Details of the Probe

General Information of Probe

Probe ID
LDPC0621
Probe Name
C403
Synonyms
Z4225936100
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 387.5
Lipid-water partition coefficient (xlogp) 3.6
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C18H17N3O3S2
IUPAC Name
5-(benzenesulfonyl)-N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]thiophene-2-carboxamide
Canonical SMILES
C#CCCC1(N=N1)CCNC(=O)C2=CC=C(S2)S(=O)(=O)C3=CC=CC=C3
InChI
InChI=1S/C18H17N3O3S2/c1-2-3-11-18(20-21-18)12-13-19-17(22)15-9-10-16(25-15)26(23,24)14-7-5-4-6-8-14/h1,4-10H,3,11-13H2,(H,19,22)
InChIKey
YAUOIUFBBDISGP-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

155 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) LDTP02000 16.80  LDD2061 
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 26.54  LDD2061 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 20.97  LDD2061 
5'-nucleotidase domain-containing protein 2 (NT5DC2) LDTP18414 15.67  LDD2061 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 30.27  LDD2061 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 16.56  LDD2061 
Acid ceramidase (ASAH1) LDTP05905 19.84  LDD2061 
Acylglycerol kinase, mitochondrial (AGK) LDTP06905 15.45  LDD2061 
Adenosine 5'-monophosphoramidase HINT3 (HINT3) LDTP12415 26.17  LDD2061 
Adenosine deaminase (ADA) LDTP01803 22.47  LDD2061 
ADP-dependent glucokinase (ADPGK) LDTP11127 36.25  LDD2061 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 30.27  LDD2061 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 17.75  LDD2061 
Amidophosphoribosyltransferase (PPAT) LDTP05480 14.93  LDD2061 
Antigen peptide transporter 1 (TAP1) LDTP05408 14.22  LDD2061 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 13.93  LDD2061 
Atlastin-2 (ATL2) LDTP09251 22.63  LDD2061 
ATPase GET3 (GET3) LDTP00836 22.47  LDD2061 
Beta-galactosidase (GLB1) LDTP02837 16.00  LDD2061 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 17.15  LDD2061 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 31.12  LDD2061 
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1) LDTP06023 14.22  LDD2061 
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G) LDTP05920 16.68  LDD2061 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 44.02  LDD2061 
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) LDTP04358 14.93  LDD2061 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 16.22  LDD2061 
Catechol O-methyltransferase (COMT) LDTP03145 20.82  LDD2061 
CDGSH iron-sulfur domain-containing protein 1 (CISD1) LDTP12873 64.00  LDD2061 
Ceramide glucosyltransferase (UGCG) LDTP06617 37.27  LDD2061 
Ceramide synthase 2 (CERS2) LDTP10329 20.53  LDD2061 
COP9 signalosome complex subunit 6 (COPS6) LDTP07966 38.32  LDD2061 
Corrinoid adenosyltransferase MMAB (MMAB) LDTP10286 15.24  LDD2061 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 60.13  LDD2061 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 43.71  LDD2061 
Cytochrome b5 type B (CYB5B) LDTP00697 79.89  LDD2061 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 27.28  LDD2061 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 36.50  LDD2061 
DCN1-like protein 5 (DCUN1D5) LDTP11199 23.59  LDD2061 
Dehydrogenase/reductase SDR family member 1 (DHRS1) LDTP10550 35.51  LDD2061 
Dehydrogenase/reductase SDR family member 7 (DHRS7) LDTP13959 17.63  LDD2061 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 14.22  LDD2061 
Delta(24)-sterol reductase (DHCR24) LDTP06375 28.64  LDD2061 
Deoxyhypusine synthase (DHPS) LDTP04248 19.29  LDD2061 
Dephospho-CoA kinase domain-containing protein (DCAKD) LDTP18087 18.13  LDD2061 
DNA replication licensing factor MCM3 (MCM3) LDTP03316 14.62  LDD2061 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 22.01  LDD2061 
Dolichyldiphosphatase 1 (DOLPP1) LDTP15328 21.26  LDD2061 
Dynamin-like 120 kDa protein, mitochondrial (OPA1) LDTP00950 17.39  LDD2061 
E3 ubiquitin-protein ligase CHIP (STUB1) LDTP13655 14.72  LDD2061 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 14.83  LDD2061 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 14.83  LDD2061 
Endoplasmic reticulum metallopeptidase 1 (ERMP1) LDTP08017 15.89  LDD2061 
Endoplasmic reticulum protein SC65 (P3H4) LDTP09874 15.56  LDD2061 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 20.53  LDD2061 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 26.17  LDD2061 
Ethanolaminephosphotransferase 1 (SELENOI) LDTP11606 17.27  LDD2061 
Ferrochelatase, mitochondrial (FECH) LDTP03198 13.74  LDD2061 
Fumarylacetoacetase (FAH) LDTP02868 16.56  LDD2061 
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) LDTP06721 14.03  LDD2061 
Geranylgeranyl pyrophosphate synthase (GGPS1) LDTP01665 14.72  LDD2061 
Geranylgeranyl transferase type-2 subunit beta (RABGGTB) LDTP04569 16.34  LDD2061 
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) LDTP12253 50.21  LDD2061 
Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) LDTP17305 56.10  LDD2061 
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) LDTP12763 17.88  LDD2061 
GPI-anchor transamidase (PIGK) LDTP09835 15.89  LDD2061 
Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) LDTP15879 18.90  LDD2061 
Heme oxygenase 1 (HMOX1) LDTP02359 70.03  LDD2061 
Heme oxygenase 2 (HMOX2) LDTP03540 43.11  LDD2061 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 25.81  LDD2061 
Hexokinase-2 (HK2) LDTP04531 15.14  LDD2061 
Histone PARylation factor 1 (HPF1) LDTP12743 19.16  LDD2061 
Holocytochrome c-type synthase (HCCS) LDTP04581 22.32  LDD2061 
Hydroxysteroid dehydrogenase-like protein 2 (HSDL2) LDTP07762 13.93  LDD2061 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 43.41  LDD2061 
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) LDTP03084 15.03  LDD2061 
Inositol 1,4,5-trisphosphate receptor-interacting protein (ITPRIP) LDTP08532 14.42  LDD2061 
Inositol polyphosphate-4-phosphatase type I A (INPP4A) LDTP10676 18.00  LDD2061 
Ketosamine-3-kinase (FN3KRP) LDTP16025 15.14  LDD2061 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 33.36  LDD2061 
Legumain (LGMN) LDTP10888 16.11  LDD2061 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 18.25  LDD2061 
Leukotriene A-4 hydrolase (LTA4H) LDTP02385 16.80  LDD2061 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 30.06  LDD2061 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 51.98  LDD2061 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 14.52  LDD2061 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 17.63  LDD2061 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 24.42  LDD2061 
Lysosomal alpha-glucosidase (GAA) LDTP02486 14.52  LDD2061 
Lysosomal protective protein (CTSA) LDTP02505 22.94  LDD2061 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 32.67  LDD2061 
Mannose-1-phosphate guanyltransferase beta (GMPPB) LDTP14141 14.32  LDD2061 
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) LDTP10930 18.25  LDD2061 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 23.75  LDD2061 
Minor histocompatibility antigen H13 (HM13) LDTP09396 24.25  LDD2061 
N-alpha-acetyltransferase 35, NatC auxiliary subunit (NAA35) LDTP07259 18.64  LDD2061 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 23.59  LDD2061 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 19.16  LDD2061 
NAD-dependent protein deacetylase sirtuin-2 (SIRT2) LDTP08598 26.35  LDD2061 
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) LDTP12603 14.22  LDD2061 
NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) LDTP08385 35.02  LDD2061 
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) LDTP12959 27.47  LDD2061 
NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) LDTP01743 48.17  LDD2061 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 50.56  LDD2061 
NADH dehydrogenase 1 beta subcomplex subunit 4 (NDUFB4) LDTP01514 14.22  LDD2061 
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) LDTP14276 15.78  LDD2061 
NADH-cytochrome b5 reductase 3 (CYB5R3) LDTP01770 14.62  LDD2061 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 32.67  LDD2061 
Neurolysin, mitochondrial (NLN) LDTP11494 16.11  LDD2061 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 38.32  LDD2061 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 36.25  LDD2061 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 19.84  LDD2061 
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) LDTP06307 16.68  LDD2061 
Phosphatidylserine synthase 1 (PTDSS1) LDTP04203 22.32  LDD2061 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 35.02  LDD2061 
Probable methyltransferase TARBP1 (TARBP1) LDTP05850 15.24  LDD2061 
Prostaglandin reductase 3 (PTGR3) LDTP15422 15.67  LDD2061 
Proteasome subunit beta type-1 (PSMB1) LDTP03060 14.52  LDD2061 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 20.39  LDD2061 
Proteasome subunit beta type-4 (PSMB4) LDTP03417 14.12  LDD2061 
Protein O-GlcNAcase (OGA) LDTP00988 22.32  LDD2061 
Protein SCO1 homolog, mitochondrial (SCO1) LDTP01335 19.16  LDD2061 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 52.71  LDD2061 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 21.56  LDD2061 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 24.76  LDD2061 
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (DHX32) LDTP07974 17.75  LDD2061 
RAC-beta serine/threonine-protein kinase (AKT2) LDTP03608 25.28  LDD2061 
Ras-related protein Rab-24 (RAB24) LDTP10020 60.97  LDD2061 
Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) LDTP09666 35.75  LDD2061 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 17.63  LDD2061 
Retinol dehydrogenase 13 (RDH13) LDTP09061 16.00  LDD2061 
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) LDTP03592 16.34  LDD2061 
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) LDTP00890 14.22  LDD2061 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 18.77  LDD2061 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 19.56  LDD2061 
Serine/threonine-protein kinase PAK 1 (PAK1) LDTP05769 13.83  LDD2061 
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E) LDTP06546 14.62  LDD2061 
Serine/threonine-protein phosphatase CPPED1 (CPPED1) LDTP11107 20.25  LDD2061 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 76.11  LDD2061 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 17.88  LDD2061 
Soluble calcium-activated nucleotidase 1 (CANT1) LDTP09620 18.51  LDD2061 
Sphingolipid delta(4)-desaturase DES1 (DEGS1) LDTP00544 26.35  LDD2061 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 14.72  LDD2061 
Squalene monooxygenase (SQLE) LDTP06142 21.26  LDD2061 
Squalene synthase (FDFT1) LDTP03842 17.27  LDD2061 
Stearoyl-CoA desaturase 5 (SCD5) LDTP08171 15.78  LDD2061 
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) LDTP03139 16.11  LDD2061 
TLC domain-containing protein 1 (TLCD1) LDTP10182 19.97  LDD2061 
Torsin-1B (TOR1B) LDTP00400 19.29  LDD2061 
Trimethyllysine dioxygenase, mitochondrial (TMLHE) LDTP12679 18.64  LDD2061 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 35.02  LDD2061 
Ubiquitin conjugation factor E4 B (UBE4B) LDTP01509 15.24  LDD2061 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 26.17  LDD2061 
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) LDTP12954 16.22  LDD2061 
Very-long-chain enoyl-CoA reductase (TECR) LDTP12867 15.89  LDD2061 
Vitamin K-dependent gamma-carboxylase (GGCX) LDTP03854 20.53  LDD2061 
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⏷ Show the Full List of 155 Enzyme
104 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
45 kDa calcium-binding protein (SDF4) LDTP11116 24.42  LDD2061 
Acyl-CoA-binding domain-containing protein 5 (ACBD5) LDTP07152 14.72  LDD2061 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 25.46  LDD2061 
ADP/ATP translocase 1 (SLC25A4) LDTP02608 27.10  LDD2061 
ADP/ATP translocase 3 (SLC25A6) LDTP02609 13.74  LDD2061 
Amyloid-beta precursor protein (APP) LDTP02071 18.51  LDD2061 
Anoctamin-10 (ANO10) LDTP12704 17.51  LDD2061 
ATP synthase subunit a (MT-ATP6) LDTP01804 48.84  LDD2061 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 23.92  LDD2061 
BOS complex subunit NCLN (NCLN) LDTP10036 19.70  LDD2061 
BRI3-binding protein (BRI3BP) LDTP15648 62.25  LDD2061 
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial (COX16) LDTP16163 22.47  LDD2061 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 26.72  LDD2061 
Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) LDTP03064 14.72  LDD2061 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 72.50  LDD2061 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 28.44  LDD2061 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 99.73  LDD2061 
Exportin-4 (XPO4) LDTP11607 18.38  LDD2061 
Golgi SNAP receptor complex member 1 (GOSR1) LDTP01542 28.44  LDD2061 
High affinity cationic amino acid transporter 1 (SLC7A1) LDTP03559 23.10  LDD2061 
Importin-4 (IPO4) LDTP09515 23.92  LDD2061 
Importin-8 (IPO8) LDTP00630 14.93  LDD2061 
Importin-9 (IPO9) LDTP10663 15.24  LDD2061 
Integral membrane protein 2C (ITM2C) LDTP12451 25.63  LDD2061 
Intermembrane lipid transfer protein VPS13A (VPS13A) LDTP10769 27.28  LDD2061 
Intraflagellar transport protein 56 (IFT56) LDTP00010 14.32  LDD2061 
Leucine-rich repeat-containing protein 59 (LRRC59) LDTP10081 14.42  LDD2061 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 16.56  LDD2061 
Lysosome membrane protein 2 (SCARB2) LDTP06034 21.86  LDD2061 
Magnesium transporter NIPA3 (NIPAL1) LDTP17362 14.42  LDD2061 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 24.59  LDD2061 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 18.77  LDD2061 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 37.79  LDD2061 
Metal transporter CNNM3 (CNNM3) LDTP09144 14.62  LDD2061 
Metal transporter CNNM4 (CNNM4) LDTP07537 14.12  LDD2061 
Metaxin-1 (MTX1) LDTP05900 33.13  LDD2061 
Metaxin-2 (MTX2) LDTP01217 17.15  LDD2061 
MICOS complex subunit MIC26 (APOO) LDTP11250 16.00  LDD2061 
Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25) LDTP07439 30.48  LDD2061 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 19.97  LDD2061 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 24.42  LDD2061 
Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) LDTP08279 31.12  LDD2061 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 35.75  LDD2061 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 34.78  LDD2061 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 90.51  LDD2061 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 99.73  LDD2061 
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) LDTP00477 21.11  LDD2061 
Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) LDTP00821 14.03  LDD2061 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 29.24  LDD2061 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 16.11  LDD2061 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 14.03  LDD2061 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 16.91  LDD2061 
Mitochondrial thiamine pyrophosphate carrier (SLC25A19) LDTP12210 19.03  LDD2061 
Mpv17-like protein 2 (MPV17L2) LDTP14952 26.72  LDD2061 
Nucleoporin NDC1 (NDC1) LDTP11213 14.32  LDD2061 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 17.15  LDD2061 
Peroxisomal biogenesis factor 19 (PEX19) LDTP03905 21.71  LDD2061 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 48.17  LDD2061 
Prolactin regulatory element-binding protein (PREB) LDTP12272 14.22  LDD2061 
Protein ARV1 (ARV1) LDTP11812 26.54  LDD2061 
Protein ERGIC-53 (LMAN1) LDTP04237 14.52  LDD2061 
Protein GPR107 (GPR107) LDTP07236 36.76  LDD2061 
Protein GPR108 (GPR108) LDTP12383 44.02  LDD2061 
Protein RFT1 homolog (RFT1) LDTP10073 15.35  LDD2061 
Protein sel-1 homolog 1 (SEL1L) LDTP13164 15.56  LDD2061 
Protein spinster homolog 1 (SPNS1) LDTP11844 27.47  LDD2061 
Protein tweety homolog 3 (TTYH3) LDTP11615 22.63  LDD2061 
Proton-coupled zinc antiporter SLC30A9, mitochondrial (SLC30A9) LDTP07610 13.93  LDD2061 
Putative divalent cation/proton antiporter TMEM165 (TMEM165) LDTP12207 40.22  LDD2061 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 28.05  LDD2061 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 15.14  LDD2061 
Sideroflexin-4 (SFXN4) LDTP07531 21.41  LDD2061 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 15.56  LDD2061 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 20.53  LDD2061 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 61.39  LDD2061 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 97.01  LDD2061 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 26.91  LDD2061 
SUN domain-containing protein 2 (SUN2) LDTP13256 18.90  LDD2061 
Surfeit locus protein 4 (SURF4) LDTP00592 30.27  LDD2061 
Synaptojanin-2-binding protein (SYNJ2BP) LDTP04789 14.83  LDD2061 
Syntaxin-5 (STX5) LDTP05780 15.03  LDD2061 
Syntaxin-6 (STX6) LDTP00857 24.59  LDD2061 
Tetraspanin-3 (TSPAN3) LDTP16813 24.25  LDD2061 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 29.45  LDD2061 
Translocator protein (TSPO) LDTP03546 14.42  LDD2061 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 54.57  LDD2061 
Transmembrane 9 superfamily member 2 (TM9SF2) LDTP15845 39.40  LDD2061 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 25.28  LDD2061 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 30.91  LDD2061 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 14.72  LDD2061 
Transmembrane protein 126A (TMEM126A) LDTP15948 60.97  LDD2061 
Transmembrane protein 160 (TMEM160) LDTP20002 45.25  LDD2061 
Transmembrane protein 199 (TMEM199) LDTP08881 29.86  LDD2061 
Transmembrane protein 201 (TMEM201) LDTP07058 16.68  LDD2061 
Transmembrane protein 205 (TMEM205) LDTP07667 22.63  LDD2061 
Transmembrane protein 230 (TMEM230) LDTP10065 19.29  LDD2061 
Transmembrane protein 87A (TMEM87A) LDTP15481 47.84  LDD2061 
Trimeric intracellular cation channel type B (TMEM38B) LDTP12695 20.25  LDD2061 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 36.50  LDD2061 
Vacuole membrane protein 1 (VMP1) LDTP10343 30.48  LDD2061 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 41.64  LDD2061 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 39.67  LDD2061 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 22.63  LDD2061 
Wolframin (WFS1) LDTP01380 14.52  LDD2061 
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⏷ Show the Full List of 104 Transporter and channel
4 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 19.03  LDD2061 
Nuclear receptor corepressor 1 (NCOR1) LDTP01198 16.11  LDD2061 
Splicing factor, proline- and glutamine-rich (SFPQ) LDTP03212 18.90  LDD2061 
TSC22 domain family protein 3 (TSC22D3) LDTP10904 18.51  LDD2061 
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119 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Abnormal spindle-like microcephaly-associated protein (ASPM) LDTP08716 20.68  LDD2061 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 15.03  LDD2061 
AP-3 complex subunit mu-1 (AP3M1) LDTP13908 13.93  LDD2061 
BAG family molecular chaperone regulator 5 (BAG5) LDTP13507 13.83  LDD2061 
Bcl-2-like protein 13 (BCL2L13) LDTP11389 14.03  LDD2061 
BRISC and BRCA1-A complex member 2 (BABAM2) LDTP12788 14.12  LDD2061 
Calumenin (CALU) LDTP00887 15.03  LDD2061 
Centromere protein I (CENPI) LDTP09839 14.93  LDD2061 
Centromere protein K (CENPK) LDTP11143 14.22  LDD2061 
Centrosomal protein 43 (CEP43) LDTP01652 14.52  LDD2061 
Checkpoint protein HUS1 (HUS1) LDTP01085 19.29  LDD2061 
Clustered mitochondria protein homolog (CLUH) LDTP14486 17.03  LDD2061 
Coiled-coil domain-containing protein 6 (CCDC6) LDTP06515 18.13  LDD2061 
Coiled-coil domain-containing protein 97 (CCDC97) LDTP19860 14.22  LDD2061 
COMM domain-containing protein 1 (COMMD1) LDTP08919 16.91  LDD2061 
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) LDTP12379 17.51  LDD2061 
Conserved oligomeric Golgi complex subunit 4 (COG4) LDTP12094 19.29  LDD2061 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 69.07  LDD2061 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 17.51  LDD2061 
Divergent protein kinase domain 2A (DIPK2A) LDTP09143 19.56  LDD2061 
Dynactin subunit 3 (DCTN3) LDTP01359 19.29  LDD2061 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 16.80  LDD2061 
Emerin (EMD) LDTP04356 17.75  LDD2061 
Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ERGIC1) LDTP10046 14.93  LDD2061 
Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) LDTP10775 20.25  LDD2061 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 30.70  LDD2061 
Engulfment and cell motility protein 2 (ELMO2) LDTP10469 13.74  LDD2061 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 13.93  LDD2061 
FUN14 domain-containing protein 2 (FUNDC2) LDTP11326 18.90  LDD2061 
Ganglioside-induced differentiation-associated protein 1 (GDAP1) LDTP09324 16.56  LDD2061 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 21.86  LDD2061 
Golgi phosphoprotein 3 (GOLPH3) LDTP11911 30.70  LDD2061 
Golgi to ER traffic protein 4 homolog (GET4) LDTP07964 15.24  LDD2061 
HAUS augmin-like complex subunit 1 (HAUS1) LDTP10184 20.25  LDD2061 
HAUS augmin-like complex subunit 4 (HAUS4) LDTP11978 21.26  LDD2061 
HAUS augmin-like complex subunit 5 (HAUS5) LDTP01466 14.03  LDD2061 
Heat shock 70 kDa protein 13 (HSPA13) LDTP04207 16.11  LDD2061 
Heme-binding protein 1 (HEBP1) LDTP16078 16.34  LDD2061 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 15.24  LDD2061 
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) LDTP05530 14.62  LDD2061 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 22.16  LDD2061 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 23.43  LDD2061 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 78.79  LDD2061 
KH domain-containing RNA-binding protein QKI (QKI) LDTP10700 13.93  LDD2061 
KIF-binding protein (KIFBP) LDTP10263 16.91  LDD2061 
Kinetochore protein Spc24 (SPC24) LDTP09069 21.86  LDD2061 
Kinetochore-associated protein 1 (KNTC1) LDTP04382 14.32  LDD2061 
LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) LDTP15240 19.56  LDD2061 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 27.47  LDD2061 
Matrix-remodeling-associated protein 7 (MXRA7) LDTP17003 19.56  LDD2061 
Membralin (TMEM259) LDTP14939 31.78  LDD2061 
MICAL-like protein 1 (MICALL1) LDTP08830 18.77  LDD2061 
MICOS complex subunit MIC27 (APOOL) LDTP07718 13.93  LDD2061 
Mitochondrial fission factor (MFF) LDTP11670 13.83  LDD2061 
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) LDTP16322 21.11  LDD2061 
Mitochondrial import receptor subunit TOM20 homolog (TOMM20) LDTP06373 17.15  LDD2061 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 99.73  LDD2061 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 65.34  LDD2061 
NLR family member X1 (NLRX1) LDTP08248 13.93  LDD2061 
Nucleobindin-1 (NUCB1) LDTP05375 14.22  LDD2061 
Nucleobindin-2 (NUCB2) LDTP05160 59.30  LDD2061 
Nucleosome assembly protein 1-like 1 (NAP1L1) LDTP04684 16.91  LDD2061 
Nucleosome assembly protein 1-like 4 (NAP1L4) LDTP10965 17.88  LDD2061 
OCIA domain-containing protein 1 (OCIAD1) LDTP12755 24.25  LDD2061 
Optic atrophy 3 protein (OPA3) LDTP16006 20.82  LDD2061 
PAX3- and PAX7-binding protein 1 (PAXBP1) LDTP14107 17.63  LDD2061 
Peroxisomal targeting signal 1 receptor (PEX5) LDTP04369 15.56  LDD2061 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 42.81  LDD2061 
Prefoldin subunit 2 (PFDN2) LDTP13309 14.03  LDD2061 
Programmed cell death protein 5 (PDCD5) LDTP00417 14.52  LDD2061 
Proteasome activator complex subunit 2 (PSME2) LDTP13519 15.78  LDD2061 
Proteasome inhibitor PI31 subunit (PSMF1) LDTP09779 17.51  LDD2061 
Protein bicaudal D homolog 2 (BICD2) LDTP09410 13.83  LDD2061 
Protein CEBPZOS (CEBPZOS) LDTP18883 66.72  LDD2061 
Protein CutA (CUTA) LDTP01075 22.94  LDD2061 
Protein FAM114A2 (FAM114A2) LDTP16080 26.72  LDD2061 
Protein FAM162A (FAM162A) LDTP10056 41.93  LDD2061 
Protein FAM177A1 (FAM177A1) LDTP15398 23.43  LDD2061 
Protein FAM3C (FAM3C) LDTP09773 30.48  LDD2061 
Protein furry homolog-like (FRYL) LDTP01460 28.25  LDD2061 
Protein Hook homolog 2 (HOOK2) LDTP10255 19.97  LDD2061 
Protein jagunal homolog 1 (JAGN1) LDTP08904 18.38  LDD2061 
Protein LYRIC (MTDH) LDTP08224 18.64  LDD2061 
Protein PBDC1 (PBDC1) LDTP19924 14.42  LDD2061 
Protein SET (SET) LDTP05277 15.24  LDD2061 
Protein unc-119 homolog B (UNC119B) LDTP00105 17.39  LDD2061 
Protein UXT (UXT) LDTP13125 22.16  LDD2061 
Protein YIF1A (YIF1A) LDTP01494 26.72  LDD2061 
Ragulator complex protein LAMTOR2 (LAMTOR2) LDTP13901 15.67  LDD2061 
Receptor expression-enhancing protein 4 (REEP4) LDTP11981 16.56  LDD2061 
Regulator of microtubule dynamics protein 3 (RMDN3) LDTP10849 17.63  LDD2061 
Reticulocalbin-2 (RCN2) LDTP06097 34.30  LDD2061 
Reticulon-2 (RTN2) LDTP01167 18.38  LDD2061 
Reticulon-3 (RTN3) LDTP01522 48.50  LDD2061 
Reticulon-4 (RTN4) LDTP12412 33.36  LDD2061 
Retinol-binding protein 1 (RBP1) LDTP02345 19.84  LDD2061 
RNA-binding protein 3 (RBM3) LDTP05226 16.91  LDD2061 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 17.63  LDD2061 
SLC35A4 upstream open reading frame protein (SLC35A4) LDTP19005 14.42  LDD2061 
Small integral membrane protein 12 (SMIM12) LDTP19859 18.51  LDD2061 
Small ribosomal subunit protein eS10 (RPS10) LDTP04111 17.03  LDD2061 
Synaptic vesicle glycoprotein 2A (SV2A) LDTP07934 13.93  LDD2061 
Synaptogyrin-2 (SYNGR2) LDTP00859 29.45  LDD2061 
Syntaxin-10 (STX10) LDTP00986 66.72  LDD2061 
Syntaxin-18 (STX18) LDTP13086 54.19  LDD2061 
Testis-expressed protein 264 (TEX264) LDTP14259 14.22  LDD2061 
Tetraspanin-6 (TSPAN6) LDTP14458 36.50  LDD2061 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 17.63  LDD2061 
Tetratricopeptide repeat protein 21B (TTC21B) LDTP08073 14.93  LDD2061 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 38.32  LDD2061 
TraB domain-containing protein (TRABD) LDTP19963 39.67  LDD2061 
Transducin beta-like protein 2 (TBL2) LDTP16285 15.89  LDD2061 
Trophoblast glycoprotein (TPBG) LDTP05960 18.25  LDD2061 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 50.21  LDD2061 
UPF0729 protein C18orf32 (C18orf32) LDTP15599 41.64  LDD2061 
Vacuolar protein sorting-associated protein 51 homolog (VPS51) LDTP13338 21.71  LDD2061 
Vimentin (VIM) LDTP02297 17.27  LDD2061 
WASH complex subunit 5 (WASHC5) LDTP05641 17.75  LDD2061 
Zinc finger CCHC domain-containing protein 3 (ZCCHC3) LDTP12623 19.16  LDD2061 
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⏷ Show the Full List of 119 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD2061 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587