Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment53  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 97 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02733  Pyruvate kinase PKM (PKM) C423 20.0
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 2.3
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 2.1
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 1.3
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.3
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.2
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.2
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.1
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 1.1
 LDTP02223  Cathepsin B (CTSB) C211 1.1
 LDTP05373  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) C680 1.1
 LDTP03644  Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) C120 1.1
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 1.1
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 1.1
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 1.1
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) C205 1.1
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 1.1
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 1.1
 LDTP04424  Galactokinase (GALK1) C182 1.0
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.0
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.0
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 1.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 1.0
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 1.0
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 1.0
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.0
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.0
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 1.0
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 1.0
 LDTP04374  Dynamin-2 (DNM2) C27 1.0
 LDTP03496  Protein PML (PML) C389 1.0
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 1.0
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 1.0
 LDTP02672  Elongation factor 2 (EEF2) C41 1.0
 LDTP02672  Elongation factor 2 (EEF2) C136 1.0
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.0
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 1.0
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.0
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C147 1.0
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 1.0
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 1.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.0
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.0
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.0
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 1.0
 LDTP02223  Cathepsin B (CTSB) C319 1.0
 LDTP10929  Cell cycle checkpoint control protein RAD9A (RAD9A) C114 1.0
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.0
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 1.0
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 0.9
 LDTP13147  Cathepsin Z (CTSZ) C173 0.9
 LDTP05289  AMP deaminase 2 (AMPD2) C107 0.9
 LDTP16095  Ethylmalonyl-CoA decarboxylase (ECHDC1) C133 0.9
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 0.9
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 0.9
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 0.9
 LDTP04689  Adenosine kinase (ADK) C353 0.9
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) C622 0.9
 LDTP02502  Thioredoxin (TXN) C32 0.9
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 0.9
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 0.9
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.9
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 0.9
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 0.9
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 0.9
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 0.9
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 0.9
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 0.9
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.9
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 0.9
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.9
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.9
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 0.9
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.9
 LDTP13147  Cathepsin Z (CTSZ) C92 0.9
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.9
 LDTP13080  GMP reductase 2 (GMPR2) C186 0.9
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 0.9
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 0.8
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 0.8
 LDTP02693  Acylamino-acid-releasing enzyme (APEH) C641 0.8
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 0.8
 LDTP07098  Probable ATP-dependent RNA helicase DDX59 (DDX59) C414 0.8
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 0.8
 LDTP03400  Deoxycytidine kinase (DCK) C9 0.7
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 0.7
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 0.7
 LDTP09446  Ribonuclease H2 subunit C (RNASEH2C) C34 0.7
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C100 0.7
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.6
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 0.6
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) C308 0.5
Transporter and channel
Click to Show/Hide to Show 15 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04662  Exportin-2 (CSE1L) C842 1.1
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 1.1
 LDTP04801  Gasdermin-D (GSDMD) C268 1.1
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 1.0
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 1.0
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.0
 LDTP00196  Unconventional myosin-Ic (MYO1C) C802 1.0
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 0.9
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 0.9
 LDTP09204  Nucleoporin NUP35 (NUP35) C255 0.9
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 0.9
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 0.9
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 0.9
 LDTP00501  Exportin-1 (XPO1) C34 0.9
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 0.8
Transcription factor
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 1.1
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 1.0
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.0
 LDTP10756  Nucleus accumbens-associated protein 1 (NACC1) C416 0.9
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 0.9
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 0.9
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.8
Other
Click to Show/Hide to Show 80 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 20.0
 LDTP13925  Nucleolar protein 58 (NOP58) C106 1.8
 LDTP10613  Dedicator of cytokinesis protein 7 (DOCK7) C2125 1.5
 LDTP12412  Reticulon-4 (RTN4) C1101 1.4
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 1.3
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.2
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 1.2
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.1
 LDTP12443  Anillin (ANLN) C712 1.1
 LDTP06681  Inverted formin-2 (INF2) C332 1.1
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 1.1
 LDTP14195  FH1/FH2 domain-containing protein 1 (FHOD1) C502 1.1
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 1.1
 LDTP04487  Cyclin-H (CCNH) C244 1.1
 LDTP02205  Tubulin beta chain (TUBB) C239 1.1
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 1.1
 LDTP06330  Plectin (PLEC) C992 1.1
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.1
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.1
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 1.1
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.0
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) C253 1.0
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.0
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 1.0
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.0
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 1.0
 LDTP01320  Eukaryotic translation initiation factor 3 subunit J (EIF3J) C207 1.0
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.0
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 1.0
 LDTP10864  Calponin-2 (CNN2) C164 1.0
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 1.0
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.0
 LDTP06330  Plectin (PLEC) C3110 1.0
 LDTP10864  Calponin-2 (CNN2) C215 1.0
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) C18 1.0
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 1.0
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) C781 1.0
 LDTP04363  Serpin H1 (SERPINH1) C156 1.0
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.0
 LDTP01532  ZW10 interactor (ZWINT) C54 1.0
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 1.0
 LDTP18494  Tropomodulin-3 (TMOD3) C132 1.0
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.0
 LDTP02205  Tubulin beta chain (TUBB) C354 1.0
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 1.0
 LDTP10284  Multivesicular body subunit 12A (MVB12A) C231 1.0
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 0.9
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 0.9
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 0.9
 LDTP03620  Protein S100-A11 (S100A11) C91 0.9
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 0.9
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 0.9
 LDTP04902  Actin-related protein 3 (ACTR3) C235 0.9
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 0.9
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 0.9
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 0.9
 LDTP06542  Cysteine and glycine-rich protein 2 (CSRP2) C33 0.9
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 0.9
 LDTP13580  Coronin-1C (CORO1C) C420 0.9
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 0.9
 LDTP02692  Plastin-3 (PLS3) C33 0.9
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 0.9
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 0.9
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) C195 0.9
 LDTP12571  LanC-like protein 2 (LANCL2) C187 0.9
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.9
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.9
 LDTP12638  Protein lin-7 homolog C (LIN7C) C47 0.9
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 0.9
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.9
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 0.9
 LDTP11235  Protein PAXX (PAXX) C180 0.9
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 0.8
 LDTP02631  Alpha-actinin-1 (ACTN1) C370 0.8
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.8
 LDTP13580  Coronin-1C (CORO1C) C456 0.8
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 0.8
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.8
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 0.8
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 0.5

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.