Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment40					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	20.0
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	7.5
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	4.2
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	2.8
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	2.2
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	1.9
LDTP04601	Arginine--tRNA ligase, cytoplasmic (RARS1)				C34	1.6
LDTP00601	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)				C620	1.6
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	1.6
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	1.6
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	1.5
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)				C54	1.5
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	1.5
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	1.5
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C350	1.4
LDTP07098	Probable ATP-dependent RNA helicase DDX59 (DDX59)				C414	1.4
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C217	1.4
LDTP04076	Mitogen-activated protein kinase 9 (MAPK9)				C177	1.4
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	1.3
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	1.3
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	1.3
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	1.3
LDTP13147	Cathepsin Z (CTSZ)				C92	1.3
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	1.3
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	1.3
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	1.3
LDTP04424	Galactokinase (GALK1)				C182	1.3
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	1.3
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	1.2
LDTP03786	Glutaredoxin-1 (GLRX)				C23	1.2
LDTP03159	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)				C374	1.2
LDTP02022	Thymidine kinase, cytosolic (TK1)				C230	1.2
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	1.2
LDTP09338	NEDD8-activating enzyme E1 catalytic subunit (UBA3)				C237	1.2
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	1.1
LDTP09412	Serine/threonine-protein kinase Nek9 (NEK9)				C623	1.1
LDTP02693	Acylamino-acid-releasing enzyme (APEH)				C641	1.1
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	1.1
LDTP11931	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1)				C772	1.1
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	1.1
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	1.1
LDTP09912	DNA repair protein RAD50 (RAD50)				C1302	1.1
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	1.1
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	1.1
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	1.1
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	1.0
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C918	1.0
LDTP05289	AMP deaminase 2 (AMPD2)				C107	1.0
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	1.0
LDTP04987	26S proteasome regulatory subunit 10B (PSMC6)				C170	1.0
LDTP04374	Dynamin-2 (DNM2)				C27	1.0
LDTP04689	Adenosine kinase (ADK)				C353	1.0
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	1.0
LDTP03299	Cyclin-dependent kinase 2 (CDK2)				C177	0.9
LDTP05859	Integrin-linked protein kinase (ILK)				C346	0.9
LDTP14159	Ubiquitin carboxyl-terminal hydrolase 16 (USP16)				C205	0.9
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)				C86	0.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	0.9
LDTP10929	Cell cycle checkpoint control protein RAD9A (RAD9A)				C114	0.9
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C322	0.9
LDTP15306	Transmembrane protease serine 12 (TMPRSS12)				C64	0.9
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	0.9
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	0.9
LDTP03400	Deoxycytidine kinase (DCK)				C45	0.9
LDTP02672	Elongation factor 2 (EEF2)				C41	0.9
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	0.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	0.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	0.9
LDTP01333	Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)				C269	0.8
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	0.8
LDTP03400	Deoxycytidine kinase (DCK)				C9	0.8
LDTP02733	Pyruvate kinase PKM (PKM)				C423	0.8
LDTP10878	Parkinson disease protein 7 (PARK7)				C106	0.8
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	0.8
LDTP05314	ATP-dependent 6-phosphofructokinase, platelet type (PFKP)				C179	0.8
LDTP09446	Ribonuclease H2 subunit C (RNASEH2C)				C34	0.7
LDTP02329	3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)				C381	0.7
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	0.7
LDTP02672	Elongation factor 2 (EEF2)				C136	0.6

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	2.6
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	1.4
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	1.2
LDTP00501	Exportin-1 (XPO1)				C34	1.1
LDTP04707	Protein SEC13 homolog (SEC13)				C187	1.1
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	1.0
LDTP13661	Sorting nexin-6 (SNX6)				C264	1.0
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	0.8
LDTP01574	Importin-7 (IPO7)				C757	0.7
LDTP13490	Apoptotic chromatin condensation inducer in the nucleus (ACIN1)				C1223	0.7
LDTP03327	ATP synthase subunit alpha, mitochondrial (ATP5F1A)				C294	0.7
LDTP05057	Small ribosomal subunit protein RACK1 (RACK1)				C182	0.6

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP12792	CDKN2A-interacting protein (CDKN2AIP)				C516	1.6
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	1.3
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	1.1
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	0.9

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP12685	Integrator complex subunit 13 (INTS13)				C349	2.9
LDTP03865	Large ribosomal subunit protein uL3 (RPL3)				C253	1.9
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	1.8
LDTP12669	Mediator of RNA polymerase II transcription subunit 17 (MED17)				C649	1.7
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	1.7
LDTP11197	Mini-chromosome maintenance complex-binding protein (MCMBP)				C325	1.7
LDTP08573	Ankyrin repeat and KH domain-containing protein 1 (ANKHD1)				C615	1.7
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	1.6
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C561	1.5
LDTP06281	Condensin complex subunit 1 (NCAPD2)				C767	1.4
LDTP06684	Sister chromatid cohesion protein PDS5 homolog A (PDS5A)				C242	1.4
LDTP11191	WW domain-containing adapter protein with coiled-coil (WAC)				C553	1.4
LDTP00431	Kinetochore protein NDC80 homolog (NDC80)				C449	1.4
LDTP06268	Condensin complex subunit 2 (NCAPH)				C418	1.4
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	1.3
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C116	1.2
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	1.2
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	1.2
LDTP07755	Dynamin-binding protein (DNMBP)				C691	1.1
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	1.1
LDTP12737	BRISC and BRCA1-A complex member 1 (BABAM1)				C222	1.1
LDTP12754	H/ACA ribonucleoprotein complex subunit 2 (NHP2)				C18	1.1
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	1.1
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	1.1
LDTP12571	LanC-like protein 2 (LANCL2)				C187	1.1
LDTP13580	Coronin-1C (CORO1C)				C456	1.1
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	1.1
LDTP11890	Protein unc-45 homolog A (UNC45A)				C426	1.0
LDTP04117	Ras GTPase-activating-like protein IQGAP1 (IQGAP1)				C781	1.0
LDTP04902	Actin-related protein 3 (ACTR3)				C235	1.0
LDTP15701	EF-hand domain-containing protein D2 (EFHD2)				C172	1.0
LDTP06082	Dynactin subunit 1 (DCTN1)				C1252	1.0
LDTP01011	Protein diaphanous homolog 1 (DIAPH1)				C1227	1.0
LDTP11239	Protein misato homolog 1 (MSTO1)				C485	1.0
LDTP13580	Coronin-1C (CORO1C)				C420	1.0
LDTP03695	Heat shock 70 kDa protein 4 (HSPA4)				C34	1.0
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	1.0
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	0.9
LDTP04201	T-complex protein 1 subunit epsilon (CCT5)				C253	0.9
LDTP10771	Mediator of RNA polymerase II transcription subunit 15 (MED15)				C660	0.9
LDTP09821	Stalled ribosome sensor GCN1 (GCN1)				C1692	0.9
LDTP18494	Tropomodulin-3 (TMOD3)				C132	0.9
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	0.9
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	0.8
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	0.8
LDTP03244	Cofilin-1 (CFL1)				C80	0.8
LDTP05867	Treacle protein (TCOF1)				C1298	0.8
LDTP07947	Eukaryotic translation initiation factor 3 subunit M (EIF3M)				C134	0.8
LDTP06083	Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)				C1999	0.8
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	0.8
LDTP02934	T-complex protein 1 subunit alpha (TCP1)				C76	0.8
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	0.8
LDTP05008	Large ribosomal subunit protein uL14 (RPL23)				C28	0.7
LDTP10864	Calponin-2 (CNN2)				C164	0.6
LDTP04997	Small ribosomal subunit protein eS4, X isoform (RPS4X)				C41	0.5

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.