Details of the Target

General Information of Target

Target ID LDTP09143
Target Name Divergent protein kinase domain 2A (DIPK2A)
Gene Name DIPK2A
Gene ID 205428
Synonyms
C3orf58; DIA1; Divergent protein kinase domain 2A; Deleted in autism protein 1; Golgi Protein of 49 kDa; GoPro49; Hypoxia and AKT-induced stem cell factor; HASF
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWRLVPPKLGRLSRSLKLAALGSLLVLMVLHSPSLLASWQRNELTDRRFLQLNKCPACFG
TSWCRRFLNGQVVFEAWGRLRLLDFLNVKNVYFAQYGEPREGGRRRVVLKRLGSQRELAQ
LDQSICKRATGRPRCDLLQAMPRTEFARLNGDVRLLTPEAVEGWSDLVHCPSQRLLDRLV
RRYAETKDSGSFLLRNLKDSERMQLLLTLAFNPEPLVLQSFPSDEGWPFAKYLGACGRMV
AVNYVGEELWSYFNAPWEKRVDLAWQLMEIAEQLTNNDFEFALYLLDVSFDNFAVGPRDG
KVIIVDAENVLVADKRLIRQNKPENWDVWYESKFDDCDKEACLSFSKEILCARATVDHNY
YAVCQNLLSRHATWRGTSGGLLHDPPSEIAKDGRLEALLDECANPKKRYGRFQAAKELRE
YLAQLSNNVR
Target Bioclass
Other
Family
DIPK family
Subcellular location
Cytoplasmic vesicle, COPI-coated vesicle
Function May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade.
Uniprot ID
Q8NDZ4
Ensemble ID
ENST00000315691.8
HGNC ID
HGNC:28490

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.N428I .
HCT116 SNV: p.M28T .
HCT15 SNV: p.L24Q; p.R260Ter .
MOLT4 SNV: p.L44R .
SUPT1 SNV: p.V29A .
SW1271 SNV: p.C170S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C135(0.74)  LDD2146  [1]
IPM
 Probe Info  		C170(0.72)  LDD1701  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C236(1.04)  LDD0531  [3]
CY4
 Probe Info  		N.A.  LDD0247  [4]
IA-alkyne
 Probe Info  		C126(0.00); C170(0.00); C236(0.00); C364(0.00)  LDD0162  [5]
Ox-W18
 Probe Info  		N.A.  LDD2175  [6]
NAIA_5
 Probe Info  		C364(0.00); C135(0.00); C126(0.00); C402(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		28.84  LDD1753  [8]
C161
 Probe Info  		11.47  LDD1841  [8]
C170
 Probe Info  		14.12  LDD1850  [8]
C177
 Probe Info  		11.24  LDD1856  [8]
C186
 Probe Info  		11.79  LDD1864  [8]
C355
 Probe Info  		26.91  LDD2016  [8]
C399
 Probe Info  		6.73  LDD2058  [8]
C403
 Probe Info  		19.56  LDD2061  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C236(1.04)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C170(0.98); C55(0.75)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C170(1.14); C236(1.03)  LDD1509  [9]
 LDCM0230  AC113 HEK-293T C236(0.87)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C236(1.21)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C236(1.29)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C236(1.32)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C236(0.81)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C236(1.25)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C236(1.12)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C170(0.92)  LDD1510  [9]
 LDCM0238  AC120 HEK-293T C236(1.09)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C236(0.99)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C236(0.93)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C236(1.19)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C236(1.00)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C236(1.04)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C236(0.95)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C236(1.20)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C236(0.76)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C236(0.67)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C236(0.69)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C236(0.91)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C236(0.84)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C236(0.70)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C236(0.96)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C236(0.93)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C236(1.05)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C236(0.63)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C236(0.68)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C236(0.81)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C170(1.04)  LDD1512  [9]
 LDCM0260  AC140 HEK-293T C236(1.05)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C236(0.82)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C236(0.76)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C236(1.09)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C236(1.16)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C236(1.15)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C236(1.09)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C236(0.99)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C236(1.37)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C236(1.24)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C170(1.00)  LDD1513  [9]
 LDCM0271  AC150 HEK-293T C236(1.07)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C236(1.07)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C236(1.03)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C236(1.29)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C236(1.05)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C236(1.15)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C236(1.11)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C236(1.02)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C170(1.00)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C170(1.06); C55(0.96)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C170(1.13); C236(1.18)  LDD1517  [9]
 LDCM0279  AC2 HCT 116 C236(1.34)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C170(0.91)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C170(1.04); C126(1.07); C135(1.02)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C170(1.02)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C170(1.06)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C170(0.95); C364(0.99)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C170(0.90)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C170(1.22); C55(1.08)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C170(1.03); C236(0.99)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C170(0.94)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C170(1.04); C126(1.08); C135(0.90)  LDD1528  [9]
 LDCM0290  AC3 HCT 116 C236(1.11)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C170(0.93)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C170(0.91)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C170(0.97); C364(1.01)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C170(0.94)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C170(0.92); C55(1.10)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C170(1.01); C236(1.04)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C170(0.85)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C170(1.05); C126(1.17); C135(1.00)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C170(1.08)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C170(0.93)  LDD1539  [9]
 LDCM0301  AC4 HCT 116 C236(1.34)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C170(1.02); C364(1.16)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C170(1.18)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C170(1.21); C55(0.71)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C170(1.01); C236(1.01)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C170(0.87)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C170(1.08); C126(1.25); C135(0.99)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C170(1.13)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C170(1.04)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C170(1.01); C364(1.10)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C170(0.95)  LDD1550  [9]
 LDCM0312  AC5 HCT 116 C236(1.21)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C170(1.12); C55(0.86)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C170(0.94); C236(1.04)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C170(0.99)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C170(1.02); C126(1.03); C135(1.02)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C170(1.13)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C170(1.13)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C170(1.00); C364(1.03)  LDD1558  [9]
 LDCM0320  AC57 HCT 116 C236(0.74)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C236(0.87)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C236(0.69)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C170(0.98)  LDD1562  [9]
 LDCM0324  AC60 HCT 116 C236(0.87)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C236(0.90)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C236(1.13)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C236(0.80)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C236(0.79)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C236(0.86)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C236(0.68)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C236(0.63)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C236(0.83)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C236(0.75)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C170(0.97)  LDD1568  [9]
 LDCM0335  AC70 HCT 116 C236(0.54)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C236(1.02)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C236(0.80)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C236(0.54)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C236(0.56)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C236(0.57)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C236(0.67)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C236(0.64)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C236(0.89)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C236(0.97)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C170(1.02); C364(0.98)  LDD1569  [9]
 LDCM0346  AC80 HCT 116 C236(0.76)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C236(1.21)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C236(0.60)  LDD0665  [3]
 LDCM0349  AC83 HEK-293T C236(0.87)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C236(0.94)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C236(1.12)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C236(0.91)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C236(0.89)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C236(0.95)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C236(1.12)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C236(0.96)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C236(0.85)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C236(1.07)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C236(0.98)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C236(1.12)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C236(1.30)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C236(0.96)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C236(0.94)  LDD0962  [3]
 LDCM0248  AKOS034007472 HEK-293T C170(0.98); C126(1.06); C135(1.04)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C170(0.95)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C170(1.07); C364(1.03)  LDD1514  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HCT 116 C236(1.05)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C236(0.64)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C236(0.81)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C170(1.07); C126(0.92)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C170(0.90); C126(1.07); C135(0.96)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C170(0.93); C126(1.12)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C170(1.21)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C170(1.13); C126(0.95)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C170(1.18); C126(1.10); C135(1.35)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C170(0.89); C126(1.00)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C170(1.12)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C170(1.10); C126(0.91)  LDD1582  [9]
 LDCM0379  CL11 HCT 116 C236(0.53)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C170(1.27); C126(1.09); C135(0.92)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C170(1.01); C126(0.94)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C170(1.09)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C170(1.01); C126(0.86)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C170(0.91); C126(1.22); C135(1.02)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C170(0.97); C126(1.07)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C170(1.23)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C170(1.06); C126(0.88)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C170(1.12); C126(1.07); C135(0.99)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C170(0.98); C126(1.14)  LDD1593  [9]
 LDCM0390  CL12 HCT 116 C236(0.66)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C170(1.16)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C170(1.18); C126(0.93)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C170(0.85); C126(1.00); C135(1.05)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C170(0.92); C126(1.19)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C170(1.09)  LDD1599  [9]
 LDCM0396  CL125 HCT 116 C236(1.20)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C236(0.83)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C236(0.72)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C236(0.80)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C236(0.64)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C236(1.07)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C236(0.81)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C236(0.93)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C236(0.66)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C236(0.55)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C236(0.64)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C236(0.86)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C236(0.58)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C236(0.46)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C236(0.37)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C236(0.64)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C236(0.42)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C236(0.48)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C236(0.66)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C236(0.76)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C236(0.55)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C236(0.59)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C236(1.05)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C236(0.71)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C170(1.17); C236(1.10)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C170(0.96)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C170(1.12); C126(1.28); C135(1.20)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C170(1.17)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C170(1.01)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C170(1.16); C364(1.32)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C170(1.19); C126(0.88)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C170(1.09); C126(1.05)  LDD1632  [9]
 LDCM0429  CL4 HCT 116 C236(1.03)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C170(0.99)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C170(1.13)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C170(1.01); C55(0.69)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C170(1.44); C236(1.16)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C170(1.06)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C170(1.14); C126(1.33); C135(1.18)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C236(1.43)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C236(1.12)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C236(0.99)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C236(1.07)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C236(1.10)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C236(1.35)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C236(0.91)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C236(0.99)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C236(0.82)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C236(1.09)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C236(0.99)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C236(1.03)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C236(0.84)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C236(0.78)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C236(1.15)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C236(0.87)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C236(1.19)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C170(1.13); C126(0.95)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C170(0.75); C126(1.00); C135(0.89)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C170(1.02); C126(1.11)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C170(1.35)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C170(0.94)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C170(1.09); C55(1.16)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C170(1.23); C236(1.17)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C170(1.04)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C170(1.02); C126(1.20); C135(1.40)  LDD1664  [9]
 LDCM0462  CL7 HCT 116 C236(0.87)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C170(1.26)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C170(0.99)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C170(0.96); C364(1.20)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C170(1.15); C126(0.87)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C170(0.82); C126(0.97); C135(0.97)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C170(1.16)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C170(1.12)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C170(1.13); C55(0.82)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C170(0.98); C236(1.06)  LDD1675  [9]
 LDCM0473  CL8 HCT 116 C236(0.53)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C170(1.03)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C170(0.98); C126(1.09); C135(1.34)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C170(1.04)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C170(1.14)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C170(1.01); C364(1.18)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C170(0.97); C126(0.84)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C170(1.00); C126(0.92); C135(1.05)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C170(0.84); C126(1.12)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C170(1.03)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C170(1.23)  LDD1686  [9]
 LDCM0484  CL9 HCT 116 C236(0.92)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C170(2.25); C55(0.84)  LDD1688  [9]
 LDCM0486  CL91 HCT 116 C236(1.25)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C236(1.32)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C236(1.50)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C236(1.13)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C236(1.17)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C236(1.44)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C236(1.12)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C236(0.99)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C236(0.93)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C170(1.09); C126(1.14)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C170(1.15); C126(1.07)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C170(0.93); C126(1.03); C135(1.10)  LDD1631  [9]
 LDCM0022  KB02 HEK-293T C126(0.89); C170(0.92)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C126(0.94); C170(0.87)  LDD1497  [9]
 LDCM0024  KB05 NCI-H1792 C342(2.36)  LDD3348  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C135(0.74)  LDD2146  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840