Details of the Target

General Information of Target

Target ID LDTP05770
Target Name Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)
Gene Name AIMP2
Gene ID 7965
Synonyms
JTV1; Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Multisynthase complex auxiliary component p38; Protein JTV-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPMYQVKPYHGGGAPLRVELPTCMYRLPNVHGRSYGPAPGAGHVQEESNLSLQALESRQD
DILKRLYELKAAVDGLSKMIQTPDADLDVTNIIQADEPTTLTTNALDLNSVLGKDYGALK
DIVINANPASPPLSLLVLHRLLCEHFRVLSTVHTHSSVKSVPENLLKCFGEQNKKQPRQD
YQLGFTLIWKNVPKTQMKFSIQTMCPIEGEGNIARFLFSLFGQKHNAVNATLIDSWVDIA
IFQLKEGSSKEKAAVFRSMNSALGKSPWLAGNELTVADVVLWSVLQQIGGCSVTVPANVQ
RWMRSCENLAPFNTALKLLK
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Cytoplasm, cytosol
Function
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
TTD ID
T98569
Uniprot ID
Q13155
DrugMap ID
TTXWHGF
Ensemble ID
ENST00000223029.8
HGNC ID
HGNC:20609
ChEMBL ID
CHEMBL4523285

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BICR22 SNV: p.G42V DBIA    Probe Info 
DU145 SNV: p.P311L DBIA    Probe Info 
HCT15 SNV: p.M3V DBIA    Probe Info 
HT SNV: p.T231A DBIA    Probe Info 
JURKAT SNV: p.G75D Compound 10    Probe Info 
RL952 SNV: p.R178H DBIA    Probe Info 
SKOV3 SNV: p.A129V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 44 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y25(12.06)  LDD0257  [3]
STPyne
 Probe Info  		K159(9.09); K252(5.70); K317(4.23); K70(8.54)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
Probe 1
 Probe Info  		Y35(9.08)  LDD3495  [5]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [6]
THZ1-DTB
 Probe Info  		C306(1.03); C291(0.88)  LDD0460  [6]
BTD
 Probe Info  		C23(1.11)  LDD1700  [7]
Sulforaphane-probe2
 Probe Info  		1.40  LDD0160  [8]
AHL-Pu-1
 Probe Info  		C23(2.54)  LDD0169  [9]
EA-probe
 Probe Info  		N.A.  LDD0440  [10]
HHS-482
 Probe Info  		Y35(0.94)  LDD0285  [11]
HHS-475
 Probe Info  		Y35(0.63)  LDD0264  [12]
HHS-465
 Probe Info  		Y35(3.86)  LDD2237  [13]
DBIA
 Probe Info  		C205(1.16); C23(1.01); C143(0.95)  LDD0078  [14]
5E-2FA
 Probe Info  		H43(0.00); H153(0.00)  LDD2235  [15]
ATP probe
 Probe Info  		K7(0.00); K70(0.00); K317(0.00); K320(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C168(0.00); C205(0.00); C143(0.00); C306(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C306(0.00); C23(0.00)  LDD0032  [18]
IPIAA_L
 Probe Info  		C168(0.00); C23(0.00)  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C168(0.00); C205(0.00); C143(0.00); C306(0.00)  LDD0037  [17]
JW-RF-010
 Probe Info  		C306(0.00); C168(0.00); C205(0.00)  LDD0026  [20]
NAIA_4
 Probe Info  		C23(0.00); C291(0.00)  LDD2226  [21]
TFBX
 Probe Info  		C205(0.00); C306(0.00)  LDD0027  [20]
WYneN
 Probe Info  		N.A.  LDD0021  [22]
WYneO
 Probe Info  		N.A.  LDD0022  [22]
Compound 10
 Probe Info  		C205(0.00); C23(0.00); C306(0.00)  LDD2216  [23]
Compound 11
 Probe Info  		C23(0.00); C306(0.00)  LDD2213  [23]
ENE
 Probe Info  		N.A.  LDD0006  [22]
IPM
 Probe Info  		C23(0.00); C143(0.00)  LDD0005  [22]
NHS
 Probe Info  		N.A.  LDD0010  [22]
NPM
 Probe Info  		N.A.  LDD0016  [22]
PF-06672131
 Probe Info  		N.A.  LDD0017  [24]
SF
 Probe Info  		Y4(0.00); Y35(0.00)  LDD0028  [25]
Phosphinate-6
 Probe Info  		C143(0.00); C23(0.00)  LDD0018  [26]
1c-yne
 Probe Info  		N.A.  LDD0228  [27]
Acrolein
 Probe Info  		H43(0.00); C205(0.00); H153(0.00); C143(0.00)  LDD0217  [28]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [28]
Methacrolein
 Probe Info  		C306(0.00); C143(0.00); C205(0.00); C23(0.00)  LDD0218  [28]
W1
 Probe Info  		N.A.  LDD0236  [29]
AOyne
 Probe Info  		15.00  LDD0443  [30]
NAIA_5
 Probe Info  		C168(0.00); C205(0.00); C143(0.00); C23(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [31]
FFF probe3
 Probe Info  		20.00  LDD0464  [31]
VE-P
 Probe Info  		N.A.  LDD0396  [32]
Photocelecoxib
 Probe Info  		N.A.  LDD0019  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C306(0.65)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C306(0.88); C205(1.04)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C306(1.17); C23(0.92); C143(1.43)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C23(0.96); C143(1.60)  LDD2152  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C306(0.51); C168(0.52)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C306(0.52)  LDD2131  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C23(2.54)  LDD0169  [9]
 LDCM0214  AC1 HCT 116 C143(1.28); C168(1.06); C205(1.25); C23(0.88)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C143(1.15); C168(1.21); C205(1.01); C23(0.97)  LDD0532  [14]
 LDCM0216  AC100 HCT 116 C143(0.74); C168(1.03); C205(0.66); C23(0.80)  LDD0533  [14]
 LDCM0217  AC101 HCT 116 C143(0.72); C168(0.84); C205(0.72); C23(0.83)  LDD0534  [14]
 LDCM0218  AC102 HCT 116 C143(0.73); C168(0.90); C205(0.64); C23(1.00)  LDD0535  [14]
 LDCM0219  AC103 HCT 116 C143(0.74); C168(0.70); C205(0.65); C23(1.02)  LDD0536  [14]
 LDCM0220  AC104 HCT 116 C143(0.77); C168(0.83); C205(0.71); C23(1.03)  LDD0537  [14]
 LDCM0221  AC105 HCT 116 C143(0.74); C168(0.86); C205(0.79); C23(0.96)  LDD0538  [14]
 LDCM0222  AC106 HCT 116 C143(0.74); C168(0.84); C205(0.74); C23(0.98)  LDD0539  [14]
 LDCM0223  AC107 HCT 116 C143(0.72); C168(0.88); C205(0.74); C23(1.05)  LDD0540  [14]
 LDCM0224  AC108 HCT 116 C143(0.73); C168(0.79); C205(0.75); C23(1.01)  LDD0541  [14]
 LDCM0225  AC109 HCT 116 C143(0.69); C168(0.79); C205(0.75); C23(1.15)  LDD0542  [14]
 LDCM0226  AC11 HCT 116 C143(1.25); C168(1.15); C205(1.16); C23(0.94)  LDD0543  [14]
 LDCM0227  AC110 HCT 116 C143(0.70); C168(0.83); C205(0.69); C23(1.11)  LDD0544  [14]
 LDCM0228  AC111 HCT 116 C143(0.69); C168(0.72); C205(0.71); C23(1.00)  LDD0545  [14]
 LDCM0229  AC112 HCT 116 C143(0.64); C168(0.66); C205(0.65); C23(0.97)  LDD0546  [14]
 LDCM0230  AC113 HCT 116 C143(1.07); C205(1.04); C23(1.00); C306(1.17)  LDD0547  [14]
 LDCM0231  AC114 HCT 116 C143(1.05); C205(1.03); C23(0.99); C306(1.20)  LDD0548  [14]
 LDCM0232  AC115 HCT 116 C143(1.07); C205(0.92); C23(1.11); C306(1.10)  LDD0549  [14]
 LDCM0233  AC116 HCT 116 C143(1.00); C205(1.16); C23(1.02); C306(1.01)  LDD0550  [14]
 LDCM0234  AC117 HCT 116 C143(0.99); C205(0.98); C23(1.00); C306(0.89)  LDD0551  [14]
 LDCM0235  AC118 HCT 116 C143(1.03); C205(0.99); C23(1.02); C306(1.10)  LDD0552  [14]
 LDCM0236  AC119 HCT 116 C143(1.02); C205(1.00); C23(1.03); C306(0.99)  LDD0553  [14]
 LDCM0237  AC12 HCT 116 C143(1.11); C168(1.26); C205(0.96); C23(1.00)  LDD0554  [14]
 LDCM0238  AC120 HCT 116 C143(1.10); C205(1.07); C23(1.07); C306(1.02)  LDD0555  [14]
 LDCM0239  AC121 HCT 116 C143(0.99); C205(1.03); C23(1.20); C306(1.22)  LDD0556  [14]
 LDCM0240  AC122 HCT 116 C143(1.05); C205(1.03); C23(0.95); C306(0.89)  LDD0557  [14]
 LDCM0241  AC123 HCT 116 C143(1.04); C205(1.03); C23(1.12); C306(1.91)  LDD0558  [14]
 LDCM0242  AC124 HCT 116 C143(1.01); C205(1.03); C23(1.06); C306(1.48)  LDD0559  [14]
 LDCM0243  AC125 HCT 116 C143(1.01); C205(1.03); C23(1.13); C306(1.15)  LDD0560  [14]
 LDCM0244  AC126 HCT 116 C143(1.01); C205(1.04); C23(1.17); C306(1.39)  LDD0561  [14]
 LDCM0245  AC127 HCT 116 C143(1.07); C205(1.21); C23(1.13); C306(1.30)  LDD0562  [14]
 LDCM0246  AC128 HCT 116 C143(1.21); C205(1.51); C23(0.83); C306(1.21)  LDD0563  [14]
 LDCM0247  AC129 HCT 116 C143(1.17); C205(1.27); C23(0.89); C306(0.94)  LDD0564  [14]
 LDCM0249  AC130 HCT 116 C143(1.18); C205(1.41); C23(0.97); C306(1.17)  LDD0566  [14]
 LDCM0250  AC131 HCT 116 C143(1.05); C205(1.31); C23(0.75); C306(1.02)  LDD0567  [14]
 LDCM0251  AC132 HCT 116 C143(1.02); C205(1.29); C23(0.73); C306(0.88)  LDD0568  [14]
 LDCM0252  AC133 HCT 116 C143(1.17); C205(1.43); C23(0.91); C306(0.99)  LDD0569  [14]
 LDCM0253  AC134 HCT 116 C143(1.05); C205(1.18); C23(0.84); C306(0.82)  LDD0570  [14]
 LDCM0254  AC135 HCT 116 C143(1.18); C205(1.49); C23(0.74); C306(0.86)  LDD0571  [14]
 LDCM0255  AC136 HCT 116 C143(1.15); C205(1.14); C23(0.78); C306(0.83)  LDD0572  [14]
 LDCM0256  AC137 HCT 116 C143(1.20); C205(1.14); C23(0.81); C306(0.91)  LDD0573  [14]
 LDCM0257  AC138 HCT 116 C143(1.09); C205(1.25); C23(0.72); C306(0.76)  LDD0574  [14]
 LDCM0258  AC139 HCT 116 C143(1.08); C205(1.26); C23(0.84); C306(0.91)  LDD0575  [14]
 LDCM0259  AC14 HCT 116 C143(1.20); C168(1.61); C205(1.38); C23(0.86)  LDD0576  [14]
 LDCM0260  AC140 HCT 116 C143(1.15); C205(1.25); C23(0.81); C306(0.77)  LDD0577  [14]
 LDCM0261  AC141 HCT 116 C143(1.12); C205(1.39); C23(0.90); C306(0.77)  LDD0578  [14]
 LDCM0262  AC142 HCT 116 C143(1.26); C205(1.43); C23(0.85); C306(0.80)  LDD0579  [14]
 LDCM0263  AC143 HCT 116 C143(0.90); C205(0.82); C23(1.10); C306(0.86)  LDD0580  [14]
 LDCM0264  AC144 HCT 116 C306(0.77); C143(0.97); C205(0.99); C23(1.05)  LDD0581  [14]
 LDCM0265  AC145 HCT 116 C306(0.79); C143(0.94); C205(1.08); C23(1.09)  LDD0582  [14]
 LDCM0266  AC146 HCT 116 C306(0.79); C205(0.87); C143(0.90); C23(1.08)  LDD0583  [14]
 LDCM0267  AC147 HCT 116 C306(0.78); C23(0.96); C143(1.01); C205(1.10)  LDD0584  [14]
 LDCM0268  AC148 HCT 116 C306(0.98); C205(1.11); C143(1.16); C23(2.15)  LDD0585  [14]
 LDCM0269  AC149 HCT 116 C306(0.79); C205(0.93); C143(0.96); C23(1.29)  LDD0586  [14]
 LDCM0270  AC15 HCT 116 C306(0.88); C23(0.92); C143(1.04); C205(1.08)  LDD0587  [14]
 LDCM0271  AC150 HCT 116 C306(0.78); C205(0.81); C143(0.98); C23(1.11)  LDD0588  [14]
 LDCM0272  AC151 HCT 116 C205(0.82); C306(0.82); C143(0.97); C23(1.08)  LDD0589  [14]
 LDCM0273  AC152 HCT 116 C306(0.81); C205(0.93); C143(1.12); C23(1.36)  LDD0590  [14]
 LDCM0274  AC153 HCT 116 C306(1.10); C205(1.20); C143(1.27); C23(1.58)  LDD0591  [14]
 LDCM0621  AC154 HCT 116 C143(0.92); C205(1.01); C23(1.11); C306(0.76)  LDD2158  [14]
 LDCM0622  AC155 HCT 116 C143(0.90); C205(0.83); C23(1.27); C306(0.73)  LDD2159  [14]
 LDCM0623  AC156 HCT 116 C143(0.93); C205(0.91); C23(1.21); C306(0.82)  LDD2160  [14]
 LDCM0624  AC157 HCT 116 C143(0.89); C205(0.79); C23(1.28); C306(0.85)  LDD2161  [14]
 LDCM0276  AC17 HCT 116 C168(0.79); C23(1.02); C205(1.05); C143(1.07)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C23(0.96); C143(1.03); C205(1.08); C306(1.28)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C168(0.80); C143(1.05); C205(1.08); C23(1.18)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C168(0.80); C23(0.96); C306(0.98); C143(1.04)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C168(0.79); C205(0.99); C306(1.12); C143(1.12)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C168(0.98); C143(1.00); C205(1.08); C23(1.25)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C168(0.92); C205(1.00); C143(1.03); C23(1.15)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C168(0.90); C205(0.99); C143(1.04); C306(1.06)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C168(0.72); C143(0.99); C205(1.02); C306(1.34)  LDD0601  [14]
 LDCM0285  AC25 HCT 116 C168(0.61); C306(0.91); C205(0.93); C143(0.98)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C168(0.63); C306(0.83); C205(0.87); C143(0.99)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C168(0.66); C306(0.83); C205(0.92); C143(0.94)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C168(0.62); C306(0.80); C205(0.90); C143(0.99)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C168(0.65); C306(0.81); C205(0.92); C143(0.96)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C168(1.04); C23(1.06); C306(1.08); C143(1.19)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C306(0.70); C168(0.79); C205(0.84); C143(0.94)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C306(0.79); C168(0.90); C205(0.98); C143(1.02)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C168(0.71); C306(0.71); C205(0.91); C23(0.96)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C168(0.61); C306(0.73); C205(0.88); C143(1.01)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C168(0.69); C306(0.77); C205(0.85); C143(1.04)  LDD0612  [14]
 LDCM0296  AC35 HCT 116 C143(0.89); C205(1.12); C23(1.13); C306(1.26)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C205(0.88); C143(0.96); C23(0.97); C306(1.03)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C23(0.95); C143(1.00); C205(1.02); C306(1.31)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C306(0.96); C23(0.96); C143(0.97); C205(1.02)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C205(0.99); C143(0.99); C23(1.00); C306(1.00)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C168(0.87); C23(1.06); C306(1.12); C143(1.27)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C205(0.96); C306(0.98); C23(1.00); C143(1.07)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C205(0.97); C23(1.00); C143(1.01); C306(1.09)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C23(0.95); C306(1.00); C143(1.00); C205(1.07)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C306(0.92); C23(0.99); C143(1.00); C205(1.08)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C23(0.93); C205(1.08); C143(1.13); C306(1.26)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C23(0.97); C205(1.08); C143(1.17); C306(1.44)  LDD0624  [14]
 LDCM0308  AC46 HCT 116 C205(0.92); C306(0.94); C143(0.97); C23(1.23)  LDD0625  [14]
 LDCM0309  AC47 HCT 116 C306(0.95); C205(0.96); C143(1.06); C23(1.25)  LDD0626  [14]
 LDCM0310  AC48 HCT 116 C306(0.94); C23(0.97); C205(1.02); C143(1.08)  LDD0627  [14]
 LDCM0311  AC49 HCT 116 C306(0.96); C205(0.98); C143(1.06); C23(1.13)  LDD0628  [14]
 LDCM0312  AC5 HCT 116 C23(1.09); C168(1.11); C306(1.12); C143(1.35)  LDD0629  [14]
 LDCM0313  AC50 HCT 116 C306(0.93); C205(0.95); C143(1.07); C23(1.08)  LDD0630  [14]
 LDCM0314  AC51 HCT 116 C205(0.88); C306(0.93); C143(0.94); C23(1.04)  LDD0631  [14]
 LDCM0315  AC52 HCT 116 C306(0.86); C205(0.91); C143(0.95); C23(1.17)  LDD0632  [14]
 LDCM0316  AC53 HCT 116 C306(0.85); C205(0.94); C143(1.00); C23(1.24)  LDD0633  [14]
 LDCM0317  AC54 HCT 116 C306(0.86); C205(0.93); C143(1.06); C23(1.13)  LDD0634  [14]
 LDCM0318  AC55 HCT 116 C205(0.99); C306(1.13); C143(1.19); C23(1.45)  LDD0635  [14]
 LDCM0319  AC56 HCT 116 C205(1.08); C306(1.11); C143(1.34); C23(1.46)  LDD0636  [14]
 LDCM0320  AC57 HCT 116 C23(0.71); C306(0.94); C143(1.03); C205(1.12)  LDD0637  [14]
 LDCM0321  AC58 HCT 116 C23(0.73); C306(0.77); C143(0.92); C205(1.05)  LDD0638  [14]
 LDCM0322  AC59 HCT 116 C23(0.75); C306(0.93); C168(1.00); C143(1.10)  LDD0639  [14]
 LDCM0323  AC6 HCT 116 C306(0.79); C205(0.93); C143(0.94); C23(1.01)  LDD0640  [14]
 LDCM0324  AC60 HCT 116 C23(0.78); C168(0.92); C143(1.03); C306(1.08)  LDD0641  [14]
 LDCM0325  AC61 HCT 116 C23(0.85); C306(0.85); C143(1.04); C205(1.23)  LDD0642  [14]
 LDCM0326  AC62 HCT 116 C23(0.79); C306(0.96); C143(1.02); C168(1.10)  LDD0643  [14]
 LDCM0327  AC63 HCT 116 C23(0.78); C168(0.84); C143(0.95); C205(1.27)  LDD0644  [14]
 LDCM0328  AC64 HCT 116 C23(0.71); C168(0.99); C143(1.03); C306(1.31)  LDD0645  [14]
 LDCM0329  AC65 HCT 116 C23(0.67); C306(0.75); C143(1.01); C168(1.25)  LDD0646  [14]
 LDCM0330  AC66 HCT 116 C23(0.63); C306(0.76); C143(0.92); C168(1.17)  LDD0647  [14]
 LDCM0331  AC67 HCT 116 C23(0.64); C168(0.88); C306(0.89); C143(1.04)  LDD0648  [14]
 LDCM0332  AC68 HCT 116 C306(0.94); C23(1.04); C168(1.06); C143(1.11)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C306(1.04); C205(1.07); C23(1.11); C143(1.25)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C306(0.85); C205(0.93); C23(0.94); C143(1.07)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C306(0.96); C205(1.00); C23(1.07); C143(1.17)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C23(1.03); C205(1.07); C143(1.11); C306(1.28)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C306(0.84); C205(1.02); C143(1.05); C23(1.14)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C306(1.08); C205(1.27); C23(1.35); C143(1.39)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C23(1.21); C205(1.33); C306(1.39); C168(1.52)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C306(1.07); C205(1.24); C23(1.40); C143(1.52)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C23(1.05); C205(1.11); C306(1.15); C143(1.16)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C306(0.95); C205(1.11); C23(1.18); C143(1.20)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C306(0.88); C205(0.98); C23(1.16); C143(1.18)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C306(0.85); C205(1.11); C143(1.11); C23(1.20)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C306(0.90); C168(1.03); C143(1.04); C205(1.06)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C23(1.13); C143(1.17); C205(1.18); C306(1.31)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C205(1.11); C306(1.16); C143(1.21); C23(1.28)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C205(1.26); C23(1.36); C306(1.38); C168(1.57)  LDD0665  [14]
 LDCM0349  AC83 HCT 116 C168(0.79); C306(0.80); C143(0.89); C23(0.95)  LDD0666  [14]
 LDCM0350  AC84 HCT 116 C143(0.85); C306(0.85); C23(0.87); C168(0.88)  LDD0667  [14]
 LDCM0351  AC85 HCT 116 C306(0.71); C168(0.73); C23(0.80); C143(0.83)  LDD0668  [14]
 LDCM0352  AC86 HCT 116 C306(0.59); C168(0.63); C205(0.82); C23(0.82)  LDD0669  [14]
 LDCM0353  AC87 HCT 116 C168(0.73); C306(0.74); C143(0.88); C205(0.89)  LDD0670  [14]
 LDCM0354  AC88 HCT 116 C306(0.60); C168(0.69); C205(0.83); C23(0.86)  LDD0671  [14]
 LDCM0355  AC89 HCT 116 C168(0.65); C306(0.68); C23(0.83); C143(0.90)  LDD0672  [14]
 LDCM0357  AC90 HCT 116 C168(0.54); C306(0.66); C143(0.83); C23(0.88)  LDD0674  [14]
 LDCM0358  AC91 HCT 116 C23(0.83); C306(0.90); C143(0.95); C168(1.01)  LDD0675  [14]
 LDCM0359  AC92 HCT 116 C306(0.77); C168(0.80); C23(0.84); C205(0.91)  LDD0676  [14]
 LDCM0360  AC93 HCT 116 C306(0.71); C23(0.87); C205(0.91); C143(0.92)  LDD0677  [14]
 LDCM0361  AC94 HCT 116 C23(0.75); C205(0.96); C143(0.98); C306(1.28)  LDD0678  [14]
 LDCM0362  AC95 HCT 116 C168(0.68); C306(0.79); C143(0.80); C205(0.92)  LDD0679  [14]
 LDCM0363  AC96 HCT 116 C23(0.82); C143(0.98); C205(1.20); C306(1.20)  LDD0680  [14]
 LDCM0364  AC97 HCT 116 C306(0.57); C168(0.60); C23(0.79); C205(0.82)  LDD0681  [14]
 LDCM0365  AC98 HCT 116 C306(0.63); C168(0.80); C205(0.82); C143(0.86)  LDD0682  [14]
 LDCM0366  AC99 HCT 116 C205(0.68); C306(0.69); C143(0.79); C168(0.82)  LDD0683  [14]
 LDCM0545  Acetamide MDA-MB-231 C168(0.75)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C306(0.94); C143(0.93)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C143(1.14); C168(1.32); C205(1.03); C23(0.90)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C205(1.07); C23(1.10); C306(1.12); C143(1.21)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C306(0.88); C23(0.98); C168(1.15); C143(1.15)  LDD0592  [14]
 LDCM0156  Aniline NCI-H1299 11.89  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C205(1.16); C23(1.01); C143(0.95)  LDD0078  [14]
 LDCM0498  BS-3668 MDA-MB-231 C23(0.65); C168(0.85)  LDD2091  [7]
 LDCM0630  CCW28-3 231MFP C23(1.80); C291(1.42); C205(1.41)  LDD2214  [34]
 LDCM0108  Chloroacetamide HeLa C205(0.00); H155(0.00); C143(0.00); H153(0.00)  LDD0222  [28]
 LDCM0632  CL-Sc Hep-G2 C23(20.00); C168(1.38); C23(0.81); C291(0.29)  LDD2227  [21]
 LDCM0367  CL1 HCT 116 C205(0.91); C143(0.91); C168(0.97); C306(1.08)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C306(1.01); C168(1.05); C205(1.06); C23(1.06)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C168(0.64); C306(0.98); C23(1.00); C143(1.15)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C306(0.77); C23(0.87); C205(0.99); C143(1.05)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C23(0.89); C306(0.91); C143(1.10); C205(1.11)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C205(0.99); C306(1.04); C143(1.09); C23(1.10)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C23(0.98); C306(1.04); C205(1.08); C143(1.17)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C168(1.03); C23(1.06); C143(1.06); C205(1.11)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C143(1.17); C168(1.18); C205(1.23); C23(1.30)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C168(1.06); C23(1.10); C143(1.17); C205(1.20)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C168(0.98); C23(1.07); C306(1.27); C143(1.28)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C168(0.86); C205(1.00); C143(1.07); C306(1.16)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C168(1.11); C205(1.17); C143(1.20); C306(1.22)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C168(0.97); C205(1.02); C143(1.04); C306(1.13)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C205(1.00); C168(1.04); C143(1.05); C306(1.11)  LDD0698  [14]
 LDCM0382  CL112 HCT 116 C168(0.67); C306(0.88); C143(0.90); C205(0.95)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C306(0.70); C168(0.75); C205(0.82); C143(0.94)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C306(0.71); C168(0.72); C205(0.79); C143(0.97)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C168(0.58); C306(0.71); C205(0.79); C143(0.89)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C306(0.76); C168(0.77); C205(0.92); C143(0.97)  LDD0703  [14]
 LDCM0387  CL117 HCT 116 C306(1.07); C23(1.10); C205(1.14); C143(1.22)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C23(0.98); C143(1.03); C306(1.11); C205(1.29)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C205(0.98); C143(1.01); C306(1.02); C23(1.08)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C143(1.11); C306(1.15); C205(1.23); C168(1.34)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C23(1.00); C306(1.02); C143(1.03); C205(1.06)  LDD0708  [14]
 LDCM0392  CL121 HCT 116 C306(0.72); C205(0.80); C23(0.89); C143(1.04)  LDD0709  [14]
 LDCM0393  CL122 HCT 116 C205(0.91); C306(0.92); C143(1.03); C23(1.07)  LDD0710  [14]
 LDCM0394  CL123 HCT 116 C306(0.85); C205(0.91); C143(1.02); C23(1.24)  LDD0711  [14]
 LDCM0395  CL124 HCT 116 C205(0.90); C306(0.92); C143(1.06); C23(1.15)  LDD0712  [14]
 LDCM0396  CL125 HCT 116 C306(0.83); C23(0.85); C168(0.98); C143(1.03)  LDD0713  [14]
 LDCM0397  CL126 HCT 116 C306(0.79); C205(0.90); C168(0.95); C143(1.06)  LDD0714  [14]
 LDCM0398  CL127 HCT 116 C23(0.81); C306(0.86); C168(0.93); C205(1.02)  LDD0715  [14]
 LDCM0399  CL128 HCT 116 C23(0.77); C306(0.90); C143(1.02); C205(1.20)  LDD0716  [14]
 LDCM0400  CL13 HCT 116 C306(1.14); C143(1.16); C23(1.19); C205(1.22)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C143(1.01); C168(1.03); C306(1.03); C205(1.11)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C168(1.05); C205(1.07); C306(1.08); C143(1.08)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C168(0.80); C306(0.90); C205(0.93); C143(1.02)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C306(0.82); C205(0.88); C168(0.96); C143(0.97)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C205(1.10); C168(1.12); C306(1.14); C143(1.19)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C306(0.80); C168(0.97); C205(1.01); C143(1.06)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C205(0.92); C168(0.97); C23(1.03); C143(1.04)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C306(0.81); C205(0.88); C143(0.98); C168(1.08)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C306(0.80); C143(1.01); C205(1.06); C168(1.08)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C306(1.04); C23(1.11); C205(1.22); C143(1.37)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C306(0.79); C168(0.89); C205(1.04); C143(1.19)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C306(0.87); C168(1.06); C205(1.09); C143(1.09)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C143(1.09); C168(0.93); C205(0.97); C23(1.31)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C143(1.00); C168(0.88); C205(0.92); C23(1.58)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C143(0.99); C168(1.06); C205(0.96); C23(1.07)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C143(1.02); C168(0.90); C205(1.03); C23(0.95)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C143(1.07); C168(1.08); C205(1.04); C23(1.33)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C143(0.94); C168(0.96); C205(1.01); C23(0.98)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C143(1.22); C168(0.94); C205(1.00); C23(1.38)  LDD0736  [14]
 LDCM0420  CL31 HCT 116 C143(0.95); C168(0.90); C205(1.10); C23(0.91)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C143(1.11); C168(1.01); C205(1.05); C23(0.83)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C143(1.00); C168(0.89); C205(0.91); C23(0.94)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C143(1.02); C168(1.08); C205(1.17); C23(0.89)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C143(0.99); C168(0.82); C205(1.04); C23(1.07)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C143(1.04); C168(1.02); C205(1.13); C23(0.96)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C143(1.12); C168(1.04); C205(1.13); C23(1.03)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C143(1.03); C168(1.03); C205(1.10); C23(1.03)  LDD0745  [14]
 LDCM0429  CL4 HCT 116 C143(0.94); C168(1.00); C205(1.03); C23(1.08)  LDD0746  [14]
 LDCM0430  CL40 HCT 116 C143(0.88); C168(0.76); C205(1.06); C23(1.03)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C143(0.96); C168(1.05); C205(1.18); C23(0.93)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C143(1.04); C168(1.23); C205(1.32); C23(1.08)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C143(1.00); C168(1.13); C205(1.22); C23(1.08)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C143(1.02); C168(1.06); C205(1.17); C23(1.06)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C143(1.03); C168(0.98); C205(1.23); C23(1.08)  LDD0752  [14]
 LDCM0436  CL46 HCT 116 C143(0.96); C205(0.92); C23(1.05); C306(0.92)  LDD0753  [14]
 LDCM0437  CL47 HCT 116 C143(1.05); C205(0.90); C23(1.13); C306(0.78)  LDD0754  [14]
 LDCM0438  CL48 HCT 116 C143(1.01); C205(0.88); C23(1.20); C306(1.12)  LDD0755  [14]
 LDCM0439  CL49 HCT 116 C143(1.04); C205(0.97); C23(1.14); C306(1.02)  LDD0756  [14]
 LDCM0440  CL5 HCT 116 C143(1.06); C168(1.09); C205(0.99); C23(1.24)  LDD0757  [14]
 LDCM0441  CL50 HCT 116 C143(0.93); C205(0.95); C23(1.24); C306(1.02)  LDD0758  [14]
 LDCM0442  CL51 HCT 116 C143(0.96); C205(0.95); C23(1.11); C306(1.17)  LDD0759  [14]
 LDCM0443  CL52 HCT 116 C143(0.84); C205(0.89); C23(1.09); C306(0.67)  LDD0760  [14]
 LDCM0444  CL53 HCT 116 C143(0.98); C205(0.89); C23(1.43); C306(0.86)  LDD0761  [14]
 LDCM0445  CL54 HCT 116 C143(0.97); C205(0.86); C23(1.19); C306(0.93)  LDD0762  [14]
 LDCM0446  CL55 HCT 116 C143(0.96); C205(0.91); C23(1.16); C306(0.90)  LDD0763  [14]
 LDCM0447  CL56 HCT 116 C143(1.00); C205(1.00); C23(1.08); C306(0.91)  LDD0764  [14]
 LDCM0448  CL57 HCT 116 C143(0.92); C205(0.97); C23(1.18); C306(0.73)  LDD0765  [14]
 LDCM0449  CL58 HCT 116 C143(0.98); C205(1.09); C23(1.22); C306(1.01)  LDD0766  [14]
 LDCM0450  CL59 HCT 116 C143(0.99); C205(1.00); C23(1.13); C306(0.99)  LDD0767  [14]
 LDCM0451  CL6 HCT 116 C143(1.03); C168(1.06); C205(1.06); C23(1.09)  LDD0768  [14]
 LDCM0452  CL60 HCT 116 C143(1.00); C205(0.88); C23(1.17); C306(0.80)  LDD0769  [14]
 LDCM0453  CL61 HCT 116 C143(1.28); C168(0.78); C205(0.98); C23(1.24)  LDD0770  [14]
 LDCM0454  CL62 HCT 116 C143(1.31); C168(0.62); C205(0.94); C23(1.35)  LDD0771  [14]
 LDCM0455  CL63 HCT 116 C143(1.13); C168(0.69); C205(1.06); C23(1.20)  LDD0772  [14]
 LDCM0456  CL64 HCT 116 C143(1.24); C168(0.93); C205(1.18); C23(1.06)  LDD0773  [14]
 LDCM0457  CL65 HCT 116 C143(1.30); C168(0.79); C205(1.04); C23(1.10)  LDD0774  [14]
 LDCM0458  CL66 HCT 116 C143(1.24); C168(0.76); C205(1.17); C23(1.30)  LDD0775  [14]
 LDCM0459  CL67 HCT 116 C143(1.10); C168(0.69); C205(1.02); C23(1.16)  LDD0776  [14]
 LDCM0460  CL68 HCT 116 C143(1.15); C168(0.67); C205(1.07); C23(1.25)  LDD0777  [14]
 LDCM0461  CL69 HCT 116 C143(1.21); C168(0.62); C205(1.14); C23(1.39)  LDD0778  [14]
 LDCM0462  CL7 HCT 116 C143(1.17); C168(1.28); C205(1.25); C23(1.26)  LDD0779  [14]
 LDCM0463  CL70 HCT 116 C143(1.18); C168(0.51); C205(1.06); C23(1.13)  LDD0780  [14]
 LDCM0464  CL71 HCT 116 C143(1.00); C168(0.69); C205(1.04); C23(1.36)  LDD0781  [14]
 LDCM0465  CL72 HCT 116 C143(1.13); C168(0.87); C205(0.95); C23(1.49)  LDD0782  [14]
 LDCM0466  CL73 HCT 116 C143(1.16); C168(0.79); C205(1.06); C23(1.12)  LDD0783  [14]
 LDCM0467  CL74 HCT 116 C143(1.12); C168(0.60); C205(1.08); C23(1.35)  LDD0784  [14]
 LDCM0469  CL76 HCT 116 C143(1.01); C168(1.33); C205(1.08); C23(0.99)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C143(1.00); C168(1.59); C205(1.09); C23(0.85)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C143(1.05); C168(0.99); C205(0.96); C23(0.91)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C143(1.03); C168(1.34); C205(1.18); C23(0.93)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C143(1.15); C168(1.04); C205(1.06); C23(1.38)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C143(1.12); C168(1.08); C205(1.20); C23(0.96)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C143(1.04); C168(1.49); C205(1.17); C23(1.00)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C143(1.22); C168(1.15); C205(1.35); C23(0.93)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C143(1.21); C168(1.44); C205(1.25); C23(0.93)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C143(1.27); C168(1.24); C205(1.43); C23(1.03)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C143(1.08); C168(1.25); C205(1.10); C23(0.97)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C143(1.12); C168(1.39); C205(1.16); C23(0.95)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C143(1.05); C168(1.26); C205(1.16); C23(0.88)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C143(1.14); C168(1.39); C205(1.34); C23(0.86)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C143(1.42); C168(1.23); C205(1.51); C23(1.07)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C143(0.99); C168(0.95); C205(1.03); C23(1.20)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C143(0.98); C168(1.30); C205(1.06); C23(0.98)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C143(1.07); C168(0.89); C205(1.09); C23(0.94)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C143(1.04); C168(0.86); C205(1.01); C23(0.96)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C143(1.15); C168(0.82); C205(1.10); C23(1.20)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C143(1.06); C168(0.80); C205(1.03); C23(0.88)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C143(0.94); C168(0.82); C205(1.01); C23(0.87)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C143(1.06); C168(1.09); C205(1.04); C23(1.01)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C143(1.01); C168(0.76); C205(1.06); C23(0.91)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C143(1.21); C168(0.98); C205(1.20); C23(0.98)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C143(1.17); C168(0.99); C205(1.16); C23(0.91)  LDD0811  [14]
 LDCM0634  CY-0357 Hep-G2 C291(4.23); C168(2.02)  LDD2228  [21]
 LDCM0495  E2913 HEK-293T C143(0.90); C23(1.02); C205(1.01); C306(0.84)  LDD1698  [35]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C23(2.55); C143(1.41)  LDD1702  [7]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [10]
 LDCM0625  F8 Ramos C168(1.51); C143(0.93); C306(0.79); C205(0.91)  LDD2187  [36]
 LDCM0572  Fragment10 MDA-MB-231 C291(1.85); C23(2.53)  LDD1389  [37]
 LDCM0573  Fragment11 MDA-MB-231 C291(2.35); C23(2.19)  LDD1391  [37]
 LDCM0574  Fragment12 MDA-MB-231 C291(1.28); C23(2.02)  LDD1393  [37]
 LDCM0575  Fragment13 MDA-MB-231 C291(0.88)  LDD1395  [37]
 LDCM0576  Fragment14 MDA-MB-231 C291(1.98); C23(1.45)  LDD1397  [37]
 LDCM0577  Fragment15 MDA-MB-231 C291(1.05)  LDD1399  [37]
 LDCM0579  Fragment20 MDA-MB-231 C291(1.42)  LDD1402  [37]
 LDCM0580  Fragment21 MDA-MB-231 C291(0.94); C23(1.10)  LDD1404  [37]
 LDCM0581  Fragment22 Ramos C291(1.04); C23(0.89)  LDD1407  [37]
 LDCM0582  Fragment23 MDA-MB-231 C291(1.27); C23(0.98)  LDD1408  [37]
 LDCM0583  Fragment24 Ramos C291(1.73); C23(1.37)  LDD1410  [37]
 LDCM0584  Fragment25 MDA-MB-231 C291(1.00); C23(0.95)  LDD1411  [37]
 LDCM0585  Fragment26 Ramos C291(1.00); C23(1.09)  LDD1412  [37]
 LDCM0578  Fragment27 MDA-MB-231 C291(0.93); C23(0.80)  LDD1401  [37]
 LDCM0586  Fragment28 MDA-MB-231 C291(0.96); C23(0.91)  LDD1415  [37]
 LDCM0587  Fragment29 MDA-MB-231 C291(1.23)  LDD1417  [37]
 LDCM0588  Fragment30 MDA-MB-231 C291(0.80); C23(0.92)  LDD1419  [37]
 LDCM0589  Fragment31 MDA-MB-231 C291(1.48); C23(2.02)  LDD1421  [37]
 LDCM0590  Fragment32 MDA-MB-231 C291(1.78); C23(4.08)  LDD1423  [37]
 LDCM0468  Fragment33 HCT 116 C143(1.13); C168(0.82); C205(1.07); C23(1.19)  LDD0785  [14]
 LDCM0592  Fragment34 Ramos C23(0.98)  LDD1428  [37]
 LDCM0593  Fragment35 Ramos C23(1.02)  LDD1430  [37]
 LDCM0594  Fragment36 MDA-MB-231 C291(1.75); C23(2.04)  LDD1431  [37]
 LDCM0595  Fragment37 Ramos C23(0.87)  LDD1432  [37]
 LDCM0596  Fragment38 MDA-MB-231 C291(1.03); C23(1.29)  LDD1433  [37]
 LDCM0597  Fragment39 MDA-MB-231 C291(1.51)  LDD1435  [37]
 LDCM0566  Fragment4 MDA-MB-231 C291(14.76); C23(1.53)  LDD1378  [37]
 LDCM0598  Fragment40 MDA-MB-231 C291(0.94); C23(0.70)  LDD1436  [37]
 LDCM0599  Fragment41 MDA-MB-231 C291(1.39); C23(1.20)  LDD1438  [37]
 LDCM0600  Fragment42 Ramos C291(0.90); C23(0.85)  LDD1440  [37]
 LDCM0601  Fragment43 MDA-MB-231 C291(2.09)  LDD1441  [37]
 LDCM0602  Fragment44 MDA-MB-231 C291(0.97)  LDD1443  [37]
 LDCM0603  Fragment45 MDA-MB-231 C291(20.00); C23(20.00)  LDD1444  [37]
 LDCM0604  Fragment46 MDA-MB-231 C291(1.00); C23(0.82)  LDD1445  [37]
 LDCM0605  Fragment47 MDA-MB-231 C291(1.36); C23(1.34)  LDD1446  [37]
 LDCM0606  Fragment48 MDA-MB-231 C291(1.22)  LDD1447  [37]
 LDCM0607  Fragment49 MDA-MB-231 C23(5.26)  LDD1448  [37]
 LDCM0608  Fragment50 MDA-MB-231 C291(20.00)  LDD1449  [37]
 LDCM0427  Fragment51 HCT 116 C143(0.87); C168(0.93); C205(1.25); C23(0.97)  LDD0744  [14]
 LDCM0610  Fragment52 MDA-MB-231 C291(1.21); C23(0.85)  LDD1452  [37]
 LDCM0611  Fragment53 MDA-MB-231 C291(1.04)  LDD1454  [37]
 LDCM0614  Fragment56 MDA-MB-231 C291(1.12); C23(1.04)  LDD1458  [37]
 LDCM0568  Fragment6 MDA-MB-231 C291(1.39)  LDD1382  [37]
 LDCM0569  Fragment7 MDA-MB-231 C291(1.72); C23(1.30)  LDD1383  [37]
 LDCM0570  Fragment8 MDA-MB-231 C291(3.09)  LDD1385  [37]
 LDCM0571  Fragment9 MDA-MB-231 C291(1.11); C23(1.54)  LDD1387  [37]
 LDCM0116  HHS-0101 DM93 Y35(0.63)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y35(0.55)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y35(0.66)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y35(0.56)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y35(0.65)  LDD0268  [12]
 LDCM0015  HNE MDA-MB-231 C23(0.92)  LDD0346  [36]
 LDCM0107  IAA HeLa H155(0.00); H153(0.00); C143(0.00); H145(0.00)  LDD0221  [28]
 LDCM0123  JWB131 DM93 Y35(0.94)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y35(0.53)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y35(1.22)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y35(5.74)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y35(1.71)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y35(2.52)  LDD0290  [11]
 LDCM0130  JWB211 DM93 Y35(0.70)  LDD0292  [11]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [6]
 LDCM0022  KB02 MDA-MB-231 C291(20.00); C23(4.03)  LDD1374  [37]
 LDCM0023  KB03 Jurkat C23(36.81)  LDD0209  [38]
 LDCM0024  KB05 COLO792 C205(1.95); C74(3.21); C306(5.78); C23(5.69)  LDD3310  [39]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C23(0.82); C168(0.98)  LDD2121  [7]
 LDCM0109  NEM HeLa H153(0.00); H43(0.00); H155(0.00); H145(0.00)  LDD0223  [28]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C23(0.66); C168(0.89)  LDD2089  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C143(1.03)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C306(1.28); C23(1.23); C143(1.33)  LDD2093  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C306(0.98); C143(1.04)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C143(0.94)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C23(0.79)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C306(0.34)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C306(0.82)  LDD2101  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C205(0.73)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C23(0.89); C143(1.24)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C306(0.94); C168(0.55)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C306(0.72); C23(0.98); C205(0.91); C143(0.78)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C306(1.05); C23(1.14); C143(1.29)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C205(0.80)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C306(0.59); C143(0.47)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C306(1.04)  LDD2116  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C306(1.21); C23(2.17); C143(1.52)  LDD2119  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C306(0.98); C23(0.83); C143(1.26)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C306(1.43); C23(0.85); C205(1.03)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C306(1.10); C23(0.98); C143(1.57)  LDD2127  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C306(1.16); C23(0.78)  LDD2129  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C306(0.64); C23(0.26); C143(0.47)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C306(1.47); C23(0.92); C143(2.89)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C306(1.17); C23(1.48); C143(1.82)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C306(0.90); C23(1.17); C205(1.18); C143(1.08)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C23(1.11)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C306(1.22); C23(0.74); C143(0.63)  LDD2140  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C306(2.16); C23(2.31); C143(1.66)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C306(0.94); C23(0.83); C205(1.22); C143(1.22)  LDD2146  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C306(1.00)  LDD2150  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C23(0.96); C168(0.88)  LDD2206  [40]
 LDCM0628  OTUB2-COV-1 HEK-293T C23(2.19); C168(0.99); C291(0.92); C205(0.61)  LDD2207  [40]
 LDCM0131  RA190 MM1.R C306(1.90); C23(1.54); C205(1.38)  LDD0304  [41]
 LDCM0003  Sulforaphane MDA-MB-231 1.40  LDD0160  [8]
 LDCM0021  THZ1 HeLa S3 C306(1.03); C291(0.88)  LDD0460  [6]
 LDCM0111  W14 Hep-G2 C23(12.12)  LDD0238  [29]
 LDCM0112  W16 Hep-G2 C23(1.23)  LDD0239  [29]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysine--tRNA ligase (KARS1) Class-II aminoacyl-tRNA synthetase family Q15046
Aspartate--tRNA ligase, cytoplasmic (DARS1) Class-II aminoacyl-tRNA synthetase family P14868
Glycogen [starch] synthase, muscle (GYS1) Glycosyltransferase 3 family P13807
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) L-isoaspartyl/D-aspartyl protein methyltransferase family P22061
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Uncharacterized serine/threonine-protein kinase SBK3 (SBK3) Ser/Thr protein kinase family P0C264
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) . Q8N5A5
Other
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bystin (BYSL) Bystin family Q13895
Cep170-like protein (CEP170P1) CEP170 family Q96L14
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Mitochondria-eating protein (SPATA18) MIEAP family Q8TC71
Protein Mis18-alpha (MIS18A) Mis18 family Q9NYP9
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
Prefoldin subunit 6 (PFDN6) Prefoldin subunit beta family O15212
Rab GTPase-binding effector protein 1 (RABEP1) Rabaptin family Q15276
Pre-mRNA-splicing factor SLU7 (SLU7) SLU7 family O95391
Pre-mRNA-splicing factor SPF27 (BCAS2) SPF27 family O75934
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) . Q12904
Break repair meiotic recombinase recruitment factor 1 (BRME1) . Q0VDD7
Far upstream element-binding protein 1 (FUBP1) . Q96AE4
Four and a half LIM domains protein 3 (FHL3) . Q13643
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Rhombotin-2 (LMO2) . P25791
Testis-expressed protein 12 (TEX12) . Q9BXU0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
24 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
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Mass spectrometry data entry: PXD007094
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840
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