086 
Zinc finger CCHC domain-containing protein 3 (ZCCHC3) LDTP12623 15.78  LDD2086 
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Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD2086 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587