Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0583
Competitor Name
Fragment24
Synonyms
N-[3,5-bis(trifluoromethyl)phenyl]-2-bromopropanamide; 646497-42-9; N1-[3,5-di(trifluoromethyl)phenyl]-2-bromopropanamide; CHEMBL5266284; SCHEMBL18763026; DTXSID80381602; PCESRJVCFUAIBU-UHFFFAOYSA-N; MFCD00119263; CS-0260127; G53625; EN300-7459528
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 364.08
Lipid-water partition coefficient (xlogp) 4.9
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C11H8BrF6NO
IUPAC Name
N-[3,5-bis(trifluoromethyl)phenyl]-2-bromopropanamide
Canonical SMILES
CC(C(=O)NC1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)Br
InChI
InChI=1S/C11H8BrF6NO/c1-5(12)9(20)19-8-3-6(10(13,14)15)2-7(4-8)11(16,17)18/h2-5H,1H3,(H,19,20)
InChIKey
PCESRJVCFUAIBU-UHFFFAOYSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

ABPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
IA-alkyne
 Probe Info  		100 uM Human burkitt lymphoma cell lysate (Ramos) [1]

Target(s) List of this Competitor

76 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
26S proteasome regulatory subunit 6B (PSMC4) LDTP04061 0.49  LDD1410 
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) LDTP10954 1.29  LDD1410 
3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) LDTP03998 1.04  LDD1410 
3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) LDTP02329 1.95  LDD1410 
5'-nucleotidase domain-containing protein 1 (NT5DC1) LDTP17247 1.48  LDD1410 
6-phosphogluconolactonase (PGLS) LDTP14535 1.20  LDD1410 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 11.37  LDD1410 
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) LDTP03291 1.34; 1.08; 1.24 ...  LDD1410 
Adenosine 5'-monophosphoramidase HINT1 (HINT1) LDTP04306 1.11  LDD1410 
Adenosine kinase (ADK) LDTP04689 1.04  LDD1410 
Aldo-keto reductase family 1 member B1 (AKR1B1) LDTP02765 1.30  LDD1410 
AMP deaminase 2 (AMPD2) LDTP05289 1.30  LDD1410 
Arginine--tRNA ligase, cytoplasmic (RARS1) LDTP04601 1.66  LDD1410 
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) LDTP03159 1.78  LDD1410 
C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) LDTP02580 1.40; 1.00  LDD1410 
Caspase-8 (CASP8) LDTP06211 1.35  LDD1410 
Cathepsin Z (CTSZ) LDTP13147 1.18  LDD1410 
Cell cycle checkpoint control protein RAD9A (RAD9A) LDTP10929 1.16  LDD1410 
Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) LDTP13449 1.42  LDD1410 
Cyclin-dependent kinase 19 (CDK19) LDTP11340 1.06  LDD1410 
Cyclin-dependent kinase 2 (CDK2) LDTP03299 1.12  LDD1410 
D-3-phosphoglycerate dehydrogenase (PHGDH) LDTP00701 2.83  LDD1410 
Deoxycytidine kinase (DCK) LDTP03400 1.11  LDD1410 
DNA repair protein RAD50 (RAD50) LDTP09912 2.16; 10.51  LDD1410 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 1.17  LDD1410 
Dynamin-1-like protein (DNM1L) LDTP00273 1.29  LDD1410 
Dynamin-2 (DNM2) LDTP04374 1.64  LDD1410 
E3 ubiquitin-protein ligase UBR5 (UBR5) LDTP01495 1.07  LDD1410 
Elongation factor 2 (EEF2) LDTP02672 1.11; 1.25  LDD1410 
Elongation factor G, mitochondrial (GFM1) LDTP10774 1.48  LDD1410 
ERO1-like protein alpha (ERO1A) LDTP10386 1.33; 1.35  LDD1410 
Eukaryotic translation initiation factor 3 subunit F (EIF3F) LDTP00246 1.69  LDD1410 
Galactokinase (GALK1) LDTP04424 1.25  LDD1410 
Glutaredoxin-1 (GLRX) LDTP03786 1.83  LDD1410 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 12.55  LDD1410 
Glutathione S-transferase P (GSTP1) LDTP02333 1.62  LDD1410 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 5.32  LDD1410 
Glycerol-3-phosphate phosphatase (PGP) LDTP00089 1.12  LDD1410 
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) LDTP02611 2.01; 1.48  LDD1410 
Integrin-linked protein kinase (ILK) LDTP05859 1.92  LDD1410 
Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) LDTP17082 1.15  LDD1410 
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) LDTP01333 0.88  LDD1410 
Ketosamine-3-kinase (FN3KRP) LDTP16025 1.31  LDD1410 
Mannose-1-phosphate guanyltransferase alpha (GMPPA) LDTP10418 2.33  LDD1410 
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) LDTP07651 1.65  LDD1410 
N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) LDTP11388 1.35; 1.56  LDD1410 
NEDD8-activating enzyme E1 catalytic subunit (UBA3) LDTP09338 0.95  LDD1410 
Omega-amidase NIT2 (NIT2) LDTP12428 0.96  LDD1410 
Parkinson disease protein 7 (PARK7) LDTP10878 1.15  LDD1410 
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) LDTP05912 1.00  LDD1410 
Peroxiredoxin-4 (PRDX4) LDTP05773 1.47  LDD1410 
Peroxiredoxin-5, mitochondrial (PRDX5) LDTP03512 0.90  LDD1410 
Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) LDTP01633 1.20  LDD1410 
Pre-rRNA-processing protein TSR1 homolog (TSR1) LDTP14888 1.12  LDD1410 
Probable ATP-dependent RNA helicase DDX59 (DDX59) LDTP07098 1.70; 1.74  LDD1410 
Prostaglandin E synthase 3 (PTGES3) LDTP06338 1.04  LDD1410 
Protein arginine N-methyltransferase 1 (PRMT1) LDTP10997 0.97  LDD1410 
Protein disulfide-isomerase (P4HB) LDTP02188 2.92  LDD1410 
Protein disulfide-isomerase A3 (PDIA3) LDTP03521 1.32  LDD1410 
Protein disulfide-isomerase A4 (PDIA4) LDTP02677 1.66; 1.32  LDD1410 
Protein disulfide-isomerase A6 (PDIA6) LDTP06314 1.32  LDD1410 
Pyruvate kinase PKM (PKM) LDTP02733 1.01  LDD1410 
Ras-related GTP-binding protein C (RRAGC) LDTP12166 1.45; 0.91  LDD1410 
Serine--tRNA ligase, cytoplasmic (SARS1) LDTP04265 1.40  LDD1410 
Serine/threonine-protein kinase Nek9 (NEK9) LDTP09412 0.92  LDD1410 
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) LDTP06199 0.97  LDD1410 
Serine/threonine-protein phosphatase CPPED1 (CPPED1) LDTP11107 2.10  LDD1410 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 1.54  LDD1410 
Thioredoxin (TXN) LDTP02502 1.40  LDD1410 
Thioredoxin domain-containing protein 5 (TXNDC5) LDTP09067 1.54; 2.49  LDD1410 
Thymidine kinase, cytosolic (TK1) LDTP02022 1.25  LDD1410 
Tubulin alpha-1A chain (TUBA1A) LDTP07907 1.76; 1.60; 1.71  LDD1410 
Tubulin alpha-4A chain (TUBA4A) LDTP05075 1.36; 1.92; 1.50  LDD1410 
Ubiquitin-conjugating enzyme E2 S (UBE2S) LDTP06621 1.16  LDD1410 
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) LDTP00601 1.06  LDD1410 
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) LDTP12960 1.16  LDD1410 
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⏷ Show the Full List of 76 Enzyme
13 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Apoptotic chromatin condensation inducer in the nucleus (ACIN1) LDTP13490 1.02  LDD1410 
Chloride intracellular channel protein 4 (CLIC4) LDTP14222 1.06  LDD1410 
Exportin-1 (XPO1) LDTP00501 1.09; 20.00  LDD1410 
Exportin-2 (CSE1L) LDTP04662 1.11  LDD1410 
Gasdermin-D (GSDMD) LDTP04801 1.93  LDD1410 
Importin-7 (IPO7) LDTP01574 1.13  LDD1410 
Nuclear pore complex protein Nup214 (NUP214) LDTP03777 1.38  LDD1410 
Protein SEC13 homolog (SEC13) LDTP04707 1.53  LDD1410 
Signal recognition particle 9 kDa protein (SRP9) LDTP04259 1.15  LDD1410 
Small ribosomal subunit protein RACK1 (RACK1) LDTP05057 2.59  LDD1410 
Sorting nexin-6 (SNX6) LDTP13661 1.22  LDD1410 
Thioredoxin domain-containing protein 17 (TXNDC17) LDTP11103 1.44  LDD1410 
THO complex subunit 6 homolog (THOC6) LDTP08315 0.98  LDD1410 
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⏷ Show the Full List of 13 Transporter and channel
6 Transcription factor Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Chromatin accessibility complex protein 1 (CHRAC1) LDTP12507 1.66  LDD1410 
eIF5-mimic protein 2 (BZW1) LDTP07940 1.20  LDD1410 
Non-POU domain-containing octamer-binding protein (NONO) LDTP06341 1.16  LDD1410 
Signal transducer and activator of transcription 1-alpha/beta (STAT1) LDTP03969 1.05  LDD1410 
SWI/SNF complex subunit SMARCC2 (SMARCC2) LDTP09311 5.42  LDD1410 
Transcription factor RelB (RELB) LDTP05284 1.50  LDD1410 
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⏷ Show the Full List of 6 Transcription factor
60 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Actin-related protein 2/3 complex subunit 3 (ARPC3) LDTP00552 1.18  LDD1410 
Actin-related protein 3 (ACTR3) LDTP04902 1.37  LDD1410 
AH receptor-interacting protein (AIP) LDTP00202 1.27  LDD1410 
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) LDTP05770 1.73; 1.37  LDD1410 
Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) LDTP08573 1.23  LDD1410 
Ataxin-7-like protein 3B (ATXN7L3B) LDTP15730 1.11  LDD1410 
BRISC and BRCA1-A complex member 1 (BABAM1) LDTP12737 20.00  LDD1410 
Calponin-2 (CNN2) LDTP10864 1.51; 1.34  LDD1410 
cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) LDTP02511 1.12  LDD1410 
Condensin complex subunit 2 (NCAPH) LDTP06268 1.42  LDD1410 
Coronin-1C (CORO1C) LDTP13580 1.28  LDD1410 
Crk-like protein (CRKL) LDTP04092 1.40  LDD1410 
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) LDTP06083 1.55  LDD1410 
Cytosolic iron-sulfur assembly component 2B (CIAO2B) LDTP13979 1.31  LDD1410 
Disks large-associated protein 5 (DLGAP5) LDTP06378 20.00  LDD1410 
Dynactin subunit 1 (DCTN1) LDTP06082 3.19  LDD1410 
Dynamin-binding protein (DNMBP) LDTP07755 20.00  LDD1410 
Enhancer of mRNA-decapping protein 3 (EDC3) LDTP10299 0.99  LDD1410 
Eukaryotic translation initiation factor 3 subunit M (EIF3M) LDTP07947 0.63  LDD1410 
FH1/FH2 domain-containing protein 1 (FHOD1) LDTP14195 1.27  LDD1410 
Heat shock 70 kDa protein 4 (HSPA4) LDTP03695 1.22  LDD1410 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 1.52; 0.79  LDD1410 
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) LDTP00756 1.13  LDD1410 
Integrator complex subunit 13 (INTS13) LDTP12685 1.15  LDD1410 
KH domain-containing RNA-binding protein QKI (QKI) LDTP10700 1.55  LDD1410 
Lamina-associated polypeptide 2, isoform alpha (TMPO) LDTP03967 1.25; 1.34  LDD1410 
Large ribosomal subunit protein eL24 (RPL24) LDTP05186 1.34; 1.48  LDD1410 
Large ribosomal subunit protein uL4 (RPL4) LDTP03815 1.06  LDD1410 
Mediator of RNA polymerase II transcription subunit 17 (MED17) LDTP12669 1.29  LDD1410 
Mini-chromosome maintenance complex-binding protein (MCMBP) LDTP11197 1.66  LDD1410 
MMS19 nucleotide excision repair protein homolog (MMS19) LDTP10843 1.96  LDD1410 
MOB-like protein phocein (MOB4) LDTP13964 1.11  LDD1410 
Nuclear migration protein nudC (NUDC) LDTP13817 1.05  LDD1410 
NudC domain-containing protein 1 (NUDCD1) LDTP10781 1.15  LDD1410 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 0.95; 1.40  LDD1410 
Programmed cell death 6-interacting protein (PDCD6IP) LDTP09580 6.03  LDD1410 
Proteasome activator complex subunit 1 (PSME1) LDTP05484 1.07  LDD1410 
Proteasome activator complex subunit 4 (PSME4) LDTP06250 1.63  LDD1410 
Protein diaphanous homolog 1 (DIAPH1) LDTP01011 1.17  LDD1410 
Protein misato homolog 1 (MSTO1) LDTP11239 1.22; 0.84  LDD1410 
Protein strawberry notch homolog 1 (SBNO1) LDTP14337 1.17  LDD1410 
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) LDTP04117 0.32  LDD1410 
Ribosomal protein eL42-like (RPL36AL) LDTP15677 1.56  LDD1410 
Small ribosomal subunit protein eS4, X isoform (RPS4X) LDTP04997 1.21  LDD1410 
Small ribosomal subunit protein uS12 (RPS23) LDTP04971 1.86  LDD1410 
Small ribosomal subunit protein uS17 (RPS11) LDTP04975 1.70  LDD1410 
Small ribosomal subunit protein uS7 (RPS5) LDTP04110 3.73  LDD1410 
SNW domain-containing protein 1 (SNW1) LDTP05930 1.40  LDD1410 
Stalled ribosome sensor GCN1 (GCN1) LDTP09821 5.99  LDD1410 
T-complex protein 1 subunit alpha (TCP1) LDTP02934 1.72  LDD1410 
T-complex protein 1 subunit epsilon (CCT5) LDTP04201 1.31  LDD1410 
T-complex protein 1 subunit eta (CCT7) LDTP10990 1.92  LDD1410 
T-complex protein 1 subunit theta (CCT8) LDTP04390 1.08  LDD1410 
TBC1 domain family member 23 (TBC1D23) LDTP12651 2.05  LDD1410 
THUMP domain-containing protein 1 (THUMPD1) LDTP12780 1.09  LDD1410 
Treacle protein (TCOF1) LDTP05867 1.81  LDD1410 
Tropomodulin-3 (TMOD3) LDTP18494 1.58  LDD1410 
Tubulin beta chain (TUBB) LDTP02205 1.35; 1.29  LDD1410 
Tubulin-specific chaperone D (TBCD) LDTP11212 0.89  LDD1410 
WD repeat and HMG-box DNA-binding protein 1 (WDHD1) LDTP01299 1.07  LDD1410 
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⏷ Show the Full List of 60 Other

Full Information of The Labelling Profiles of This Competitor

IA-alkyne
 Probe Info 
Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 100 uM
Quantitative Method Isotope tag
Competitor Name Fragment24
Competitor Concentration 500 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)
Interaction Atlas ID  LDD1410  Download The Altas

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.