Details of the Target

General Information of Target

Target ID LDTP12960
Target Name [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1)
Gene Name PDP1
Gene ID 54704
Synonyms
PDP; PPM2C; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; PDP 1; EC 3.1.3.43; Protein phosphatase 2C; Pyruvate dehydrogenase phosphatase catalytic subunit 1; PDPC 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMLAIGIGTLIYGHWSIMKWNRERRRL
QIEDFEARIALLPLLQAETDRRTLQMLRENLEEEAIIMKDVPDWKVGESVFHTTRWVPPL
IGELYGLRTTEEALHASHGFMWYT
Target Bioclass
Enzyme
Family
PP2C family
Subcellular location
Mitochondrion matrix
Function
Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA.
Uniprot ID
Q9P0J1
Ensemble ID
ENST00000297598.5
HGNC ID
HGNC:9279

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.S304Ter .
COLO678 SNV: p.Y451Ter .
HCT116 SNV: p.N379D .
HCT15 SNV: p.A274V .
KASUMI2 SNV: p.R405Ter .
MOLT4 SNV: p.A478T .
TE1 SNV: p.V232F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K206(1.92); K468(0.89); K502(5.33)  LDD0277  [3]
Probe 1
 Probe Info  		Y381(14.84)  LDD3495  [4]
BTD
 Probe Info  		C132(1.27)  LDD2089  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
DBIA
 Probe Info  		C132(1.03); C275(1.09); C149(0.92)  LDD1492  [7]
CY-1
 Probe Info  		N.A.  LDD0246  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		C132(0.00); C149(0.00); C151(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
IPM
 Probe Info  		N.A.  LDD0005  [10]
Phosphinate-6
 Probe Info  		C151(0.00); C149(0.00)  LDD0018  [11]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		16.68  LDD1752  [12]
C106
 Probe Info  		53.82  LDD1793  [12]
C108
 Probe Info  		18.90  LDD1795  [12]
C169
 Probe Info  		34.78  LDD1849  [12]
C174
 Probe Info  		9.13  LDD1854  [12]
C206
 Probe Info  		99.73  LDD1881  [12]
FFF probe13
 Probe Info  		20.00  LDD0475  [13]
FFF probe2
 Probe Info  		20.00  LDD0463  [13]
JN0003
 Probe Info  		20.00  LDD0469  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C132(1.09); C149(0.98)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C132(0.96); C149(1.00)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C149(0.91)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C149(1.00)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C149(0.91)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C132(0.98); C149(0.97)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C132(0.98); C149(1.04)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C132(1.02); C149(0.95)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C149(0.81)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C132(0.91); C149(1.06)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C149(0.95)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C132(1.16); C149(0.91)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C149(0.93)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C132(0.77); C149(1.04)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C132(0.90); C149(1.06)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C132(1.09); C149(1.04)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C132(1.02); C149(0.96)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C149(1.04)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C149(0.96)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C132(1.28); C149(0.97)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C149(0.94)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C149(0.93)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C132(0.85); C149(1.00)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C132(0.98); C149(0.97)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C132(1.04); C149(0.98)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C132(1.05); C149(1.00)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C149(0.98)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C149(0.98)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C132(1.03); C149(0.95)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C149(1.01)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C132(0.87); C149(0.97)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C149(0.96)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C132(1.03); C149(0.89)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C132(1.07); C149(1.03)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C132(0.99); C149(1.00)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C149(0.98)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C149(0.91)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C132(1.18); C149(0.91)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C149(0.98)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C132(0.96); C149(1.01)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C132(0.85); C149(0.96)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C132(1.00); C149(1.03)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C132(1.33); C149(0.94)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C132(0.95); C149(1.00)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C149(0.89)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C149(0.93)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C132(1.12); C149(0.97)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C149(0.91)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C132(0.96); C149(1.01)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C132(0.88); C149(0.92)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C132(1.01); C149(1.03)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C132(0.99); C149(0.97)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C149(0.94)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C149(0.88)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C149(0.97)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C132(0.98); C149(0.90)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C149(0.95)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C132(0.94); C149(0.98)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C132(0.76); C149(1.03)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C132(0.67); C149(0.99)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C132(0.87); C149(0.92)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C132(1.13); C149(0.93)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C132(1.02); C149(0.98)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C132(0.98); C149(0.90)  LDD1514  [7]
 LDCM0156  Aniline NCI-H1299 12.00  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C149(2.74)  LDD2214  [14]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C132(1.00); C149(0.99)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C149(1.02)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C132(0.91); C149(1.09)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C132(0.98); C149(1.15)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C132(0.99); C149(1.13)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C132(1.08); C149(1.03)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C132(0.86); C149(1.16)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C132(1.02); C149(1.07)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C132(0.84); C149(1.12)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C132(1.23); C149(0.95)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C132(0.97); C149(1.11)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C132(0.86); C149(1.25)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C132(0.75); C149(1.30)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C132(0.67); C149(1.62)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C132(0.93); C149(1.13)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C132(1.02); C149(1.23)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C132(1.15); C149(0.87)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C132(0.75); C149(1.98)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C132(1.07); C149(1.09)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C132(0.95); C149(1.13)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C132(1.00); C149(0.98)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C132(1.06); C149(0.89)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C132(1.16); C149(0.99)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C132(0.82); C149(1.29)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C132(1.01); C149(1.05)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C132(0.99); C149(1.16)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C132(1.03); C149(0.88)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C132(0.94); C149(0.98)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C132(0.90); C149(1.14)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C132(1.05); C149(0.98)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C132(0.88); C149(0.97)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C132(1.17); C149(1.02)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C132(0.95); C149(1.06)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C132(0.99); C149(1.34)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C132(1.22); C149(1.00)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C132(0.81); C149(1.06)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C132(0.96); C149(1.07)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C132(0.77); C149(1.24)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C132(1.07); C149(1.07)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C149(1.08)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C132(1.08); C149(0.98)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C149(1.20)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C132(1.00); C149(1.18)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C149(1.10)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C132(1.05); C149(1.13)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C132(0.86); C149(1.10)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C132(0.88); C149(1.10)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C132(1.11); C149(0.85)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C132(1.29); C149(0.94)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C132(1.06); C149(1.05)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C132(1.04); C149(0.98)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C132(1.02); C149(1.17)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C132(1.09); C149(0.96)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C149(1.03)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C149(1.16)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C132(1.03); C149(0.87)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C149(1.12)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C132(0.89); C149(1.21)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C132(0.86); C149(1.16)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C132(1.01); C149(0.93)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C132(0.98); C149(1.11)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C132(0.96); C149(1.18)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C132(1.10); C149(1.10)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C132(0.96); C149(1.44)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C132(1.11); C149(1.12)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C149(0.90)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C149(1.09)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C132(1.13); C149(1.02)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C149(1.14)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C132(0.95); C149(1.21)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C132(0.77); C149(1.16)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C132(1.11); C149(0.88)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C132(1.04); C149(1.09)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C132(0.99); C149(1.41)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C132(1.23); C149(1.02)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C132(0.90); C149(1.77)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C132(1.10); C149(0.93)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C149(1.12)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C149(1.15)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C132(1.05); C149(1.07)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C149(1.01)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C132(1.01); C149(1.22)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C132(0.82); C149(2.53)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C132(0.84); C149(1.30)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C132(1.02); C149(0.92)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C132(1.17); C149(0.89)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C132(1.20); C149(1.03)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C132(0.65); C149(1.25)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C132(1.18); C149(1.00)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C132(1.02); C149(1.12)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C149(1.03)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C149(1.02)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C132(1.17); C149(0.95)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C149(1.05)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C149(1.11)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C132(0.83); C149(1.72)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C132(0.84); C149(1.21)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C132(1.09); C149(0.96)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C132(0.93); C149(1.11)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C132(1.02); C149(1.09)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C132(0.88); C149(1.27)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C132(1.06); C149(1.03)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C149(0.89)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C149(0.94)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C149(0.99)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C132(1.16); C149(0.99)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C149(1.07)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C132(0.86); C149(1.24)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C132(0.84); C149(1.42)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C132(1.09); C149(0.91)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C132(1.11); C149(0.92)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C132(1.08); C149(1.02)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C132(1.04); C149(1.07)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C132(0.99); C149(1.03)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C132(1.30); C149(1.11)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C132(1.15); C149(0.86)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C149(0.98)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C149(0.96)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C132(1.03); C149(1.06)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C149(0.93)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C132(0.42); C149(2.84)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C132(0.74); C149(1.16)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C132(0.85); C149(1.59)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C132(1.07); C149(1.00)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C132(1.11); C149(1.00)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C132(1.12); C149(1.08)  LDD1698  [7]
 LDCM0625  F8 Ramos C132(1.32)  LDD2187  [15]
 LDCM0572  Fragment10 MDA-MB-231 C149(17.98)  LDD1465  [16]
 LDCM0573  Fragment11 MDA-MB-231 C149(20.00)  LDD1391  [16]
 LDCM0574  Fragment12 MDA-MB-231 C149(2.16)  LDD1393  [16]
 LDCM0575  Fragment13 MDA-MB-231 C149(1.48)  LDD1395  [16]
 LDCM0576  Fragment14 MDA-MB-231 C149(0.99)  LDD1397  [16]
 LDCM0579  Fragment20 MDA-MB-231 C149(3.69)  LDD1402  [16]
 LDCM0580  Fragment21 Ramos C132(0.42)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C132(0.38)  LDD2196  [15]
 LDCM0583  Fragment24 Ramos C149(1.16)  LDD1410  [16]
 LDCM0584  Fragment25 MDA-MB-231 C149(1.11)  LDD1411  [16]
 LDCM0578  Fragment27 MDA-MB-231 C149(0.91)  LDD1401  [16]
 LDCM0586  Fragment28 MDA-MB-231 C149(1.15)  LDD1415  [16]
 LDCM0587  Fragment29 MDA-MB-231 C149(1.35)  LDD1417  [16]
 LDCM0588  Fragment30 MDA-MB-231 C149(1.28)  LDD1419  [16]
 LDCM0589  Fragment31 MDA-MB-231 C149(1.70)  LDD1421  [16]
 LDCM0590  Fragment32 MDA-MB-231 C149(3.13)  LDD1423  [16]
 LDCM0468  Fragment33 MDA-MB-231 C149(1.77)  LDD1425  [16]
 LDCM0596  Fragment38 MDA-MB-231 C149(1.15)  LDD1433  [16]
 LDCM0597  Fragment39 MDA-MB-231 C149(11.39)  LDD1435  [16]
 LDCM0566  Fragment4 MDA-MB-231 C149(20.00)  LDD1378  [16]
 LDCM0598  Fragment40 MDA-MB-231 C149(0.92)  LDD1436  [16]
 LDCM0599  Fragment41 MDA-MB-231 C149(0.97)  LDD1438  [16]
 LDCM0601  Fragment43 MDA-MB-231 C149(6.06)  LDD1441  [16]
 LDCM0602  Fragment44 MDA-MB-231 C149(0.81)  LDD1443  [16]
 LDCM0603  Fragment45 MDA-MB-231 C149(20.00)  LDD1444  [16]
 LDCM0604  Fragment46 MDA-MB-231 C149(0.76)  LDD1445  [16]
 LDCM0607  Fragment49 MDA-MB-231 C149(6.42)  LDD1448  [16]
 LDCM0608  Fragment50 MDA-MB-231 C149(1.26)  LDD1449  [16]
 LDCM0427  Fragment51 MDA-MB-231 C149(3.52)  LDD1450  [16]
 LDCM0610  Fragment52 MDA-MB-231 C149(0.96)  LDD1452  [16]
 LDCM0611  Fragment53 MDA-MB-231 C149(0.90)  LDD1454  [16]
 LDCM0612  Fragment54 MDA-MB-231 C149(1.28)  LDD1456  [16]
 LDCM0614  Fragment56 MDA-MB-231 C149(1.15)  LDD1458  [16]
 LDCM0568  Fragment6 MDA-MB-231 C149(0.91)  LDD1382  [16]
 LDCM0569  Fragment7 MDA-MB-231 C149(20.00)  LDD1383  [16]
 LDCM0570  Fragment8 MDA-MB-231 C149(20.00)  LDD1385  [16]
 LDCM0571  Fragment9 MDA-MB-231 C149(1.43)  LDD1387  [16]
 LDCM0022  KB02 MDA-MB-231 C149(20.00)  LDD1374  [16]
 LDCM0023  KB03 MDA-MB-231 C149(2.81)  LDD1376  [16]
 LDCM0024  KB05 MDA-MB-231 C149(1.58)  LDD1380  [16]
 LDCM0109  NEM HeLa N.A.  LDD0227  [6]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C132(1.27)  LDD2089  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein CBFA2T2 (CBFA2T2) CBFA2T family O43439
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.