Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | C174 | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | Probe:50uM; negative probe:50uM | |||||
| Criteria | Quantification: AfBPP Probe vs Negative Probe | |||||
| Quantitative Method |
TMT
|
|||||
| In Vivo Experiment Model | Model Type |
|
Living cell | |||
| Derived Tissue |
|
Peripheral blood | ||||
| Disease Model | Normal | |||||
| Model Name | Human normal cells (HEK-293T) | |||||
| Note | Negative probe:C#CCCC1(CCC(NC)=O)N=N1 | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP11321 | Acetyl-CoA acetyltransferase, cytosolic (ACAT2) | 54.9 | ||||
| LDTP04689 | Adenosine kinase (ADK) | 25.6 | ||||
| LDTP09666 | Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) | 21.1 | ||||
| LDTP06150 | DNA replication licensing factor MCM6 (MCM6) | 20.7 | ||||
| LDTP09984 | Phosphorylase b kinase regulatory subunit beta (PHKB) | 16.8 | ||||
| LDTP02175 | Epoxide hydrolase 1 (EPHX1) | 16.2 | ||||
| LDTP04211 | Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) | 15.9 | ||||
| LDTP06375 | Delta(24)-sterol reductase (DHCR24) | 15.6 | ||||
| LDTP06648 | Lanosterol 14-alpha demethylase (CYP51A1) | 15.0 | ||||
| LDTP00697 | Cytochrome b5 type B (CYB5B) | 13.5 | ||||
| LDTP01687 | Apoptosis-inducing factor 1, mitochondrial (AIFM1) | 12.6 | ||||
| LDTP01329 | Lathosterol oxidase (SC5D) | 12.1 | ||||
| LDTP09110 | NAD(P)H-hydrate epimerase (NAXE) | 11.5 | ||||
| LDTP03159 | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) | 9.6 | ||||
| LDTP05476 | 3-ketodihydrosphingosine reductase (KDSR) | 9.2 | ||||
| LDTP03394 | Ceramide synthase 1 (CERS1) | 9.2 | ||||
| LDTP12960 | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) | 9.1 | ||||
| LDTP03257 | Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) | 8.9 | ||||
| LDTP03540 | Heme oxygenase 2 (HMOX2) | 8.6 | ||||
| LDTP06384 | Ribosomal protein S6 kinase alpha-1 (RPS6KA1) | 8.2 | ||||
| LDTP06618 | ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) | 7.9 | ||||
| LDTP01039 | Protein-S-isoprenylcysteine O-methyltransferase (ICMT) | 7.5 | ||||
| LDTP04712 | Puromycin-sensitive aminopeptidase (NPEPPS) | 7.5 | ||||
| LDTP13751 | Exonuclease 1 (EXO1) | 7.1 | ||||
| LDTP08933 | Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) | 6.9 | ||||
| LDTP12253 | Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) | 6.9 | ||||
| LDTP05447 | Dynamin-1 (DNM1) | 6.8 | ||||
| LDTP05758 | S-methyl-5'-thioadenosine phosphorylase (MTAP) | 6.7 | ||||
| LDTP06477 | Methylsterol monooxygenase 1 (MSMO1) | 6.6 | ||||
| LDTP04374 | Dynamin-2 (DNM2) | 6.1 | ||||
| LDTP00758 | Thioredoxin-like protein 1 (TXNL1) | 6.1 | ||||
| LDTP08246 | Telomerase-binding protein EST1A (SMG6) | 6.0 | ||||
| LDTP14904 | DNA-directed RNA polymerase I subunit RPA43 (POLR1F) | 5.9 | ||||
| LDTP00832 | NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) | 5.8 | ||||
| LDTP02713 | Macrophage migration inhibitory factor (MIF) | 5.7 | ||||
| LDTP03419 | Proteasome subunit beta type-5 (PSMB5) | 5.7 | ||||
| LDTP04471 | Ribosomal protein S6 kinase alpha-3 (RPS6KA3) | 5.6 | ||||
| LDTP12013 | dCTP pyrophosphatase 1 (DCTPP1) | 5.6 | ||||
| LDTP12279 | Endoplasmic reticulum transmembrane helix translocase (ATP13A1) | 5.5 | ||||
| LDTP05724 | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) | 5.4 | ||||
| LDTP04051 | Nicotinamide phosphoribosyltransferase (NAMPT) | 5.4 | ||||
| LDTP00890 | S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) | 5.3 | ||||
| LDTP07283 | E3 ubiquitin-protein ligase RNF213 (RNF213) | 5.0 | ||||
| LDTP13972 | Oligoribonuclease, mitochondrial (REXO2) | 5.0 | ||||
| LDTP14030 | V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) | 5.0 | ||||
| LDTP01803 | Adenosine deaminase (ADA) | 5.0 | ||||
| LDTP19745 | ADP-ribosylation factor-like protein 10 (ARL10) | 5.0 | ||||
| LDTP17410 | Cytochrome P450 20A1 (CYP20A1) | 5.0 | ||||
| LDTP10961 | BRCA1-associated RING domain protein 1 (BARD1) | 4.9 | ||||
| LDTP00886 | Nardilysin (NRDC) | 4.9 | ||||
| LDTP12720 | Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) | 4.9 | ||||
| LDTP12490 | Sphingosine kinase 2 (SPHK2) | 4.9 | ||||
Transporter and channel
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP04071 | Voltage-dependent anion-selective channel protein 2 (VDAC2) | 16.0 | ||||
| LDTP03132 | Voltage-dependent anion-selective channel protein 1 (VDAC1) | 15.7 | ||||
| LDTP14952 | Mpv17-like protein 2 (MPV17L2) | 14.9 | ||||
| LDTP06945 | Sigma intracellular receptor 2 (TMEM97) | 9.8 | ||||
| LDTP10913 | Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) | 8.7 | ||||
| LDTP01745 | Putative lipid scramblase CLPTM1 (CLPTM1) | 8.4 | ||||
| LDTP05900 | Metaxin-1 (MTX1) | 8.3 | ||||
| LDTP04033 | Translocon-associated protein subunit alpha (SSR1) | 6.9 | ||||
| LDTP11813 | Solute carrier family 25 member 32 (SLC25A32) | 6.8 | ||||
| LDTP00541 | NPC intracellular cholesterol transporter 1 (NPC1) | 6.4 | ||||
| LDTP06426 | Translocating chain-associated membrane protein 1 (TRAM1) | 6.4 | ||||
| LDTP09968 | V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) | 6.4 | ||||
| LDTP09547 | Scavenger receptor class B member 1 (SCARB1) | 6.3 | ||||
| LDTP03277 | ER lumen protein-retaining receptor 1 (KDELR1) | 6.0 | ||||
| LDTP08881 | Transmembrane protein 199 (TMEM199) | 5.9 | ||||
| LDTP17362 | Magnesium transporter NIPA3 (NIPAL1) | 5.9 | ||||
| LDTP11406 | Transmembrane protein 59 (TMEM59) | 5.7 | ||||
| LDTP00592 | Surfeit locus protein 4 (SURF4) | 5.4 | ||||
| LDTP10958 | Sigma non-opioid intracellular receptor 1 (SIGMAR1) | 5.3 | ||||
| LDTP11812 | Protein ARV1 (ARV1) | 5.0 | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP03520 | Phosphatidylethanolamine-binding protein 1 (PEBP1) | 16.9 | ||||
| LDTP15623 | Neuferricin (CYB5D2) | 13.6 | ||||
| LDTP15896 | Ashwin (C2orf49) | 11.8 | ||||
| LDTP16006 | Optic atrophy 3 protein (OPA3) | 9.1 | ||||
| LDTP15420 | Mitochondrial import receptor subunit TOM5 homolog (TOMM5) | 9.0 | ||||
| LDTP14486 | Clustered mitochondria protein homolog (CLUH) | 8.6 | ||||
| LDTP13902 | Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) | 8.4 | ||||
| LDTP03678 | ER lumen protein-retaining receptor 2 (KDELR2) | 8.2 | ||||
| LDTP05160 | Nucleobindin-2 (NUCB2) | 7.8 | ||||
| LDTP01652 | Centrosomal protein 43 (CEP43) | 7.2 | ||||
| LDTP12565 | Mitochondrial import receptor subunit TOM22 homolog (TOMM22) | 6.9 | ||||
| LDTP08000 | Dymeclin (DYM) | 6.8 | ||||
| LDTP13086 | Syntaxin-18 (STX18) | 6.3 | ||||
| LDTP11076 | Apolipoprotein L2 (APOL2) | 6.1 | ||||
| LDTP13946 | U6 snRNA-associated Sm-like protein LSm2 (LSM2) | 6.1 | ||||
| LDTP00105 | Protein unc-119 homolog B (UNC119B) | 6.0 | ||||
| LDTP11239 | Protein misato homolog 1 (MSTO1) | 5.7 | ||||
| LDTP01608 | Proteasome assembly chaperone 1 (PSMG1) | 5.6 | ||||
| LDTP15067 | Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) | 5.5 | ||||
| LDTP08073 | Tetratricopeptide repeat protein 21B (TTC21B) | 5.4 | ||||
| LDTP06051 | Kelch-like ECH-associated protein 1 (KEAP1) | 5.3 | ||||
| LDTP00887 | Calumenin (CALU) | 5.1 | ||||
| LDTP13828 | Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) | 5.1 | ||||
| LDTP03615 | Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) | 5.1 | ||||
| LDTP01522 | Reticulon-3 (RTN3) | 5.0 | ||||
| LDTP09881 | TATA-binding protein-associated factor 2N (TAF15) | 5.0 | ||||