Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0600
Competitor Name
Fragment42
Synonyms
301691-16-7; (E)-3-(5-(2-chlorophenyl)furan-2-yl)-2-cyanoacrylamide; (E)-3-[5-(2-chlorophenyl)furan-2-yl]-2-cyanoprop-2-enamide; (2E)-3-[5-(2-CHLOROPHENYL)FURAN-2-YL]-2-CYANOPROP-2-ENAMIDE; SCHEMBL22196893; AKOS000522338; F0350-0110; 3-(5-(2-CHLOROPHENYL)-2-FURYL)-2-CYANOACRYLAMIDE
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 272.68
Lipid-water partition coefficient (xlogp) 2.5
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C14H9ClN2O2
IUPAC Name
(E)-3-[5-(2-chlorophenyl)furan-2-yl]-2-cyanoprop-2-enamide
Canonical SMILES
C1=CC=C(C(=C1)C2=CC=C(O2)C=C(C#N)C(=O)N)Cl
InChI
InChI=1S/C14H9ClN2O2/c15-12-4-2-1-3-11(12)13-6-5-10(19-13)7-9(8-16)14(17)18/h1-7H,(H2,17,18)/b9-7+
InChIKey
UTNXVTBOJXHUAL-VQHVLOKHSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

ABPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
IA-alkyne
 Probe Info  		100 uM Human burkitt lymphoma cell lysate (Ramos) [1]

Target(s) List of this Competitor

72 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
26S proteasome regulatory subunit 10B (PSMC6) LDTP04987 0.37  LDD1440 
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) LDTP10954 0.81  LDD1440 
3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) LDTP03998 0.84  LDD1440 
5'-nucleotidase domain-containing protein 1 (NT5DC1) LDTP17247 0.90  LDD1440 
6-phosphogluconolactonase (PGLS) LDTP14535 0.90  LDD1440 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 0.89  LDD1440 
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) LDTP03291 0.81; 0.84; 0.70 ...  LDD1440 
Adenosine kinase (ADK) LDTP04689 1.10  LDD1440 
Aldo-keto reductase family 1 member B1 (AKR1B1) LDTP02765 1.05  LDD1440 
AMP deaminase 2 (AMPD2) LDTP05289 0.82  LDD1440 
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) LDTP03159 0.80  LDD1440 
Bleomycin hydrolase (BLMH) LDTP05992 1.25  LDD1440 
Cell cycle checkpoint control protein RAD9A (RAD9A) LDTP10929 0.99  LDD1440 
Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) LDTP13449 0.96  LDD1440 
Cyclin-dependent kinase 19 (CDK19) LDTP11340 0.97  LDD1440 
Cyclin-dependent kinase 2 (CDK2) LDTP03299 0.87  LDD1440 
Cyclin-dependent kinase inhibitor 3 (CDKN3) LDTP06603 0.97  LDD1440 
D-3-phosphoglycerate dehydrogenase (PHGDH) LDTP00701 0.90  LDD1440 
Deoxycytidine kinase (DCK) LDTP03400 1.02; 0.90  LDD1440 
DNA repair protein RAD50 (RAD50) LDTP09912 1.49  LDD1440 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 0.87  LDD1440 
Dynamin-1-like protein (DNM1L) LDTP00273 0.89  LDD1440 
Dynamin-2 (DNM2) LDTP04374 0.97  LDD1440 
E3 ubiquitin-protein ligase UBR5 (UBR5) LDTP01495 0.81  LDD1440 
Elongation factor 2 (EEF2) LDTP02672 1.01; 0.86  LDD1440 
Elongation factor G, mitochondrial (GFM1) LDTP10774 0.52  LDD1440 
ERO1-like protein alpha (ERO1A) LDTP10386 1.02; 0.79  LDD1440 
Eukaryotic translation initiation factor 3 subunit F (EIF3F) LDTP00246 0.82  LDD1440 
Glutaredoxin-1 (GLRX) LDTP03786 0.88  LDD1440 
Glutaredoxin-related protein 5, mitochondrial (GLRX5) LDTP08181 0.84  LDD1440 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 1.01  LDD1440 
Glutathione S-transferase P (GSTP1) LDTP02333 0.74  LDD1440 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 0.91  LDD1440 
Glycerol-3-phosphate phosphatase (PGP) LDTP00089 0.82  LDD1440 
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) LDTP02611 0.89  LDD1440 
Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) LDTP17082 0.86  LDD1440 
Ketosamine-3-kinase (FN3KRP) LDTP16025 0.81  LDD1440 
Lysine-specific demethylase 4B (KDM4B) LDTP01470 0.85  LDD1440 
Lysine-specific demethylase RSBN1L (RSBN1L) LDTP17384 0.81  LDD1440 
Mannose-1-phosphate guanyltransferase alpha (GMPPA) LDTP10418 0.94  LDD1440 
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) LDTP10177 1.00  LDD1440 
Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) LDTP09598 0.97  LDD1440 
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) LDTP07651 0.78  LDD1440 
N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) LDTP11388 0.89  LDD1440 
NEDD8-activating enzyme E1 catalytic subunit (UBA3) LDTP09338 0.84  LDD1440 
NmrA-like family domain-containing protein 1 (NMRAL1) LDTP12190 0.78  LDD1440 
Omega-amidase NIT2 (NIT2) LDTP12428 0.77  LDD1440 
Parkinson disease protein 7 (PARK7) LDTP10878 0.98  LDD1440 
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) LDTP05912 0.87  LDD1440 
Peroxiredoxin-5, mitochondrial (PRDX5) LDTP03512 0.80; 0.90  LDD1440 
Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) LDTP01633 0.89  LDD1440 
Probable ATP-dependent RNA helicase DDX59 (DDX59) LDTP07098 0.98  LDD1440 
Prostaglandin E synthase 3 (PTGES3) LDTP06338 1.05  LDD1440 
Protein arginine N-methyltransferase 1 (PRMT1) LDTP10997 0.89  LDD1440 
Protein disulfide-isomerase (P4HB) LDTP02188 0.73  LDD1440 
Protein disulfide-isomerase A3 (PDIA3) LDTP03521 0.89  LDD1440 
Protein disulfide-isomerase A4 (PDIA4) LDTP02677 0.92; 0.89  LDD1440 
Protein disulfide-isomerase A6 (PDIA6) LDTP06314 0.90  LDD1440 
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) LDTP03152 0.85  LDD1440 
Pyruvate kinase PKM (PKM) LDTP02733 20.00  LDD1440 
Serine--tRNA ligase, cytoplasmic (SARS1) LDTP04265 0.88  LDD1440 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 0.96  LDD1440 
Thioredoxin (TXN) LDTP02502 1.35  LDD1440 
Thioredoxin domain-containing protein 5 (TXNDC5) LDTP09067 0.87; 0.86  LDD1440 
Thymidine kinase, cytosolic (TK1) LDTP02022 0.94; 1.25  LDD1440 
Transmembrane protease serine 12 (TMPRSS12) LDTP15306 0.98  LDD1440 
Tubulin alpha-1A chain (TUBA1A) LDTP07907 1.14; 0.94; 0.94  LDD1440 
Tubulin alpha-4A chain (TUBA4A) LDTP05075 1.13; 0.93; 0.90  LDD1440 
Tudor-interacting repair regulator protein (NUDT16L1) LDTP11111 0.87  LDD1440 
Ubiquitin carboxyl-terminal hydrolase 16 (USP16) LDTP14159 1.46  LDD1440 
Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) LDTP05070 0.83  LDD1440 
Ubiquitin-conjugating enzyme E2 S (UBE2S) LDTP06621 0.82  LDD1440 
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⏷ Show the Full List of 72 Enzyme
12 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
ATP synthase subunit alpha, mitochondrial (ATP5F1A) LDTP03327 1.04  LDD1440 
Chloride intracellular channel protein 4 (CLIC4) LDTP14222 0.81  LDD1440 
Exportin-1 (XPO1) LDTP00501 0.89  LDD1440 
Gasdermin-D (GSDMD) LDTP04801 0.84  LDD1440 
Nuclear pore complex protein Nup93 (NUP93) LDTP08769 0.57  LDD1440 
Pinin (PNN) LDTP11855 1.18  LDD1440 
Protein SEC13 homolog (SEC13) LDTP04707 0.85  LDD1440 
Signal recognition particle 9 kDa protein (SRP9) LDTP04259 0.99  LDD1440 
Small ribosomal subunit protein RACK1 (RACK1) LDTP05057 0.84  LDD1440 
Sorting nexin-6 (SNX6) LDTP13661 0.76  LDD1440 
Thioredoxin domain-containing protein 17 (TXNDC17) LDTP11103 1.02  LDD1440 
THO complex subunit 6 homolog (THOC6) LDTP08315 0.88  LDD1440 
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⏷ Show the Full List of 12 Transporter and channel
7 Transcription factor Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
CDKN2A-interacting protein (CDKN2AIP) LDTP12792 1.28  LDD1440 
Chromatin accessibility complex protein 1 (CHRAC1) LDTP12507 1.00  LDD1440 
eIF5-mimic protein 2 (BZW1) LDTP07940 0.82  LDD1440 
Non-POU domain-containing octamer-binding protein (NONO) LDTP06341 0.94  LDD1440 
Signal transducer and activator of transcription 1-alpha/beta (STAT1) LDTP03969 0.90  LDD1440 
SWI/SNF complex subunit SMARCC2 (SMARCC2) LDTP09311 0.96  LDD1440 
Zinc finger protein 217 (ZNF217) LDTP01191 0.98  LDD1440 
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⏷ Show the Full List of 7 Transcription factor
61 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Actin-related protein 2/3 complex subunit 3 (ARPC3) LDTP00552 0.72  LDD1440 
Actin-related protein 3 (ACTR3) LDTP04902 0.79  LDD1440 
AH receptor-interacting protein (AIP) LDTP00202 0.80  LDD1440 
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) LDTP05770 0.90; 0.85  LDD1440 
Ataxin-7-like protein 3B (ATXN7L3B) LDTP15730 0.83  LDD1440 
Calponin-2 (CNN2) LDTP10864 1.04; 1.03  LDD1440 
Cleavage stimulation factor subunit 2 (CSTF2) LDTP03665 0.79  LDD1440 
Condensin complex subunit 1 (NCAPD2) LDTP06281 0.93  LDD1440 
Condensin complex subunit 2 (NCAPH) LDTP06268 0.99  LDD1440 
Crk-like protein (CRKL) LDTP04092 0.84  LDD1440 
Cyclin-H (CCNH) LDTP04487 0.68  LDD1440 
Cytosolic iron-sulfur assembly component 2B (CIAO2B) LDTP13979 0.89  LDD1440 
Disks large-associated protein 5 (DLGAP5) LDTP06378 0.97  LDD1440 
Dynactin subunit 1 (DCTN1) LDTP06082 0.82  LDD1440 
EF-hand domain-containing protein D2 (EFHD2) LDTP15701 1.14  LDD1440 
Enhancer of mRNA-decapping protein 3 (EDC3) LDTP10299 0.93  LDD1440 
Eukaryotic translation initiation factor 3 subunit M (EIF3M) LDTP07947 0.98  LDD1440 
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) LDTP00756 0.91  LDD1440 
Integrator complex subunit 13 (INTS13) LDTP12685 0.88  LDD1440 
KH domain-containing RNA-binding protein QKI (QKI) LDTP10700 0.97  LDD1440 
Kinetochore protein NDC80 homolog (NDC80) LDTP00431 0.83  LDD1440 
Lamina-associated polypeptide 2, isoform alpha (TMPO) LDTP03967 1.43  LDD1440 
Large ribosomal subunit protein eL24 (RPL24) LDTP05186 1.14; 0.98  LDD1440 
Large ribosomal subunit protein eL30 (RPL30) LDTP05021 0.92  LDD1440 
Large ribosomal subunit protein uL14 (RPL23) LDTP05008 1.20  LDD1440 
Large ribosomal subunit protein uL16 (RPL10) LDTP03395 1.04  LDD1440 
Large ribosomal subunit protein uL3 (RPL3) LDTP03865 1.10  LDD1440 
Large ribosomal subunit protein uL4 (RPL4) LDTP03815 1.10  LDD1440 
Mediator of RNA polymerase II transcription subunit 15 (MED15) LDTP10771 0.87  LDD1440 
Mediator of RNA polymerase II transcription subunit 17 (MED17) LDTP12669 0.80  LDD1440 
MMS19 nucleotide excision repair protein homolog (MMS19) LDTP10843 0.68  LDD1440 
Nuclear migration protein nudC (NUDC) LDTP13817 0.84  LDD1440 
NudC domain-containing protein 1 (NUDCD1) LDTP10781 0.95  LDD1440 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 0.76; 1.18  LDD1440 
Programmed cell death 6-interacting protein (PDCD6IP) LDTP09580 1.01  LDD1440 
Proteasome activator complex subunit 1 (PSME1) LDTP05484 0.88  LDD1440 
Proteasome activator complex subunit 4 (PSME4) LDTP06250 1.00  LDD1440 
Protein misato homolog 1 (MSTO1) LDTP11239 0.85  LDD1440 
RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) LDTP14351 0.68  LDD1440 
Reticulon-4 (RTN4) LDTP12412 0.98  LDD1440 
Ribosomal protein eL42-like (RPL36AL) LDTP15677 1.18  LDD1440 
Sister chromatid cohesion protein PDS5 homolog A (PDS5A) LDTP06684 0.88  LDD1440 
Small ribosomal subunit protein eS27 (RPS27) LDTP03987 1.14  LDD1440 
Small ribosomal subunit protein eS4, X isoform (RPS4X) LDTP04997 1.10  LDD1440 
Small ribosomal subunit protein uS12 (RPS23) LDTP04971 1.18  LDD1440 
Small ribosomal subunit protein uS17 (RPS11) LDTP04975 1.28; 1.25  LDD1440 
Small ribosomal subunit protein uS7 (RPS5) LDTP04110 1.29  LDD1440 
SNW domain-containing protein 1 (SNW1) LDTP05930 0.96  LDD1440 
Stalled ribosome sensor GCN1 (GCN1) LDTP09821 1.27  LDD1440 
Structural maintenance of chromosomes protein 2 (SMC2) LDTP01567 0.79  LDD1440 
T-complex protein 1 subunit alpha (TCP1) LDTP02934 1.08  LDD1440 
T-complex protein 1 subunit epsilon (CCT5) LDTP04201 0.88  LDD1440 
T-complex protein 1 subunit eta (CCT7) LDTP10990 1.08  LDD1440 
T-complex protein 1 subunit theta (CCT8) LDTP04390 0.82  LDD1440 
THUMP domain-containing protein 1 (THUMPD1) LDTP12780 0.92  LDD1440 
Trafficking protein particle complex subunit 4 (TRAPPC4) LDTP13837 0.91  LDD1440 
Transcription initiation factor IIA subunit 2 (GTF2A2) LDTP04517 0.86  LDD1440 
Tropomodulin-3 (TMOD3) LDTP18494 1.11  LDD1440 
Tubulin beta chain (TUBB) LDTP02205 0.98; 1.00  LDD1440 
WW domain-containing adapter protein with coiled-coil (WAC) LDTP11191 0.88  LDD1440 
ZW10 interactor (ZWINT) LDTP01532 1.06  LDD1440 
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⏷ Show the Full List of 61 Other

Full Information of The Labelling Profiles of This Competitor

IA-alkyne
 Probe Info 
Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 100 uM
Quantitative Method Isotope tag
Competitor Name Fragment42
Competitor Concentration 500 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)
Interaction Atlas ID  LDD1440  Download The Altas

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.