Details of the Probe

General Information of Probe

Probe ID
LDPC0576
Probe Name
C355
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 390.365
Lipid-water partition coefficient (xlogp) 3.9576
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C19H17F3N4O2
Canonical SMILES
[H]C#CC([H])([H])C([H])([H])C1(C([H])([H])C([H])([H])N([H])C(=O)c2c([H])nc3c([H])c([H])c(OC([H])([H])[H])c([H])c3c2C(F)(F)F)N=N1
InChI
InChI=1S/C19H17F3N4O2/c1-3-4-7-18(25-26-18)8-9-23-17(27)14-11-24-15-6-5-12(28-2)10-13(15)16(14)19(20,21)22/h1,5-6,10-11H,4,7-9H2,2H3,(H,23,27)
InChIKey
CJTDBVIGBINLBY-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

142 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) LDTP06325 43.11  LDD2016 
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) LDTP02000 22.94  LDD2016 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 76.11  LDD2016 
Acid ceramidase (ASAH1) LDTP05905 45.89  LDD2016 
Adenosine deaminase (ADA) LDTP01803 36.50  LDD2016 
Adipocyte plasma membrane-associated protein (APMAP) LDTP12293 44.02  LDD2016 
ADP-dependent glucokinase (ADPGK) LDTP11127 28.64  LDD2016 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 38.59  LDD2016 
All-trans-retinol 13,14-reductase (RETSAT) LDTP15097 27.28  LDD2016 
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT2) LDTP05622 25.99  LDD2016 
Alpha-galactosidase A (GLA) LDTP02141 22.63  LDD2016 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 38.85  LDD2016 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 41.64  LDD2016 
Atlastin-2 (ATL2) LDTP09251 27.47  LDD2016 
ATP synthase subunit beta, mitochondrial (ATP5F1B) LDTP02150 22.94  LDD2016 
ATP-binding cassette sub-family C member 10 (ABCC10) LDTP07109 24.59  LDD2016 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 62.25  LDD2016 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 23.75  LDD2016 
ATPase family AAA domain-containing protein 3A (ATAD3A) LDTP12681 23.75  LDD2016 
Beta-1,3-galactosyltransferase 6 (B3GALT6) LDTP10530 31.34  LDD2016 
Beta-galactosidase (GLB1) LDTP02837 32.00  LDD2016 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 25.81  LDD2016 
Beta-hexosaminidase subunit beta (HEXB) LDTP02216 25.63  LDD2016 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 94.35  LDD2016 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 34.30  LDD2016 
Calcium-transporting ATPase type 2C member 1 (ATP2C1) LDTP05228 32.00  LDD2016 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 40.50  LDD2016 
Carboxypeptidase D (CPD) LDTP01372 22.63  LDD2016 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 32.67  LDD2016 
Catechol O-methyltransferase (COMT) LDTP03145 27.47  LDD2016 
Ceramide glucosyltransferase (UGCG) LDTP06617 40.22  LDD2016 
Ceramide synthase 1 (CERS1) LDTP03394 35.75  LDD2016 
Ceramide synthase 2 (CERS2) LDTP10329 25.46  LDD2016 
Chitinase domain-containing protein 1 (CHID1) LDTP11336 39.95  LDD2016 
Choline kinase alpha (CHKA) LDTP03787 36.25  LDD2016 
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) LDTP08933 23.59  LDD2016 
COP9 signalosome complex subunit 4 (COPS4) LDTP11187 27.28  LDD2016 
Copper-transporting ATPase 2 (ATP7B) LDTP03779 22.78  LDD2016 
Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) LDTP03189 27.67  LDD2016 
Cytochrome b-c1 complex subunit 7 (UQCRB) LDTP02757 28.44  LDD2016 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 39.95  LDD2016 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 54.19  LDD2016 
Cytochrome b5 type B (CYB5B) LDTP00697 64.45  LDD2016 
Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7A2L) LDTP14427 23.10  LDD2016 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 41.07  LDD2016 
DCN1-like protein 4 (DCUN1D4) LDTP09799 22.16  LDD2016 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 29.45  LDD2016 
Delta(14)-sterol reductase TM7SF2 (TM7SF2) LDTP01389 30.70  LDD2016 
Delta(24)-sterol reductase (DHCR24) LDTP06375 24.59  LDD2016 
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) LDTP05724 31.56  LDD2016 
Deoxyhypusine hydroxylase (DOHH) LDTP11225 27.47  LDD2016 
Dephospho-CoA kinase domain-containing protein (DCAKD) LDTP18087 23.75  LDD2016 
DNA replication licensing factor MCM4 (MCM4) LDTP03680 27.10  LDD2016 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 24.76  LDD2016 
Dynamin-like 120 kDa protein, mitochondrial (OPA1) LDTP00950 25.63  LDD2016 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 23.43  LDD2016 
Endoplasmic reticulum metallopeptidase 1 (ERMP1) LDTP08017 34.78  LDD2016 
Endoplasmic reticulum protein SC65 (P3H4) LDTP09874 30.06  LDD2016 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 30.06  LDD2016 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 75.06  LDD2016 
Epoxide hydrolase 1 (EPHX1) LDTP02175 25.63  LDD2016 
Ethanolamine kinase 1 (ETNK1) LDTP12197 40.22  LDD2016 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 61.82  LDD2016 
Fatty acyl-CoA reductase 1 (FAR1) LDTP09628 26.91  LDD2016 
Geranylgeranyl transferase type-2 subunit beta (RABGGTB) LDTP04569 66.26  LDD2016 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 30.27  LDD2016 
Glycerophosphodiester phosphodiesterase 1 (GDE1) LDTP12886 39.12  LDD2016 
Guanine nucleotide-binding protein-like 3-like protein (GNL3L) LDTP12687 48.50  LDD2016 
Heme oxygenase 1 (HMOX1) LDTP02359 64.00  LDD2016 
Heme oxygenase 2 (HMOX2) LDTP03540 99.73  LDD2016 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 26.35  LDD2016 
Holocytochrome c-type synthase (HCCS) LDTP04581 24.08  LDD2016 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 43.71  LDD2016 
L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) LDTP12105 22.63  LDD2016 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 34.06  LDD2016 
Lathosterol oxidase (SC5D) LDTP01329 23.43  LDD2016 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 37.79  LDD2016 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 84.45  LDD2016 
Lysine-specific histone demethylase 2 (KDM1B) LDTP09043 26.17  LDD2016 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 28.25  LDD2016 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 25.28  LDD2016 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 28.84  LDD2016 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 52.35  LDD2016 
Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) LDTP03858 25.63  LDD2016 
Lysosomal acid phosphatase (ACP2) LDTP02539 41.93  LDD2016 
Lysosomal alpha-glucosidase (GAA) LDTP02486 27.47  LDD2016 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 49.18  LDD2016 
Lysosomal protective protein (CTSA) LDTP02505 27.86  LDD2016 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 91.14  LDD2016 
Minor histocompatibility antigen H13 (HM13) LDTP09396 36.00  LDD2016 
Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) LDTP06810 27.86  LDD2016 
MYG1 exonuclease (MYG1) LDTP12154 22.94  LDD2016 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 27.47  LDD2016 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 29.45  LDD2016 
NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) LDTP08385 22.94  LDD2016 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 88.65  LDD2016 
NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial (NDUFB5) LDTP00831 22.16  LDD2016 
NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8) LDTP01515 39.67  LDD2016 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 34.54  LDD2016 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 99.73  LDD2016 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 24.25  LDD2016 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 22.47  LDD2016 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 24.25  LDD2016 
Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) LDTP01562 23.10  LDD2016 
Phospholipase A2 group XV (PLA2G15) LDTP09088 35.02  LDD2016 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 29.65  LDD2016 
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) LDTP05624 27.86  LDD2016 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 69.55  LDD2016 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 40.22  LDD2016 
Prostaglandin E synthase 2 (PTGES2) LDTP12040 27.47  LDD2016 
Prostaglandin reductase 3 (PTGR3) LDTP15422 22.94  LDD2016 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 27.28  LDD2016 
Protein O-GlcNAcase (OGA) LDTP00988 32.90  LDD2016 
Protein SCO1 homolog, mitochondrial (SCO1) LDTP01335 24.76  LDD2016 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 74.03  LDD2016 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 28.84  LDD2016 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 99.73  LDD2016 
Ras-related protein Rab-24 (RAB24) LDTP10020 28.64  LDD2016 
Retinal dehydrogenase 2 (ALDH1A2) LDTP01419 22.63  LDD2016 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 99.73  LDD2016 
Ribitol 5-phosphate transferase FKRP (FKRP) LDTP12109 27.10  LDD2016 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 30.70  LDD2016 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 66.26  LDD2016 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 28.25  LDD2016 
Serine palmitoyltransferase 2 (SPTLC2) LDTP00598 22.47  LDD2016 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 30.70  LDD2016 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 26.17  LDD2016 
Signal peptide peptidase-like 2A (SPPL2A) LDTP09395 22.47  LDD2016 
Soluble calcium-activated nucleotidase 1 (CANT1) LDTP09620 30.06  LDD2016 
Sphingolipid delta(4)-desaturase DES1 (DEGS1) LDTP00544 30.27  LDD2016 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 57.28  LDD2016 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 31.34  LDD2016 
Squalene monooxygenase (SQLE) LDTP06142 29.45  LDD2016 
Squalene synthase (FDFT1) LDTP03842 29.86  LDD2016 
Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) LDTP04438 25.11  LDD2016 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 30.06  LDD2016 
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) LDTP14189 39.40  LDD2016 
Ubiquitin carboxyl-terminal hydrolase 28 (USP28) LDTP10785 22.47  LDD2016 
UDP-glucuronic acid decarboxylase 1 (UXS1) LDTP09074 28.25  LDD2016 
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) LDTP06901 25.28  LDD2016 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 32.22  LDD2016 
Vitamin K-dependent gamma-carboxylase (GGCX) LDTP03854 32.22  LDD2016 
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⏷ Show the Full List of 142 Enzyme
86 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
45 kDa calcium-binding protein (SDF4) LDTP11116 26.91  LDD2016 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 34.30  LDD2016 
Amyloid-beta precursor protein (APP) LDTP02071 29.86  LDD2016 
AP-4 complex subunit mu-1 (AP4M1) LDTP00208 36.25  LDD2016 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 24.25  LDD2016 
ATP synthase subunit a (MT-ATP6) LDTP01804 30.48  LDD2016 
ATP synthase subunit e, mitochondrial (ATP5ME) LDTP14717 24.59  LDD2016 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 81.01  LDD2016 
ATP synthase subunit gamma, mitochondrial (ATP5F1C) LDTP03810 22.16  LDD2016 
Autophagy-related protein 9A (ATG9A) LDTP08030 23.92  LDD2016 
B-cell receptor-associated protein 31 (BCAP31) LDTP04426 22.94  LDD2016 
BRI3-binding protein (BRI3BP) LDTP15648 56.49  LDD2016 
Calcium uptake protein 2, mitochondrial (MICU2) LDTP08673 25.81  LDD2016 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 31.34  LDD2016 
Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) LDTP03064 24.59  LDD2016 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 74.54  LDD2016 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 32.90  LDD2016 
Derlin-2 (DERL2) LDTP11634 25.11  LDD2016 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) LDTP02057 23.26  LDD2016 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 31.34  LDD2016 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 56.49  LDD2016 
G-protein coupled receptor-associated protein LMBRD2 (LMBRD2) LDTP15064 25.28  LDD2016 
Golgi SNAP receptor complex member 1 (GOSR1) LDTP01542 32.45  LDD2016 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 36.00  LDD2016 
Heme transporter FLVCR1 (FLVCR1) LDTP14178 41.07  LDD2016 
Integral membrane protein 2C (ITM2C) LDTP12451 26.91  LDD2016 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 27.28  LDD2016 
Lysosome membrane protein 2 (SCARB2) LDTP06034 83.87  LDD2016 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 31.12  LDD2016 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 33.13  LDD2016 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 44.32  LDD2016 
Metaxin-1 (MTX1) LDTP05900 49.18  LDD2016 
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) LDTP11095 23.92  LDD2016 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 22.32  LDD2016 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 22.94  LDD2016 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 32.90  LDD2016 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 43.71  LDD2016 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 99.73  LDD2016 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 99.73  LDD2016 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 37.01  LDD2016 
Mitochondrial import receptor subunit TOM40 homolog (TOMM40) LDTP01748 22.16  LDD2016 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 39.12  LDD2016 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 32.22  LDD2016 
Mpv17-like protein 2 (MPV17L2) LDTP14952 26.72  LDD2016 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 30.27  LDD2016 
Nucleoporin NDC1 (NDC1) LDTP11213 25.81  LDD2016 
Occludin (OCLN) LDTP06581 23.10  LDD2016 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 33.59  LDD2016 
Peroxisomal biogenesis factor 3 (PEX3) LDTP04749 24.42  LDD2016 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 42.81  LDD2016 
Peroxisomal membrane protein PEX14 (PEX14) LDTP01200 23.10  LDD2016 
Prenylated Rab acceptor protein 1 (RABAC1) LDTP13320 24.42  LDD2016 
Prosaposin (PSAP) LDTP02215 88.03  LDD2016 
Protein FAM8A1 (FAM8A1) LDTP16190 25.81  LDD2016 
Protein spinster homolog 1 (SPNS1) LDTP11844 42.52  LDD2016 
Protein tweety homolog 3 (TTYH3) LDTP11615 99.73  LDD2016 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 37.01  LDD2016 
Renin receptor (ATP6AP2) LDTP01309 23.10  LDD2016 
Reticulon-1 (RTN1) LDTP06633 56.89  LDD2016 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 56.89  LDD2016 
Sideroflexin-4 (SFXN4) LDTP07531 24.42  LDD2016 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 29.65  LDD2016 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 78.79  LDD2016 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 22.63  LDD2016 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 25.81  LDD2016 
Sorting and assembly machinery component 50 homolog (SAMM50) LDTP14084 58.08  LDD2016 
Sorting nexin-5 (SNX5) LDTP14174 22.78  LDD2016 
StAR-related lipid transfer protein 7, mitochondrial (STARD7) LDTP18459 30.06  LDD2016 
SUN domain-containing protein 2 (SUN2) LDTP13256 30.70  LDD2016 
Tetraspanin-10 (TSPAN10) LDTP15967 85.04  LDD2016 
Tetraspanin-3 (TSPAN3) LDTP16813 73.01  LDD2016 
THO complex subunit 7 homolog (THOC7) LDTP07397 24.93  LDD2016 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 32.45  LDD2016 
Translocator protein (TSPO) LDTP03546 28.25  LDD2016 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 87.43  LDD2016 
Transmembrane 9 superfamily member 2 (TM9SF2) LDTP15845 27.10  LDD2016 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 25.46  LDD2016 
Transmembrane protein 126A (TMEM126A) LDTP15948 31.34  LDD2016 
Transmembrane protein 160 (TMEM160) LDTP20002 49.52  LDD2016 
Transmembrane protein 199 (TMEM199) LDTP08881 28.05  LDD2016 
Transmembrane protein 230 (TMEM230) LDTP10065 28.64  LDD2016 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 38.32  LDD2016 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 77.17  LDD2016 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 99.73  LDD2016 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 36.00  LDD2016 
Zinc transporter 7 (SLC30A7) LDTP09180 45.57  LDD2016 
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⏷ Show the Full List of 86 Transporter and channel
2 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 29.04  LDD2016 
Transcription factor A, mitochondrial (TFAM) LDTP05235 22.32  LDD2016 
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1 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Membrane progestin receptor alpha (PAQR7) LDTP15303 54.19  LDD2016 
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107 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Angiomotin (AMOT) LDTP06868 31.34  LDD2016 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 26.54  LDD2016 
Apolipoprotein L2 (APOL2) LDTP11076 61.82  LDD2016 
ATP synthase mitochondrial F1 complex assembly factor 1 (ATPAF1) LDTP17240 26.54  LDD2016 
Bcl-2-like protein 13 (BCL2L13) LDTP11389 25.99  LDD2016 
Calmodulin-3 (CALM3) LDTP02443 22.47  LDD2016 
Calumenin (CALU) LDTP00887 24.25  LDD2016 
Centrin-2 (CETN2) LDTP03926 38.85  LDD2016 
Centromere protein K (CENPK) LDTP11143 39.95  LDD2016 
Centrosomal protein 43 (CEP43) LDTP01652 24.76  LDD2016 
Clustered mitochondria protein homolog (CLUH) LDTP14486 25.63  LDD2016 
Coiled-coil domain-containing protein 167 (CCDC167) LDTP12956 26.35  LDD2016 
Cold-inducible RNA-binding protein (CIRBP) LDTP06022 31.78  LDD2016 
Complex I intermediate-associated protein 30, mitochondrial (NDUFAF1) LDTP13954 28.44  LDD2016 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 99.73  LDD2016 
DENN domain-containing protein 11 (DENND11) LDTP16577 24.42  LDD2016 
Desmocollin-3 (DSC3) LDTP06154 48.50  LDD2016 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 23.43  LDD2016 
Divergent protein kinase domain 2A (DIPK2A) LDTP09143 26.91  LDD2016 
Dynactin subunit 3 (DCTN3) LDTP01359 24.59  LDD2016 
Emerin (EMD) LDTP04356 22.94  LDD2016 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 45.89  LDD2016 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 31.12  LDD2016 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 30.70  LDD2016 
Galectin-3-binding protein (LGALS3BP) LDTP05558 29.65  LDD2016 
Ganglioside GM2 activator (GM2A) LDTP02927 29.04  LDD2016 
General transcription factor IIF subunit 1 (GTF2F1) LDTP03729 26.72  LDD2016 
HAUS augmin-like complex subunit 1 (HAUS1) LDTP10184 31.34  LDD2016 
HCLS1-associated protein X-1 (HAX1) LDTP00199 36.76  LDD2016 
Heat shock 70 kDa protein 13 (HSPA13) LDTP04207 23.26  LDD2016 
Heme-binding protein 1 (HEBP1) LDTP16078 29.24  LDD2016 
Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) LDTP10962 23.26  LDD2016 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 23.26  LDD2016 
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) LDTP04714 23.92  LDD2016 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 29.45  LDD2016 
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) LDTP03182 22.47  LDD2016 
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) LDTP05530 26.17  LDD2016 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 40.79  LDD2016 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 44.32  LDD2016 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 30.27  LDD2016 
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) LDTP01246 23.43  LDD2016 
Lamin-B1 (LMNB1) LDTP03065 22.32  LDD2016 
Large ribosomal subunit protein mL40 (MRPL40) LDTP12395 25.63  LDD2016 
Large ribosomal subunit protein mL64 (GADD45GIP1) LDTP09297 24.76  LDD2016 
Large ribosomal subunit protein uL23m (MRPL23) LDTP06548 36.50  LDD2016 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 99.73  LDD2016 
Mediator of RNA polymerase II transcription subunit 4 (MED4) LDTP12377 24.42  LDD2016 
Membralin (TMEM259) LDTP14939 26.17  LDD2016 
MICOS complex subunit MIC13 (MICOS13) LDTP07274 25.99  LDD2016 
MICOS complex subunit MIC19 (CHCHD3) LDTP12764 28.25  LDD2016 
Microfibrillar-associated protein 1 (MFAP1) LDTP04668 29.04  LDD2016 
Mitochondrial antiviral-signaling protein (MAVS) LDTP08058 24.59  LDD2016 
Mitochondrial fission 1 protein (FIS1) LDTP13982 26.72  LDD2016 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 40.79  LDD2016 
Mitochondrial import receptor subunit TOM20 homolog (TOMM20) LDTP06373 26.17  LDD2016 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 99.73  LDD2016 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 99.73  LDD2016 
Mitochondrial import receptor subunit TOM7 homolog (TOMM7) LDTP12982 23.26  LDD2016 
NADH dehydrogenase 1 alpha subcomplex assembly factor 2 (NDUFAF2) LDTP08761 25.28  LDD2016 
Neudesin (NENF) LDTP13630 39.40  LDD2016 
Neuferricin (CYB5D2) LDTP15623 27.67  LDD2016 
Neurofilament medium polypeptide (NEFM) LDTP02181 25.81  LDD2016 
Nucleobindin-1 (NUCB1) LDTP05375 37.27  LDD2016 
Nucleobindin-2 (NUCB2) LDTP05160 49.87  LDD2016 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 26.54  LDD2016 
Optic atrophy 3 protein (OPA3) LDTP16006 29.04  LDD2016 
Oxysterol-binding protein-related protein 6 (OSBPL6) LDTP11533 24.93  LDD2016 
Periphilin-1 (PPHLN1) LDTP09183 22.94  LDD2016 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 51.27  LDD2016 
Pre-mRNA-splicing factor SLU7 (SLU7) LDTP01582 23.10  LDD2016 
Pre-mRNA-splicing regulator WTAP (WTAP) LDTP06272 22.94  LDD2016 
Prefoldin subunit 6 (PFDN6) LDTP00573 24.25  LDD2016 
Programmed cell death protein 5 (PDCD5) LDTP00417 26.17  LDD2016 
Prohibitin-2 (PHB2) LDTP10924 23.92  LDD2016 
Proline-rich protein PRCC (PRCC) LDTP09850 24.76  LDD2016 
Protein FAM114A2 (FAM114A2) LDTP16080 70.52  LDD2016 
Protein FAM162A (FAM162A) LDTP10056 38.59  LDD2016 
Protein jagunal homolog 1 (JAGN1) LDTP08904 22.16  LDD2016 
Protein unc-119 homolog A (UNC119) LDTP05868 22.16  LDD2016 
Protein unc-119 homolog B (UNC119B) LDTP00105 69.07  LDD2016 
Protein YIF1A (YIF1A) LDTP01494 28.44  LDD2016 
Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L) LDTP16730 28.44  LDD2016 
Reticulocalbin-2 (RCN2) LDTP06097 35.51  LDD2016 
Reticulon-3 (RTN3) LDTP01522 36.50  LDD2016 
Reticulon-4 (RTN4) LDTP12412 24.93  LDD2016 
Reticulophagy regulator 2 (RETREG2) LDTP09080 28.44  LDD2016 
Ribosomal RNA processing protein 36 homolog (RRP36) LDTP10277 24.25  LDD2016 
RNA-binding motif protein, X chromosome (RBMX) LDTP03850 32.22  LDD2016 
RNA-binding protein 3 (RBM3) LDTP05226 36.50  LDD2016 
RNA-binding protein FUS (FUS) LDTP03775 28.44  LDD2016 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 35.02  LDD2016 
Single-stranded DNA-binding protein, mitochondrial (SSBP1) LDTP05437 22.63  LDD2016 
Spliceosome-associated protein CWC15 homolog (CWC15) LDTP12951 23.75  LDD2016 
Synaptogyrin-2 (SYNGR2) LDTP00859 47.50  LDD2016 
Syntaxin-10 (STX10) LDTP00986 22.78  LDD2016 
Syntaxin-18 (STX18) LDTP13086 52.71  LDD2016 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 25.81  LDD2016 
Tetraspanin-6 (TSPAN6) LDTP14458 35.26  LDD2016 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 32.67  LDD2016 
Tetratricopeptide repeat protein 38 (TTC38) LDTP19372 23.75  LDD2016 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 55.72  LDD2016 
TraB domain-containing protein (TRABD) LDTP19963 48.50  LDD2016 
Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) LDTP15634 26.72  LDD2016 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 39.40  LDD2016 
Vacuolar protein sorting-associated protein 18 homolog (VPS18) LDTP13019 22.94  LDD2016 
Vesicle transport protein SEC20 (BNIP1) LDTP05715 24.59  LDD2016 
Vimentin (VIM) LDTP02297 40.50  LDD2016 
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Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD2016 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587