General Information of Experiment

Probe Name KY-26  Probe Info 
Probe concentration 12.5 uM
Criteria Qualitation: Labeling site identification
In Vivo Experiment Model Model Type Living cell
Derived Tissue Bone marrow
Disease Model T acute lymphoblastic leukemia [ICD-11:2A90]
Model Name Human T acute lymphoblastic leukemia cells (Jurkat)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 57 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP12673  4'-phosphopantetheine phosphatase (PANK4) Y258
 LDTP05761  5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) K56
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) Y227
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) K235
 LDTP02902  Aldo-keto reductase family 1 member C4 (AKR1C4) Y24
 LDTP02159  Alpha-enolase (ENO1) K60
 LDTP04561  ATP-citrate synthase (ACLY) Y384
 LDTP02925  ATP-dependent 6-phosphofructokinase, liver type (PFKL) Y674
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) Y223
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) Y73
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) Y240
 LDTP02149  Cyclin-dependent kinase 1 (CDK1) K33
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) K33
 LDTP05245  Cyclin-dependent kinase 5 (CDK5) K33
 LDTP05244  Cyclin-dependent kinase 6 (CDK6) K43
 LDTP00194  Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) K286
 LDTP03400  Deoxycytidine kinase (DCK) Y86
 LDTP12803  Dipeptidyl peptidase 3 (DPP3) Y417
 LDTP03808  Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) K101
 LDTP13062  eIF-2-alpha kinase GCN2 (EIF2AK4) K619
 LDTP02008  Fructose-bisphosphate aldolase A (ALDOA) Y328
 LDTP02868  Fumarylacetoacetase (FAH) Y244
 LDTP03420  Glutathione S-transferase Mu 2 (GSTM2) K50
 LDTP02225  Heat shock protein HSP 90-alpha (HSP90AA1) Y61
 LDTP06645  Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) Y264
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) Y430
 LDTP03003  Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) K296
 LDTP12744  Interleukin-1 receptor-associated kinase 4 (IRAK4) K213
 LDTP03908  Malate dehydrogenase, mitochondrial (MDH2) K105
 LDTP09931  Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) K46
 LDTP05669  Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) Y27
 LDTP14065  Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5) Y31
 LDTP03220  NAD-dependent malic enzyme, mitochondrial (ME2) Y84
 LDTP03169  Nucleoside diphosphate kinase B (NME2) K12
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) Y232
 LDTP00252  Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD) K708
 LDTP01787  Phosphoglycerate kinase 1 (PGK1) K323
 LDTP01787  Phosphoglycerate kinase 1 (PGK1) Y76
 LDTP00449  Proteasome subunit alpha type-7 (PSMA7) Y118
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) Y149
 LDTP04246  Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) Y166
 LDTP04246  Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) K164
 LDTP06100  Protein-tyrosine kinase 2-beta (PTK2B) K457
 LDTP02733  Pyruvate kinase PKM (PKM) Y370
 LDTP05917  Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) Y308
 LDTP03688  Serine hydroxymethyltransferase, cytosolic (SHMT1) Y82
 LDTP05733  Serine/threonine-protein kinase 4 (STK4) Y41
 LDTP07930  Serine/threonine-protein kinase MARK2 (MARK2) K82
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) K81
 LDTP13455  Serine/threonine-protein kinase tousled-like 1 (TLK1) K485
 LDTP08226  Serine/threonine-protein kinase tousled-like 2 (TLK2) K491
 LDTP03258  Thymidylate kinase (DTYMK) Y151
 LDTP06067  Tubulin--tyrosine ligase-like protein 12 (TTLL12) Y452
 LDTP03944  Tyrosine-protein kinase CSK (CSK) K222
 LDTP02859  Tyrosine-protein kinase Fer (FER) K591
 LDTP02859  Tyrosine-protein kinase Fer (FER) Y714
 LDTP02138  Tyrosine-protein kinase Lck (LCK) K273
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP05292  Fatty acid-binding protein 5 (FABP5) Y131
Other
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) Y12
 LDTP10990  T-complex protein 1 subunit eta (CCT7) K157

References

1 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.