Details of the Target

General Information of Target

Target ID LDTP01542
Target Name Golgi SNAP receptor complex member 1 (GOSR1)
Gene Name GOSR1
Gene ID 9527
Synonyms
GS28; Golgi SNAP receptor complex member 1; 28 kDa Golgi SNARE protein; 28 kDa cis-Golgi SNARE p28; GOS-28
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGTSSYWEDLRKQARQLENELDLKLVSFSKLCTSYSHSSTRDGRRDRYSSDTTPLLNG
SSQDRMFETMAIEIEQLLARLTGVNDKMAEYTNSAGVPSLNAALMHTLQRHRDILQDYTH
EFHKTKANFMAIRERENLMGSVRKDIESYKSGSGVNNRRTELFLKEHDHLRNSDRLIEET
ISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQRINLRKRRDSLILGGVIGIC
TILLLLYAFH
Target Bioclass
Transporter and channel
Family
GOSR1 family
Subcellular location
Golgi apparatus membrane
Function
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
Uniprot ID
O95249
Ensemble ID
ENST00000225724.9
HGNC ID
HGNC:4430

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C34(1.54)  LDD3330  [1]
BTD
 Probe Info  		C34(0.66)  LDD2097  [2]
ATP probe
 Probe Info  		K144(0.00); K124(0.00); K126(0.00)  LDD0199  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
STPyne
 Probe Info  		N.A.  LDD0009  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
AOyne
 Probe Info  		14.60  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 63 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		29.04  LDD1740  [10]
C041
 Probe Info  		8.22  LDD1741  [10]
C049
 Probe Info  		6.96  LDD1747  [10]
C053
 Probe Info  		5.10  LDD1751  [10]
C055
 Probe Info  		14.32  LDD1752  [10]
C056
 Probe Info  		32.67  LDD1753  [10]
C063
 Probe Info  		15.67  LDD1760  [10]
C082
 Probe Info  		5.46  LDD1774  [10]
C087
 Probe Info  		9.85  LDD1779  [10]
C091
 Probe Info  		13.64  LDD1782  [10]
C092
 Probe Info  		22.94  LDD1783  [10]
C094
 Probe Info  		25.46  LDD1785  [10]
C106
 Probe Info  		25.28  LDD1793  [10]
C107
 Probe Info  		5.58  LDD1794  [10]
C112
 Probe Info  		38.05  LDD1799  [10]
C130
 Probe Info  		7.01  LDD1812  [10]
C134
 Probe Info  		34.30  LDD1816  [10]
C135
 Probe Info  		10.63  LDD1817  [10]
C143
 Probe Info  		21.71  LDD1825  [10]
C159
 Probe Info  		9.85  LDD1839  [10]
C160
 Probe Info  		9.25  LDD1840  [10]
C161
 Probe Info  		17.39  LDD1841  [10]
C169
 Probe Info  		40.50  LDD1849  [10]
C178
 Probe Info  		15.45  LDD1857  [10]
C186
 Probe Info  		15.56  LDD1864  [10]
C187
 Probe Info  		16.56  LDD1865  [10]
C201
 Probe Info  		88.65  LDD1877  [10]
C206
 Probe Info  		25.28  LDD1881  [10]
C210
 Probe Info  		94.35  LDD1884  [10]
C213
 Probe Info  		15.45  LDD1887  [10]
C243
 Probe Info  		17.15  LDD1916  [10]
C244
 Probe Info  		17.51  LDD1917  [10]
C246
 Probe Info  		32.67  LDD1919  [10]
C249
 Probe Info  		16.68  LDD1922  [10]
C264
 Probe Info  		19.97  LDD1935  [10]
C285
 Probe Info  		36.50  LDD1955  [10]
C287
 Probe Info  		20.11  LDD1957  [10]
C288
 Probe Info  		8.57  LDD1958  [10]
C289
 Probe Info  		99.73  LDD1959  [10]
C293
 Probe Info  		17.27  LDD1963  [10]
C310
 Probe Info  		12.13  LDD1977  [10]
C313
 Probe Info  		14.12  LDD1980  [10]
C314
 Probe Info  		18.38  LDD1981  [10]
C355
 Probe Info  		32.45  LDD2016  [10]
C356
 Probe Info  		8.57  LDD2017  [10]
C357
 Probe Info  		5.10  LDD2018  [10]
C362
 Probe Info  		99.73  LDD2023  [10]
C363
 Probe Info  		24.42  LDD2024  [10]
C364
 Probe Info  		28.64  LDD2025  [10]
C366
 Probe Info  		8.46  LDD2027  [10]
C367
 Probe Info  		5.78  LDD2028  [10]
C382
 Probe Info  		9.71  LDD2041  [10]
C388
 Probe Info  		99.73  LDD2047  [10]
C390
 Probe Info  		64.45  LDD2049  [10]
C399
 Probe Info  		7.06  LDD2058  [10]
C403
 Probe Info  		28.44  LDD2061  [10]
C407
 Probe Info  		25.63  LDD2064  [10]
C429
 Probe Info  		15.35  LDD2084  [10]
C431
 Probe Info  		20.82  LDD2086  [10]
FFF probe11
 Probe Info  		20.00  LDD0471  [11]
FFF probe14
 Probe Info  		20.00  LDD0477  [11]
Alk-rapa
 Probe Info  		3.80  LDD0213  [12]
OEA-DA
 Probe Info  		17.60  LDD0046  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C34(0.41)  LDD2142  [2]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C34(0.66)  LDD2112  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C34(1.17)  LDD2152  [2]
 LDCM0214  AC1 HEK-293T C34(0.92)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C34(0.87)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C34(0.93)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C34(1.03)  LDD1510  [14]
 LDCM0270  AC15 HEK-293T C34(1.01)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C34(1.12)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C34(0.93)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C34(0.83)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C34(1.09)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C34(1.07)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C34(0.97)  LDD1520  [14]
 LDCM0283  AC23 HEK-293T C34(1.14)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C34(1.18)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C34(0.99)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C34(1.08)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C34(0.95)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C34(1.05)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C34(0.98)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C34(1.13)  LDD1529  [14]
 LDCM0292  AC31 HEK-293T C34(1.18)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C34(1.03)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C34(1.03)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C34(1.00)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C34(1.06)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C34(0.96)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C34(1.18)  LDD1537  [14]
 LDCM0300  AC39 HEK-293T C34(1.01)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C34(1.07)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C34(0.97)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C34(1.04)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C34(0.98)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C34(0.95)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C34(1.12)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C34(1.06)  LDD1546  [14]
 LDCM0309  AC47 HEK-293T C34(1.04)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C34(1.00)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C34(0.80)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C34(1.04)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C34(0.89)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C34(0.98)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C34(1.16)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C34(0.96)  LDD1555  [14]
 LDCM0318  AC55 HEK-293T C34(0.88)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C34(0.95)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C34(0.91)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C34(0.89)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C34(0.98)  LDD1561  [14]
 LDCM0324  AC60 HEK-293T C34(0.90)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C34(0.86)  LDD1564  [14]
 LDCM0327  AC63 HEK-293T C34(0.91)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C34(0.96)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C34(1.13)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C34(1.04)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C34(0.99)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C34(0.99)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C34(0.99)  LDD1514  [14]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C34(1.15)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C34(0.94)  LDD1571  [14]
 LDCM0369  CL100 HEK-293T C34(1.02)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C34(0.94)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C34(0.92)  LDD1575  [14]
 LDCM0373  CL104 HEK-293T C34(0.98)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C34(0.91)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C34(0.95)  LDD1579  [14]
 LDCM0377  CL108 HEK-293T C34(0.96)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C34(0.96)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C34(0.95)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C34(0.90)  LDD1584  [14]
 LDCM0382  CL112 HEK-293T C34(0.94)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C34(1.06)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C34(0.89)  LDD1588  [14]
 LDCM0386  CL116 HEK-293T C34(1.04)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C34(0.99)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C34(0.89)  LDD1592  [14]
 LDCM0390  CL12 HEK-293T C34(0.95)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C34(0.98)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C34(0.93)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C34(0.81)  LDD1597  [14]
 LDCM0395  CL124 HEK-293T C34(0.95)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C34(0.62)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C34(0.78)  LDD1601  [14]
 LDCM0399  CL128 HEK-293T C34(0.99)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C34(0.86)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C34(1.06)  LDD1605  [14]
 LDCM0403  CL16 HEK-293T C34(1.05)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C34(0.86)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C34(0.91)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C34(0.85)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C34(0.91)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C34(1.09)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C34(0.93)  LDD1613  [14]
 LDCM0411  CL23 HEK-293T C34(1.06)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C34(1.02)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C34(0.74)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C34(0.96)  LDD1618  [14]
 LDCM0416  CL28 HEK-293T C34(0.97)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C34(1.14)  LDD1621  [14]
 LDCM0419  CL30 HEK-293T C34(1.11)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C34(0.94)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C34(1.07)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C34(0.78)  LDD1626  [14]
 LDCM0424  CL35 HEK-293T C34(0.89)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C34(1.18)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C34(0.94)  LDD1630  [14]
 LDCM0429  CL4 HEK-293T C34(0.94)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C34(1.01)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C34(1.10)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C34(0.91)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C34(0.96)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C34(1.07)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C34(0.93)  LDD1639  [14]
 LDCM0437  CL47 HEK-293T C34(1.05)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C34(1.13)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C34(0.93)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C34(0.85)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C34(1.01)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C34(0.96)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C34(1.01)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C34(0.77)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C34(1.03)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C34(0.95)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C34(1.01)  LDD1651  [14]
 LDCM0450  CL59 HEK-293T C34(1.00)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C34(0.74)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C34(1.00)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C34(0.91)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C34(1.14)  LDD1657  [14]
 LDCM0456  CL64 HEK-293T C34(1.03)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C34(0.96)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C34(1.00)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C34(1.05)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C34(1.04)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C34(0.85)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C34(0.96)  LDD1665  [14]
 LDCM0464  CL71 HEK-293T C34(0.88)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C34(1.04)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C34(0.88)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C34(0.91)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C34(1.03)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C34(0.87)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C34(1.07)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C34(1.08)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C34(0.63)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C34(1.08)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C34(0.91)  LDD1678  [14]
 LDCM0477  CL83 HEK-293T C34(1.06)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C34(0.92)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C34(0.64)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C34(0.69)  LDD1683  [14]
 LDCM0482  CL88 HEK-293T C34(0.96)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C34(0.78)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C34(1.00)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C34(0.61)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C34(0.86)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C34(0.88)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C34(0.86)  LDD1691  [14]
 LDCM0490  CL95 HEK-293T C34(0.83)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C34(0.63)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C34(0.94)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C34(0.92)  LDD1696  [14]
 LDCM0625  F8 Ramos C34(1.54)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C34(0.51)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C34(19.10)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C34(0.44)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C34(0.99)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C34(0.76)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C34(0.41)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C34(0.81)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C34(0.90)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C34(0.88)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C34(0.62)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C34(1.06)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C34(0.96)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C34(0.70)  LDD2201  [15]
 LDCM0468  Fragment33 Ramos C34(0.90)  LDD2202  [15]
 LDCM0596  Fragment38 Ramos C34(1.06)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C34(0.72)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C34(1.02)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C34(1.08)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C34(1.47)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C34(0.51)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C34(0.45)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C34(1.07)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C34(0.92)  LDD1497  [14]
 LDCM0024  KB05 MIA PaCa-2 C34(1.54)  LDD3330  [1]
 LDCM0109  NEM HeLa N.A.  LDD0225  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C34(0.66)  LDD2097  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C34(0.88)  LDD2098  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C34(0.81)  LDD2099  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C34(0.46)  LDD2100  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C34(0.57)  LDD2101  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C34(0.37)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C34(1.15)  LDD2105  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C34(0.35)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C34(0.74)  LDD2107  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C34(0.51)  LDD2108  [2]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C34(0.47)  LDD2110  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C34(1.01)  LDD2111  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C34(0.41)  LDD2115  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C34(1.34)  LDD2119  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C34(1.71)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C34(0.68)  LDD2135  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C34(0.83)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C34(0.70)  LDD2141  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C34(0.58)  LDD2146  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C34(0.44)  LDD2148  [2]
 LDCM0090  Rapamycin JHH-7 3.80  LDD0213  [12]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
13 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578