Details of the Target

General Information of Target

Target ID LDTP11321
Target Name Acetyl-CoA acetyltransferase, cytosolic (ACAT2)
Gene Name ACAT2
Gene ID 39
Synonyms
ACTL; Acetyl-CoA acetyltransferase, cytosolic; EC 2.3.1.9; Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNDRSSRRRTMKDDETFEISIPFDEAPHLDPQIFYSLSPSRRNFEEPPEAASSALALMNS
VKTQLHMALERNSWLQKRIEDLEEERDFLRCQLDKFISSARMEAEDHCRMKPGPRRMEGD
SRGGAGGEASDPESAASSLSGASEEGSASERRRQKQKGGASRRRFGKPKARERQRVKDAD
GVLCRYKKILGTFQKLKSMSRAFEHHRVDRNTVALTTPIAELLIVAPEKLAEVGEFDPSK
ERLLEYSRRCFLALDDETLKKVQALKKSKLLLPITYRFKR
Target Bioclass
Enzyme
Family
Thiolase-like superfamily, Thiolase family
Subcellular location
Cytoplasm, cytosol
Function Involved in the biosynthetic pathway of cholesterol.
Uniprot ID
Q9BWD1
Ensemble ID
ENST00000367048.5
HGNC ID
HGNC:94

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.D270G .
JURKAT SNV: p.A348V Compound 10    Probe Info 
MDAMB453 SNV: p.R375K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 3
 Probe Info  		15.69  LDD0381  [1]
W1
 Probe Info  		14.21  LDD0235  [2]
TH211
 Probe Info  		Y237(16.42)  LDD0257  [3]
TH214
 Probe Info  		Y237(12.50)  LDD0258  [3]
TH216
 Probe Info  		Y237(16.76)  LDD0259  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [5]
STPyne
 Probe Info  		K170(10.00); K180(4.69)  LDD0277  [6]
ONAyne
 Probe Info  		N.A.  LDD0273  [6]
IPM
 Probe Info  		C360(0.00); C65(0.00)  LDD0241  [2]
Probe 1
 Probe Info  		Y130(19.88)  LDD3495  [7]
m-APA
 Probe Info  		11.84  LDD0403  [8]
THZ1-DTB
 Probe Info  		C65(1.02)  LDD0460  [9]
BTD
 Probe Info  		C360(2.00); C65(1.46)  LDD1700  [10]
HHS-482
 Probe Info  		Y237(0.99)  LDD0285  [11]
HHS-475
 Probe Info  		Y81(1.55); Y237(8.67)  LDD0264  [12]
HHS-465
 Probe Info  		Y237(3.07)  LDD2237  [13]
DBIA
 Probe Info  		C65(2.00); C148(2.40); C158(2.40); C88(2.15)  LDD0080  [14]
5E-2FA
 Probe Info  		N.A.  LDD2235  [15]
ATP probe
 Probe Info  		N.A.  LDD0199  [16]
1d-yne
 Probe Info  		K235(0.00); K233(0.00)  LDD0358  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C65(0.00); C148(0.00); C158(0.00); C360(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		C65(0.00); C360(0.00)  LDD0032  [19]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [20]
IPIAA_L
 Probe Info  		C148(0.00); C65(0.00)  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		C65(0.00); C360(0.00); C148(0.00); C158(0.00)  LDD0037  [18]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [21]
NAIA_4
 Probe Info  		C158(0.00); C148(0.00); C65(0.00); C360(0.00)  LDD2226  [22]
KY-26
 Probe Info  		N.A.  LDD0301  [23]
Compound 10
 Probe Info  		C158(0.00); C360(0.00); C65(0.00); C92(0.00)  LDD2216  [24]
Compound 11
 Probe Info  		C158(0.00); C360(0.00); C65(0.00); C92(0.00)  LDD2213  [24]
SF
 Probe Info  		Y237(0.00); Y130(0.00); K235(0.00)  LDD0028  [25]
TFBX
 Probe Info  		C65(0.00); C360(0.00)  LDD0148  [21]
Ox-W18
 Probe Info  		N.A.  LDD2175  [26]
1c-yne
 Probe Info  		K307(0.00); K39(0.00); K43(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		C360(0.00); C65(0.00); H224(0.00); C148(0.00)  LDD0217  [27]
Methacrolein
 Probe Info  		N.A.  LDD0218  [27]
NAIA_5
 Probe Info  		C65(0.00); C360(0.00); C158(0.00); C148(0.00)  LDD2223  [22]
PAL-AfBPP Probe
Click To Hide/Show 82 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C002
 Probe Info  		4.92  LDD1712  [28]
C028
 Probe Info  		16.11  LDD1734  [28]
C059
 Probe Info  		99.73  LDD1756  [28]
C064
 Probe Info  		11.31  LDD1761  [28]
C067
 Probe Info  		24.59  LDD1763  [28]
C070
 Probe Info  		21.56  LDD1766  [28]
C071
 Probe Info  		9.85  LDD1767  [28]
C089
 Probe Info  		6.36  LDD1781  [28]
C107
 Probe Info  		7.78  LDD1794  [28]
C108
 Probe Info  		17.63  LDD1795  [28]
C134
 Probe Info  		99.73  LDD1816  [28]
C145
 Probe Info  		11.08  LDD1827  [28]
C147
 Probe Info  		13.18  LDD1829  [28]
C153
 Probe Info  		15.24  LDD1834  [28]
C160
 Probe Info  		6.92  LDD1840  [28]
C163
 Probe Info  		6.06  LDD1843  [28]
C166
 Probe Info  		6.63  LDD1846  [28]
C173
 Probe Info  		5.94  LDD1853  [28]
C174
 Probe Info  		54.95  LDD1854  [28]
C176
 Probe Info  		12.13  LDD1855  [28]
C177
 Probe Info  		8.28  LDD1856  [28]
C187
 Probe Info  		42.52  LDD1865  [28]
C190
 Probe Info  		5.39  LDD1867  [28]
C193
 Probe Info  		7.46  LDD1869  [28]
C198
 Probe Info  		91.77  LDD1874  [28]
C199
 Probe Info  		5.10  LDD1875  [28]
C206
 Probe Info  		18.25  LDD1881  [28]
C210
 Probe Info  		63.56  LDD1884  [28]
C219
 Probe Info  		6.59  LDD1893  [28]
C220
 Probe Info  		18.64  LDD1894  [28]
C222
 Probe Info  		12.04  LDD1896  [28]
C225
 Probe Info  		7.78  LDD1898  [28]
C240
 Probe Info  		14.83  LDD1913  [28]
C244
 Probe Info  		17.88  LDD1917  [28]
C255
 Probe Info  		32.90  LDD1928  [28]
C258
 Probe Info  		5.13  LDD1931  [28]
C265
 Probe Info  		99.04  LDD1936  [28]
C269
 Probe Info  		25.11  LDD1939  [28]
C277
 Probe Info  		7.73  LDD1947  [28]
C284
 Probe Info  		42.81  LDD1954  [28]
C288
 Probe Info  		19.16  LDD1958  [28]
C290
 Probe Info  		10.34  LDD1960  [28]
C293
 Probe Info  		21.26  LDD1963  [28]
C305
 Probe Info  		17.39  LDD1974  [28]
C307
 Probe Info  		18.25  LDD1975  [28]
C313
 Probe Info  		19.84  LDD1980  [28]
C314
 Probe Info  		16.91  LDD1981  [28]
C317
 Probe Info  		14.42  LDD1983  [28]
C322
 Probe Info  		6.87  LDD1988  [28]
C326
 Probe Info  		9.06  LDD1990  [28]
C338
 Probe Info  		19.56  LDD2001  [28]
C342
 Probe Info  		6.15  LDD2004  [28]
C347
 Probe Info  		5.31  LDD2008  [28]
C354
 Probe Info  		9.99  LDD2015  [28]
C356
 Probe Info  		19.16  LDD2017  [28]
C363
 Probe Info  		58.89  LDD2024  [28]
C366
 Probe Info  		6.19  LDD2027  [28]
C376
 Probe Info  		7.89  LDD2036  [28]
C380
 Probe Info  		6.50  LDD2039  [28]
C382
 Probe Info  		12.55  LDD2041  [28]
C386
 Probe Info  		17.51  LDD2045  [28]
C388
 Probe Info  		74.54  LDD2047  [28]
C390
 Probe Info  		49.52  LDD2049  [28]
C391
 Probe Info  		30.06  LDD2050  [28]
C399
 Probe Info  		12.82  LDD2058  [28]
C403
 Probe Info  		16.56  LDD2061  [28]
C408
 Probe Info  		4.96  LDD2065  [28]
C413
 Probe Info  		99.73  LDD2069  [28]
C419
 Probe Info  		54.57  LDD2074  [28]
C426
 Probe Info  		20.82  LDD2081  [28]
C431
 Probe Info  		17.88  LDD2086  [28]
C433
 Probe Info  		10.56  LDD2088  [28]
FFF probe13
 Probe Info  		17.67  LDD0475  [29]
FFF probe14
 Probe Info  		5.95  LDD0477  [29]
FFF probe15
 Probe Info  		5.17  LDD0478  [29]
FFF probe3
 Probe Info  		6.21  LDD0464  [29]
FFF probe7
 Probe Info  		11.87  LDD0483  [29]
VE-P
 Probe Info  		N.A.  LDD0396  [30]
BD-F
 Probe Info  		T245(0.00); T247(0.00); L239(0.00); V246(0.00)  LDD0024  [31]
LD-F
 Probe Info  		G244(0.00); L234(0.00); K235(0.00)  LDD0015  [31]
Photoindomethacin
 Probe Info  		N.A.  LDD0154  [32]
OEA-DA
 Probe Info  		6.84  LDD0046  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C360(0.61)  LDD2142  [10]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C360(0.70)  LDD2112  [10]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C360(0.60)  LDD2095  [10]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C360(1.01)  LDD2130  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C360(1.13); C65(0.82)  LDD2117  [10]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C360(1.17); C65(1.05)  LDD2152  [10]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C360(1.30)  LDD2103  [10]
 LDCM0214  AC1 HCT 116 C148(0.96); C158(0.96); C65(1.18); C88(0.79)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C148(1.16); C158(1.16); C88(1.17); C92(1.17)  LDD0532  [14]
 LDCM0216  AC100 HCT 116 C148(0.97); C158(0.97); C88(0.68); C92(0.68)  LDD0533  [14]
 LDCM0217  AC101 HCT 116 C148(0.81); C158(0.81); C88(0.98); C92(0.98)  LDD0534  [14]
 LDCM0218  AC102 HCT 116 C148(0.92); C158(0.92); C88(1.10); C92(1.10)  LDD0535  [14]
 LDCM0219  AC103 HCT 116 C148(1.16); C158(1.16); C88(0.90); C92(0.90)  LDD0536  [14]
 LDCM0220  AC104 HCT 116 C148(1.45); C158(1.45); C88(0.88); C92(0.88)  LDD0537  [14]
 LDCM0221  AC105 HCT 116 C148(1.19); C158(1.19); C88(1.00); C92(1.00)  LDD0538  [14]
 LDCM0222  AC106 HCT 116 C148(0.80); C158(0.80); C88(0.95); C92(0.95)  LDD0539  [14]
 LDCM0223  AC107 HCT 116 C148(1.16); C158(1.16); C88(0.71); C92(0.65)  LDD0540  [14]
 LDCM0224  AC108 HCT 116 C148(0.91); C158(0.91); C88(0.81); C92(1.24)  LDD0541  [14]
 LDCM0225  AC109 HCT 116 C148(1.05); C158(1.05); C88(0.83); C92(0.99)  LDD0542  [14]
 LDCM0226  AC11 HCT 116 C148(1.26); C158(1.26); C88(1.16); C92(1.16)  LDD0543  [14]
 LDCM0227  AC110 HCT 116 C148(1.09); C158(1.09); C88(1.00); C92(0.89)  LDD0544  [14]
 LDCM0228  AC111 HCT 116 C148(0.91); C158(0.91); C88(0.81); C92(0.97)  LDD0545  [14]
 LDCM0229  AC112 HCT 116 C148(1.09); C158(1.09); C88(0.87); C92(0.76)  LDD0546  [14]
 LDCM0230  AC113 HEK-293T C92(1.02); C360(1.30)  LDD0828  [14]
 LDCM0231  AC114 HEK-293T C92(1.13); C360(1.39)  LDD0829  [14]
 LDCM0232  AC115 HEK-293T C92(1.18); C360(1.56)  LDD0830  [14]
 LDCM0233  AC116 HEK-293T C92(1.35); C360(1.22)  LDD0831  [14]
 LDCM0234  AC117 HEK-293T C92(1.47); C360(1.06)  LDD0832  [14]
 LDCM0235  AC118 HEK-293T C92(1.50); C360(1.51)  LDD0833  [14]
 LDCM0236  AC119 HEK-293T C92(1.93); C360(0.96)  LDD0834  [14]
 LDCM0237  AC12 HCT 116 C148(1.03); C158(1.03); C88(1.12); C92(1.12)  LDD0554  [14]
 LDCM0238  AC120 HEK-293T C92(1.50); C360(1.17)  LDD0836  [14]
 LDCM0239  AC121 HEK-293T C92(1.73); C360(1.14)  LDD0837  [14]
 LDCM0240  AC122 HEK-293T C92(2.39); C360(1.11)  LDD0838  [14]
 LDCM0241  AC123 HEK-293T C92(3.11); C360(0.92)  LDD0839  [14]
 LDCM0242  AC124 HEK-293T C92(1.70); C360(2.74)  LDD0840  [14]
 LDCM0243  AC125 HEK-293T C92(2.70); C360(1.03)  LDD0841  [14]
 LDCM0244  AC126 HEK-293T C92(3.64); C360(1.56)  LDD0842  [14]
 LDCM0245  AC127 HEK-293T C92(3.63); C360(1.37)  LDD0843  [14]
 LDCM0246  AC128 HEK-293T C92(1.18); C148(0.82); C158(1.19)  LDD0844  [14]
 LDCM0247  AC129 HEK-293T C92(1.25); C148(0.73); C158(1.36)  LDD0845  [14]
 LDCM0249  AC130 HEK-293T C92(1.73); C148(0.75); C158(1.18)  LDD0847  [14]
 LDCM0250  AC131 HEK-293T C92(1.36); C148(0.86); C158(1.03)  LDD0848  [14]
 LDCM0251  AC132 HEK-293T C92(1.34); C148(0.82); C158(1.13)  LDD0849  [14]
 LDCM0252  AC133 HEK-293T C92(1.63); C148(0.70); C158(1.32)  LDD0850  [14]
 LDCM0253  AC134 HEK-293T C92(1.49); C148(0.87); C158(1.39)  LDD0851  [14]
 LDCM0254  AC135 HEK-293T C92(1.65); C148(0.92); C158(1.42)  LDD0852  [14]
 LDCM0255  AC136 HEK-293T C92(1.18); C148(0.74); C158(1.00)  LDD0853  [14]
 LDCM0256  AC137 HEK-293T C92(1.82); C148(0.84); C158(2.11)  LDD0854  [14]
 LDCM0257  AC138 HEK-293T C92(2.18); C148(0.92); C158(2.06)  LDD0855  [14]
 LDCM0258  AC139 HEK-293T C92(1.93); C148(0.82); C158(1.62)  LDD0856  [14]
 LDCM0259  AC14 HCT 116 C148(1.28); C158(1.28); C88(1.27); C92(1.27)  LDD0576  [14]
 LDCM0260  AC140 HEK-293T C92(1.55); C148(0.74); C158(1.90)  LDD0858  [14]
 LDCM0261  AC141 HEK-293T C92(1.64); C148(0.87); C158(1.82)  LDD0859  [14]
 LDCM0262  AC142 HEK-293T C92(1.68); C148(0.78); C158(1.38)  LDD0860  [14]
 LDCM0263  AC143 HEK-293T C88(1.29); C92(1.06); C148(0.93)  LDD0861  [14]
 LDCM0264  AC144 HEK-293T C88(1.20); C92(1.09); C148(0.77)  LDD0862  [14]
 LDCM0265  AC145 HEK-293T C88(1.05); C92(1.47); C148(0.76)  LDD0863  [14]
 LDCM0266  AC146 HEK-293T C88(1.16); C92(1.55); C148(0.78)  LDD0864  [14]
 LDCM0267  AC147 HEK-293T C88(1.17); C92(1.50); C148(0.91)  LDD0865  [14]
 LDCM0268  AC148 HEK-293T C88(1.09); C92(1.67); C148(0.87)  LDD0866  [14]
 LDCM0269  AC149 HEK-293T C88(1.06); C92(1.12); C148(0.75)  LDD0867  [14]
 LDCM0270  AC15 HCT 116 C88(1.23); C92(1.23); C148(1.31); C158(1.31)  LDD0587  [14]
 LDCM0271  AC150 HEK-293T C88(1.26); C92(1.25); C148(0.91)  LDD0869  [14]
 LDCM0272  AC151 HEK-293T C88(1.12); C92(1.54); C148(0.77)  LDD0870  [14]
 LDCM0273  AC152 HEK-293T C88(0.90); C92(1.16); C148(0.70)  LDD0871  [14]
 LDCM0274  AC153 HEK-293T C88(1.14); C92(1.16); C148(0.71)  LDD0872  [14]
 LDCM0621  AC154 HEK-293T C88(1.11); C92(1.13); C148(0.71)  LDD2162  [14]
 LDCM0622  AC155 HEK-293T C88(1.14); C92(1.18); C148(0.82)  LDD2163  [14]
 LDCM0623  AC156 HEK-293T C88(1.01); C92(1.37); C148(0.87)  LDD2164  [14]
 LDCM0624  AC157 HEK-293T C88(1.02); C92(1.12); C148(1.25)  LDD2165  [14]
 LDCM0276  AC17 HCT 116 C92(0.78); C148(0.84); C158(0.84); C65(1.08)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C65(1.03); C92(1.08); C148(2.22); C158(2.22)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C92(0.96); C148(1.05); C158(1.05); C65(1.17)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C88(0.87); C148(0.98); C158(0.98); C65(1.22)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C65(0.80); C148(0.93); C158(0.93); C92(1.01)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C65(0.83); C92(1.03); C148(1.36); C158(1.36)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C92(0.74); C148(0.90); C158(0.90); C65(0.96)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C65(0.70); C148(0.84); C158(0.84); C92(0.87)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C148(0.97); C158(0.97); C65(1.01); C92(1.03)  LDD0601  [14]
 LDCM0285  AC25 HCT 116 C88(0.73); C148(0.82); C158(0.82); C92(0.93)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C88(0.81); C148(0.90); C158(0.90); C92(0.94)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C148(0.94); C158(0.94); C65(1.04); C88(1.09)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C88(0.89); C92(0.94); C148(1.10); C158(1.10)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C88(0.85); C92(1.09); C148(1.59); C158(1.59)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C88(1.01); C148(1.13); C158(1.13); C92(1.25)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C148(0.87); C158(0.87); C88(1.03); C65(1.10)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C92(1.06); C88(1.09); C148(1.13); C158(1.13)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C88(1.09); C92(1.25); C148(1.72); C158(1.72)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C88(1.04); C65(1.25); C148(1.25); C158(1.25)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C88(1.06); C92(1.30); C65(1.34); C148(1.70)  LDD0612  [14]
 LDCM0296  AC35 HCT 116 C148(0.73); C158(0.73); C360(0.75)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C148(0.53); C158(0.53); C360(0.87)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C148(0.63); C158(0.63); C360(0.70)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C148(0.80); C158(0.80); C360(0.96)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C148(0.77); C158(0.77); C360(0.83)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C88(0.93); C92(1.27); C148(1.55); C158(1.55)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C360(0.69); C148(0.71); C158(0.71)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C360(0.66); C148(0.79); C158(0.79)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C360(0.77); C148(0.86); C158(0.86)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C360(0.71); C148(0.88); C158(0.88)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C360(0.65); C148(1.28); C158(1.28)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C360(0.69); C148(0.78); C158(0.78)  LDD0624  [14]
 LDCM0308  AC46 HEK-293T C88(1.02); C92(1.22); C360(0.84)  LDD0906  [14]
 LDCM0309  AC47 HEK-293T C88(0.91); C92(1.35); C360(0.79)  LDD0907  [14]
 LDCM0310  AC48 HEK-293T C88(0.85); C92(1.09); C360(0.72)  LDD0908  [14]
 LDCM0311  AC49 HEK-293T C88(0.97); C92(1.20); C360(0.77)  LDD0909  [14]
 LDCM0312  AC5 HCT 116 C88(1.08); C148(1.22); C158(1.22); C92(1.35)  LDD0629  [14]
 LDCM0313  AC50 HEK-293T C88(0.90); C92(1.04); C360(0.75)  LDD0911  [14]
 LDCM0314  AC51 HEK-293T C88(0.92); C92(1.32); C360(0.70)  LDD0912  [14]
 LDCM0315  AC52 HEK-293T C88(0.91); C92(1.45); C360(0.66)  LDD0913  [14]
 LDCM0316  AC53 HEK-293T C88(0.97); C92(1.28); C360(0.72)  LDD0914  [14]
 LDCM0317  AC54 HEK-293T C88(0.84); C92(1.49); C360(0.65)  LDD0915  [14]
 LDCM0318  AC55 HEK-293T C88(0.91); C92(1.40); C360(0.78)  LDD0916  [14]
 LDCM0319  AC56 HEK-293T C88(0.94); C92(1.19); C360(0.73)  LDD0917  [14]
 LDCM0320  AC57 HCT 116 C88(0.91); C92(0.91)  LDD0637  [14]
 LDCM0321  AC58 HCT 116 C88(0.91); C92(0.91)  LDD0638  [14]
 LDCM0322  AC59 HCT 116 C88(1.21); C92(1.21)  LDD0639  [14]
 LDCM0323  AC6 HCT 116 C148(1.14); C158(1.14); C88(1.15); C92(1.15)  LDD0640  [14]
 LDCM0324  AC60 HCT 116 C88(0.96); C92(0.96)  LDD0641  [14]
 LDCM0325  AC61 HCT 116 C88(1.12); C92(1.12)  LDD0642  [14]
 LDCM0326  AC62 HCT 116 C88(1.21); C92(1.21)  LDD0643  [14]
 LDCM0327  AC63 HCT 116 C88(0.81); C92(0.81)  LDD0644  [14]
 LDCM0328  AC64 HCT 116 C88(0.87); C92(0.87)  LDD0645  [14]
 LDCM0329  AC65 HCT 116 C88(1.00); C92(1.00)  LDD0646  [14]
 LDCM0330  AC66 HCT 116 C88(1.11); C92(1.11)  LDD0647  [14]
 LDCM0331  AC67 HCT 116 C88(0.85); C92(0.85)  LDD0648  [14]
 LDCM0332  AC68 HCT 116 C92(1.08)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C92(0.78)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C148(0.99); C158(0.99); C88(1.11); C92(1.11)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C92(1.12)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C92(0.95)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C92(1.08)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C92(1.22)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C92(1.18)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C92(0.84)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C92(0.80)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C92(1.01)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C92(0.80)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C92(0.96)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C88(1.19); C92(1.19); C148(1.24); C158(1.24)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C92(0.66)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C92(0.90)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C92(0.99)  LDD0665  [14]
 LDCM0349  AC83 HCT 116 C360(1.06)  LDD0666  [14]
 LDCM0350  AC84 HCT 116 C360(0.94)  LDD0667  [14]
 LDCM0351  AC85 HCT 116 C360(1.32)  LDD0668  [14]
 LDCM0352  AC86 HCT 116 C360(0.96)  LDD0669  [14]
 LDCM0353  AC87 HCT 116 C360(0.98)  LDD0670  [14]
 LDCM0354  AC88 HCT 116 C360(0.92)  LDD0671  [14]
 LDCM0355  AC89 HCT 116 C360(1.07)  LDD0672  [14]
 LDCM0357  AC90 HCT 116 C360(1.17)  LDD0674  [14]
 LDCM0358  AC91 HCT 116 C360(1.02)  LDD0675  [14]
 LDCM0359  AC92 HCT 116 C360(1.26)  LDD0676  [14]
 LDCM0360  AC93 HCT 116 C360(1.15)  LDD0677  [14]
 LDCM0361  AC94 HCT 116 C360(1.15)  LDD0678  [14]
 LDCM0362  AC95 HCT 116 C360(0.95)  LDD0679  [14]
 LDCM0363  AC96 HCT 116 C360(1.16)  LDD0680  [14]
 LDCM0364  AC97 HCT 116 C360(1.32)  LDD0681  [14]
 LDCM0365  AC98 HCT 116 C88(0.78); C92(0.78); C148(0.87); C158(0.87)  LDD0682  [14]
 LDCM0366  AC99 HCT 116 C88(0.69); C92(0.69); C148(0.76); C158(0.76)  LDD0683  [14]
 LDCM0545  Acetamide MDA-MB-231 C360(0.52)  LDD2138  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C360(0.70)  LDD2113  [10]
 LDCM0248  AKOS034007472 HCT 116 C148(1.05); C158(1.05); C88(1.02); C92(1.02)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C148(0.91); C158(0.91); C88(1.00); C92(1.00)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C88(1.29); C92(1.29); C148(1.58); C158(1.58)  LDD0592  [14]
 LDCM0156  Aniline NCI-H1299 11.84  LDD0403  [8]
 LDCM0020  ARS-1620 HCC44 C88(1.18); C92(1.18); C65(1.09)  LDD2171  [14]
 LDCM0498  BS-3668 MDA-MB-231 C360(0.69)  LDD2091  [10]
 LDCM0630  CCW28-3 231MFP C360(2.30); C65(1.32)  LDD2214  [34]
 LDCM0108  Chloroacetamide HeLa C65(0.00); C360(0.00); H224(0.00); H368(0.00)  LDD0222  [27]
 LDCM0632  CL-Sc Hep-G2 C88(1.80); C360(1.24); C360(1.03); C65(0.74)  LDD2227  [22]
 LDCM0367  CL1 HCT 116 C148(0.94); C158(0.94); C92(1.03)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C92(1.18); C148(1.51); C158(1.51)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C88(0.92); C148(1.24); C158(1.24); C65(1.32)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C148(0.96); C158(0.96); C88(1.18); C92(1.18)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C148(0.93); C158(0.93); C88(1.19); C92(1.19)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C148(0.74); C158(0.74); C88(0.97); C92(0.97)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C148(0.91); C158(0.91); C88(1.05); C92(1.05)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C92(0.78); C148(0.80); C158(0.80); C65(0.92)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C92(0.78); C65(0.90); C148(1.52); C158(1.52)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C92(0.71); C65(0.93); C148(1.15); C158(1.15)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C92(0.61); C148(1.44); C158(1.44); C65(1.46)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C65(0.89); C92(0.96); C148(1.20); C158(1.20)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C92(1.04); C148(1.74); C158(1.74)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C65(1.03); C92(1.10); C148(1.15); C158(1.15)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C92(0.97); C65(1.04); C148(1.20); C158(1.20)  LDD0698  [14]
 LDCM0382  CL112 HCT 116 C88(0.90); C148(0.95); C158(0.95); C92(1.06)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C88(1.00); C65(1.33); C92(1.47); C148(1.71)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C148(0.83); C158(0.83); C88(0.98); C65(1.44)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C88(0.81); C148(1.10); C158(1.10); C65(1.16)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C88(0.99); C148(1.07); C158(1.07); C65(1.10)  LDD0703  [14]
 LDCM0387  CL117 HCT 116 C360(0.82); C148(1.33); C158(1.33)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C148(0.79); C158(0.79); C360(0.81)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C148(0.73); C158(0.73); C360(0.86)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C92(1.30); C148(1.53); C158(1.53)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C148(0.70); C158(0.70); C360(0.93)  LDD0708  [14]
 LDCM0392  CL121 HEK-293T C88(0.86); C92(1.52); C360(0.69)  LDD0990  [14]
 LDCM0393  CL122 HEK-293T C88(0.82); C92(1.29); C360(0.76)  LDD0991  [14]
 LDCM0394  CL123 HEK-293T C88(0.99); C92(1.32); C360(0.72)  LDD0992  [14]
 LDCM0395  CL124 HEK-293T C88(0.82); C92(1.29); C360(0.72)  LDD0993  [14]
 LDCM0396  CL125 HCT 116 C88(0.73); C92(0.73)  LDD0713  [14]
 LDCM0397  CL126 HCT 116 C88(1.10); C92(1.10)  LDD0714  [14]
 LDCM0398  CL127 HCT 116 C88(0.79); C92(0.79)  LDD0715  [14]
 LDCM0399  CL128 HCT 116 C88(1.06); C92(1.06)  LDD0716  [14]
 LDCM0400  CL13 HCT 116 C92(0.99); C148(1.31); C158(1.31)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C92(1.04); C148(1.31); C158(1.31)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C92(0.94); C148(1.44); C158(1.44)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C65(0.90); C88(1.11); C92(1.24)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C88(0.98); C65(1.00); C92(1.20)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C65(0.99); C88(1.14); C92(1.36)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C65(1.17); C88(1.28); C92(1.38)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C148(0.80); C158(0.80); C92(0.94)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C88(1.17); C92(1.43); C65(1.53)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C65(0.94); C88(1.24); C92(1.36)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C92(1.46); C88(1.53); C65(1.57)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C65(0.98); C88(1.11); C92(1.22)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C88(1.22); C65(1.54); C92(1.60)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C65(1.05); C88(0.95); C92(1.11)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C65(1.07); C88(1.25); C92(1.38)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C65(0.88); C88(0.85); C92(1.02)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C65(1.02); C88(1.03); C92(1.23)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C65(1.05); C88(1.05); C92(1.35)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C148(0.88); C158(0.88); C92(1.04)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C65(0.94); C88(0.98); C92(1.20)  LDD0736  [14]
 LDCM0420  CL31 HEK-293T C88(1.01); C92(1.37); C148(0.59); C158(0.86)  LDD1018  [14]
 LDCM0421  CL32 HEK-293T C88(1.11); C92(1.40); C148(0.67); C158(1.02)  LDD1019  [14]
 LDCM0422  CL33 HEK-293T C88(1.27); C92(1.83); C148(0.60); C158(1.27)  LDD1020  [14]
 LDCM0423  CL34 HEK-293T C88(1.11); C92(1.35); C148(0.69); C158(1.29)  LDD1021  [14]
 LDCM0424  CL35 HEK-293T C88(1.04); C92(1.14); C148(0.57); C158(0.95)  LDD1022  [14]
 LDCM0425  CL36 HEK-293T C88(1.05); C92(1.15); C148(0.67); C158(0.85)  LDD1023  [14]
 LDCM0426  CL37 HEK-293T C88(1.05); C92(1.15); C148(0.63); C158(0.94)  LDD1024  [14]
 LDCM0428  CL39 HEK-293T C88(0.96); C92(0.96); C148(0.47); C158(1.60)  LDD1026  [14]
 LDCM0429  CL4 HCT 116 C148(1.02); C158(1.02); C92(0.92)  LDD0746  [14]
 LDCM0430  CL40 HEK-293T C88(1.01); C92(1.15); C148(0.62); C158(1.13)  LDD1028  [14]
 LDCM0431  CL41 HEK-293T C88(1.04); C92(1.42); C148(0.48); C158(1.45)  LDD1029  [14]
 LDCM0432  CL42 HEK-293T C88(1.04); C92(1.19); C148(0.54); C158(1.46)  LDD1030  [14]
 LDCM0433  CL43 HEK-293T C88(1.08); C92(1.07); C148(0.51); C158(1.22)  LDD1031  [14]
 LDCM0434  CL44 HEK-293T C88(0.96); C92(0.83); C148(0.72); C158(1.08)  LDD1032  [14]
 LDCM0435  CL45 HEK-293T C88(0.91); C92(1.03); C148(0.46); C158(1.37)  LDD1033  [14]
 LDCM0436  CL46 HCT 116 C148(0.51); C158(0.51); C360(1.04); C65(0.66)  LDD0753  [14]
 LDCM0437  CL47 HCT 116 C148(0.59); C158(0.59); C360(1.15); C65(0.63)  LDD0754  [14]
 LDCM0438  CL48 HCT 116 C148(0.72); C158(0.72); C360(0.84); C65(0.88)  LDD0755  [14]
 LDCM0439  CL49 HCT 116 C148(0.88); C158(0.88); C360(0.84); C65(0.81)  LDD0756  [14]
 LDCM0440  CL5 HCT 116 C148(1.26); C158(1.26); C92(0.82)  LDD0757  [14]
 LDCM0441  CL50 HCT 116 C148(0.67); C158(0.67); C360(0.80); C65(0.79)  LDD0758  [14]
 LDCM0442  CL51 HCT 116 C148(0.92); C158(0.92); C360(0.79); C65(0.66)  LDD0759  [14]
 LDCM0443  CL52 HCT 116 C148(0.75); C158(0.75); C360(0.72); C65(0.72)  LDD0760  [14]
 LDCM0444  CL53 HCT 116 C148(0.64); C158(0.64); C360(1.14); C65(0.80)  LDD0761  [14]
 LDCM0445  CL54 HCT 116 C148(0.59); C158(0.59); C360(0.97); C65(0.86)  LDD0762  [14]
 LDCM0446  CL55 HCT 116 C148(0.70); C158(0.70); C360(1.01); C65(0.78)  LDD0763  [14]
 LDCM0447  CL56 HCT 116 C148(0.64); C158(0.64); C360(1.18); C65(0.82)  LDD0764  [14]
 LDCM0448  CL57 HCT 116 C148(1.34); C158(1.34); C360(1.25); C65(0.96)  LDD0765  [14]
 LDCM0449  CL58 HCT 116 C148(0.72); C158(0.72); C360(0.89); C65(0.85)  LDD0766  [14]
 LDCM0450  CL59 HCT 116 C148(0.84); C158(0.84); C360(1.03); C65(1.13)  LDD0767  [14]
 LDCM0451  CL6 HCT 116 C148(0.79); C158(0.79); C92(2.34)  LDD0768  [14]
 LDCM0452  CL60 HCT 116 C148(0.65); C158(0.65); C360(0.69); C65(1.01)  LDD0769  [14]
 LDCM0453  CL61 HCT 116 C360(1.46); C65(1.08)  LDD0770  [14]
 LDCM0454  CL62 HCT 116 C360(1.17); C65(1.14)  LDD0771  [14]
 LDCM0455  CL63 HCT 116 C360(1.45); C65(1.23)  LDD0772  [14]
 LDCM0456  CL64 HCT 116 C360(1.43); C65(1.18)  LDD0773  [14]
 LDCM0457  CL65 HCT 116 C360(1.63); C65(1.12)  LDD0774  [14]
 LDCM0458  CL66 HCT 116 C360(1.26); C65(1.95)  LDD0775  [14]
 LDCM0459  CL67 HCT 116 C360(1.76); C65(1.74)  LDD0776  [14]
 LDCM0460  CL68 HCT 116 C360(1.77); C65(1.45)  LDD0777  [14]
 LDCM0461  CL69 HCT 116 C360(1.13); C65(1.08)  LDD0778  [14]
 LDCM0462  CL7 HCT 116 C148(1.79); C158(1.79); C92(0.84)  LDD0779  [14]
 LDCM0463  CL70 HCT 116 C360(1.39); C65(1.21)  LDD0780  [14]
 LDCM0464  CL71 HCT 116 C360(1.60); C65(1.21)  LDD0781  [14]
 LDCM0465  CL72 HCT 116 C360(1.32); C65(1.09)  LDD0782  [14]
 LDCM0466  CL73 HCT 116 C360(1.19); C65(1.27)  LDD0783  [14]
 LDCM0467  CL74 HCT 116 C360(1.40); C65(1.59)  LDD0784  [14]
 LDCM0469  CL76 HCT 116 C360(0.98); C65(0.91)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C360(0.78); C65(0.72)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C360(1.29); C65(0.88)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C360(1.11); C65(1.08)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C148(1.72); C158(1.72); C92(1.17)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C360(0.72); C65(0.97)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C360(0.92); C65(1.07)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C360(1.10); C65(1.56)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C360(1.22); C65(1.15)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C360(1.95); C65(1.68)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C360(1.15); C65(0.64)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C360(0.92); C65(0.80)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C360(1.15); C65(0.93)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C360(1.11); C65(1.11)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C360(1.46); C65(1.02)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C148(1.13); C158(1.13); C92(0.92)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C360(0.91); C65(0.83)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C148(1.18); C158(1.18); C65(1.14); C88(1.12)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C148(1.03); C158(1.03); C65(1.01); C88(0.84)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C148(0.75); C158(0.75); C65(0.93); C88(0.80)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C148(1.33); C158(1.33); C65(1.31); C88(0.88)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C148(0.99); C158(0.99); C65(1.22); C88(0.78)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C148(1.00); C158(1.00); C65(1.01); C88(0.80)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C148(1.05); C158(1.05); C65(1.16); C88(1.25)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C148(1.25); C158(1.25); C65(1.48); C88(1.26)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C148(1.20); C158(1.20); C65(1.50); C88(1.01)  LDD0811  [14]
 LDCM0495  E2913 HEK-293T C360(1.07); C65(1.05); C148(0.72); C158(0.96)  LDD1698  [35]
 LDCM0625  F8 Ramos C360(0.99); C65(0.84); C148(0.60)  LDD2187  [36]
 LDCM0572  Fragment10 Ramos C360(0.49); C65(0.88); C148(0.86)  LDD2189  [36]
 LDCM0573  Fragment11 Ramos C360(0.05); C65(0.45); 2.28; C148(0.87)  LDD2190  [36]
 LDCM0574  Fragment12 Ramos C360(0.76); C65(1.25); C148(0.64)  LDD2191  [36]
 LDCM0575  Fragment13 Ramos C360(0.98); C65(0.75); C148(0.84)  LDD2192  [36]
 LDCM0576  Fragment14 Ramos C360(0.83); C65(0.98); 1.07; C148(0.89)  LDD2193  [36]
 LDCM0579  Fragment20 Ramos C360(0.69); C65(1.26); C148(0.68)  LDD2194  [36]
 LDCM0580  Fragment21 Ramos C360(1.02); C65(1.21); C148(0.82)  LDD2195  [36]
 LDCM0582  Fragment23 Ramos C360(1.07); C65(1.21); C148(0.97)  LDD2196  [36]
 LDCM0578  Fragment27 Ramos C360(1.10); C65(0.77); C148(0.97)  LDD2197  [36]
 LDCM0586  Fragment28 Ramos C360(0.88); C65(0.74); 0.64; C148(0.49)  LDD2198  [36]
 LDCM0588  Fragment30 Ramos C360(0.89); C65(1.03)  LDD2199  [36]
 LDCM0589  Fragment31 Ramos C360(1.24); C65(1.01); C148(0.64)  LDD2200  [36]
 LDCM0590  Fragment32 Ramos C360(0.79); C65(1.52)  LDD2201  [36]
 LDCM0468  Fragment33 HCT 116 C360(1.45); C65(1.24)  LDD0785  [14]
 LDCM0596  Fragment38 Ramos C360(1.13); C65(0.69); C148(1.32)  LDD2203  [36]
 LDCM0566  Fragment4 Ramos C360(1.04); C65(0.89); C148(0.70)  LDD2184  [36]
 LDCM0427  Fragment51 HEK-293T C88(0.99); C92(0.92); C148(0.69); C158(1.36)  LDD1025  [14]
 LDCM0610  Fragment52 Ramos C360(0.74); C65(0.57)  LDD2204  [36]
 LDCM0614  Fragment56 Ramos C360(0.76); C65(0.99); C148(0.79)  LDD2205  [36]
 LDCM0569  Fragment7 Ramos C360(0.63); C65(0.64); 0.79; C148(0.50)  LDD2186  [36]
 LDCM0571  Fragment9 Ramos C360(0.72); C65(1.84); C148(0.59)  LDD2188  [36]
 LDCM0116  HHS-0101 DM93 Y81(1.55); Y237(8.67)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y81(0.67); Y237(7.86)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y81(3.55); Y237(6.25)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y81(0.85); Y237(12.70)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y237(1.13); Y81(1.31)  LDD0268  [12]
 LDCM0107  IAA HeLa H59(0.00); C360(0.00); H368(0.00); H224(0.00)  LDD0221  [27]
 LDCM0123  JWB131 DM93 Y237(0.99)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y237(0.59)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y237(1.66)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y237(1.78)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y237(2.16)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y237(1.17)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y237(0.77)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y237(0.95)  LDD0292  [11]
 LDCM0022  KB02 HCT 116 C65(2.00); C148(2.40); C158(2.40); C88(2.15)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C65(1.57); C148(2.50); C158(2.50); C88(1.40)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C65(1.68); C148(1.53); C158(1.53); C88(1.49)  LDD0082  [14]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C65(1.23)  LDD2102  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C360(0.59)  LDD2121  [10]
 LDCM0109  NEM HeLa H224(0.00); H368(0.00); H59(0.00)  LDD0223  [27]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C360(0.68); C65(0.51)  LDD2089  [10]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C360(0.95); C65(0.80)  LDD2090  [10]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C360(1.01)  LDD2092  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C360(1.03); C65(0.77)  LDD2093  [10]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C360(0.14)  LDD2096  [10]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C65(0.84)  LDD2097  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C360(0.97)  LDD2099  [10]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C360(0.45); C65(0.38)  LDD2100  [10]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C360(0.97)  LDD2101  [10]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C65(0.89)  LDD2106  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C360(0.92)  LDD2107  [10]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C360(0.67); C65(0.66)  LDD2108  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C360(0.73); C65(0.42)  LDD2109  [10]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C360(1.07)  LDD2110  [10]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C360(1.15); C65(0.84)  LDD2111  [10]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C360(0.69)  LDD2114  [10]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C360(0.96); C65(0.38)  LDD2115  [10]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C360(0.29)  LDD2116  [10]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C360(0.30)  LDD2118  [10]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C360(2.02); C65(2.73)  LDD2119  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C360(0.83)  LDD2120  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C360(1.00); C65(0.83)  LDD2123  [10]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C360(0.25)  LDD2124  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C360(1.03); C65(0.71)  LDD2125  [10]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C360(0.38)  LDD2126  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C360(1.09); C65(1.02)  LDD2127  [10]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C360(0.75)  LDD2128  [10]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C360(1.03); C65(0.84)  LDD2129  [10]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C360(0.54); C65(0.28)  LDD2134  [10]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C360(1.30); C65(1.35)  LDD2135  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C360(1.13); C65(0.92)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C360(1.08)  LDD2137  [10]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C360(2.00); C65(1.46)  LDD1700  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C360(0.78)  LDD2140  [10]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C65(0.28)  LDD2141  [10]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C360(0.77)  LDD2143  [10]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C360(2.08); C65(3.47)  LDD2144  [10]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C65(0.21)  LDD2145  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C360(1.00); C65(0.79)  LDD2146  [10]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C360(0.53)  LDD2148  [10]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C360(0.43)  LDD2149  [10]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C360(0.70); C65(0.54)  LDD2150  [10]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C65(1.20)  LDD2153  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C148(1.72); C92(0.09)  LDD2206  [37]
 LDCM0628  OTUB2-COV-1 HEK-293T C65(0.88); C92(0.17)  LDD2207  [37]
 LDCM0131  RA190 MM1.R C88(1.86); C92(1.86)  LDD0304  [38]
 LDCM0021  THZ1 HeLa S3 C65(1.02)  LDD0460  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 1 (TERF1) . P54274

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Coenzyme A Small molecular drug DB01992
S-hydroxycysteine Small molecular drug DB01915

References

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2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.
24 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
25 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
26 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
27 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
28 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
29 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
30 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
31 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
32 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
33 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
34 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
35 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
36 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
37 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
38 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.