Details of the Target

General Information of Target

Target ID LDTP04424
Target Name Galactokinase (GALK1)
Gene Name GALK1
Gene ID 2584
Synonyms
GALK; Galactokinase; EC 2.7.1.6; Galactose kinase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALRQPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELM
TVLVGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSLEPGTPRWANYVKGVIQYYPAA
PLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQVCQQAEHSFAGM
PCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRR
RQCEEVARALGKESLREVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDY
RAFGRLMVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLLEASA
APHAMRHIQEHYGGTATFYLSQAADGAKVLCL
Target Bioclass
Enzyme
Family
GHMP kinase family, GalK subfamily
Function Catalyzes the transfer of a phosphate from ATP to alpha-D-galactose and participates in the first committed step in the catabolism of galactose.
Uniprot ID
P51570
Ensemble ID
ENST00000225614.6
HGNC ID
HGNC:4118
ChEMBL ID
CHEMBL1293257

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y109(11.21); Y236(11.01); Y318(5.14)  LDD0257  [2]
TH214
 Probe Info  		Y236(9.61)  LDD0258  [2]
TH216
 Probe Info  		Y236(14.36)  LDD0259  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
Probe 1
 Probe Info  		Y109(41.91)  LDD3495  [5]
BTD
 Probe Info  		C243(0.97)  LDD1700  [6]
DA-P3
 Probe Info  		9.14  LDD0183  [7]
DBIA
 Probe Info  		C203(5.55); C243(5.51); C170(290.63); C182(290.63)  LDD0209  [8]
HHS-482
 Probe Info  		Y109(0.99)  LDD0285  [9]
HHS-465
 Probe Info  		Y109(10.00); Y236(10.00)  LDD2237  [10]
5E-2FA
 Probe Info  		N.A.  LDD2235  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C203(0.00); C351(0.00); C243(0.00); C322(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C170(0.00); C322(0.00); C203(0.00)  LDD0032  [13]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C203(0.00); C351(0.00); C322(0.00); C182(0.00)  LDD0037  [12]
NAIA_4
 Probe Info  		C203(0.00); C322(0.00)  LDD2226  [15]
TFBX
 Probe Info  		N.A.  LDD0027  [16]
WYneO
 Probe Info  		N.A.  LDD0022  [17]
IPM
 Probe Info  		N.A.  LDD0005  [17]
Phosphinate-6
 Probe Info  		C243(0.00); C170(0.00); C322(0.00)  LDD0018  [18]
1c-yne
 Probe Info  		K69(0.00); K217(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		C203(0.00); C243(0.00)  LDD0217  [20]
Methacrolein
 Probe Info  		C203(0.00); C243(0.00)  LDD0218  [20]
W1
 Probe Info  		N.A.  LDD0236  [21]
AOyne
 Probe Info  		15.00  LDD0443  [22]
NAIA_5
 Probe Info  		C182(0.00); C203(0.00); C351(0.00); C243(0.00)  LDD2223  [15]
HHS-475
 Probe Info  		Y236(1.19)  LDD2238  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C243(0.61)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C243(0.54)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C243(1.01)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C243(1.52)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C243(0.85)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C243(0.70)  LDD2131  [6]
 LDCM0214  AC1 HCT 116 C170(1.21); C182(1.12); C203(0.81); C243(1.34)  LDD0531  [23]
 LDCM0215  AC10 HCT 116 C170(1.42); C182(1.43); C203(1.33); C243(1.10)  LDD0532  [23]
 LDCM0216  AC100 HCT 116 C203(1.05); C243(1.58)  LDD0533  [23]
 LDCM0217  AC101 HCT 116 C203(1.02); C243(1.68)  LDD0534  [23]
 LDCM0218  AC102 HCT 116 C203(0.99); C243(1.39)  LDD0535  [23]
 LDCM0219  AC103 HCT 116 C203(0.89); C243(1.33)  LDD0536  [23]
 LDCM0220  AC104 HCT 116 C203(0.85); C243(1.68)  LDD0537  [23]
 LDCM0221  AC105 HCT 116 C203(0.96); C243(1.18)  LDD0538  [23]
 LDCM0222  AC106 HCT 116 C203(0.99); C243(1.32)  LDD0539  [23]
 LDCM0223  AC107 HCT 116 C203(0.89); C243(2.04)  LDD0540  [23]
 LDCM0224  AC108 HCT 116 C203(0.94); C243(1.98)  LDD0541  [23]
 LDCM0225  AC109 HCT 116 C203(1.01); C243(1.32)  LDD0542  [23]
 LDCM0226  AC11 HCT 116 C170(1.39); C182(1.44); C203(0.99); C243(1.15)  LDD0543  [23]
 LDCM0227  AC110 HCT 116 C203(1.02); C243(1.75)  LDD0544  [23]
 LDCM0228  AC111 HCT 116 C203(0.94); C243(2.10)  LDD0545  [23]
 LDCM0229  AC112 HCT 116 C203(0.94); C243(1.87)  LDD0546  [23]
 LDCM0230  AC113 HCT 116 C170(0.98); C182(0.98); C203(0.98); C243(1.25)  LDD0547  [23]
 LDCM0231  AC114 HCT 116 C170(0.98); C182(0.98); C203(0.96); C243(1.32)  LDD0548  [23]
 LDCM0232  AC115 HCT 116 C170(1.08); C182(1.08); C203(1.12); C243(1.04)  LDD0549  [23]
 LDCM0233  AC116 HCT 116 C170(1.11); C182(1.11); C203(1.09); C243(1.12)  LDD0550  [23]
 LDCM0234  AC117 HCT 116 C170(1.03); C182(1.03); C203(1.05); C243(1.04)  LDD0551  [23]
 LDCM0235  AC118 HCT 116 C170(1.46); C182(1.46); C203(1.12); C243(1.05)  LDD0552  [23]
 LDCM0236  AC119 HCT 116 C170(1.17); C182(1.17); C203(1.08); C243(1.29)  LDD0553  [23]
 LDCM0237  AC12 HCT 116 C170(1.41); C182(1.35); C203(0.95); C243(0.93)  LDD0554  [23]
 LDCM0238  AC120 HCT 116 C170(1.15); C182(1.15); C203(1.16); C243(1.26)  LDD0555  [23]
 LDCM0239  AC121 HCT 116 C170(1.06); C182(1.06); C203(1.06); C243(0.98)  LDD0556  [23]
 LDCM0240  AC122 HCT 116 C170(1.18); C182(1.18); C203(1.09); C243(1.12)  LDD0557  [23]
 LDCM0241  AC123 HCT 116 C170(0.99); C182(0.99); C203(0.97); C243(1.30)  LDD0558  [23]
 LDCM0242  AC124 HCT 116 C170(0.99); C182(0.99); C203(0.99); C243(1.42)  LDD0559  [23]
 LDCM0243  AC125 HCT 116 C170(1.05); C182(1.05); C203(1.03); C243(1.04)  LDD0560  [23]
 LDCM0244  AC126 HCT 116 C170(0.98); C182(0.98); C203(0.95); C243(0.99)  LDD0561  [23]
 LDCM0245  AC127 HCT 116 C170(1.04); C182(1.04); C203(0.97); C243(1.06)  LDD0562  [23]
 LDCM0246  AC128 HCT 116 C170(0.94); C182(0.94); C203(0.73); C243(1.24)  LDD0563  [23]
 LDCM0247  AC129 HCT 116 C170(0.87); C182(0.87); C203(0.81); C243(1.32)  LDD0564  [23]
 LDCM0249  AC130 HCT 116 C170(0.98); C182(0.98); C203(0.86); C243(1.12)  LDD0566  [23]
 LDCM0250  AC131 HCT 116 C170(0.80); C182(0.80); C203(0.74); C243(1.10)  LDD0567  [23]
 LDCM0251  AC132 HCT 116 C170(1.11); C182(1.11); C203(1.07); C243(0.86)  LDD0568  [23]
 LDCM0252  AC133 HCT 116 C170(1.20); C182(1.20); C203(1.07); C243(1.13)  LDD0569  [23]
 LDCM0253  AC134 HCT 116 C170(1.18); C182(1.18); C203(0.97); C243(1.41)  LDD0570  [23]
 LDCM0254  AC135 HCT 116 C170(1.06); C182(1.06); C203(1.03); C243(1.23)  LDD0571  [23]
 LDCM0255  AC136 HCT 116 C170(1.08); C182(1.08); C203(1.01); C243(1.41)  LDD0572  [23]
 LDCM0256  AC137 HCT 116 C170(1.09); C182(1.09); C203(1.15); C243(1.08)  LDD0573  [23]
 LDCM0257  AC138 HCT 116 C170(1.14); C182(1.14); C203(1.11); C243(1.25)  LDD0574  [23]
 LDCM0258  AC139 HCT 116 C170(1.03); C182(1.03); C203(1.02); C243(1.94)  LDD0575  [23]
 LDCM0259  AC14 HCT 116 C170(1.56); C182(1.53); C203(1.02); C243(0.89)  LDD0576  [23]
 LDCM0260  AC140 HCT 116 C170(1.10); C182(1.10); C203(1.01); C243(1.04)  LDD0577  [23]
 LDCM0261  AC141 HCT 116 C170(1.17); C182(1.17); C203(1.12); C243(1.32)  LDD0578  [23]
 LDCM0262  AC142 HCT 116 C170(1.20); C182(1.20); C203(0.98); C243(1.60)  LDD0579  [23]
 LDCM0263  AC143 HCT 116 C170(0.93); C182(0.93); C203(1.14); C243(1.00)  LDD0580  [23]
 LDCM0264  AC144 HCT 116 C170(0.94); C182(0.94); C203(1.19); C243(1.35)  LDD0581  [23]
 LDCM0265  AC145 HCT 116 C243(1.09); C170(1.12); C182(1.12); C203(1.16)  LDD0582  [23]
 LDCM0266  AC146 HCT 116 C243(0.91); C170(1.11); C182(1.11); C203(1.21)  LDD0583  [23]
 LDCM0267  AC147 HCT 116 C243(0.84); C170(1.01); C182(1.01); C203(1.05)  LDD0584  [23]
 LDCM0268  AC148 HCT 116 C243(0.47); C170(0.61); C182(0.61); C203(0.93)  LDD0585  [23]
 LDCM0269  AC149 HCT 116 C170(0.88); C182(0.88); C243(1.00); C203(1.29)  LDD0586  [23]
 LDCM0270  AC15 HCT 116 C243(0.98); C182(1.29); C203(1.31); C170(1.32)  LDD0587  [23]
 LDCM0271  AC150 HCT 116 C170(1.14); C182(1.14); C203(1.29); C243(1.34)  LDD0588  [23]
 LDCM0272  AC151 HCT 116 C243(0.82); C170(1.00); C182(1.00); C203(1.16)  LDD0589  [23]
 LDCM0273  AC152 HCT 116 C170(0.90); C182(0.90); C243(0.95); C203(1.09)  LDD0590  [23]
 LDCM0274  AC153 HCT 116 C243(0.43); C170(0.58); C182(0.58); C203(0.86)  LDD0591  [23]
 LDCM0621  AC154 HCT 116 C170(1.06); C182(1.06); C203(1.10); C243(1.22)  LDD2158  [23]
 LDCM0622  AC155 HCT 116 C170(0.94); C182(0.94); C203(1.24); C243(1.33)  LDD2159  [23]
 LDCM0623  AC156 HCT 116 C170(0.77); C182(0.77); C203(1.01); C243(1.26)  LDD2160  [23]
 LDCM0624  AC157 HCT 116 C170(0.75); C182(0.75); C203(1.02); C243(0.80)  LDD2161  [23]
 LDCM0276  AC17 HCT 116 C203(1.12); C243(1.12); C170(1.39); C182(1.39)  LDD0593  [23]
 LDCM0277  AC18 HCT 116 C243(0.94); C203(1.16); C170(1.94); C182(1.94)  LDD0594  [23]
 LDCM0278  AC19 HCT 116 C243(0.86); C203(1.13); C170(1.19); C182(1.19)  LDD0595  [23]
 LDCM0279  AC2 HCT 116 C203(0.72); C182(1.12); C170(1.15); C243(1.24)  LDD0596  [23]
 LDCM0280  AC20 HCT 116 C243(0.74); C170(1.08); C182(1.08); C203(1.41)  LDD0597  [23]
 LDCM0281  AC21 HCT 116 C243(0.84); C170(1.10); C182(1.10); C203(1.36)  LDD0598  [23]
 LDCM0282  AC22 HCT 116 C243(0.64); C203(0.94); C170(0.99); C182(0.99)  LDD0599  [23]
 LDCM0283  AC23 HCT 116 C203(0.82); C170(0.89); C182(0.89); C243(0.90)  LDD0600  [23]
 LDCM0284  AC24 HCT 116 C203(0.86); C170(1.07); C182(1.07); C243(1.10)  LDD0601  [23]
 LDCM0285  AC25 HCT 116 C203(0.99); C170(1.20); C182(1.20); C243(1.65)  LDD0602  [23]
 LDCM0286  AC26 HCT 116 C203(1.16); C243(1.41); C170(1.70); C182(1.70)  LDD0603  [23]
 LDCM0287  AC27 HCT 116 C203(1.09); C243(1.45); C170(1.49); C182(1.49)  LDD0604  [23]
 LDCM0288  AC28 HCT 116 C203(1.05); C170(1.16); C182(1.16); C243(1.38)  LDD0605  [23]
 LDCM0289  AC29 HCT 116 C170(1.04); C182(1.04); C203(1.24); C243(1.47)  LDD0606  [23]
 LDCM0290  AC3 HCT 116 C203(0.86); C182(1.05); C170(1.11); C243(1.42)  LDD0607  [23]
 LDCM0291  AC30 HCT 116 C203(1.09); C243(1.37); C170(2.31); C182(2.31)  LDD0608  [23]
 LDCM0292  AC31 HCT 116 C203(0.94); C243(1.02); C170(1.32); C182(1.32)  LDD0609  [23]
 LDCM0293  AC32 HCT 116 C203(1.07); C243(1.22); C170(1.26); C182(1.26)  LDD0610  [23]
 LDCM0294  AC33 HCT 116 C203(1.08); C170(1.24); C182(1.24); C243(1.28)  LDD0611  [23]
 LDCM0295  AC34 HCT 116 C203(1.15); C243(1.30); C170(1.32); C182(1.32)  LDD0612  [23]
 LDCM0296  AC35 HCT 116 C243(0.79); C203(1.09); C170(1.25); C182(1.25)  LDD0613  [23]
 LDCM0297  AC36 HCT 116 C243(0.83); C203(1.06); C170(1.07); C182(1.07)  LDD0614  [23]
 LDCM0298  AC37 HCT 116 C170(0.94); C182(0.94); C203(1.15); C243(1.16)  LDD0615  [23]
 LDCM0299  AC38 HCT 116 C203(1.03); C170(1.05); C182(1.05); C243(1.30)  LDD0616  [23]
 LDCM0300  AC39 HCT 116 C243(0.94); C203(1.11); C170(1.37); C182(1.37)  LDD0617  [23]
 LDCM0301  AC4 HCT 116 C203(0.89); C182(1.17); C170(1.24); C243(1.24)  LDD0618  [23]
 LDCM0302  AC40 HCT 116 C170(0.93); C182(0.93); C203(1.04); C243(1.15)  LDD0619  [23]
 LDCM0303  AC41 HCT 116 C203(1.04); C243(1.08); C170(1.22); C182(1.22)  LDD0620  [23]
 LDCM0304  AC42 HCT 116 C243(0.96); C203(1.02); C170(1.35); C182(1.35)  LDD0621  [23]
 LDCM0305  AC43 HCT 116 C203(0.96); C243(1.14); C170(1.31); C182(1.31)  LDD0622  [23]
 LDCM0306  AC44 HCT 116 C203(1.06); C243(1.14); C170(1.16); C182(1.16)  LDD0623  [23]
 LDCM0307  AC45 HCT 116 C243(0.99); C170(1.05); C182(1.05); C203(1.05)  LDD0624  [23]
 LDCM0308  AC46 HCT 116 C170(0.90); C182(0.90); C203(1.26); C243(1.47)  LDD0625  [23]
 LDCM0309  AC47 HCT 116 C170(0.96); C182(0.96); C203(1.13); C243(1.81)  LDD0626  [23]
 LDCM0310  AC48 HCT 116 C170(0.86); C182(0.86); C203(1.22); C243(1.37)  LDD0627  [23]
 LDCM0311  AC49 HCT 116 C170(0.78); C182(0.78); C243(0.90); C203(1.08)  LDD0628  [23]
 LDCM0312  AC5 HCT 116 C203(0.85); C182(1.16); C170(1.34); C243(1.59)  LDD0629  [23]
 LDCM0313  AC50 HCT 116 C170(0.85); C182(0.85); C203(1.18); C243(1.41)  LDD0630  [23]
 LDCM0314  AC51 HCT 116 C170(0.96); C182(0.96); C203(1.05); C243(1.44)  LDD0631  [23]
 LDCM0315  AC52 HCT 116 C170(0.96); C182(0.96); C203(1.12); C243(2.46)  LDD0632  [23]
 LDCM0316  AC53 HCT 116 C203(0.99); C170(1.00); C182(1.00); C243(1.25)  LDD0633  [23]
 LDCM0317  AC54 HCT 116 C203(1.07); C243(1.32); C170(1.36); C182(1.36)  LDD0634  [23]
 LDCM0318  AC55 HCT 116 C170(0.80); C182(0.80); C203(0.93); C243(1.12)  LDD0635  [23]
 LDCM0319  AC56 HCT 116 C170(0.71); C182(0.71); C203(0.93); C243(1.11)  LDD0636  [23]
 LDCM0320  AC57 HCT 116 C170(1.27); C182(1.27); C203(1.31)  LDD0637  [23]
 LDCM0321  AC58 HCT 116 C203(1.10); C170(1.25); C182(1.25)  LDD0638  [23]
 LDCM0322  AC59 HCT 116 C170(1.18); C182(1.18); C203(1.21)  LDD0639  [23]
 LDCM0323  AC6 HCT 116 C243(1.31); C203(1.31); C182(1.43); C170(1.46)  LDD0640  [23]
 LDCM0324  AC60 HCT 116 C203(1.13); C170(1.53); C182(1.53)  LDD0641  [23]
 LDCM0325  AC61 HCT 116 C203(1.13); C170(1.47); C182(1.47)  LDD0642  [23]
 LDCM0326  AC62 HCT 116 C170(1.31); C182(1.31); C203(1.46)  LDD0643  [23]
 LDCM0327  AC63 HCT 116 C203(0.97); C170(1.44); C182(1.44)  LDD0644  [23]
 LDCM0328  AC64 HCT 116 C203(1.05); C170(1.31); C182(1.31)  LDD0645  [23]
 LDCM0329  AC65 HCT 116 C203(1.04); C170(1.73); C182(1.73)  LDD0646  [23]
 LDCM0330  AC66 HCT 116 C203(0.88); C170(1.86); C182(1.86)  LDD0647  [23]
 LDCM0331  AC67 HCT 116 C170(0.79); C182(0.79); C203(1.35)  LDD0648  [23]
 LDCM0332  AC68 HCT 116 C243(1.11); C170(1.13); C182(1.13); C203(1.78)  LDD0649  [23]
 LDCM0333  AC69 HCT 116 C203(0.92); C170(0.92); C182(0.92); C243(1.21)  LDD0650  [23]
 LDCM0334  AC7 HCT 116 C243(1.02); C203(1.06); C182(1.14); C170(1.18)  LDD0651  [23]
 LDCM0335  AC70 HCT 116 C170(0.50); C182(0.50); C203(0.88); C243(1.46)  LDD0652  [23]
 LDCM0336  AC71 HCT 116 C170(0.89); C182(0.89); C243(1.05); C203(1.32)  LDD0653  [23]
 LDCM0337  AC72 HCT 116 C243(1.11); C203(1.11); C170(1.27); C182(1.27)  LDD0654  [23]
 LDCM0338  AC73 HCT 116 C170(0.48); C182(0.48); C203(0.77); C243(1.27)  LDD0655  [23]
 LDCM0339  AC74 HCT 116 C170(0.57); C182(0.57); C203(0.71); C243(1.17)  LDD0656  [23]
 LDCM0340  AC75 HCT 116 C170(0.48); C182(0.48); C203(0.67); C243(1.42)  LDD0657  [23]
 LDCM0341  AC76 HCT 116 C170(0.72); C182(0.72); C243(0.93); C203(1.04)  LDD0658  [23]
 LDCM0342  AC77 HCT 116 C203(0.80); C170(0.82); C182(0.82); C243(1.00)  LDD0659  [23]
 LDCM0343  AC78 HCT 116 C170(0.92); C182(0.92); C203(0.96); C243(1.46)  LDD0660  [23]
 LDCM0344  AC79 HCT 116 C170(0.87); C182(0.87); C203(1.13); C243(1.24)  LDD0661  [23]
 LDCM0345  AC8 HCT 116 C243(1.01); C203(1.12); C182(1.36); C170(1.39)  LDD0662  [23]
 LDCM0346  AC80 HCT 116 C170(1.20); C182(1.20); C203(1.21); C243(1.24)  LDD0663  [23]
 LDCM0347  AC81 HCT 116 C170(0.76); C182(0.76); C243(1.35); C203(1.61)  LDD0664  [23]
 LDCM0348  AC82 HCT 116 C170(0.48); C182(0.48); C203(0.83); C243(1.18)  LDD0665  [23]
 LDCM0349  AC83 HCT 116 C243(0.52); C203(0.93); C170(1.09); C182(1.09)  LDD0666  [23]
 LDCM0350  AC84 HCT 116 C243(0.58); C203(0.89); C170(0.93); C182(0.93)  LDD0667  [23]
 LDCM0351  AC85 HCT 116 C243(0.72); C170(1.01); C182(1.01); C203(1.14)  LDD0668  [23]
 LDCM0352  AC86 HCT 116 C243(0.91); C203(0.98); C170(1.21); C182(1.21)  LDD0669  [23]
 LDCM0353  AC87 HCT 116 C243(0.72); C170(0.88); C182(0.88); C203(0.97)  LDD0670  [23]
 LDCM0354  AC88 HCT 116 C170(0.78); C182(0.78); C203(1.12); C243(1.46)  LDD0671  [23]
 LDCM0355  AC89 HCT 116 C243(0.73); C170(0.96); C182(0.96); C203(1.12)  LDD0672  [23]
 LDCM0357  AC90 HCT 116 C243(0.73); C203(1.09); C170(1.14); C182(1.14)  LDD0674  [23]
 LDCM0358  AC91 HCT 116 C243(0.53); C170(0.76); C182(0.76); C203(0.85)  LDD0675  [23]
 LDCM0359  AC92 HCT 116 C243(0.66); C203(0.97); C170(1.18); C182(1.18)  LDD0676  [23]
 LDCM0360  AC93 HCT 116 C243(0.70); C203(1.02); C170(1.04); C182(1.04)  LDD0677  [23]
 LDCM0361  AC94 HCT 116 C243(0.91); C170(1.03); C182(1.03); C203(1.10)  LDD0678  [23]
 LDCM0362  AC95 HCT 116 C170(1.10); C182(1.10); C203(1.10); C243(1.10)  LDD0679  [23]
 LDCM0363  AC96 HCT 116 C243(0.83); C170(0.85); C182(0.85); C203(0.98)  LDD0680  [23]
 LDCM0364  AC97 HCT 116 C243(0.66); C203(0.94); C170(1.08); C182(1.08)  LDD0681  [23]
 LDCM0365  AC98 HCT 116 C203(0.71); C243(1.25)  LDD0682  [23]
 LDCM0366  AC99 HCT 116 C203(0.98); C243(1.32)  LDD0683  [23]
 LDCM0545  Acetamide MDA-MB-231 C243(0.29)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C243(0.76)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C170(1.39); C182(1.32); C203(1.18); C243(1.19)  LDD0565  [23]
 LDCM0356  AKOS034007680 HCT 116 C243(1.01); C203(1.07); C170(1.34); C182(1.35)  LDD0673  [23]
 LDCM0275  AKOS034007705 HCT 116 C243(1.10); C203(1.32); C170(1.44); C182(1.55)  LDD0592  [23]
 LDCM0156  Aniline NCI-H1299 11.77  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C243(0.55)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C182(1.04); C322(1.03)  LDD2214  [24]
 LDCM0108  Chloroacetamide HeLa C351(0.00); C203(0.00); C243(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C243(1.45); C351(0.88); C203(0.80)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C170(0.90); C182(0.90); C203(1.03); C243(1.07)  LDD0684  [23]
 LDCM0368  CL10 HCT 116 C243(0.88); C170(0.98); C182(0.98); C203(2.25)  LDD0685  [23]
 LDCM0369  CL100 HCT 116 C203(0.99); C182(1.08); C170(1.20); C243(1.56)  LDD0686  [23]
 LDCM0370  CL101 HCT 116 C243(0.81); C203(1.10); C182(1.39); C170(1.53)  LDD0687  [23]
 LDCM0371  CL102 HCT 116 C243(0.79); C203(1.01); C182(1.33); C170(1.39)  LDD0688  [23]
 LDCM0372  CL103 HCT 116 C243(1.03); C182(1.14); C170(1.17); C203(1.18)  LDD0689  [23]
 LDCM0373  CL104 HCT 116 C243(0.87); C203(1.17); C182(1.26); C170(1.29)  LDD0690  [23]
 LDCM0374  CL105 HCT 116 C243(0.95); C203(1.22); C170(1.53); C182(1.53)  LDD0691  [23]
 LDCM0375  CL106 HCT 116 C243(0.74); C203(1.35); C170(1.60); C182(1.60)  LDD0692  [23]
 LDCM0376  CL107 HCT 116 C243(1.11); C170(1.12); C182(1.12); C203(1.14)  LDD0693  [23]
 LDCM0377  CL108 HCT 116 C243(0.95); C203(1.12); C170(1.60); C182(1.60)  LDD0694  [23]
 LDCM0378  CL109 HCT 116 C243(0.91); C203(0.92); C170(1.20); C182(1.20)  LDD0695  [23]
 LDCM0379  CL11 HCT 116 C170(0.88); C182(0.88); C243(0.88); C203(1.41)  LDD0696  [23]
 LDCM0380  CL110 HCT 116 C203(0.88); C243(0.91); C170(1.16); C182(1.16)  LDD0697  [23]
 LDCM0381  CL111 HCT 116 C203(0.85); C170(1.00); C182(1.00); C243(1.06)  LDD0698  [23]
 LDCM0382  CL112 HCT 116 C203(0.92); C243(1.20); C170(1.24); C182(1.24)  LDD0699  [23]
 LDCM0383  CL113 HCT 116 C203(1.11); C170(1.29); C182(1.29); C243(1.34)  LDD0700  [23]
 LDCM0384  CL114 HCT 116 C203(1.02); C170(1.16); C182(1.16); C243(1.22)  LDD0701  [23]
 LDCM0385  CL115 HCT 116 C203(1.08); C170(1.30); C182(1.30); C243(1.41)  LDD0702  [23]
 LDCM0386  CL116 HCT 116 C203(1.06); C243(1.45); C170(1.77); C182(1.77)  LDD0703  [23]
 LDCM0387  CL117 HCT 116 C170(0.79); C182(0.79); C243(0.80); C203(0.80)  LDD0704  [23]
 LDCM0388  CL118 HCT 116 C243(1.07); C170(1.18); C182(1.18); C203(1.22)  LDD0705  [23]
 LDCM0389  CL119 HCT 116 C243(1.00); C203(1.07); C170(1.08); C182(1.08)  LDD0706  [23]
 LDCM0390  CL12 HCT 116 C243(0.71); C170(0.94); C182(0.94); C203(1.74)  LDD0707  [23]
 LDCM0391  CL120 HCT 116 C203(1.01); C170(1.05); C182(1.05); C243(1.22)  LDD0708  [23]
 LDCM0392  CL121 HCT 116 C203(1.05); C243(1.43); C170(2.05); C182(2.05)  LDD0709  [23]
 LDCM0393  CL122 HCT 116 C170(0.97); C182(0.97); C203(1.19); C243(2.14)  LDD0710  [23]
 LDCM0394  CL123 HCT 116 C170(0.89); C182(0.89); C203(0.95); C243(1.13)  LDD0711  [23]
 LDCM0395  CL124 HCT 116 C170(1.00); C182(1.00); C203(1.10); C243(1.46)  LDD0712  [23]
 LDCM0396  CL125 HCT 116 C170(0.98); C182(0.98); C203(1.61)  LDD0713  [23]
 LDCM0397  CL126 HCT 116 C203(0.98); C170(1.13); C182(1.13)  LDD0714  [23]
 LDCM0398  CL127 HCT 116 C203(1.01); C170(1.46); C182(1.46)  LDD0715  [23]
 LDCM0399  CL128 HCT 116 C203(1.17); C170(1.49); C182(1.49)  LDD0716  [23]
 LDCM0400  CL13 HCT 116 C243(0.88); C170(1.25); C182(1.25); C203(1.51)  LDD0717  [23]
 LDCM0401  CL14 HCT 116 C170(0.96); C182(0.96); C243(1.00); C203(1.55)  LDD0718  [23]
 LDCM0402  CL15 HCT 116 C203(1.12); C243(1.15); C170(1.17); C182(1.17)  LDD0719  [23]
 LDCM0403  CL16 HCT 116 C203(1.00); C243(1.28); C170(20.00); C182(20.00)  LDD0720  [23]
 LDCM0404  CL17 HCT 116 C203(1.01); C243(1.02); C170(3.52); C182(3.52)  LDD0721  [23]
 LDCM0405  CL18 HCT 116 C170(1.11); C182(1.11); C243(1.37); C203(1.60)  LDD0722  [23]
 LDCM0406  CL19 HCT 116 C243(1.03); C203(1.19); C170(2.22); C182(2.22)  LDD0723  [23]
 LDCM0407  CL2 HCT 116 C170(0.91); C182(0.91); C203(1.01); C243(1.86)  LDD0724  [23]
 LDCM0408  CL20 HCT 116 C243(0.86); C203(1.19); C170(1.57); C182(1.57)  LDD0725  [23]
 LDCM0409  CL21 HCT 116 C243(0.86); C170(1.01); C182(1.01); C203(1.14)  LDD0726  [23]
 LDCM0410  CL22 HCT 116 C203(1.18); C170(1.20); C182(1.20); C243(1.54)  LDD0727  [23]
 LDCM0411  CL23 HCT 116 C203(1.15); C243(1.19); C170(1.82); C182(1.82)  LDD0728  [23]
 LDCM0412  CL24 HCT 116 C170(0.88); C182(0.88); C203(1.13); C243(1.27)  LDD0729  [23]
 LDCM0413  CL25 HCT 116 C170(1.17); C182(1.17); C203(0.97); C243(1.12)  LDD0730  [23]
 LDCM0414  CL26 HCT 116 C170(1.13); C182(1.13); C203(1.11); C243(0.76)  LDD0731  [23]
 LDCM0415  CL27 HCT 116 C170(1.04); C182(1.04); C203(1.26); C243(1.33)  LDD0732  [23]
 LDCM0416  CL28 HCT 116 C170(1.57); C182(1.57); C203(1.09); C243(1.21)  LDD0733  [23]
 LDCM0417  CL29 HCT 116 C170(1.96); C182(1.96); C203(1.25); C243(1.38)  LDD0734  [23]
 LDCM0418  CL3 HCT 116 C170(1.03); C182(1.03); C203(1.06); C243(0.85)  LDD0735  [23]
 LDCM0419  CL30 HCT 116 C170(1.66); C182(1.66); C203(1.16); C243(1.44)  LDD0736  [23]
 LDCM0420  CL31 HCT 116 C170(1.14); C182(1.14); C203(1.13); C243(1.33)  LDD0737  [23]
 LDCM0421  CL32 HCT 116 C170(1.58); C182(1.58); C203(1.39); C243(0.98)  LDD0738  [23]
 LDCM0422  CL33 HCT 116 C170(0.94); C182(0.94); C203(1.03); C243(1.20)  LDD0739  [23]
 LDCM0423  CL34 HCT 116 C170(1.09); C182(1.09); C203(1.10); C243(0.96)  LDD0740  [23]
 LDCM0424  CL35 HCT 116 C170(0.96); C182(0.96); C203(0.92); C243(1.08)  LDD0741  [23]
 LDCM0425  CL36 HCT 116 C170(1.07); C182(1.07); C203(0.96); C243(0.97)  LDD0742  [23]
 LDCM0426  CL37 HCT 116 C170(0.92); C182(0.92); C203(0.87); C243(0.89)  LDD0743  [23]
 LDCM0428  CL39 HCT 116 C170(1.02); C182(1.02); C203(1.03); C243(0.88)  LDD0745  [23]
 LDCM0429  CL4 HCT 116 C170(1.02); C182(1.02); C203(0.96); C243(1.17)  LDD0746  [23]
 LDCM0430  CL40 HCT 116 C170(1.04); C182(1.04); C203(1.04); C243(1.04)  LDD0747  [23]
 LDCM0431  CL41 HCT 116 C170(1.18); C182(1.18); C203(0.96); C243(1.16)  LDD0748  [23]
 LDCM0432  CL42 HCT 116 C170(0.88); C182(0.88); C203(0.83); C243(0.89)  LDD0749  [23]
 LDCM0433  CL43 HCT 116 C170(1.04); C182(1.04); C203(0.94); C243(0.70)  LDD0750  [23]
 LDCM0434  CL44 HCT 116 C170(1.23); C182(1.23); C203(1.10); C243(0.83)  LDD0751  [23]
 LDCM0435  CL45 HCT 116 C170(1.22); C182(1.22); C203(1.11); C243(0.88)  LDD0752  [23]
 LDCM0436  CL46 HCT 116 C203(1.20); C243(1.20)  LDD0753  [23]
 LDCM0437  CL47 HCT 116 C203(1.04); C243(0.95)  LDD0754  [23]
 LDCM0438  CL48 HCT 116 C203(1.00); C243(0.88)  LDD0755  [23]
 LDCM0439  CL49 HCT 116 C203(0.96); C243(1.37)  LDD0756  [23]
 LDCM0440  CL5 HCT 116 C170(1.06); C182(1.06); C203(1.27); C243(1.36)  LDD0757  [23]
 LDCM0441  CL50 HCT 116 C203(0.98); C243(1.02)  LDD0758  [23]
 LDCM0442  CL51 HCT 116 C203(1.10); C243(1.06)  LDD0759  [23]
 LDCM0443  CL52 HCT 116 C203(1.10); C243(1.00)  LDD0760  [23]
 LDCM0444  CL53 HCT 116 C203(1.08); C243(0.92)  LDD0761  [23]
 LDCM0445  CL54 HCT 116 C203(0.94); C243(0.96)  LDD0762  [23]
 LDCM0446  CL55 HCT 116 C203(0.83); C243(1.17)  LDD0763  [23]
 LDCM0447  CL56 HCT 116 C203(0.98); C243(1.00)  LDD0764  [23]
 LDCM0448  CL57 HCT 116 C203(0.93); C243(1.04)  LDD0765  [23]
 LDCM0449  CL58 HCT 116 C203(0.93); C243(1.11)  LDD0766  [23]
 LDCM0450  CL59 HCT 116 C203(1.05); C243(1.12)  LDD0767  [23]
 LDCM0451  CL6 HCT 116 C170(1.03); C182(1.03); C203(1.15); C243(1.24)  LDD0768  [23]
 LDCM0452  CL60 HCT 116 C203(0.99); C243(0.99)  LDD0769  [23]
 LDCM0453  CL61 HCT 116 C170(0.97); C182(0.90); C203(1.01)  LDD0770  [23]
 LDCM0454  CL62 HCT 116 C170(0.90); C182(0.86); C203(0.94)  LDD0771  [23]
 LDCM0455  CL63 HCT 116 C170(0.96); C182(0.88); C203(1.02)  LDD0772  [23]
 LDCM0456  CL64 HCT 116 C170(1.06); C182(1.03); C203(1.01)  LDD0773  [23]
 LDCM0457  CL65 HCT 116 C170(0.88); C182(0.94); C203(0.96)  LDD0774  [23]
 LDCM0458  CL66 HCT 116 C170(1.13); C182(1.14); C203(1.02)  LDD0775  [23]
 LDCM0459  CL67 HCT 116 C170(1.18); C182(1.24); C203(1.12)  LDD0776  [23]
 LDCM0460  CL68 HCT 116 C170(1.02); C182(1.15); C203(0.98)  LDD0777  [23]
 LDCM0461  CL69 HCT 116 C170(0.91); C182(0.84); C203(0.99)  LDD0778  [23]
 LDCM0462  CL7 HCT 116 C170(1.14); C182(1.14); C203(1.67); C243(0.98)  LDD0779  [23]
 LDCM0463  CL70 HCT 116 C170(0.97); C182(0.98); C203(1.17)  LDD0780  [23]
 LDCM0464  CL71 HCT 116 C170(1.01); C182(1.05); C203(1.07)  LDD0781  [23]
 LDCM0465  CL72 HCT 116 C170(0.98); C182(0.92); C203(0.99)  LDD0782  [23]
 LDCM0466  CL73 HCT 116 C170(1.00); C182(0.95); C203(1.27)  LDD0783  [23]
 LDCM0467  CL74 HCT 116 C170(0.99); C182(1.04); C203(1.03)  LDD0784  [23]
 LDCM0469  CL76 HCT 116 C170(1.07); C182(1.07); C203(0.88)  LDD0786  [23]
 LDCM0470  CL77 HCT 116 C170(1.06); C182(1.06); C203(0.98)  LDD0787  [23]
 LDCM0471  CL78 HCT 116 C170(1.24); C182(1.24); C203(0.94)  LDD0788  [23]
 LDCM0472  CL79 HCT 116 C170(1.19); C182(1.19); C203(1.13)  LDD0789  [23]
 LDCM0473  CL8 HCT 116 C170(0.94); C182(0.94); C203(0.98); C243(1.07)  LDD0790  [23]
 LDCM0474  CL80 HCT 116 C170(1.34); C182(1.34); C203(1.13)  LDD0791  [23]
 LDCM0475  CL81 HCT 116 C170(1.03); C182(1.03); C203(1.02)  LDD0792  [23]
 LDCM0476  CL82 HCT 116 C170(0.91); C182(0.91); C203(1.06)  LDD0793  [23]
 LDCM0477  CL83 HCT 116 C170(1.10); C182(1.10); C203(1.13)  LDD0794  [23]
 LDCM0478  CL84 HCT 116 C170(0.82); C182(0.82); C203(1.03)  LDD0795  [23]
 LDCM0479  CL85 HCT 116 C170(1.18); C182(1.18); C203(0.89)  LDD0796  [23]
 LDCM0480  CL86 HCT 116 C170(1.18); C182(1.18); C203(1.02)  LDD0797  [23]
 LDCM0481  CL87 HCT 116 C170(1.27); C182(1.27); C203(1.14)  LDD0798  [23]
 LDCM0482  CL88 HCT 116 C170(1.03); C182(1.03); C203(1.15)  LDD0799  [23]
 LDCM0483  CL89 HCT 116 C170(0.81); C182(0.81); C203(1.02)  LDD0800  [23]
 LDCM0484  CL9 HCT 116 C170(1.10); C182(1.10); C203(1.50); C243(1.19)  LDD0801  [23]
 LDCM0485  CL90 HCT 116 C170(0.70); C182(0.70); C203(0.93)  LDD0802  [23]
 LDCM0486  CL91 HCT 116 C170(0.99); C182(0.94); C203(0.97); C243(1.16)  LDD0803  [23]
 LDCM0487  CL92 HCT 116 C170(0.92); C182(0.89); C203(0.81); C243(1.12)  LDD0804  [23]
 LDCM0488  CL93 HCT 116 C170(0.94); C182(0.88); C203(0.90); C243(1.29)  LDD0805  [23]
 LDCM0489  CL94 HCT 116 C170(1.05); C182(0.98); C203(0.77); C243(1.14)  LDD0806  [23]
 LDCM0490  CL95 HCT 116 C170(1.02); C182(0.97); C203(0.74); C243(1.00)  LDD0807  [23]
 LDCM0491  CL96 HCT 116 C170(1.05); C182(1.02); C203(0.84); C243(1.39)  LDD0808  [23]
 LDCM0492  CL97 HCT 116 C170(1.18); C182(1.12); C203(0.97); C243(1.30)  LDD0809  [23]
 LDCM0493  CL98 HCT 116 C170(1.17); C182(1.06); C203(1.02); C243(1.50)  LDD0810  [23]
 LDCM0494  CL99 HCT 116 C170(1.15); C182(1.10); C203(0.88); C243(1.81)  LDD0811  [23]
 LDCM0634  CY-0357 Hep-G2 C203(0.82)  LDD2228  [15]
 LDCM0495  E2913 HEK-293T C243(1.10); C322(1.21); C170(1.19); C182(0.90)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C203(4.45)  LDD1702  [6]
 LDCM0031  Epigallocatechin gallate HEK-293T 9.14  LDD0183  [7]
 LDCM0625  F8 Ramos C243(1.53); C351(1.08); C203(1.15); 0.47  LDD2187  [26]
 LDCM0572  Fragment10 MDA-MB-231 C182(2.28)  LDD1389  [27]
 LDCM0573  Fragment11 Ramos C182(1.19)  LDD1392  [27]
 LDCM0574  Fragment12 Ramos C182(0.92)  LDD1394  [27]
 LDCM0575  Fragment13 MDA-MB-231 C182(0.24)  LDD1395  [27]
 LDCM0576  Fragment14 MDA-MB-231 C182(2.10)  LDD1397  [27]
 LDCM0577  Fragment15 Ramos C182(2.01)  LDD1400  [27]
 LDCM0579  Fragment20 Ramos C182(3.34)  LDD1403  [27]
 LDCM0580  Fragment21 Ramos C182(1.34)  LDD1405  [27]
 LDCM0581  Fragment22 Ramos C182(0.94)  LDD1407  [27]
 LDCM0582  Fragment23 Ramos C182(1.25)  LDD1409  [27]
 LDCM0583  Fragment24 Ramos C182(1.25)  LDD1410  [27]
 LDCM0585  Fragment26 Ramos C182(0.92)  LDD1412  [27]
 LDCM0578  Fragment27 MDA-MB-231 C182(1.10)  LDD1401  [27]
 LDCM0586  Fragment28 MDA-MB-231 C182(1.17)  LDD1415  [27]
 LDCM0588  Fragment30 MDA-MB-231 C182(0.81)  LDD1419  [27]
 LDCM0589  Fragment31 Ramos C182(1.19)  LDD1422  [27]
 LDCM0590  Fragment32 MDA-MB-231 C182(1.78)  LDD1423  [27]
 LDCM0468  Fragment33 HCT 116 C170(1.09); C182(1.23); C203(1.09)  LDD0785  [23]
 LDCM0592  Fragment34 MDA-MB-231 C182(0.90)  LDD1427  [27]
 LDCM0593  Fragment35 MDA-MB-231 C182(1.34)  LDD1429  [27]
 LDCM0596  Fragment38 MDA-MB-231 C182(0.90)  LDD1433  [27]
 LDCM0597  Fragment39 MDA-MB-231 C182(1.39)  LDD1435  [27]
 LDCM0566  Fragment4 MDA-MB-231 C182(1.42)  LDD1378  [27]
 LDCM0598  Fragment40 Ramos C182(1.27)  LDD1437  [27]
 LDCM0599  Fragment41 MDA-MB-231 C182(0.81)  LDD1438  [27]
 LDCM0601  Fragment43 MDA-MB-231 C182(2.47)  LDD1441  [27]
 LDCM0604  Fragment46 MDA-MB-231 C182(1.34)  LDD1445  [27]
 LDCM0427  Fragment51 HCT 116 C170(0.86); C182(0.86); C203(0.75); C243(0.61)  LDD0744  [23]
 LDCM0610  Fragment52 MDA-MB-231 C182(1.20)  LDD1452  [27]
 LDCM0611  Fragment53 MDA-MB-231 C182(1.04)  LDD1454  [27]
 LDCM0614  Fragment56 MDA-MB-231 C182(1.03)  LDD1458  [27]
 LDCM0569  Fragment7 MDA-MB-231 C182(1.48)  LDD1383  [27]
 LDCM0570  Fragment8 Ramos C182(1.17)  LDD1386  [27]
 LDCM0571  Fragment9 MDA-MB-231 C182(1.46)  LDD1387  [27]
 LDCM0107  IAA HeLa C243(0.00); C203(0.00); H280(0.00); H229(0.00)  LDD0221  [20]
 LDCM0123  JWB131 DM93 Y109(0.99)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y109(0.61)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y109(1.44)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y109(1.76)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y109(1.51)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y109(0.88)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y109(0.40)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y109(0.98)  LDD0292  [9]
 LDCM0022  KB02 MDA-MB-231 C182(20.00)  LDD1374  [27]
 LDCM0023  KB03 Jurkat C203(5.55); C243(5.51); C170(290.63); C182(290.63)  LDD0209  [8]
 LDCM0024  KB05 COLO792 C233(1.36)  LDD3310  [28]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C243(0.47)  LDD2121  [6]
 LDCM0109  NEM HeLa H229(0.00); H280(0.00)  LDD0223  [20]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C243(0.39)  LDD2089  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C243(0.62)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C243(0.66)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C243(0.94)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C243(0.40)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C243(1.06)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C243(0.70)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C243(0.86)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C243(1.09)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C243(1.12)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C243(0.83)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C243(1.02)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C243(1.01)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C243(0.73)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C243(0.80)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C243(0.83)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C243(0.66)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C243(0.48)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C243(0.77)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C243(1.06)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C243(1.83)  LDD2119  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C243(0.65)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C243(0.75)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C243(0.59)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C243(0.72)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C243(0.99)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C243(1.18)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C243(0.71)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C243(0.54)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C243(0.50)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C243(0.81)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C243(1.15)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C243(0.92)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C243(0.97)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C243(0.56)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C243(0.57)  LDD2141  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C243(2.67)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C243(0.62)  LDD2146  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C243(0.64)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C243(0.28)  LDD2150  [6]
 LDCM0628  OTUB2-COV-1 HEK-293T C351(1.85); C203(0.71)  LDD2207  [29]
 LDCM0131  RA190 MM1.R C203(0.94)  LDD0304  [30]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proline-rich nuclear receptor coactivator 2 (PNRC2) PNRC family Q9NPJ4

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phosphoaminophosphonic Acid-adenylate Ester . DB04395

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
24 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
28 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
29 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
30 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.