Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment40  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 81 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 6.5
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 5.7
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 3.8
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 1.6
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 1.2
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 1.1
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 1.1
 LDTP02198  Cathepsin D (CTSD) C117 1.0
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 1.0
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.0
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.0
 LDTP02502  Thioredoxin (TXN) C32 1.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 0.9
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 0.9
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 0.9
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 0.9
 LDTP02672  Elongation factor 2 (EEF2) C41 0.9
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 0.9
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 0.9
 LDTP09446  Ribonuclease H2 subunit C (RNASEH2C) C34 0.9
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 0.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 0.9
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 0.9
 LDTP02223  Cathepsin B (CTSB) C211 0.9
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 0.9
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 0.9
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.9
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 0.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 0.9
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 0.9
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 0.9
 LDTP03496  Protein PML (PML) C389 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 0.9
 LDTP13147  Cathepsin Z (CTSZ) C173 0.9
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.9
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 0.9
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 0.9
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 0.9
 LDTP03163  Sterol carrier protein 2 (SCP2) C94 0.9
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 0.9
 LDTP13147  Cathepsin Z (CTSZ) C92 0.9
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 0.9
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 0.8
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 0.8
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.8
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 0.8
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 0.8
 LDTP03400  Deoxycytidine kinase (DCK) C9 0.8
 LDTP02672  Elongation factor 2 (EEF2) C136 0.8
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 0.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 0.8
 LDTP04689  Adenosine kinase (ADK) C353 0.8
 LDTP04374  Dynamin-2 (DNM2) C27 0.8
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) C622 0.8
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 0.8
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 0.8
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 0.8
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 0.8
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 0.8
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.8
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.8
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 0.8
 LDTP02733  Pyruvate kinase PKM (PKM) C423 0.8
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 0.8
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 0.8
 LDTP02223  Cathepsin B (CTSB) C319 0.7
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.7
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 0.7
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 0.7
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 0.7
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 0.7
 LDTP03644  Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) C120 0.7
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 0.7
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 0.7
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 0.6
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 0.6
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C100 0.6
Transporter and channel
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04662  Exportin-2 (CSE1L) C842 1.0
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.0
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 0.8
 LDTP00501  Exportin-1 (XPO1) C34 0.8
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 0.8
 LDTP04707  Protein SEC13 homolog (SEC13) C187 0.8
 LDTP00196  Unconventional myosin-Ic (MYO1C) C802 0.8
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 0.7
Transcription factor
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 20.0
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 0.9
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 0.9
 LDTP10756  Nucleus accumbens-associated protein 1 (NACC1) C416 0.8
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 0.8
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.7
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 0.7
Other
Click to Show/Hide to Show 62 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12443  Anillin (ANLN) C712 1.7
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.3
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.2
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 1.1
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 1.1
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 1.1
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 1.1
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 1.0
 LDTP05867  Treacle protein (TCOF1) C38 1.0
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 1.0
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 1.0
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 0.9
 LDTP13705  LIM and calponin homology domains-containing protein 1 (LIMCH1) C140 0.9
 LDTP06330  Plectin (PLEC) C3110 0.9
 LDTP02205  Tubulin beta chain (TUBB) C239 0.9
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 0.9
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 0.9
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 0.9
 LDTP13925  Nucleolar protein 58 (NOP58) C106 0.9
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 0.9
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 0.9
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 0.9
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) C18 0.9
 LDTP04487  Cyclin-H (CCNH) C244 0.9
 LDTP01320  Eukaryotic translation initiation factor 3 subunit J (EIF3J) C207 0.9
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 0.9
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 0.9
 LDTP10864  Calponin-2 (CNN2) C215 0.9
 LDTP06542  Cysteine and glycine-rich protein 2 (CSRP2) C33 0.9
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 0.9
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 0.9
 LDTP13964  MOB-like protein phocein (MOB4) C134 0.9
 LDTP04902  Actin-related protein 3 (ACTR3) C235 0.9
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 0.9
 LDTP10864  Calponin-2 (CNN2) C164 0.8
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 0.8
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 0.8
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 0.8
 LDTP02205  Tubulin beta chain (TUBB) C354 0.8
 LDTP13580  Coronin-1C (CORO1C) C420 0.8
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 0.8
 LDTP18494  Tropomodulin-3 (TMOD3) C132 0.8
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 0.8
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 0.8
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.8
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 0.8
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.8
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 0.8
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 0.8
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 0.8
 LDTP13580  Coronin-1C (CORO1C) C456 0.8
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 0.8
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 0.7
 LDTP10700  KH domain-containing RNA-binding protein QKI (QKI) C35 0.7
 LDTP08885  Actin filament-associated protein 1 (AFAP1) C713 0.7
 LDTP03620  Protein S100-A11 (S100A11) C91 0.7
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.7
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 0.7
 LDTP03244  Cofilin-1 (CFL1) C80 0.7
 LDTP12638  Protein lin-7 homolog C (LIN7C) C47 0.7
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 0.6
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 0.6

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.