Details of the Target

General Information of Target

Target ID LDTP03299
Target Name Cyclin-dependent kinase 2 (CDK2)
Gene Name CDK2
Gene ID 1017
Synonyms
CDKN2; Cyclin-dependent kinase 2; EC 2.7.11.22; Cell division protein kinase 2; p33 protein kinase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1. Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability. Phosphorylates CDK2AP2. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks.
TTD ID
T70176
Uniprot ID
P24941
DrugMap ID
TT7HF4W
Ensemble ID
ENST00000266970.9
HGNC ID
HGNC:1771
ChEMBL ID
CHEMBL301

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.L175M .
MEWO SNV: p.P61S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		10.40  LDD0214  [1]
m-APA
 Probe Info  		15.00  LDD0402  [2]
TH211
 Probe Info  		Y269(20.00); Y236(11.28)  LDD0257  [3]
STPyne
 Probe Info  		K20(8.46)  LDD0277  [4]
BTD
 Probe Info  		C177(0.72)  LDD2089  [5]
EA-probe
 Probe Info  		C177(1.07)  LDD2210  [6]
HHS-482
 Probe Info  		Y15(0.67); Y19(0.81)  LDD0285  [7]
HHS-475
 Probe Info  		Y19(0.89); Y159(1.04)  LDD0264  [8]
HHS-465
 Probe Info  		Y19(10.00)  LDD2237  [9]
DBIA
 Probe Info  		C118(0.40); C177(1.26)  LDD0531  [10]
AMP probe
 Probe Info  		K33(0.00); K34(0.00)  LDD0200  [11]
ATP probe
 Probe Info  		K33(0.00); K34(0.00); K129(0.00); K6(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C177(0.00); C118(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C177(0.00); C118(0.00)  LDD0036  [12]
Lodoacetamide azide
 Probe Info  		C177(0.00); C118(0.00)  LDD0037  [12]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
KY-26
 Probe Info  		N.A.  LDD0301  [15]
ENE
 Probe Info  		N.A.  LDD0006  [14]
IPM
 Probe Info  		N.A.  LDD0005  [14]
NHS
 Probe Info  		N.A.  LDD0010  [14]
SF
 Probe Info  		K33(0.00); Y19(0.00)  LDD0028  [16]
VSF
 Probe Info  		N.A.  LDD0007  [14]
1c-yne
 Probe Info  		K129(0.00); K237(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
AOyne
 Probe Info  		11.10  LDD0443  [19]
NAIA_5
 Probe Info  		N.A.  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C070
 Probe Info  		10.63  LDD1766  [21]
C391
 Probe Info  		33.13  LDD2050  [21]
C432
 Probe Info  		5.46  LDD2087  [21]
FFF probe11
 Probe Info  		5.97  LDD0472  [22]
FFF probe12
 Probe Info  		20.00  LDD0473  [22]
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe14
 Probe Info  		20.00  LDD0477  [22]
FFF probe2
 Probe Info  		13.94  LDD0463  [22]
FFF probe3
 Probe Info  		12.30  LDD0464  [22]
STS-2
 Probe Info  		N.A.  LDD0138  [23]
VE-P
 Probe Info  		N.A.  LDD0396  [24]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [25]
DA-2
 Probe Info  		N.A.  LDD0070  [26]
Probe 12
 Probe Info  		N.A.  LDD0420  [27]
STS-1
 Probe Info  		N.A.  LDD0068  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C177(0.98)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C177(1.05)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C177(1.07)  LDD2103  [5]
 LDCM0214  AC1 HCT 116 C118(0.40); C177(1.26)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C177(1.24)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C177(1.09)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C177(1.06)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C177(1.05)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C177(1.21)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C177(1.24)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C177(1.14)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C177(1.19)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C177(1.31)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C177(1.14)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C177(0.86)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C177(1.40)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C177(1.09)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C177(1.17)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C177(1.23)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C177(0.99)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C177(1.20)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C177(1.24)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C177(1.30)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C177(1.17)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C177(1.15)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C177(1.15)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C177(1.13)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C177(1.29)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C177(1.13)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C177(1.20)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C177(1.17)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C177(1.10)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C177(1.16)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C177(1.30)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C177(1.36)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C177(1.28)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C177(1.18)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C177(1.32)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C177(1.00)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C177(1.33)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C177(1.24)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C177(1.39)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C177(1.25)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C177(1.36)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C177(1.33)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C177(1.66)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C177(1.42)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C177(1.17)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C177(1.74)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C177(1.62)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C177(1.32)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C177(1.14)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C177(1.46)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C177(1.10)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C177(1.40)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C177(1.45)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C177(1.76)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C177(1.55)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C177(1.26)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C177(1.30)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C177(1.03)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C177(1.42)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C177(2.26)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C177(1.29)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C177(1.18)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C177(1.05)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C177(0.95)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C177(1.17)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C177(1.39)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C177(1.10)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C118(0.70); C177(1.16)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C177(1.14)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C177(1.17)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C177(1.16)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C177(1.25)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C177(1.03)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C118(0.95); C177(1.24)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C118(0.76); C177(1.34)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C118(0.74); C177(1.23)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C118(0.78); C177(1.29)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C118(0.70); C177(1.31)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C118(0.72); C177(1.10)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C118(0.78); C177(1.33)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C118(0.61); C177(1.31)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C118(0.64); C177(1.61)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C118(0.69); C177(1.36)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C118(0.73); C177(1.62)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C177(0.88); C118(1.41)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C177(0.94); C118(1.20)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C177(0.97); C118(1.11)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C177(0.92); C118(1.07)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C118(0.99); C177(1.14)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C118(0.65); C177(1.27)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C118(0.97); C177(1.20)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C118(0.98); C177(1.20)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C118(0.96); C177(1.08)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C118(0.91); C177(1.17)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C118(1.02); C177(1.12)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C118(0.92); C177(1.27)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C118(0.84); C177(1.14)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C118(1.02); C177(1.14)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C118(0.66); C177(1.22)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C118(0.79); C177(1.30)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C118(0.64); C177(1.34)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C118(0.77); C177(1.34)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C118(0.96); C177(1.06)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C118(0.94); C177(1.16)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C118(0.83); C177(1.25)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C118(0.87); C177(1.22)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C118(0.75); C177(1.42)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C118(0.70); C177(1.42)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C177(1.46)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C177(1.52)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C177(1.54)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C177(1.38)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C177(1.53)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C177(1.52)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C177(1.75)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C177(1.70)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C177(1.76)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C177(1.86)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C177(1.77)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C177(2.38)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C118(0.69); C177(1.19)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C118(0.62); C177(1.26)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C177(1.17)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C118(0.64); C177(1.43)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C118(0.85); C177(1.11)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C118(0.81); C177(1.28)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C118(0.67); C177(1.93)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C118(0.60); C177(1.90)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C118(0.62); C177(2.22)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C118(0.82); C177(1.34)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C118(0.86); C177(1.38)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C118(0.59); C177(1.20)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C118(0.83); C177(1.25)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C177(1.30)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C118(0.74); C177(1.22)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C118(0.80); C177(1.09)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C118(0.58); C177(2.57)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C177(1.67)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C177(1.59)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C177(1.36)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C177(1.17)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C177(1.06)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C177(1.18)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C177(1.38)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C177(1.06)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C177(1.61)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C177(1.63)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C177(1.35)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C177(1.32)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C177(1.22)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C177(1.28)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C177(1.45)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C177(1.28)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C177(1.17)  LDD0683  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C177(1.04)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C177(1.05)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C177(1.13)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C177(1.75)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 11.82  LDD0403  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C177(0.92)  LDD2227  [20]
 LDCM0367  CL1 HCT 116 C177(1.05)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C177(1.58)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C118(0.58); C177(1.36)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C177(1.24)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C177(1.23)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C177(1.01)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C177(1.06)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C177(1.39)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C177(1.85)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C177(1.64)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C177(1.59)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C177(1.30)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C177(1.67)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C177(1.38)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C177(1.45)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C177(1.22); C118(1.23)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C118(0.71); C177(1.60)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C118(0.87); C177(1.49)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C118(0.81); C177(1.31)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C118(0.74); C177(1.31)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C118(0.85); C177(1.61)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C177(1.13); C118(1.16)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C118(0.97); C177(1.17)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C177(1.49)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C118(1.04); C177(1.17)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C118(0.78); C177(0.87)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C118(0.70); C177(1.17)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C118(0.76); C177(1.26)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C118(0.77); C177(1.32)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C177(1.19)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C177(1.20)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C177(1.26)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C177(1.42)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C177(1.44)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C177(1.19)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C177(1.44)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C177(1.14)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C177(1.24)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C177(1.16)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C177(1.05)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C177(1.08)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C177(1.19)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C177(1.62)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C177(1.73)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C177(1.16)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C177(1.31)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C177(1.40)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C177(1.29)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C177(1.07)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C177(1.28)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C177(1.25)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C177(1.06)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C177(1.13)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C177(1.15)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C177(1.28)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C177(1.53)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C177(1.47)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C177(1.35)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C177(1.29)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C177(1.39)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C177(1.61)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C177(0.98)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C177(1.44)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C177(1.24)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C177(2.14)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C177(1.62)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C177(1.49)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C177(1.83)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C177(0.93)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C177(0.93)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C177(0.83)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C177(0.88)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C177(1.10)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C177(0.87)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C177(0.86)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C177(0.85)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C177(0.81)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C177(0.79)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C177(0.82)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C177(1.01)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C177(0.99)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C177(0.87)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C177(0.89)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C177(1.20)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C177(0.98)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C177(1.39)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C177(1.40)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C177(1.56)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C177(1.56)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C177(1.31)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C177(1.62)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C177(1.26)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C177(1.26)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C177(1.46)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C177(1.26)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C177(1.51)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C177(1.60)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C177(1.30)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C177(1.36)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C177(1.37)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C118(0.56); C177(1.15)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C118(1.06); C177(1.13)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C118(0.87); C177(1.20)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C118(0.78); C177(1.29)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C177(1.74)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C118(0.53); C177(1.09)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C118(0.90); C177(1.19)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C118(0.63); C177(1.46)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C118(0.69); C177(1.64)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C118(0.57); C177(2.09)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C118(0.81); C177(1.36)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C118(0.98); C177(1.27)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C118(0.75); C177(1.32)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C118(0.70); C177(1.46)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C118(0.63); C177(2.29)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C177(1.35)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C118(1.17); C177(1.30)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C118(0.78); C177(1.22)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C118(0.85); C177(1.23)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C118(0.82); C177(1.16)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C118(0.63); C177(1.68)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C118(0.64); C177(1.88)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C118(0.67); C177(1.17)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C118(0.52); C177(1.17)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C118(0.66); C177(1.28)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C118(0.60); C177(1.32)  LDD0811  [10]
 LDCM0191  Compound 21 HEK-293T 8.15  LDD0508  [22]
 LDCM0190  Compound 34 HEK-293T 6.72  LDD0510  [22]
 LDCM0192  Compound 35 HEK-293T 3.88  LDD0509  [22]
 LDCM0165  Compound 9 HL-60 N.A.  LDD0420  [27]
 LDCM0495  E2913 HEK-293T C177(1.13); C118(0.92)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C177(1.74)  LDD1702  [5]
 LDCM0175  Ethacrynic acid HeLa C177(1.07)  LDD2210  [6]
 LDCM0625  F8 Ramos C177(0.66)  LDD2187  [30]
 LDCM0572  Fragment10 MDA-MB-231 C177(2.30)  LDD1389  [31]
 LDCM0573  Fragment11 MDA-MB-231 C177(7.72)  LDD1391  [31]
 LDCM0574  Fragment12 MDA-MB-231 C177(1.70)  LDD1393  [31]
 LDCM0575  Fragment13 Ramos C177(1.00)  LDD2192  [30]
 LDCM0576  Fragment14 MDA-MB-231 C177(1.12)  LDD1397  [31]
 LDCM0577  Fragment15 Ramos C177(0.89)  LDD1400  [31]
 LDCM0579  Fragment20 MDA-MB-231 C177(1.20)  LDD1402  [31]
 LDCM0580  Fragment21 MDA-MB-231 C177(0.99)  LDD1404  [31]
 LDCM0581  Fragment22 MDA-MB-231 C177(1.43)  LDD1406  [31]
 LDCM0582  Fragment23 Ramos C177(0.94)  LDD1409  [31]
 LDCM0583  Fragment24 Ramos C177(1.12)  LDD1410  [31]
 LDCM0584  Fragment25 MDA-MB-231 C177(0.45)  LDD1411  [31]
 LDCM0578  Fragment27 MDA-MB-231 C177(0.98)  LDD1401  [31]
 LDCM0586  Fragment28 MDA-MB-231 C177(0.96)  LDD1415  [31]
 LDCM0587  Fragment29 MDA-MB-231 C177(1.49)  LDD1417  [31]
 LDCM0588  Fragment30 Ramos C177(1.44)  LDD1420  [31]
 LDCM0589  Fragment31 MDA-MB-231 C177(1.59)  LDD1421  [31]
 LDCM0590  Fragment32 Ramos C177(4.24)  LDD1424  [31]
 LDCM0468  Fragment33 HCT 116 C177(1.39)  LDD0785  [10]
 LDCM0592  Fragment34 Ramos C177(1.06)  LDD1428  [31]
 LDCM0593  Fragment35 Ramos C177(0.87)  LDD1430  [31]
 LDCM0594  Fragment36 MDA-MB-231 C177(1.89)  LDD1431  [31]
 LDCM0595  Fragment37 Ramos C177(0.90)  LDD1432  [31]
 LDCM0596  Fragment38 MDA-MB-231 C177(1.02)  LDD1433  [31]
 LDCM0566  Fragment4 MDA-MB-231 C177(1.29)  LDD1378  [31]
 LDCM0598  Fragment40 MDA-MB-231 C177(0.82)  LDD1436  [31]
 LDCM0599  Fragment41 MDA-MB-231 C177(1.05)  LDD1438  [31]
 LDCM0600  Fragment42 Ramos C177(0.87)  LDD1440  [31]
 LDCM0601  Fragment43 Ramos C177(2.67)  LDD1442  [31]
 LDCM0602  Fragment44 MDA-MB-231 C177(0.79)  LDD1443  [31]
 LDCM0603  Fragment45 MDA-MB-231 C177(1.93)  LDD1444  [31]
 LDCM0604  Fragment46 MDA-MB-231 C177(1.00)  LDD1445  [31]
 LDCM0427  Fragment51 HCT 116 C177(1.74)  LDD0744  [10]
 LDCM0610  Fragment52 MDA-MB-231 C177(0.53)  LDD1452  [31]
 LDCM0611  Fragment53 MDA-MB-231 C177(0.98)  LDD1454  [31]
 LDCM0612  Fragment54 MDA-MB-231 C177(1.11)  LDD1456  [31]
 LDCM0614  Fragment56 MDA-MB-231 C177(0.89)  LDD1458  [31]
 LDCM0569  Fragment7 Ramos C177(1.61)  LDD1384  [31]
 LDCM0570  Fragment8 Ramos C177(3.72)  LDD1386  [31]
 LDCM0571  Fragment9 MDA-MB-231 C177(1.28)  LDD1387  [31]
 LDCM0116  HHS-0101 DM93 Y19(0.89); Y159(1.04)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y19(0.56); Y159(0.87)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y159(0.63); Y19(0.72)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y159(0.66); Y19(0.67)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y19(0.87); Y159(0.90)  LDD0268  [8]
 LDCM0123  JWB131 DM93 Y15(0.67); Y19(0.81)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y15(0.60); Y19(0.63)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y15(0.96); Y19(1.09); Y236(2.99)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y15(3.00); Y19(2.91); Y236(16.45)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y15(1.55); Y19(1.74); Y236(9.72)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y15(0.58); Y19(1.06); Y236(4.42)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y15(0.44); Y19(0.55); Y236(0.75)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y15(0.83); Y19(0.89)  LDD0292  [7]
 LDCM0022  KB02 MDA-MB-231 C177(6.74)  LDD1374  [31]
 LDCM0023  KB03 MDA-MB-231 C177(1.62)  LDD1376  [31]
 LDCM0024  KB05 MKN45 C118(2.02)  LDD3332  [32]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C177(1.32)  LDD2102  [5]
 LDCM0109  NEM HeLa N.A.  LDD0225  [18]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C177(0.72)  LDD2089  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C177(1.56)  LDD2090  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C177(1.02)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C177(1.05)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C177(1.31)  LDD2094  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C177(1.04)  LDD2096  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C177(1.37)  LDD2097  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C177(0.91)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C177(1.16)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C177(0.99)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C177(0.84)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C177(0.87)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C177(0.87)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C177(0.92)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C177(0.86)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C177(0.85)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C177(0.93)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C177(0.87)  LDD2114  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C177(1.71)  LDD2116  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C177(1.66)  LDD2118  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C177(1.23)  LDD2119  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C177(2.74)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C177(0.81)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C177(2.01)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C177(0.78)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C177(1.96)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C177(0.94)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C177(1.23)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C177(0.65)  LDD2133  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C177(1.12)  LDD2135  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C177(0.76)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C177(1.09)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C177(0.63)  LDD2141  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C177(2.62)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C177(0.88)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C177(1.03)  LDD2148  [5]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C177(2.22)  LDD2149  [5]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C177(2.86)  LDD2151  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C177(2.29)  LDD2153  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C177(0.82)  LDD2206  [33]
 LDCM0628  OTUB2-COV-1 HEK-293T C177(0.80)  LDD2207  [33]
 LDCM0131  RA190 MM1.R C177(1.11)  LDD0304  [34]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [25]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase LATS1 (LATS1) AGC Ser/Thr protein kinase family O95835
Cyclin-dependent kinase 7 (CDK7) CMGC Ser/Thr protein kinase family P50613
Mitogen-activated protein kinase 15 (MAPK15) CMGC Ser/Thr protein kinase family Q8TD08
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Cyclin-dependent kinase inhibitor 3 (CDKN3) Protein-tyrosine phosphatase family Q16667
GTPase HRas (HRAS) Ras family P01112
E3 ubiquitin-protein ligase UHRF2 (UHRF2) . Q96PU4
Histone acetyltransferase p300 (EP300) . Q09472
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G2/mitotic-specific cyclin-B2 (CCNB2) Cyclin family O95067
G1/S-specific cyclin-D1 (CCND1) Cyclin family P24385
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin-like protein 1 (STOML1) Band 7/mec-2 family Q9UBI4
Cyclin-dependent kinase inhibitor 1 (CDKN1A) CDI family P38936
Cyclin-dependent kinase inhibitor 1B (CDKN1B) CDI family P46527
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) CKS family P61024
Cyclin-A2 (CCNA2) Cyclin family P20248
Cyclin-H (CCNH) Cyclin family P51946
G1/S-specific cyclin-E1 (CCNE1) Cyclin family P24864
G1/S-specific cyclin-E2 (CCNE2) Cyclin family O96020
Retinoblastoma-associated protein (RB1) Retinoblastoma protein (RB) family P06400
Sex comb on midleg-like protein 2 (SCML2) SCM family Q9UQR0
Gelsolin (GSN) Villin/gelsolin family P06396
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
S phase cyclin A-associated protein in the endoplasmic reticulum (SCAPER) . Q9BY12

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bosutinib Small molecular drug DB06616
Trilaciclib . DB15442
Phase 2
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pha848125 Small molecular drug D0Q9UX
R-roscovitine Small molecular drug D05ADP
Ro 31-7453 Small molecular drug D01UMT
Tg02 Small molecular drug D0P0KN
Phase 1
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ag-024322 Small molecular drug D0IX4B
At7519 Small molecular drug D07DTV
Azd-5438 Small molecular drug D06WHY
Fn-1501 Small molecular drug DKCU40
Pf-07104091 Small molecular drug D5TH2B
Pha-793887 Small molecular drug D0P1CV
Rgb-286638 Small molecular drug D03DKV
Sns-032 Small molecular drug D0S5RC
Cyc065 . D0PL7P
Preclinical
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
L-751250 Small molecular drug D0WS1V
Inoc-005 . D07ZJC
Investigative
Click To Hide/Show 207 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(2'z,3'e)-5-chloro-5'-chloro-indirubin-3'-oxime Small molecular drug D01PSU
(2'z,3'e)-5-chloro-5'-fluoro-indirubin-3'-oxime Small molecular drug D0B1LM
(2'z,3'e)-5-chloro-5'-hydroxy-indirubin-3'-oxime Small molecular drug D0JR0G
(2'z,3'e)-5-chloro-5'-methyl-indirubin-3'-oxime Small molecular drug D03KLM
(2'z,3'e)-5-fluoro-5'-chloro-indirubin-3'-oxime Small molecular drug D06XIW
(2'z,3'e)-5-fluoro-5'-fluoro-indirubin-3'-oxime Small molecular drug D06GLV
(2'z,3'e)-5-fluoro-5'-hydroxy-indirubin-3'-oxime Small molecular drug D0J3RS
(2'z,3'e)-5-fluoro-5'-methoxy-indirubin-3'-oxime Small molecular drug D04AGE
(2'z,3'e)-5-fluoro-5'-methyl-indirubin-3'-oxime Small molecular drug D0W2FM
(2'z,3'e)-5-nitro-5'-chloro-indirubin-3'-oxime Small molecular drug D0I6AE
(2'z,3'e)-5-nitro-5'-fluoro-indirubin-3'-oxime Small molecular drug D0L5PI
(2'z,3'e)-5-nitro-5'-hydroxy-indirubin-3'-oxime Small molecular drug D0YZ9Y
(2'z,3'e)-5-nitro-5'-methoxy-indirubin-3'-oxime Small molecular drug D0M4XD
(2'z,3'e)-5-nitro-5'-methyl-indirubin-3'-oxime Small molecular drug D0H0EN
1-amino-6-cyclohex-3-enylmethyloxypurine Small molecular drug D0I9VN
10z-hymenialdisine Small molecular drug D0F0AX
2-((3,5-diamino-1h-pyrazol-4-yl)Diazenyl)Phenol Small molecular drug D0F3OM
2-amino-6-chloropyrazine Small molecular drug D0W0PF
2-anilino-6-cyclohexylmethoxypurine Small molecular drug D0QI7H
3,4-di-(4-methoxyphenyl)-1h-pyrrole-2,5-dione Small molecular drug D00NYT
3,4-diphenyl-1h-pyrrole-2,5-dione Small molecular drug D0C3WY
3-((3,5-diamino-1h-pyrazol-4-yl)Diazenyl)Phenol Small molecular drug D0W0BL
3-(4-methoxyphenyl)-4-phenyl-1h-pyrrole-2,5-dione Small molecular drug D0EK0G
3-(Indole-3-yl)-4-phenyl-1h-pyrrole-2,5-dione Small molecular drug D06AOY
4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-ylamine Small molecular drug D0U0GE
4-(24-dimethyl-thiazol-5-yl)-pyrimidin-2-ylamine Small molecular drug DB02091
4-(4-methoxy-1h-pyrrolo[23-b]Pyridin-3-yl)Pyrimidin-2-amine Small molecular drug DB08178
4-(4-propoxy-1h-pyrrolo[23-b]Pyridin-3-yl)Pyrimidin-2-amine Small molecular drug DB08182
4-[(3,5-diamino-1h-pyrazol-4-yl)Diazenyl]Phenol Small molecular drug D0A5RM
4-[(6-chloropyrazin-2-yl)Amino]Benzenesulfonamide Small molecular drug D01LPG
4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline Small molecular drug D0KH5T
4-[3-hydroxyanilino]-67-dimethoxyquinazoline Small molecular drug DB03365
5-hydroxynaphthalene-1-sulfonamide Small molecular drug D07SGT
5-nitroindirubin-3'-oxime Small molecular drug D0GP3R
6-(3-amino-benzyloxy)-9h-purin-2-ylamine Small molecular drug D07JHG
6-(3-methyl-benzyloxy)-9h-purin-2-ylamine Small molecular drug D03XKK
6-(Cyclohex-3-enylmethoxy)-9h-purin-2-ylamine Small molecular drug D01FJB
6-cyclohexylmethoxy-2-(3'-chloroanilino) Purine Small molecular drug D06FIQ
6-cyclohexylmethoxy-pyrimidine-2,4,5-triamine Small molecular drug D02ZYA
6-cyclohexylmethyloxy-2-(4'-hydroxyanilino)Purine Small molecular drug D0Y6DX
6-cyclohexylmethyloxy-2-(4'-hydroxyanilino)Purine Small molecular drug DB08233
6-o-cyclohexylmethyl Guanine Small molecular drug D0R1FT
9-nitropaullone Small molecular drug D0H3EV
Aloisine Small molecular drug D00SEC
Aloisine A Small molecular drug D02XHC
Alvocidib Small molecular drug DB03496
Aminopurvalanol A Small molecular drug D0G2GA
At-7519 Small molecular drug DB08142
Benzyl-(9-isopropyl-9h-purin-6-yl)-amine Small molecular drug D0M5PI
Bms-265246 Small molecular drug D05SZH
Bms-536924 Small molecular drug D0M4SY
Bohemine Small molecular drug D07ADR
Bx-795 Small molecular drug D0RG0Z
Bx-912 Small molecular drug D0IX7Y
Can-508 Small molecular drug DB07731
Cdk1/2 Inhibitor Iii Small molecular drug D07OCA
Cdk4 Inhibitor Iii Small molecular drug D07HPE
Cvt-313 Small molecular drug D0P2WA
Double Oxidized Cysteine Small molecular drug D0H1GU
Gw-8510 Small molecular drug D04RBG
Indirubin-3'-monoxime Small molecular drug D0Y0ES
Indirubin-5-sulfonate Small molecular drug D0G2CT
Jnj-7706621 Small molecular drug D04NGS
K00024 Small molecular drug D0D5HQ
Lysine Nz-carboxylic Acid Small molecular drug D0CC0B
Meriolin 1 Small molecular drug D08KSQ
Meriolin 2 Small molecular drug D0U1WL
Meriolin 3 Small molecular drug D0S8VE
Meriolin 4 Small molecular drug D0B9YR
Meriolin 5 Small molecular drug D0H6CQ
Meriolin 6 Small molecular drug D0D0ZQ
Meriolin 8 Small molecular drug D01PEF
N(6)-dimethylallyladenine Small molecular drug DB08768
N-(3-methylbut-2-en-1-yl)-9h-purin-6-amine Small molecular drug D0I1SZ
N-(4-amino-5-cyano-6-phenylpyridin-2-yl)Acetamide Small molecular drug D0S7IE
N-(4-sulfamoylphenyl)-1h-indazole-3-carboxamide Small molecular drug D0D3HB
N-(5-cyclopropyl-1h-pyrazol-3-yl)Benzamide Small molecular drug D0MK6D
N-phenyl-1h-pyrazole-3-carboxamide Small molecular drug D07ODE
Nsc-625987 Small molecular drug D0VD8B
Nu-6102 Small molecular drug D0Y5RO
Nu6140 Small molecular drug D04WFN
O6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) Purine Small molecular drug DB07126
Pf-228 Small molecular drug D02QAZ
Pha-690509 Small molecular drug D0T5AH
Phenylaminoimidazo(1,2-alpha)Pyridine Small molecular drug D03BZV
Phenylaminoimidazo(12-alpha)Pyridine Small molecular drug DB04607
Pmid18986805c9b Small molecular drug D0P6JS
Pmid19115845c89s Small molecular drug D0T8NU
Purvalanol Small molecular drug DB02733
Purvalanol A Small molecular drug D07OAT
Pyrazolopyridazine 1 Small molecular drug D02DLC
Pyrazolopyridazine 2 Small molecular drug D0O0VP
Rescovitine Small molecular drug D07AEC
Ro-4584820 Small molecular drug DB08094
Sch-546909 Small molecular drug D0T4SJ
Seliciclib Small molecular drug DB06195
Staurosporine Small molecular drug DB02010
Su9516 Small molecular drug D0L3FK
Triazolopyrimidine Small molecular drug D0P7RO
(13r15s)-13-methyl-16-oxa-89122224-pentaazahexacyclo[15.6.2.169.11215.027.02125]Heptacosa-1(24)24617(25)1820-heptaene-2326-dione . DB06888
(2e3s)-3-hydroxy-5'-[(4-hydroxypiperidin-1-yl)Sulfonyl]-3-methyl-13-dihydro-23'-biindol-2'(1'h)-one . DB03583
(2r)-1-(Dimethylamino)-3-{4-[(6-{[2-fluoro-5-(Trifluoromethyl)Phenyl]Amino}Pyrimidin-4-yl)Amino]Phenoxy}Propan-2-ol . DB07054
(2r)-1-[4-({4-[(25-dichlorophenyl)Amino]-2-pyrimidinyl}Amino)Phenoxy]-3-(Dimethylamino)-2-propanol . DB07750
(2r)-1-[4-({6-[(26-difluorophenyl)Amino]-4-pyrimidinyl}Amino)Phenoxy]-3-(Dimethylamino)-2-propanol . DB07761
(2r)-1-{4-[(4-anilino-5-bromo-2-pyrimidinyl)Amino]Phenoxy}-3-(Dimethylamino)-2-propanol . DB07504
(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)Amino]-9h-purin-2-yl}Amino)Butan-1-ol . DB08463
(2r)-2-{[4-(Benzylamino)-8-(1-methylethyl)Pyrazolo[15-a][135]Triazin-2-yl]Amino}Butan-1-ol . DB08285
(2s)-1-(Dimethylamino)-3-(4-{[4-(2-methylimidazo[12-a]Pyridin-3-yl)-2-pyrimidinyl]Amino}Phenoxy)-2-propanol . DB07889
(2s)-1-[4-({4-[(25-dichlorophenyl)Amino]-2-pyrimidinyl}Amino)Phenoxy]-3-(Dimethylamino)-2-propanol . DB07755
(2s)-1-[4-({6-[(26-difluorophenyl)Amino]-4-pyrimidinyl}Amino)Phenoxy]-3-(Dimethylamino)-2-propanol . DB07751
(2s)-1-{4-[(4-anilino-5-bromo-2-pyrimidinyl)Amino]Phenoxy}-3-(Dimethylamino)-2-propanol . DB07501
(2s)-n-[(3e)-5-cyclopropyl-3h-pyrazol-3-ylidene]-2-[4-(2-oxo-1-imidazolidinyl)Phenyl]Propanamide . DB07137
(3r)-3-(Aminomethyl)-9-methoxy-1234-tetrahydro-5h-[1]Benzothieno[32-e][14]Diazepin-5-one . DB07431
(4e)-n-(4-fluorophenyl)-4-[(Phenylcarbonyl)Imino]-4h-pyrazole-3-carboxamide . DB08137
(5-chloropyrazolo[15-a]Pyrimidin-7-yl)-(4-methanesulfonylphenyl)Amine . DB02963
(5-phenyl-7-(Pyridin-3-ylmethylamino)Pyrazolo[15-a]Pyrimidin-3-yl)Methanol . DB06983
(5e)-2-amino-5-(2-pyridinylmethylene)-13-thiazol-4(5h)-one . DB07529
(5r)-5-{[(2-amino-3h-purin-6-yl)Oxy]Methyl}-2-pyrrolidinone . DB02898
(5z)-5-(3-bromocyclohexa-25-dien-1-ylidene)-n-(Pyridin-4-ylmethyl)-15-dihydropyrazolo[15-a]Pyrimidin-7-amine . DB07595
1-(3-(24-dimethylthiazol-5-yl)-4-oxo-24-dihydroindeno[12-c]Pyrazol-5-yl)-3-(4-methylpiperazin-1-yl)Urea . DB07622
1-(35-dichlorophenyl)-5-methyl-1h-124-triazole-3-carboxylic Acid . DB07852
1-(5-oxo-2359b-tetrahydro-1h-pyrrolo[21-a]Isoindol-9-yl)-3-(5-pyrrolidin-2-yl-1h-pyrazol-3-yl)-urea . DB06976
1-methyl-8-(Phenylamino)-45-dihydro-1h-pyrazolo[43-h]Quinazoline-3-carboxylic Acid . DB08355
1-[(2-amino-69-dihydro-1h-purin-6-yl)Oxy]-3-methyl-2-butanol . DB03663
1-[4-(Aminosulfonyl)Phenyl]-16-dihydropyrazolo[34-e]Indazole-3-carboxamide . DB08527
2-(34-dihydroxyphenyl)-8-(11-dioxidoisothiazolidin-2-yl)-3-hydroxy-6-methyl-4h-chromen-4-one . DB07024
2-(4-(Aminomethyl)Piperidin-1-yl)-n-(3_cyclohexyl-4-oxo-24-dihydroindeno[12-c]Pyrazol-5-yl)Acetamide . DB07618
2-[Trans-(4-aminocyclohexyl)Amino]-6-(Benzyl-amino)-9-cyclopentylpurine . DB04288
2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1h-imidazol-5-yl]Pyrimidin-2-yl}Amino)Phenyl]Piperazin-1-yl}-2-oxoethanol . DB07982
3-((3-bromo-5-o-tolylpyrazolo[15-a]Pyrimidin-7-ylamino)Methyl)Pyridine 1-oxide . DB07179
3-(6-cyclohexylmethoxy-9h-purin-2-ylamino)-benzenesulfonamide . DB08248
3-({2-[(4-{[6-(Cyclohexylmethoxy)-9h-purin-2-yl]Amino}Phenyl)Sulfonyl]Ethyl}Amino)Propan-1-ol . DB08309
3-bromo-5-phenyl-n-(Pyridin-3-ylmethyl)Pyrazolo[15-a]Pyrimidin-7-amine . DB08535
3-bromo-5-phenyl-n-(Pyridin-4-ylmethyl)Pyrazolo[15-a]Pyrimidin-7-amine . DB07210
3-bromo-5-phenyl-n-(Pyrimidin-5-ylmethyl)Pyrazolo[15-a]Pyridin-7-amine . DB08536
3-bromo-6-phenyl-n-(Pyrimidin-5-ylmethyl)Imidazo[12-a]Pyridin-8-amine . DB08537
3-cyclopropyl-5-phenyl-n-(Pyridin-3-ylmethyl)Pyrazolo[15-a]Pyrimidin-7-amine . DB08539
3-methyl-n-(Pyridin-4-ylmethyl)Imidazo[12-a]Pyrazin-8-amine . DB08533
3-pyridin-4-yl-24-dihydro-indeno[12-.C.]Pyrazole . DB03490
3-[4-(24-dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol . DB04518
3-{[(22-dioxido-13-dihydro-2-benzothien-5-yl)Amino]Methylene}-5-(13-oxazol-5-yl)-13-dihydro-2h-indol-2-one . DB08124
3-{[4-([Amino(Imino)Methyl]Aminosulfonyl)Anilino]Methylene}-2-oxo-23-dihydro-1h-indole . DB08126
4-((3r4s5r)-4-amino-35-dihydroxy-hex-1-ynyl)-5-fluoro-3-[1-(3-methoxy-1h-pyrrol-2-yl)-meth-(Z)-ylidene]-13-dihydro-indol-2-one . DB03737
4-(24-dimethyl-13-thiazol-5-yl)-n-[4-(Trifluoromethyl)Phenyl]-2-pyrimidinamine . DB02915
4-(25-dichloro-thiophen-3-yl)-pyrimidin-2-ylamine . DB03019
4-(5-bromo-2-oxo-2h-indol-3-ylazo)-benzenesulfonamide . DB02973
4-(6-cyclohexylmethoxy-9h-purin-2-ylamino)--benzamide . DB08241
4-(Acetylamino)-n-(4-fluorophenyl)-1h-pyrazole-3-carboxamide . DB08136
4-({5-[(4-aminocyclohexyl)Amino][124]Triazolo[15-a]Pyrimidin-7-yl}Amino)Benzenesulfonamide . DB07687
4-methyl-5-[(2z)-2-{[4-(4-morpholinyl)Phenyl]Imino}-25-dihydro-4-pyrimidinyl]-13-thiazol-2-amine . DB08219
4-[(4-imidazo[12-a]Pyridin-3-ylpyrimidin-2-yl)Amino]Benzenesulfonamide . DB02197
4-[(5-isopropyl-13-thiazol-2-yl)Amino]Benzenesulfonamide . DB08673
4-[(6-amino-4-pyrimidinyl)Amino]Benzenesulfonamide . DB03307
4-[(7-oxo-7h-thiazolo[54-e]Indol-8-ylmethyl)-amino]-n-pyridin-2-yl-benzenesulfonamide . DB06844
4-[4-(4-methyl-2-methylamino-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol . DB04407
4-[5-(Trans-4-aminocyclohexylamino)-3-isopropylpyrazolo[15-a]Pyrimidin-7-ylamino]-nn-dimethylbenzenesulfonamide . DB01888
4-{5-[(1z)-1-(2-imino-4-oxo-13-thiazolidin-5-ylidene)Ethyl]-2-furyl}Benzenesulfonamide . DB07540
4-{5-[(Z)-(2-imino-4-oxo-13-thiazolidin-5-ylidene)Methyl]-2-furyl}-n-methylbenzenesulfonamide . DB07533
4-{5-[(Z)-(2-imino-4-oxo-13-thiazolidin-5-ylidene)Methyl]Furan-2-yl}-2-(Trifluoromethyl)Benzenesulfonamide . DB07538
4-{5-[(Z)-(2-imino-4-oxo-13-thiazolidin-5-ylidene)Methyl]Furan-2-yl}Benzenesulfonamide . DB07534
4-{5-[(Z)-(2-imino-4-oxo-13-thiazolidin-5-ylidene)Methyl]Furan-2-yl}Benzoic Acid . DB07539
4-{5-[(Z)-(24-dioxo-13-thiazolidin-5-ylidene)Methyl]Furan-2-yl}Benzenesulfonamide . DB07531
4-{[(2-oxo-12-dihydro-3h-indol-3-ylidene)Methyl]Amino}-n-(13-thiazol-2-yl)Benzenesulfonamide . DB08125
4-{[(26-difluorophenyl)Carbonyl]Amino}-n-[(3s)-piperidin-3-yl]-1h-pyrazole-3-carboxamide . DB08141
4-{[4-(1-cyclopropyl-2-methyl-1h-imidazol-5-yl)Pyrimidin-2-yl]Amino}-n-methylbenzenesulfonamide . DB07791
4-{[4-amino-6-(Cyclohexylmethoxy)-5-nitrosopyrimidin-2-yl]Amino}Benzamide . DB08572
4-{[5-(Cyclohexylamino)[124]Triazolo[15-a]Pyrimidin-7-yl]Amino}Benzenesulfonamide . DB07686
4-{[5-(Cyclohexylmethoxy)[124]Triazolo[15-a]Pyrimidin-7-yl]Amino}Benzenesulfonamide . DB07685
4-{[5-(Cyclohexyloxy)[124]Triazolo[15-a]Pyrimidin-7-yl]Amino}Benzenesulfonamide . DB07688
5-(2-fluorophenyl)-n-(Pyridin-4-ylmethyl)Pyrazolo[15-a]Pyrimidin-7-amine . DB08534
5-(23-dichlorophenyl)-n-(Pyridin-4-ylmethyl)-3-thiocyanatopyrazolo[15-a]Pyrimidin-7-amine . DB07065
5-(23-dichlorophenyl)-n-(Pyridin-4-ylmethyl)Pyrazolo[15-a]Pyrimidin-7-amine . DB08531
5-bromoindirubin . DB07493
5-chloro-7-[(1-methylethyl)Amino]Pyrazolo[15-a]Pyrimidine-3-carbonitrile . DB08139
5-[(2-aminoethyl)Amino]-6-fluoro-3-(1h-pyrrol-2-yl)Benzo[Cd]Indol-2(1h)-one . DB07163
5-[(4-aminocyclohexyl)Amino]-7-(Propan-2-ylamino)Pyrazolo[15-a]Pyrimidine-3-carbonitrile . DB08140
5-[56-bis(Methyloxy)-1h-benzimidazol-1-yl]-3-{[1-(2-chlorophenyl)Ethyl]Oxy}-2-thiophenecarboxamide . DB07471
6-(2-fluorophenyl)-n-(Pyridin-3-ylmethyl)Imidazo[12-a]Pyrazin-8-amine . DB08532
6-(3-aminophenyl)-n-(Tert-butyl)-2-(Trifluoromethyl)Quinazolin-4-amine . DB07612
6-(34-dihydroxybenzyl)-3-ethyl-1-(246-trichlorophenyl)-1h-pyrazolo[34-d]Pyrimidin-4(5h)-one . DB07606
6-(Cyclohexylmethoxy)-8-isopropyl-9h-purin-2-amine . DB08247
6-bromo-13-thia-2481219-pentaazatricyclo[12.3.1.1~37~]Nonadeca-1(18)3(19)461416-hexaene 1313-dioxide . DB08441
6-cyclohexylmethyloxy-5-nitroso-pyrimidine-24-diamine . DB08312
Hydroxy(Oxo)(3-{[(2z)-4-[3-(1h-124-triazol-1-ylmethyl)Phenyl]Pyrimidin-2(5h)-ylidene]Amino}Phenyl)Ammonium . DB08218
Hymenialdisine . DB02950
N'-(Pyrrolidino[21-b]Isoindolin-4-on-8-yl)-n-(Pyridin-2-yl)Urea . DB04186
N'-[4-(24-dimethyl-13-thiazol-5-yl)-2-pyrimidinyl]-n-hydroxyimidoformamide . DB04101
N-((2-aminopyrimidin-5-yl)Methyl)-5-(26-difluorophenyl)-3-ethylpyrazolo[15-a]Pyrimidin-7-amine . DB08538
N-(2-methoxyethyl)-4-({4-[2-methyl-1-(1-methylethyl)-1h-imidazol-5-yl]Pyrimidin-2-yl}Amino)Benzenesulfonamide . DB07790
N-(3-cyclopropyl-1h-pyrazol-5-yl)-2-(2-naphthyl)Acetamide . DB06944
N-(4-{[(3s)-3-(Dimethylamino)Pyrrolidin-1-yl]Carbonyl}Phenyl)-5-fluoro-4-[2-methyl-1-(1-methylethyl)-1h-imidazol-5-yl]Pyrimidin-2-amine . DB07936
N-(5-isopropyl-thiazol-2-yl)-2-pyridin-3-yl-acetamide . DB08677
N-cyclopropyl-4-pyrazolo[15-b]Pyridazin-3-ylpyrimidin-2-amine . DB07164
N-methyl-4-{[(2-oxo-12-dihydro-3h-indol-3-ylidene)Methyl]Amino}Benzenesulfonamide . DB08122
N-methyl-{4-[2-(7-oxo-67-dihydro-8h-[13]Thiazolo[54-e]Indol-8-ylidene)Hydrazino]Phenyl}Methanesulfonamide . DB08123
N-[3-(1h-benzimidazol-2-yl)-1h-pyrazol-4-yl]Benzamide . DB08066
N-[4-(2-methylimidazo[12-a]Pyridin-3-yl)-2-pyrimidinyl]Acetamide . DB02538
N-[4-(24-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-n'n'-dimethyl-benzene-14-diamine . DB07562
N-[5-(11-dioxidoisothiazolidin-2-yl)-1h-indazol-3-yl]-2-(4-piperidin-1-ylphenyl)Acetamide . DB07220
Nu-6027 . D0U8YN
Olomoucine Ii . DB04662
Oxindole 95 . D0MS4R
Variolin B . DB08694
Ver-54505 . D0V1NK
[2-amino-6-(26-difluoro-benzoyl)-imidazo[12-a]Pyridin-3-yl]-phenyl-methanone . DB04006
[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amine . DB02833
{[(26-difluorophenyl)Carbonyl]Amino}-n-(4-fluorophenyl)-1h-pyrazole-3-carboxamide . DB08138
Patented
Click To Hide/Show 28 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1,5-di-substituted Pyridine Derivative 1 Small molecular drug D0UU0V
4-(Thiazol-5-yl)-pyrimidine Derivative 1 Small molecular drug D07QIP
4-(Thiazol-5-yl)-pyrimidine Derivative 2 Small molecular drug D01CJE
4-amino-3,5-di-substituted-thiazole Derivative 1 Small molecular drug D0JU4Z
5-fluoro-n-(Pyridin-2-yl)Pyridin-2-amine Derivative 1 Small molecular drug D0V7RP
Alkyl Sulfone Derivative 1 Small molecular drug D05UJQ
Aniline Derivative 1 Small molecular drug D06QPW
Diamidothiazole Derivative 1 Small molecular drug D0LR2Y
Diaryl Amine Derivative 1 Small molecular drug D0P4NP
Flavopiridol Analog 1 Small molecular drug D0P9WR
Fluorinated Compound 1 Small molecular drug D09ISI
Indole-based Analog 11 Small molecular drug D02KWX
Indole-based Analog 13 Small molecular drug D0LX6X
Isosteric Imidazolyl Pyrimidine Derivative 1 Small molecular drug D0QR1Z
N-(Pyridin-2-yl)Pyridine Methylsulfone Derivative 1 Small molecular drug D03EYT
N-(Pyridin-2-yl)Pyrimidin-4-amine Derivative 2 Small molecular drug D0QS2B
N-phenyl-pyrimidin-4-amine Derivative 1 Small molecular drug D0AY5G
Naphthyridine And Isoquinoline Derivative 1 Small molecular drug D08WJG
Nitrogen Mustard Derivative 1 Small molecular drug D0LK4L
Oxazolyl Methylthiothiazole Derivative 1 Small molecular drug D0M5DX
Palbociclib/Ribociclib Analog 1 Small molecular drug D03HED
Pmid25991433-compound-a1 Small molecular drug D0H4HD
Pmid26161698-compound-25 Small molecular drug D0GQ7L
Pyrazolo-triazine Derivative 2 Small molecular drug D0T6CM
Pyrazolo[1,5-a]-1,3,5-triazine Derivative 1 Small molecular drug D0NB7Y
Pyrrolo[2,3-d]Pyrimidine Derivative 9 Small molecular drug D08KKC
Roscovitine Derivative 1 Small molecular drug D07DUX
Isoquinoline 1,3-dione Derivative 1 . D0W4MN
Discontinued
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bay 10-00394 Small molecular drug D0NV9O
Olomoucine Small molecular drug D00BPA
Pd-0183812 Small molecular drug D0Z0KD
R547 Small molecular drug D04FHB
Sch 727965 Small molecular drug D0D3PX
Zk 304709 Small molecular drug D00VBT

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
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