Details of the Target

General Information of Target

Target ID LDTP09311
Target Name SWI/SNF complex subunit SMARCC2 (SMARCC2)
Gene Name SMARCC2
Gene ID 6601
Synonyms
BAF170; SWI/SNF complex subunit SMARCC2; BRG1-associated factor 170; BAF170; SWI/SNF complex 170 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAVRKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQ
EEVFGKHVSNAPLTKLPIKCFLDFKAGGSLCHILAAAYKFKSDQGWRRYDFQNPSRMDRN
VEMFMTIEKSLVQNNCLSRPNIFLCPEIEPKLLGKLKDIIKRHQGTVTEDKNNASHVVYP
VPGNLEEEEWVRPVMKRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAK
WILDTDTFNEWMNEEDYEVNDDKNPVSRRKKISAKTLTDEVNSPDSDRRDKKGGNYKKRK
RSPSPSPTPEAKKKNAKKGPSTPYTKSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKT
VNTKKDSESAPVKGGTMTDLDEQEDESMETTGKDEDENSTGNKGEQTKNPDLHEDNVTEQ
THHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEY
LTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLADTPSG
LVPLQPKTPQQTSASQQMLNFPDKGKEKPTDMQNFGLRTDMYTKKNVPSKSKAAASATRE
WTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLEDSEASLGPLA
YQPIPFSQSGNPVMSTVAFLASVVDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVE
EAAKVTGKADPAFGLESSGIAGTTSDEPERIEESGNDEARVEGQATDEKKEPKEPREGGG
AIEEEAKEKTSEAPKKDEEKGKEGDSEKESEKSDGDPIVDPEKEKEPKEGQEEVLKEVVE
SEGERKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERKIKSLVALLVETQMKKLE
IKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQLKYAEMRARQQHFQQMHQQQQQ
PPPALPPGSQPIPPTGAAGPPAVHGLAVAPASVVPAPAGSGAPPGSLGPSEQIGQAGSTA
GPQQQQPAGAPQPGAVPPGVPPPGPHGPSPFPNQQTPPSMMPGAVPGSGHPGVAGNAPLG
LPFGMPPPPPPPAPSIIPFGSLADSISINLPAPPNLHGHHHHLPFAPGTLPPPNLPVSMA
NPLHPNLPATTTMPSSLPLGPGLGSAAAQSPAIVAAVQGNLLPSASPLPDPGTPLPPDPT
APSPGTVTPVPPPQ
Target Bioclass
Transcription factor
Family
SMARCC family
Subcellular location
Nucleus
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation.
Uniprot ID
Q8TAQ2
Ensemble ID
ENST00000267064.8
HGNC ID
HGNC:11105

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.83  LDD0402  [1]
STPyne
 Probe Info  		K592(0.63); K694(1.38); K872(10.00); K874(3.27)  LDD0277  [2]
Probe 1
 Probe Info  		Y14(86.27); Y15(105.97); Y109(34.59); Y324(26.12)  LDD3495  [3]
BTD
 Probe Info  		C495(1.25)  LDD2107  [4]
AHL-Pu-1
 Probe Info  		C145(2.72)  LDD0168  [5]
HHS-475
 Probe Info  		Y38(0.79)  LDD0264  [6]
DBIA
 Probe Info  		C145(2.68); C635(2.31)  LDD0080  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C91(0.00); C495(0.00); C145(0.00); C136(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C486(0.00); C635(0.00)  LDD0032  [10]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C91(0.00); C495(0.00); C145(0.00); C136(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
IPM
 Probe Info  		C145(0.00); C635(0.00)  LDD0005  [13]
NHS
 Probe Info  		K872(0.00); K37(0.00); K874(0.00)  LDD0010  [13]
SF
 Probe Info  		Y38(0.00); Y324(0.00)  LDD0028  [14]
TFBX
 Probe Info  		C495(0.00); C635(0.00); C486(0.00); C80(0.00)  LDD0148  [12]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
Acrolein
 Probe Info  		C486(0.00); H875(0.00); H905(0.00); H67(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		C635(0.00); H626(0.00); C495(0.00); C486(0.00)  LDD0219  [16]
Methacrolein
 Probe Info  		C486(0.00); C635(0.00); C495(0.00)  LDD0218  [16]
W1
 Probe Info  		C145(0.00); C635(0.00); C486(0.00)  LDD0236  [17]
NAIA_5
 Probe Info  		C91(0.00); C80(0.00); C486(0.00); C495(0.00)  LDD2223  [18]
HHS-465
 Probe Info  		Y324(0.00); K326(0.00)  LDD2240  [19]
HHS-482
 Probe Info  		Y324(1.77)  LDD2239  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C486(1.27); C91(1.00); C495(0.87); C136(0.85)  LDD2117  [4]
 LDCM0025  4SU-RNA HEK-293T C145(2.72)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C145(3.93)  LDD0169  [5]
 LDCM0561  Abegg_cp(-)-10 HeLa C486(2.20)  LDD0312  [12]
 LDCM0214  AC1 HCT 116 C136(2.30); C145(1.21); C486(1.12); C495(1.06)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C136(1.16); C145(1.04); C486(0.64); C495(1.13)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C136(1.29); C145(1.13); C486(0.49); C495(0.78)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C136(1.05); C145(0.99); C486(0.50); C495(0.84)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C136(0.98); C145(0.91); C486(0.48); C495(0.73)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C136(1.03); C145(1.18); C486(0.40); C495(0.74)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C136(1.37); C145(1.16); C486(0.52); C495(0.81)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C136(1.02); C145(1.15); C486(0.44); C495(0.75)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C136(1.20); C145(1.22); C486(0.36); C495(0.73)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C136(1.28); C145(1.35); C486(0.33); C495(0.65)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C136(1.13); C145(0.99); C486(0.47); C495(0.89)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C136(1.29); C145(1.04); C486(0.66); C495(0.94)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C136(0.77); C145(0.86); C486(0.65); C495(0.94)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C136(1.02); C145(0.99); C486(0.93); C495(0.99)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C136(1.32); C145(1.13); C486(0.72); C495(0.96)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C136(0.87); C145(1.09); C486(0.42); C495(0.68)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C136(1.11); C145(0.97); C486(1.22); C495(1.23)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C136(1.14); C145(1.14); C486(1.10); C495(1.03)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C136(0.86); C145(0.92); C486(1.04); C495(0.94)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C136(0.84); C145(1.04); C486(0.98); C495(1.10)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C136(0.81); C145(0.97); C486(0.86); C495(1.02)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C136(0.88); C145(0.96); C486(1.00); C495(1.02)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C136(0.84); C145(0.95); C486(1.04); C495(0.98)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C136(1.00); C145(0.92); C486(0.84); C495(1.10)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C136(0.79); C145(0.87); C486(1.24); C495(1.13)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C136(0.89); C145(0.92); C486(1.11); C495(0.90)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C136(0.72); C145(0.90); C486(1.11); C495(1.02)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C136(1.08); C145(1.03); C486(1.40); C495(1.10)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C136(1.01); C145(1.00); C486(1.16); C495(1.10)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C136(1.00); C145(0.85); C486(1.21); C495(1.10)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C136(0.77); C145(0.86); C486(1.22); C495(1.02)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C136(0.77); C145(0.97); C486(1.19); C495(1.01)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C136(1.08); C145(1.08); C486(1.03); C495(1.69)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C136(1.73); C145(1.73); C486(2.04); C495(1.49)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C136(1.09); C145(1.09); C486(1.06); C495(1.35)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C136(1.60); C145(1.60); C486(2.25); C495(1.32)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C136(1.38); C145(1.38); C486(0.73); C495(1.21)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C136(1.19); C145(1.19); C486(0.73); C495(1.23)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C136(1.12); C145(1.12); C486(0.69); C495(1.15)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C136(1.13); C145(1.13); C486(0.59); C495(1.17)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C136(1.17); C145(1.17); C486(0.70); C495(1.17)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C136(1.20); C145(1.20); C486(0.65); C495(1.25)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C136(1.22); C145(1.22); C486(0.45); C495(1.20)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C136(1.11); C145(1.11); C486(0.62); C495(1.11)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C136(1.24); C145(1.01); C486(0.93); C495(1.34)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C136(1.00); C145(1.00); C486(0.50); C495(1.20)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C136(1.15); C145(1.15); C486(0.56); C495(1.19)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C136(1.63); C145(1.63); C486(0.69); C495(1.23)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C486(0.72); C495(0.91); C635(1.02); C136(1.09)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C136(0.81); C486(0.84); C145(0.87); C635(0.93)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C486(0.82); C136(1.01); C635(1.02); C145(1.04)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C136(0.91); C145(0.92); C486(0.92); C635(0.98)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C486(0.74); C136(0.78); C145(0.84); C635(0.94)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C486(0.78); C136(0.80); C635(0.83); C145(1.02)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C486(0.77); C136(0.80); C635(0.89); C145(0.97)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C486(0.91); C145(0.95); C136(0.99); C495(1.14)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C486(0.81); C635(1.05); C145(1.05); C136(1.05)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C136(0.80); C486(0.84); C635(0.92); C145(0.95)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C635(0.84); C486(0.90); C145(0.95); C136(1.00)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C136(0.66); C635(0.70); C145(0.81); C486(0.82)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C136(0.93); C145(0.93); C486(0.86); C495(1.33)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C136(0.76); C145(0.90); C486(0.95); C495(1.46)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C136(1.03); C145(0.99); C486(1.16); C495(1.22)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C136(1.29); C145(1.18); C486(1.60); C495(1.27)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C635(0.94); C145(1.06); C495(1.06); C136(1.18)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C486(0.85); C495(0.89); C635(0.97); C145(1.00)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C635(0.89); C145(1.08); C495(1.08); C136(1.19)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C486(0.88); C495(1.05); C635(1.13); C145(1.23)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C635(0.86); C495(0.98); C486(1.07); C145(1.28)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C635(0.84); C495(0.98); C486(1.09); C145(1.13)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C635(0.89); C495(1.03); C136(1.05); C145(1.11)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C635(0.89); C495(1.04); C145(1.17); C486(1.19)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C635(1.05); C495(1.12); C145(1.43); C486(1.57)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C635(0.77); C136(0.84); C145(0.86); C486(0.90)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C136(0.66); C486(0.67); C635(0.67); C495(0.83)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C486(0.73); C635(0.74); C136(0.75); C145(0.85)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C136(0.57); C486(0.62); C635(0.82); C495(0.85)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C635(0.55); C486(0.59); C136(0.68); C495(0.73)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C486(0.92); C495(1.18); C145(1.20); C635(1.24)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C136(0.53); C486(0.56); C495(0.71); C635(0.80)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C486(0.60); C136(0.65); C145(0.82); C495(0.84)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C486(0.37); C136(0.62); C495(0.89); C145(0.99)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C635(0.72); C486(0.81); C495(0.86); C136(0.92)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C495(0.70); C486(0.79); C635(0.81); C145(0.97)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C495(0.79); C486(1.04); C635(1.13); C136(1.37)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C495(0.66); C635(0.94); C486(1.10); C136(1.36)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C495(0.79); C136(1.02); C635(1.04); C145(1.19)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C495(0.84); C486(0.84); C136(0.98); C145(1.01)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C495(0.74); C145(0.91); C635(0.91); C136(0.91)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C486(0.90); C635(1.18); C495(1.25); C145(1.37)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C495(0.68); C635(0.85); C136(0.97); C145(0.97)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C635(0.86); C495(0.94); C136(1.04); C486(1.10)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C495(0.79); C635(0.89); C136(1.00); C486(1.05)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C486(0.84); C495(0.94); C635(0.98); C136(1.10)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C495(0.76); C136(0.99); C635(1.00); C145(1.16)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C495(0.78); C635(0.80); C136(0.88); C145(1.05)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C486(0.80); C495(0.82); C635(1.07); C145(1.10)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C486(0.80); C145(0.88); C495(0.89); C635(1.00)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C145(0.69); C486(0.75); C136(0.83); C495(0.89)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C486(0.67); C145(0.71); C136(0.75); C635(0.79)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C486(0.81); C635(1.17); C495(1.18); C145(1.49)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C145(0.72); C486(0.74); C136(0.85); C635(0.90)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C495(0.81); C486(1.01); C145(1.05); C635(1.11)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C486(0.79); C495(0.79); C635(0.89); C145(0.90)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C495(0.76); C145(0.82); C635(0.85); C486(0.85)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C495(0.74); C486(0.76); C635(0.86); C145(0.87)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C145(0.68); C136(0.73); C635(0.81); C486(0.85)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C145(0.61); C495(0.74); C136(0.75); C635(0.76)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C486(0.85); C635(0.90); C495(1.03); C145(1.16)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C635(0.88); C486(0.95); C495(1.01); C145(1.23)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C486(0.73); C635(0.91); C495(1.05); C145(1.08)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C486(0.59); C136(0.82); C495(0.90); C145(0.95)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C486(0.77); C635(1.04); C495(1.05); C145(1.17)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C486(0.80); C495(0.93); C635(1.16); C145(1.16)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C486(0.84); C635(0.85); C495(1.20); C145(1.40)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C486(0.84); C635(0.90); C495(1.05); C145(1.27)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C486(0.76); C635(0.90); C145(1.22); C495(1.25)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C486(0.73); C635(0.93); C495(1.00); C145(1.27)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C486(0.83); C635(0.98); C495(1.04); C145(1.26)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C486(0.63); C635(0.69); C495(1.08); C145(1.13)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C486(0.74); C145(0.82); C495(0.84); C136(0.89)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C145(0.80); C136(0.87); C635(0.91); C495(0.95)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C486(0.66); C495(0.94); C145(1.05); C136(1.05)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C136(0.58); C486(0.65); C145(0.75); C635(0.81)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C486(0.83); C145(1.00); C635(1.05); C495(1.13)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C635(0.86); C486(0.97); C495(1.00); C145(1.08)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C136(0.54); C145(0.71); C486(0.73); C635(0.77)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C136(0.69); C145(0.71); C486(0.77); C635(0.86)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C136(0.65); C635(0.71); C486(0.81); C145(0.85)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C136(0.74); C145(0.80); C635(0.84); C486(0.86)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C145(0.71); C136(0.71); C486(0.81); C495(0.88)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C145(0.84); C495(0.91); C136(0.93); C486(0.98)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C486(0.81); C495(0.87); C145(0.90); C136(0.95)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C486(0.69); C145(0.90); C495(1.03); C136(1.07)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C145(0.84); C136(0.85); C486(0.87); C635(0.87)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C635(0.84); C495(0.94); C486(0.95); C145(1.25)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C136(0.66); C635(0.68); C486(0.72); C145(0.75)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C635(0.77); C136(0.85); C495(0.87); C486(0.90)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C635(0.77); C136(0.83); C495(0.92); C486(0.98)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C136(0.66); C495(0.76); C486(0.81); C635(0.85)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C136(0.69); C486(0.81); C635(0.82); C495(0.85)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C486(0.85); C495(0.95); C635(1.04); C136(1.13)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C486(0.78); C495(0.87); C635(0.88); C136(0.99)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C136(0.74); C495(0.84); C486(0.86); C635(0.92)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C486(0.79); C495(0.79); C136(0.89); C635(1.06)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C136(0.82); C635(0.86); C495(0.97); C486(1.03)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C635(0.79); C486(0.82); C495(0.86); C136(0.99)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C635(0.82); C136(0.90); C486(0.91); C495(0.92)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C136(0.73); C635(0.77); C486(1.01); C145(1.16)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C495(0.77); C486(0.85); C635(0.88); C136(1.08)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C136(0.80); C635(0.90); C486(1.10); C495(1.21)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C495(0.66); C486(0.70); C136(0.80); C635(0.81)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C486(0.24); C635(0.66); C495(0.67); C136(0.83)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C486(0.45); C495(0.75); C635(0.84); C136(0.95)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C136(1.01); C145(0.96); C486(0.74); C495(1.02)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C486(0.65); C635(0.82); C495(1.09); C136(1.17)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C136(0.58); C486(0.68); C145(0.90); C495(1.00)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C495(1.11)  LDD2171  [7]
 LDCM0630  CCW28-3 231MFP C145(1.49)  LDD2214  [21]
 LDCM0108  Chloroacetamide HeLa C635(0.00); H875(0.00); C495(0.00); H331(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C635(0.94); C91(0.75)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C486(0.79); C495(0.96); C635(1.30); C136(1.35)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C486(0.60); C495(0.91); C635(1.55); C145(1.70)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C486(0.88); C635(1.02); C495(1.16); C145(1.25)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C486(0.77); C136(0.82); C145(0.92); C495(0.97)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C486(0.90); C145(1.04); C635(1.06); C495(1.12)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C145(0.87); C136(0.99); C486(1.01); C495(1.15)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C145(0.95); C136(1.11); C495(1.12); C486(1.13)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C486(0.80); C635(0.83); C145(0.84); C136(1.00)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C145(0.85); C635(0.90); C136(0.92); C486(0.95)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C136(0.66); C145(0.70); C486(0.78); C635(0.87)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C486(0.74); C635(0.87); C145(0.92); C136(1.04)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C136(0.55); C145(0.75); C635(0.88); C486(0.93)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C486(0.70); C136(0.82); C145(0.92); C495(0.98)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C486(0.73); C635(0.95); C495(1.06); C145(1.40)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C486(0.86); C635(0.90); C495(0.98); C145(1.21)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C486(0.62); C635(0.89); C145(0.90); C136(0.90)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C486(0.52); C136(0.74); C495(0.75); C145(0.85)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C486(0.59); C495(0.68); C136(0.86); C635(0.86)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C486(0.67); C495(0.72); C635(0.85); C136(0.94)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C486(0.65); C495(0.77); C136(0.94); C145(0.97)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C495(0.66); C635(0.79); C486(0.91); C136(0.93)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C635(0.97); C136(0.98); C495(1.04); C486(1.05)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C136(0.93); C495(0.94); C635(0.97); C486(0.97)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C486(0.70); C145(0.94); C136(1.07); C495(1.09)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C495(0.94); C136(0.95); C486(1.02); C635(1.05)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C495(0.83); C635(0.85); C486(0.89); C145(0.91)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C495(0.74); C486(0.80); C145(0.88); C136(0.96)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C486(0.68); C495(0.72); C635(0.82); C145(0.94)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C145(0.69); C486(0.72); C495(0.73); C635(0.77)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C486(0.81); C495(0.87); C635(1.00); C145(1.44)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C495(0.87); C486(0.88); C635(0.99); C145(2.09)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C635(0.82); C486(0.89); C495(0.94); C145(1.23)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C495(0.91); C486(0.92); C635(1.01); C145(1.09)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C486(0.93); C145(0.98); C495(1.07); C136(1.20)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C486(0.80); C495(1.07); C635(1.33); C145(1.34)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C495(1.18); C486(1.21); C635(1.35); C136(1.41)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C486(0.72); C495(0.91); C136(1.00); C635(1.03)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C486(0.93); C495(1.00); C635(1.06); C136(1.24)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C486(0.87); C495(0.98); C136(1.10); C145(1.12)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C136(0.72); C145(0.87); C635(1.07); C495(1.11)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C495(1.09); C635(1.13); C486(1.32); C136(1.35)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C136(0.72); C145(1.00); C486(1.01); C495(1.20)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C136(0.94); C486(0.96); C495(1.17); C145(1.37)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C136(0.33); C145(0.76); C635(0.94); C486(0.99)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C136(0.55); C145(0.76); C635(0.83); C486(0.94)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C136(0.44); C145(0.79); C486(0.96); C495(0.93)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C136(0.45); C145(0.87); C486(0.93); C495(0.93)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C136(0.70); C145(0.87); C486(0.89); C495(1.12)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C136(0.66); C145(0.88); C486(0.93); C495(1.05)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C136(0.71); C145(0.98); C486(1.00); C495(0.96)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C136(0.61); C145(0.90); C486(1.19); C495(1.05)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C136(1.03); C145(0.99); C486(1.00); C495(1.09)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C136(0.87); C145(0.99); C486(1.00); C495(0.68)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C136(1.64); C145(1.33); C486(0.95); C495(0.98)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C136(1.14); C145(1.21); C486(0.87); C495(1.11)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C136(1.60); C145(1.65); C486(0.91); C495(0.94)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C136(0.99); C145(1.17); C486(0.79); C495(0.95)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C136(1.07); C145(1.07); C486(0.99); C495(1.11)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C136(1.15); C145(1.12); C486(0.96); C495(0.90)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C136(1.06); C145(1.05); C486(1.03); C495(1.25)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C136(1.48); C145(1.53); C486(0.87); C495(1.21)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C136(0.97); C145(1.05); C486(1.24); C495(1.04)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C136(1.45); C145(1.52); C486(0.88); C495(0.97)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C136(1.20); C145(1.18); C486(0.95); C495(1.01)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C136(1.00); C145(1.10); C486(0.78); C495(1.03)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C136(0.95); C145(1.14); C486(1.03); C495(1.07)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C136(1.46); C145(1.51); C486(0.97); C495(1.20)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C136(1.06); C145(1.25); C486(0.76); C495(0.93)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C136(2.15); C145(1.49); C486(2.59); C495(0.90)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C136(0.98); C145(1.22); C486(1.65); C495(0.93)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C136(1.20); C145(1.04); C486(1.80); C495(1.02)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C136(0.96); C145(0.86); C486(3.09); C495(1.10)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C136(0.94); C145(0.87); C486(1.56); C495(1.08)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C136(1.37); C145(1.19); C486(2.24); C495(0.97)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C136(1.04); C145(0.95); C486(1.94); C495(0.96)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C136(1.33); C145(1.07); C486(1.61); C495(0.75)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C136(1.37); C145(1.57); C486(1.98); C495(0.91)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C136(1.26); C145(1.03); C486(2.62); C495(0.97)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C136(1.24); C145(1.06); C486(2.58); C495(1.01)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C136(1.12); C145(1.10); C486(1.28); C495(1.00)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C136(1.38); C145(1.45); C486(1.96); C495(1.12)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C136(1.22); C145(1.04); C486(2.01); C495(0.91)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C136(0.94); C145(0.91); C486(1.56); C495(1.07)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C136(1.02); C145(0.97); C486(1.25); C495(1.03)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C136(1.20); C145(0.99); C486(2.08); C495(1.00)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C136(1.24); C145(1.16); C486(1.05); C495(0.91)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C136(1.03); C145(1.06); C486(0.91); C495(1.05)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C136(0.83); C145(0.99); C486(0.75); C495(0.89)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C136(0.88); C145(0.93); C486(0.88); C495(1.10)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C136(0.93); C145(1.00); C486(0.85); C495(1.06)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C136(0.76); C145(0.92); C486(0.70); C495(1.02)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C136(0.78); C145(0.91); C486(0.84); C495(0.92)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C136(0.96); C145(1.17); C486(0.73); C495(0.82)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C136(1.87); C145(1.67); C486(1.03); C495(0.80)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C136(1.04); C145(0.89); C486(0.80); C495(1.23)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C136(1.03); C145(1.01); C486(0.86); C495(0.73)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C136(0.99); C145(1.08); C486(0.73); C495(0.81)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C136(1.25); C145(1.27); C486(0.75); C495(0.65)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C136(0.95); C145(1.13); C486(0.94); C495(0.89)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C136(0.96); C145(1.08); C486(0.90); C495(0.78)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C136(2.69); C145(1.61); C486(1.07); C495(1.04)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C136(3.14); C145(1.71); C486(1.23); C495(1.09)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C136(1.98); C145(1.42); C486(0.78); C495(0.98)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C136(1.63); C145(1.17); C486(0.90); C495(1.18)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C136(1.18); C145(1.52); C486(0.66); C495(0.89)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C136(1.63); C145(1.20); C486(1.24); C495(1.15)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C136(1.26); C145(1.14); C486(1.13); C495(1.14)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C136(1.21); C145(1.10); C486(0.78); C495(1.21)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C136(1.20); C145(0.95); C486(0.72); C495(1.10)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C136(1.26); C145(0.99); C486(0.77); C495(1.20)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C136(1.72); C145(1.25); C486(0.88); C495(1.09)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C136(2.11); C145(1.30); C486(1.00); C495(1.02)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C136(2.64); C145(1.85); C486(0.95); C495(1.09)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C136(2.80); C145(1.62); C486(0.79); C495(1.04)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C136(1.84); C145(1.16); C486(0.62); C495(1.19)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C136(1.06); C145(1.17); C486(0.77); C495(1.02)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C136(3.09); C145(2.21); C486(1.02); C495(0.96)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C136(1.47); C145(1.09); C486(1.05); C495(1.01)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C136(1.01); C145(1.17); C486(1.06); C495(0.93)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C136(1.89); C145(1.07); C486(1.26); C495(1.09)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C136(1.52); C145(1.65); C486(1.05); C495(1.10)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C136(1.06); C145(1.63); C486(0.85); C495(0.93)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C136(1.35); C145(1.23); C486(0.91); C495(0.97)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C136(1.08); C145(1.20); C486(1.03); C495(0.95)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C136(1.39); C145(1.43); C486(0.84); C495(1.04)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C136(1.81); C145(1.87); C486(0.87); C495(1.08)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C136(1.11); C486(0.98); C495(1.24); C145(3.16)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C145(1.43); C136(1.03); C495(0.97)  LDD1702  [4]
 LDCM0625  F8 Ramos C495(0.76); C635(1.89); C486(1.17)  LDD2187  [23]
 LDCM0572  Fragment10 MDA-MB-231 C145(4.17)  LDD1389  [24]
 LDCM0573  Fragment11 MDA-MB-231 C145(20.00)  LDD1391  [24]
 LDCM0574  Fragment12 MDA-MB-231 C145(2.79)  LDD1393  [24]
 LDCM0575  Fragment13 Ramos C145(0.79)  LDD1396  [24]
 LDCM0576  Fragment14 MDA-MB-231 C145(1.08)  LDD1397  [24]
 LDCM0577  Fragment15 Ramos C145(1.16)  LDD1400  [24]
 LDCM0579  Fragment20 MDA-MB-231 C145(2.90)  LDD1402  [24]
 LDCM0580  Fragment21 MDA-MB-231 C145(1.15)  LDD1404  [24]
 LDCM0581  Fragment22 Ramos C145(1.23)  LDD1407  [24]
 LDCM0582  Fragment23 MDA-MB-231 C145(1.26)  LDD1408  [24]
 LDCM0583  Fragment24 Ramos C145(5.42)  LDD1410  [24]
 LDCM0584  Fragment25 MDA-MB-231 C145(0.94)  LDD1411  [24]
 LDCM0585  Fragment26 Ramos C145(0.90)  LDD1412  [24]
 LDCM0578  Fragment27 MDA-MB-231 C145(0.86)  LDD1401  [24]
 LDCM0586  Fragment28 MDA-MB-231 C145(1.13)  LDD1415  [24]
 LDCM0587  Fragment29 MDA-MB-231 C145(1.01)  LDD1417  [24]
 LDCM0588  Fragment30 MDA-MB-231 C145(1.09)  LDD1419  [24]
 LDCM0589  Fragment31 MDA-MB-231 C145(1.11)  LDD1421  [24]
 LDCM0590  Fragment32 MDA-MB-231 C145(20.00)  LDD1423  [24]
 LDCM0468  Fragment33 HCT 116 C136(1.11); C145(1.20); C486(0.69); C495(0.94)  LDD0785  [7]
 LDCM0593  Fragment35 MDA-MB-231 C145(0.90)  LDD1429  [24]
 LDCM0596  Fragment38 MDA-MB-231 C145(1.10)  LDD1433  [24]
 LDCM0597  Fragment39 MDA-MB-231 C145(1.17)  LDD1435  [24]
 LDCM0566  Fragment4 MDA-MB-231 C145(1.29)  LDD1378  [24]
 LDCM0598  Fragment40 MDA-MB-231 C145(0.86)  LDD1436  [24]
 LDCM0599  Fragment41 MDA-MB-231 C145(1.82)  LDD1438  [24]
 LDCM0600  Fragment42 Ramos C145(0.96)  LDD1440  [24]
 LDCM0601  Fragment43 MDA-MB-231 C145(20.00)  LDD1441  [24]
 LDCM0602  Fragment44 MDA-MB-231 C145(0.97)  LDD1443  [24]
 LDCM0603  Fragment45 MDA-MB-231 C145(2.90)  LDD1482  [24]
 LDCM0604  Fragment46 MDA-MB-231 C145(1.02)  LDD1445  [24]
 LDCM0605  Fragment47 MDA-MB-231 C145(1.45)  LDD1446  [24]
 LDCM0606  Fragment48 MDA-MB-231 C145(1.10)  LDD1447  [24]
 LDCM0608  Fragment50 MDA-MB-231 C145(2.82)  LDD1449  [24]
 LDCM0427  Fragment51 HCT 116 C136(1.11); C145(1.30); C486(0.85); C495(0.86)  LDD0744  [7]
 LDCM0610  Fragment52 MDA-MB-231 C145(0.94)  LDD1452  [24]
 LDCM0611  Fragment53 Ramos C145(1.16)  LDD1455  [24]
 LDCM0614  Fragment56 MDA-MB-231 C145(1.43)  LDD1458  [24]
 LDCM0569  Fragment7 MDA-MB-231 C145(0.97)  LDD1383  [24]
 LDCM0570  Fragment8 MDA-MB-231 C145(3.12)  LDD1385  [24]
 LDCM0571  Fragment9 MDA-MB-231 C145(1.01)  LDD1387  [24]
 LDCM0116  HHS-0101 DM93 Y38(0.79)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y38(2.15)  LDD0265  [6]
 LDCM0120  HHS-0701 DM93 Y38(3.01)  LDD0268  [6]
 LDCM0015  HNE MDA-MB-231 C145(0.99)  LDD0346  [23]
 LDCM0107  IAA HeLa C486(0.00); H905(0.00); H331(0.00); H875(0.00)  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C145(2.68); C635(2.31)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C145(2.81); C635(3.08)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C145(2.40); C635(2.23)  LDD0082  [7]
 LDCM0109  NEM HeLa H905(0.00); H875(0.00); H638(0.00); H331(0.00)  LDD0223  [16]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C495(1.25)  LDD2107  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C486(0.68)  LDD2114  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C91(0.77)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C486(1.44); C136(0.64)  LDD2125  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C136(1.07)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C495(1.23)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C495(1.22)  LDD2137  [4]
 LDCM0131  RA190 MM1.R C145(1.13)  LDD0304  [25]
 LDCM0021  THZ1 HCT 116 C495(1.11)  LDD2173  [7]
 LDCM0112  W16 Hep-G2 C145(0.58)  LDD0239  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chromodomain-helicase-DNA-binding protein 7 (CHD7) SNF2/RAD54 helicase family Q9P2D1
Probable global transcription activator SNF2L2 (SMARCA2) SNF2/RAD54 helicase family P51531
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
20 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
21 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
25 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.