Details of the Target

General Information of Target

Target ID LDTP03152
Target Name Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)
Gene Name PCMT1
Gene ID 5110
Synonyms
Protein-L-isoaspartate(D-aspartate) O-methyltransferase; PIMT; EC 2.1.1.77; L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATIS
APHMHAYALELLFDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSV
NNVRKDDPTLLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLI
LPVGPAGGNQMLEQYDKLQDGSIKMKPLMGVIYVPLTDKEKQWSRWK
Target Bioclass
Enzyme
Family
Methyltransferase superfamily, L-isoaspartyl/D-aspartyl protein methyltransferase family
Subcellular location
Cytoplasm, cytosol
Function
Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein.
Uniprot ID
P22061
Ensemble ID
ENST00000367378.6
HGNC ID
HGNC:8728
ChEMBL ID
CHEMBL4240

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC15 SNV: p.H157L DBIA    Probe Info 
KMCH1 SNV: p.A186P DBIA    Probe Info 
TE1 SNV: p.I109M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.63  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y213(6.56)  LDD0257  [4]
YN-4
 Probe Info  		100.00  LDD0445  [5]
BTD
 Probe Info  		C102(6.69)  LDD1699  [6]
OPA-S-S-alkyne
 Probe Info  		K125(1.38)  LDD3494  [7]
DBIA
 Probe Info  		C102(0.88)  LDD3312  [8]
DA-P3
 Probe Info  		7.51  LDD0183  [9]
AHL-Pu-1
 Probe Info  		C95(2.14)  LDD0169  [10]
HHS-475
 Probe Info  		Y213(2.35)  LDD0264  [11]
HHS-465
 Probe Info  		Y213(4.59)  LDD2237  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
ATP probe
 Probe Info  		K4(0.00); K105(0.00); K125(0.00)  LDD0199  [14]
ATP probe
 Probe Info  		N.A.  LDD0035  [15]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [16]
NAIA_4
 Probe Info  		N.A.  LDD2226  [17]
TFBX
 Probe Info  		N.A.  LDD0027  [16]
WYneN
 Probe Info  		N.A.  LDD0021  [18]
WYneO
 Probe Info  		N.A.  LDD0022  [18]
IA-alkyne
 Probe Info  		N.A.  LDD0151  [19]
IPM
 Probe Info  		N.A.  LDD0005  [18]
NHS
 Probe Info  		N.A.  LDD0010  [18]
STPyne
 Probe Info  		N.A.  LDD0009  [18]
Phosphinate-6
 Probe Info  		C43(0.00); C102(0.00)  LDD0018  [20]
Acrolein
 Probe Info  		N.A.  LDD0217  [21]
Methacrolein
 Probe Info  		N.A.  LDD0218  [21]
W1
 Probe Info  		C102(0.00); D154(0.00); E150(0.00); Y153(0.00)  LDD0236  [22]
AOyne
 Probe Info  		15.00  LDD0443  [23]
NAIA_5
 Probe Info  		C95(0.00); C43(0.00)  LDD2223  [17]
TER-AC
 Probe Info  		N.A.  LDD0426  [24]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		9.99  LDD1868  [25]
FFF probe13
 Probe Info  		12.00  LDD0475  [26]
FFF probe14
 Probe Info  		20.00  LDD0477  [26]
FFF probe2
 Probe Info  		14.18  LDD0463  [26]
FFF probe3
 Probe Info  		7.84  LDD0465  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C102(0.76)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C102(0.90)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C102(0.89)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C102(0.96)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C102(0.91)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C102(1.11)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C102(0.96)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C102(0.51)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C102(1.68)  LDD2131  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C95(2.14)  LDD0169  [10]
 LDCM0545  Acetamide MDA-MB-231 C102(0.41)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C102(0.61)  LDD2113  [6]
 LDCM0156  Aniline NCI-H1299 13.56  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C102(0.53)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C95(0.00); H157(0.00); C102(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C95(0.99)  LDD2227  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C102(0.87)  LDD1702  [6]
 LDCM0031  Epigallocatechin gallate HEK-293T 7.51  LDD0183  [9]
 LDCM0625  F8 Ramos C102(1.06); C95(0.69)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C102(1.42)  LDD1390  [28]
 LDCM0573  Fragment11 Ramos C102(1.08)  LDD1392  [28]
 LDCM0574  Fragment12 Ramos C102(0.53)  LDD1394  [28]
 LDCM0575  Fragment13 MDA-MB-231 C102(0.93)  LDD1395  [28]
 LDCM0576  Fragment14 Ramos C102(1.35)  LDD1398  [28]
 LDCM0577  Fragment15 Ramos C102(1.44)  LDD1400  [28]
 LDCM0579  Fragment20 Ramos C102(0.63); C95(0.63)  LDD2194  [27]
 LDCM0580  Fragment21 MDA-MB-231 C102(0.86)  LDD1404  [28]
 LDCM0581  Fragment22 MDA-MB-231 C102(1.08)  LDD1406  [28]
 LDCM0582  Fragment23 Ramos C102(1.16); C95(1.14)  LDD2196  [27]
 LDCM0584  Fragment25 MDA-MB-231 C102(0.94)  LDD1411  [28]
 LDCM0585  Fragment26 Ramos C102(0.87)  LDD1412  [28]
 LDCM0578  Fragment27 MDA-MB-231 C102(1.19)  LDD1401  [28]
 LDCM0586  Fragment28 MDA-MB-231 C102(0.81)  LDD1415  [28]
 LDCM0587  Fragment29 Ramos C102(1.43)  LDD1418  [28]
 LDCM0588  Fragment30 MDA-MB-231 C102(0.68)  LDD1419  [28]
 LDCM0589  Fragment31 MDA-MB-231 C102(1.11)  LDD1421  [28]
 LDCM0590  Fragment32 MDA-MB-231 C102(1.11)  LDD1423  [28]
 LDCM0468  Fragment33 MDA-MB-231 C102(0.86)  LDD1425  [28]
 LDCM0592  Fragment34 Ramos C102(1.04)  LDD1428  [28]
 LDCM0593  Fragment35 Ramos C102(0.97)  LDD1430  [28]
 LDCM0595  Fragment37 Ramos C102(0.84)  LDD1432  [28]
 LDCM0596  Fragment38 MDA-MB-231 C102(0.94)  LDD1433  [28]
 LDCM0566  Fragment4 MDA-MB-231 C102(0.99)  LDD1378  [28]
 LDCM0598  Fragment40 MDA-MB-231 C102(0.83)  LDD1436  [28]
 LDCM0599  Fragment41 MDA-MB-231 C102(1.03)  LDD1438  [28]
 LDCM0600  Fragment42 Ramos C102(0.85)  LDD1440  [28]
 LDCM0601  Fragment43 MDA-MB-231 C102(0.73)  LDD1441  [28]
 LDCM0604  Fragment46 MDA-MB-231 C102(0.86)  LDD1445  [28]
 LDCM0605  Fragment47 MDA-MB-231 C102(0.95)  LDD1446  [28]
 LDCM0607  Fragment49 MDA-MB-231 C102(1.24)  LDD1448  [28]
 LDCM0608  Fragment50 MDA-MB-231 C102(20.00)  LDD1449  [28]
 LDCM0427  Fragment51 Ramos C102(0.83)  LDD1451  [28]
 LDCM0610  Fragment52 MDA-MB-231 C102(0.78)  LDD1452  [28]
 LDCM0612  Fragment54 MDA-MB-231 C102(1.03)  LDD1456  [28]
 LDCM0613  Fragment55 MDA-MB-231 C102(0.86)  LDD1457  [28]
 LDCM0614  Fragment56 MDA-MB-231 C102(0.87)  LDD1458  [28]
 LDCM0569  Fragment7 Ramos C102(0.64); C95(0.34)  LDD2186  [27]
 LDCM0570  Fragment8 MDA-MB-231 C102(0.94)  LDD1385  [28]
 LDCM0571  Fragment9 MDA-MB-231 C102(0.91)  LDD1387  [28]
 LDCM0116  HHS-0101 DM93 Y213(2.35)  LDD0264  [11]
 LDCM0118  HHS-0301 DM93 Y213(1.18)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y213(1.24)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y213(1.23)  LDD0268  [11]
 LDCM0107  IAA HeLa H15(0.00); H157(0.00)  LDD0221  [21]
 LDCM0022  KB02 MDA-MB-231 C102(1.37)  LDD1374  [28]
 LDCM0023  KB03 MDA-MB-231 C102(1.22)  LDD1376  [28]
 LDCM0024  KB05 HMCB C102(0.88)  LDD3312  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C102(1.09)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C102(0.71)  LDD2121  [6]
 LDCM0109  NEM HeLa H15(0.00); K4(0.00)  LDD0223  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C102(0.65)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C102(1.35)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C102(1.21)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C102(1.28)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C102(2.03)  LDD2094  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C102(0.82)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C102(0.80)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C102(0.79)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C102(1.76)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C102(0.63)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C102(0.65)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C102(1.44)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C102(1.01); C95(0.74)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C102(0.76)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C102(0.99)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C102(0.69)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C102(0.89)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C102(1.07)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C102(0.51)  LDD2115  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C102(2.86)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C102(0.86)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C102(0.07)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C102(0.78)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C102(0.73)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C102(0.04)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C102(0.87)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C102(0.96)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C102(0.94)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C102(0.49)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C102(0.45)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C102(0.87)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C102(0.92)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C102(0.91)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C102(1.16)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C102(0.80)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C102(0.93)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C102(3.51)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C102(0.84)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C102(2.66)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C102(0.44)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C102(0.48)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C102(0.08)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C102(1.96)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C43(0.83)  LDD2206  [29]
 LDCM0628  OTUB2-COV-1 HEK-293T C102(0.72); C95(0.71); C43(0.71)  LDD2207  [29]
 LDCM0131  RA190 MM1.R C95(1.35)  LDD0304  [30]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Polyribonucleotide 5'-hydroxyl-kinase Clp1 (CLP1) Clp1 family Q92989
Ribose-5-phosphate isomerase (RPIA) Ribose 5-phosphate isomerase family P49247
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) . Q13155
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
S-adenosyl-l-homocysteine Small molecular drug DB01752

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
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Mass spectrometry data entry: PXD041587
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